Cankon Germiyanoğlu

Publications (40)67.66 Total impact

• Article: Ginkgo biloba (EGB 761) affects apoptosis and nitric-oxide synthases in testicular torsion: an experimental study

  Turgay Akgül, Ersagun Karagüzel, Hatice Sürer, Hatice Yağmurdur, Ali Ayyıldız, Hüseyin Üstün, Cankon Germiyanoğlu
  [show abstract] [hide abstract]
  ABSTRACT: IntroductionWe investigated the effect of ginkgo biloba on germ cell apoptosis and also on expressions of endothelial (eNOS) and inducible (iNOS) nitric oxide synthases after testicular torsion. Materials and methodsThirty-two Wistar albino rats were randomly assigned into four groups. Torsion/detorsion (T/D) was performed on the rats in group 1, group 2 received ginkgo biloba for a month before T/D, group 3 received only gingko biloba for a month, and group 4 was the sham group. Left testicular torsion was created in group 1 and group 2, and the testes were untwisted and replaced in the scrotum for reperfusion. No procedure was applied to group 3, and after 1 month, testes were removed in all groups. ResultsMean apoptotic cell, eNOS, and iNOS were increased in group 1. Group 2 showed significantly decreased apoptotic cells, eNOS, and iNOS in testes compared to group 1 (P<0.05). The rats in group 3 had significantly decreased apoptotic cell, eNOS, and iNOS values, like the sham group (P<0.05), and this group provided basal values. ConclusionsGinkgo biloba, as a free radical scavenger, seems to have a protective role against apoptosis in testicular ischemia reperfusion injury.
  International Urology and Nephrology 04/2012; 41(3):531-536. · 1.47 Impact Factor
• Article: Do hydronephrosis and extracorporeal shock wave lithotripsy affect carbohydrate antigens?

  Turgay Akgül, Barış Nuhoğlu, Ali Ayyıldız, Uğur Balcı, Sema Nur Ayyıldız, Cankon Germiyanoğlu
  [show abstract] [hide abstract]
  ABSTRACT: ObjectivesTo investigate carbohydrate antigen (CA 19-9, CA 15-3, and CA 125) levels in the patients who had hydronephrosis with renal stones and in whom Extracorporeal shock wave lithotripsy (ESWL) was performed. Materials and MethodsThis prospective study included 20 people with no known disease for control group and 30 patients who had hydronephrosis with renal stones and in whom ESWL was performed between January 2005 and January 2006. None of patients had urinary infection and malignancy. The blood for carbohydrate antigens was taken pre-ESWL and 30min after ESWL in both groups. CA 19-9, CA 15-3, and CA 125 in the serum were tested with the electro-immunoassay method on the Roche® E-170 apparatus with the original Roche® kit. ResultsThe CA 19-9 and CA 125 values in the patients group were found to be statistically significant when compared with the control group but the CA 15-3 was not found to be significant. However, CA 19-9, CA 15-3, and CA 125 values of post-ESWL were not statistically significant when compared with pre-ESWL group (P>0.05). ConclusionsThe average serum values of CA 125 and CA 19-9 in patients were found to be significantly high. However, serum values of CA 19-9, CA 15-3, and CA 125 were not affected by ESWL.
  International Urology and Nephrology 04/2012; 39(4):1001-1004. · 1.47 Impact Factor
• Article: Comparison of transurethral prostate resection and plasmakinetic prostate resection according to cautery artefacts in tissue specimens

  K. Turgay Akgül, Ali Ayyıldız, Barış Nuhoğlu, Muzaffer Çaydere, Hüseyin Üstün, Cankon Germiyanoğlu
  [show abstract] [hide abstract]
  ABSTRACT: ObjectivesThe objectives were to evaluate cautery artifacts histopathologically in tissue specimens after plasmakinetic prostate resection (PKRP) and transurethral prostatectomy (TURP), and compare the results of the two procedures. Materials and MethodsThe histopathological specimens of 65 patients who underwent PKRP and TURP were examined retrospectively. Tissue chips for examination were selected randomly. Artifactual pathological patterns that were identified in the specimens included: abnormal cellular orientation and spindling, artifactual cellular detachment from the underlying basement membrane, atypical cytological changes and stromal coagulative necrosis. Each pattern identified was awarded 1 point. The severity of the cautery artefact was graded as absent, mild, moderate or severe according to the sum of points in each specimen. ResultsIn TURP, the artefacts were graded absent (9%), mild (6%), moderate (18.7%), and severe (65.6%) changes. In PKRP, the artefacts were graded absent (6%), mild (18.1%), moderate (36.3%), and severe (39.4%) changes. While the number of mild and moderate artefacts observed was higher in PKRP (P=0.023), severe artefacts were observed in higher numbers with TURP (P=0.034). No prostate cancer was detected during the follow-up period. ConclusionsIt has been observed that the application of TURP causes fewer mild to moderate artefacts and PKRP causes fewer severe artefacts in the histopathological evaluation of specimens in comparison to each other.
  International Urology and Nephrology 04/2012; 39(4):1091-1096. · 1.47 Impact Factor
• Article: A very unusual anatomical variation and complication of common iliac artery and ureter in retroperitonoscopic ureterolithotomy.

  Emre Huri, Turgay Akgül, Tolga Karakan, Mustafa Sargon, Cankon Germiyanoğlu
  [show abstract] [hide abstract]
  ABSTRACT: Anatomical localization of theureter comes along psoas major muscle and crosses over common iliac artery bifurcation. Common iliac artery aneurysm and impacted atherosclerosis are a rare condition that should be differed from the impacted ureter stone to avoid from undesirable complication. In this case, we present a very unusual anatomical variation and complication of common iliac artery and ureter in retroperitonoscopic ureterolithotomy.
  Journal of Minimal Access Surgery 04/2011; 7(2):145-6.
• Article: Phosphodiesterase 5 inhibitors attenuate renal tubular apoptosis after partial unilateral ureteral obstruction: an experimental study.

  Turgay Akgül, Emre Huri, Hatice Yagmurdur, Ali Ayyıldız, Hüseyin Ustün, Cankon Germiyanoğlu
  [show abstract] [hide abstract]
  ABSTRACT: The aim of the present study was to evaluate the effects of phosphodiesterase 5 inhibitors on renal tubular apoptosis and also on expressions of endothelial and inducible nitric oxide synthases (eNOS and iNOS) in the ipsilateral kidney after partial unilateral ureteral obstruction (PUUO) in a rat model. Forty Wistar albino rats were divided into five groups. In Groups 1-4, left experimental PUUO was created. Sildenafil, vardenafil, and tadalafil were administrated to the rats of Groups 2-4, respectively. The pills were orally given to the rats for 30 days. Group 5 was defined as sham. After 30 days, all rats were sacrificed, and nephrectomy was performed. The renal specimens were examined histopathologically. Left hydroureteronephrosis was observed in Groups 1-4. Mean apoptotic cell count and eNOS and iNOS levels were significantly increased in Group 1 when compared with the other groups. The rats in Groups 2-4 showed significantly decreased apoptotic cell count and eNOS and iNOS values in the renal tubular tissue in accordance with Group 1 (p<0.05). There were significant differences in apoptotic cell counts between sildenafil group and the other two study groups. The sildenafil group demonstrated lesser apoptotic cell count than the vardenafil (p=0.021) and tadalafil (p=0.009) groups. PUUO increases the renal tubular apoptosis and elevates NOS concentrations in renal tubular tissue after PUUO. Phosphodiesterase 5 inhibitors have a protective effect against the tubular apoptosis.
  The Kaohsiung journal of medical sciences 01/2011; 27(1):15-9. · 0.61 Impact Factor
• Article: First clinical experience of Ankaferd BloodStopper as a hemostatic agent in partial nephrectomy.

  Emre Huri, Turgay Akgül, Ali Ayyildiz, Murat Bağcioğlu, Cankon Germiyanoğlu
  [show abstract] [hide abstract]
  ABSTRACT: Open partial nephrectomy is an effective and safe alternative treatment modality to radical nephrectomy for small renal tumors. Many techniques that use hemostatic agents have been described to provide hemostasis during this procedure. Ankaferd BloodStopper® (ABS) is a unique folkloric medicinal plant extract that has been used historically in Turkish traditional medicine as a hemostatic agent. ABS has therapeutic potential to manage hemorrhage and this agent should be investigated in clinical trials. In the present case, we evaluated the effectiveness of ABS in partial nephrectomy and reviewed the literature.
  The Kaohsiung journal of medical sciences 09/2010; 26(9):493-5. · 0.61 Impact Factor
• Article: Re: Effect of Suturing Technique and Urethral Plate Characteristics on Complication Rate Following Hypospadias Repair: A Prospective Randomized Study.

  Emre Huri, Turgay Akgül, Cankon Germiyanoğlu
  The Journal of urology 03/2010; · 4.02 Impact Factor
• Article: Re: The incidence of disorders of sexual differentiation and chromosomal abnormalities of cryptorchidism and hypospadias stratified by meatal location. M. J. Cox, D. E. Coplen and P. F. Austin. J Urol 2008; 180: 2649-2652.

  Cankon Germiyanoğlu, Emre Huri, Erim Ersoy
  The Journal of urology 08/2009; 182(1):398. · 4.02 Impact Factor
• Article: Hemostatic role of a folkloric medicinal plant extract in a rat partial nephrectomy model: controlled experimental trial.

  Emre Huri, Turgay Akgül, Ali Ayyildiz, Hüseyin Ustün, Cankon Germiyanoğlu
  [show abstract] [hide abstract]
  ABSTRACT: Ankaferd BloodStopper is a mixture of 5 plants used in traditional Turkish medicine as hemostatic agent for external traumatic, postoperative and dental bleeding. We investigated the hemostatic efficacy of Ankaferd BloodStopper for partial nephrectomy. A total of 24 Wistar rats were divided into 4 groups of 6 each. Group 1 underwent partial nephrectomy with hilar control as the conventional technique. Group 2 underwent the conventional technique with hemostatic agent application. Group 3 underwent hemostatic agent application to the renal parenchyma. In Group 4 partial nephrectomy was performed and the hemostatic agent was used without hilar control. Warm ischemia and partial nephrectomy times, and the number of hemostatic agent applications were recorded. Histopathological evaluations were completed. The Fisher, Kruskal-Wallis and Mann-Whitney U tests were used for statistical analysis. Mean kidney size was 2 x 2.5 x 0.05 cm. Mean partial nephrectomy time was 3.7, 2.7, 1.8 and 3.2 minutes in groups 1 to 4, respectively, which was significantly different between groups 1 and 3 (p = 0.007). Warm ischemia time in group 3 was less than in group 1 (p = 0.011). The number of hemostatic agent applications was higher in groups 3 and 4 compared to those in group 2 (p = 0.003). Glomerular necrosis was detected at a higher rate in group 1 compared to that in groups 3 and 4 (p = 0.015). Calcification formed significantly more in group 1 than in groups 2 to 4 (p <0.05). Erythrocyte aggregation was greater in groups 2 to 4 than in group 1 (p = 0.015). Giant cell reaction, fibrosis, inflammation and microvascular proliferation were not statistically different among the groups (p >0.05). Ankaferd BloodStopper decreases partial nephrectomy and warm ischemia times, and provides hemostasis. Erythrocyte aggregation confirmed the hemostatic action of the agent, while the absence of glomerular necrosis and calcification may have positive relevance.
  The Journal of urology 03/2009; 181(5):2349-54. · 4.02 Impact Factor
• Article: An in vitro study comparing the coagulation and cautery effects of bipolar and unipolar cutting modalities on prostatic tissue.

  Turgay Akgül, Bariş Nuhoğlu, Osman Polat, Ali Ayyildiz, Müzeyyen Astarci, Cankon Germiyanoğlu, Hüseyin Ustün
  [show abstract] [hide abstract]
  ABSTRACT: We aimed to compare plasmakinetic prostate resection (PKRP), plasmakinetic prostate vaporization (PKVP) and transurethral prostate resection (TURP) procedures according to cautery artifacts in tissue specimens and to compare the coagulation depths of these procedures. The prostate specimens of 10 patients that underwent open transvesical prostatectomy were used. TURP, PKVP and PKRP procedures were performed immediately. Artifactual pathological patterns that were identified in the specimens included: abnormal cellular orientation and spindling, artifactual cellular detachment from the underlying basement membrane, atypical cytological changes and stromal coagulative artifacts. The severity of cautery artifact was graded as absent, mild, moderate or severe according to the sum of points in each specimen. When the groups were compared according to moderate and severe artifacts, it was observed that PKRP caused more moderate artifacts and TURP caused more severe artifacts than the other two groups (p < 0.05). The depth of the tissue affected by coagulation was 1.52 +/- 1.29 mm with the TURP procedure. There were significant differences between TURP and the other two methods (p < 0.05). Three transurethral procedures cause cautery artifacts of varying grades. The application of TURP seems to cause more severe artifacts and PKRP and PKVP procedures seem to result in a deeper coagulation zone in the residual prostatic tissue.
  Urologia Internationalis 01/2009; 83(4):458-62. · 0.99 Impact Factor
• Article: Effect of tadalafil on renal resistivity and pulsatility index in partial ureteral obstruction.

  Ali Ayyildiz, Mahir Kaya, Ersagun Karaguzel, Ali Bumin, Turgay Akgul, Zeki Aklan, Cankon Germiyanoğlu
  [show abstract] [hide abstract]
  ABSTRACT: To investigate the effect of tadalafil on Resistivity Index (RI) and Pulsatility Index (PI) in partial unilateral ureteral obstruction (PUUO). Twelve New Zealand rabbits were assigned into two groups. Baseline renal Doppler ultrasonography (USG) was performed in all rabbits. The rabbits in group 1 received tadalafil for a month (10 mg/72 h) and group 2 was defined as sham. After 1 month, in both groups left PUUO was created. Renal Doppler USG was performed to measure RI and PI parameters of both kidneys on the 4th hour and 1st and 3rd days postoperatively. Baseline renal Doppler USG revealed that there was no difference between two kidneys in both groups. The differences in mean RI and PI values of the kidneys between the sham and tadalafil groups were not statistically significant. Compared with the preoperative values, postoperative RI and PI values for the left kidneys were significantly increased in the period from 4 h to 3 days postoperatively in the sham group (p < 0.05). However, mean RI and PI values were not increased in the tadalafil group when compared with the sham group and this difference between the two groups was significant (p < 0.05). Tadalafil has a lowering affect on RI and PI in experimentally created PUUO.
  Urologia Internationalis 01/2009; 83(1):75-9. · 0.99 Impact Factor
• Article: Effect of cyanoacrylic glue on penile fracture: an experimental study.

  Turgay Akgül, Ali Ayyildiz, Ozden Cebeci, Bariş Nuhoğlu, Elif Ozer, Cankon Germiyanoğlu, Hüseyin Ustün
  [show abstract] [hide abstract]
  ABSTRACT: We investigated the effect of Glubran(R)2 cyanoacrylic glue on rat cavernous tissue after forming penile fractures experimentally as well as the histopathological effect. We also investigated its clinical use. Experimental penile fracture was formed by incising from the proximal dorsal side of the penis in 32 Wistar Albino rats. The rats were randomly assigned to 4 main groups of 8 each. In the control group the incision was not repaired and it was left to secondary healing. In the glue group cyanoacrylic glue was only applied to the incision region. In the primary repair group the incision was primarily repaired and in the final group cyanoacrylic glue was applied to the incision region following primary repair. Three weeks later penectomy materials were examined histopathologically. When the control group was compared with the other groups, the differences in cavernous tissue healing with fibrosis and hyperemia-bleeding were statistically significant (p = 0.043 and 0.003, respectively). In the glue group fibrosis was observed in 2 rats. This group was the best according to cavernous healing. Although there was no significant difference between the control group and the other groups according to inflammation (p = 0.057), the glue group was better than the primary repair group (p = 0.026). No significant inflammation or hyperemia-bleeding was observed in the glue group. When the experimental groups were evaluated for histopathological parameters, it was observed that the best results were obtained in the glue group. Cyanoacrylic glue can be used in cavernous surgery due to its hemostatic, adhesive and anti-inflammatory properties.
  The Journal of urology 09/2008; 180(2):749-52. · 4.02 Impact Factor
• Article: Ginkgo biloba (EGb 761) usage attenuates testicular injury induced by testicular ischemia/reperfusion in rats

  Turgay Akgül, Ali Ayyıldız, Barış Nuhoğlu, Ersagun Karagüzel, Elmas Öğüş, Hatice Yağmurdur, Hüseyin Üstün, Cankon Germiyanoğlu
  [show abstract] [hide abstract]
  ABSTRACT: IntroductionWe investigated the effect of ginkgo biloba on testicular ischemia-reperfusion (IR) injury. Materials and methodsThirty-two Wistar Albino rats were randomly assigned into four groups. Torsion/detorsion (T/D) performed to the rats in group 1, group 2 received ginkgo biloba (50mg/day) for a month before T/D, group 3 received only gingko biloba (50mg/day) for a month and group 4 was defined as sham group. After 1month the testes were removed. ResultsMean testicular malondialdehyde, nitrate and nitrite levels were significantly increased in group 1 compared to groups 2, 3 and 4 (P<0.05). The rats in group 3 provided basal histological appearance. In group 1, edema, congestion and hemorrhage between seminiferous tubules were predominant. In group 2, histopathologic features were markedly less than group 1. ConclusionsMalondialdehyde, nitrate and nitrite levels were increased after unilateral testicular torsion. EGb 761 has a protective effect on testicular injury induced by IR.
  International Urology and Nephrology 08/2008; 40(3):685-690. · 1.47 Impact Factor
• Article: Effect of phospodiesterase 5 inhibitors on apoptosis and nitric oxide synthases in testis torsion: an experimental study.

  Hüseyin Ustün, K Turgay Akgül, Ali Ayyildiz, Hatice Yağmurdur, Bariş Nuhoğlu, Ersagun Karagüzel, Elmas Oğüş, Cankon Germiyanoğlu
  [show abstract] [hide abstract]
  ABSTRACT: To investigate the effects of phosphodiesterase (PDE) 5 inhibitors, sildenafil citrate and vardenafil HCl, on testicular germ cell apoptosis and also on the expressions of eNOS and iNOS within the bilateral testis after a unilateral torsion in a rat model. Forty-eight Wistar Albino rats, weighing between 210 and 262 g, were housed in individual cages. The rats were randomly assigned into four main groups and each group received drugs. Saline, sildenafil citrate and vardenafil HCl were given to each for 1 month and the last received no drug. After 1 month, testicular torsion was created for 1 h of ischemia and the left testis was untwisted and replaced to the scrotum for 2 h of reperfusion. At the end of 3 h, contralateral and ipsilateral testes were removed for histopathologic and biochemical examinations. Under light microscopy; the histopathological patterns of the contralateral testes in all groups were not affected. Mean apoptotic cell, eNOS and iNOS levels were increased in saline study group. The rats treated with vardenafil and sildenafil (groups 2s and 3s) showed significantly increased apoptotic cell, eNOS and iNOS values in ipsilateral testis (P < 0.05). Sildenafil citrate and vardenafil HCl caused an exaggerated testicular apoptosis after IR injury in rats. Additionally these drugs increased the NOSs levels in the testicular tissue.
  Pediatric Surgery International 02/2008; 24(2):205-11. · 1.25 Impact Factor
• Article: Effect of phospodiesterase 5 inhibitors on apoptosis and nitric oxide synthases in testis torsion: an experimental study

  Hüseyin Üstün, K. Turgay Akgül, Ali Ayyıldız, Hatice Yağmurdur, Barış Nuhoğlu, Ersagun Karagüzel, Elmas Öğüş, Cankon Germiyanoğlu
  [show abstract] [hide abstract]
  ABSTRACT: To investigate the effects of phosphodiesterase (PDE) 5 inhibitors, sildenafil citrate and vardenafil HCl, on testicular germ cell apoptosis and also on the expressions of eNOS and iNOS within the bilateral testis after a unilateral torsion in a rat model. Forty-eight Wistar Albino rats, weighing between 210 and 262g, were housed in individual cages. The rats were randomly assigned into four main groups and each group received drugs. Saline, sildenafil citrate and vardenafil HCl were given to each for 1month and the last received no drug. After 1month, testicular torsion was created for 1h of ischemia and the left testis was untwisted and replaced to the scrotum for 2h of reperfusion. At the end of 3h, contralateral and ipsilateral testes were removed for histopathologic and biochemical examinations. Under light microscopy; the histopathological patterns of the contralateral testes in all groups were not affected. Mean apoptotic cell, eNOS and iNOS levels were increased in saline study group. The rats treated with vardenafil and sildenafil (groups 2s and 3s) showed significantly increased apoptotic cell, eNOS and iNOS values in ipsilateral testis (P<0.05). Sildenafil citrate and vardenafil HCl caused an exaggerated testicular apoptosis after IR injury in rats. Additionally these drugs increased the NOSs levels in the testicular tissue.
  Pediatric Surgery International 01/2008; 24(2):205-211. · 1.25 Impact Factor
• Source

  Available from: urologyjournal.org

  Article: Comparison of sertraline and citalopram for treatment of premature ejaculation.

  Turgay Akgül, Tolga Karakan, Ali Ayyildiz, Cankon Germiyanoğlu
  [show abstract] [hide abstract]
  ABSTRACT: We evaluated the efficacy of citalopram and sertraline in the treatment of premature ejaculation (PE). Of 101 married men with PE, 80 were eligible and consented to participate in this randomized controlled trial. Erectile dysfunction and administration of drugs for the treatment of PE were the exclusion criteria. The patients were evaluated using index of premature ejaculation (IPE) questionnaire and were randomly assigned into groups 1 (sertraline) and 2 (citalopram). They received one of these drugs for 8 weeks and then were re-evaluated by the IPE. Pretreatment and posttreatment results were compared within and between the study groups. A total of 80 patients entered and completed the study. The mean age of the patients was 38.4 +/- 7.7 in group 1 and 37.5 +/- 6.9 in group 2 (P = .60). The mean pretreatment IPE scores were 21.4 +/- 1.8 and 20.9 +/- 1.3 in the patients of groups 1 and 2, respectively (P = .23). After 8 weeks, significant improvement was seen in both groups in terms of the IPE questionnaire results (39.8 +/- 1.4; P < .001 and 39.5 +/- 2.9; P < .001, respectively). However, the treatment response was not different between the 2 groups (P = .50). No serious adverse effects were detected in any of the patients and both drugs were tolerated well. Citalopram and sertraline are safe and effective in patients with PE. Additionally, we failed to find any difference between the effects of these two drugs in the treatment of this condition.
  Urology journal 01/2008; 5(1):41-5. · 0.58 Impact Factor
• Article: Lower urinary tract symptoms, prostate volume, uroflowmetry, residual urine volume and bladder wall thickness in Turkish men: a comparative analysis

  Levent Işıkay, K. Turgay Akgül, Barış Nuhoğlu, Gürhan Özdemir, Ali Ayyıldız, Taner Çavumirza, Cankon Germiyanoğlu
  [show abstract] [hide abstract]
  ABSTRACT: Aim To evaluate the association between lower urinary tract symptoms (LUTS) severity and bladder wall thickness (BWT). Materials and methods The study included 155 patients referred to outpatient clinics for LUTS. Patients were divided into three groups due to their IPSS. Group A included the patients with mild symptoms, group B included patients with moderate symptoms and group C included patients with severe symptoms. The patients were again divided into two groups due to their uroflowmetry results. Group 1 included the patients whose Q max≤10ml/s and group 2 included the patients whose Q max>10ml/s. Results The mean BWT was 4.14+1.03mm (from 3 to 9mm). Although there was no difference between the IPSS groups in BWT (P=0.325), it was statistically significant between uroflowmetry study groups (P<0.01). Conclusions BWT seems to be significantly increased in men who have Q max values smaller than 10ml/s.
  International Urology and Nephrology 11/2007; 39(4):1131-1135. · 1.47 Impact Factor
• Article: Ginkgo biloba (EGb 761) usage attenuates testicular injury induced by testicular ischemia/reperfusion in rats.

  Turgay Akgül, Ali Ayyildiz, Bariş Nuhoğlu, Ersagun Karagüzel, Elmas Oğüş, Hatice Yağmurdur, Hüseyin Ustün, Cankon Germiyanoğlu
  [show abstract] [hide abstract]
  ABSTRACT: We investigated the effect of ginkgo biloba on testicular ischemia-reperfusion (IR) injury. Thirty-two Wistar Albino rats were randomly assigned into four groups. Torsion/detorsion (T/D) performed to the rats in group 1, group 2 received ginkgo biloba (50 mg/day) for a month before T/D, group 3 received only gingko biloba (50 mg/day) for a month and group 4 was defined as sham group. After 1 month the testes were removed. Mean testicular malondialdehyde, nitrate and nitrite levels were significantly increased in group 1 compared to groups 2, 3 and 4 (P<0.05). The rats in group 3 provided basal histological appearance. In group 1, edema, congestion and hemorrhage between seminiferous tubules were predominant. In group 2, histopathologic features were markedly less than group 1. Malondialdehyde, nitrate and nitrite levels were increased after unilateral testicular torsion. EGb 761 has a protective effect on testicular injury induced by IR.
  International Urology and Nephrology 11/2007; 40(3):685-90. · 1.47 Impact Factor
• Article: Intraurethral honey application for urethral injury: an experimental study

  Ali Ayyıldız, K. Turgay Akgül, Özden Cebeci, Barış Nuhoğlu, Muzaffer Çaydere, Hüseyin Üstün, Cankon Germiyanoğlu
  [show abstract] [hide abstract]
  ABSTRACT: ObjectivesTo evaluate the effect of honey applied intraurethrally after urethral injury on histopathological healing. Materials and MethodsA total of Wistar male rats were used. The rats were divided into four groups: control (Group 1), sham (Group 2), 1week honey applied group (Group 3) and 3weeks honey applied group (Group 4). The urethral damage was caused with a 29 G needle. In sham group, only intraurethral saline solution was given, and 10% of honey was applied to rats in Groups 3 and 4 intraurethrally. After killing, penile tissues were investigated under a light microscopy. ResultsThe irregularities of urethral epithelium and connective tissue were observed in Group 1. Also narrowing of lumen was present in control group rats except one rat in which no inflammation and total healing were observed. Hyperemia–bleeding was found in whole rats. In Group 2, there were irregularities in urethral epithelium and connective tissue. Total healing was observed in one rat. In Group 3, while regularity in urethral epithelium was present in six rats, inflammation and fibrosis was absent in rats. In Group 4, inflammation and fibrous tissue accumulation were not observed in rats. ConclusionsIntraurethral honey, applied after urethral injury, prevents inflammation, accelerates urethral healing and provides perfect healing.
  International Urology and Nephrology 08/2007; 39(3):815-821. · 1.47 Impact Factor
• Article: Spontaneous rupture and emergency repairment of the renal pelvis.

  Emre Huri, Ali Ayyildiz, Baris Nuhoğlu, Cankon Germiyanoğlu
  [show abstract] [hide abstract]
  ABSTRACT: A case of spontaneous rupture of the renal pelvis is very rare and unusual occurrence. Our case was a young woman who did not present with any disease that was a factor for pelvic rupture. The diagnosis was confirmed by abdominopelvic CT, and emergency repair of the renal pelvis was performed and a ureteral stent was inserted. Appropriate antibiotherapy was ordered, and the recovery was rapid. The differential diagnosis of this ease is discussed and the literature is reviewed:
  International Urology and Nephrology 02/2007; 39(2):413-5. · 1.47 Impact Factor