Massimo Marroni

Publications (12)29.28 Total impact

• Article: Functional defect of natural immune system in an apparent immunocompetent patient with pulmonary cryptococcosis.

  Massimo Marroni, Eva Pericolini, Elio Cenci, Francesco Bistoni, Anna Vecchiarelli
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  ABSTRACT: We report a case of pulmonary cryptococcosis in a 21-year-old Italian female smoker with no apparent immune disorder. In this study we demonstrated that: (i) patient's neutrophils and monocytes manifested a significant reduction of killing activity against Cryptococcus neoformans as well as Candida albicans; (ii) the suppression was more pronounced in monocytes than in neutrophils; (iii) neutrophils and monocytes showed a significant impairment of TNF-alpha, IL-1beta, and nitric oxide production. These results suggest that the apparent immunocompetent host with pulmonary cryptococcosis could have specific defects in natural immune system mechanisms.
  The Journal of infection 02/2007; 54(1):e5-8. · 4.13 Impact Factor
• Article: Vancomycin-resistant Enterococcus faecium osteoarthritis following Staphylococcus aureus hip infection.

  Maria Bruna Pasticci, Franco Baldelli, Lisa Malincarne, Giovanni Battista Mancini, Massimo Marroni, Sabrina Morosi, Giuliano Stagni
  Orthopedics 01/2006; 28(12):1457-8. · 2.66 Impact Factor
• Article: [Nosocomial post-neurosurgery meningitis due to Corynebacterium jeikeium].

  Sabrina Morosi, Massimo Marroni, Ada Maristella Egidi, Giuliano Stagni
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  ABSTRACT: Among the post neurosurgery infections the meningitis due to Corynebacterium jeikeium are rare, particularly without central nervous system devices. We report a case of a 78 year-old patient with chronic myeloproliferative syndrome, who developed an acute meningeal syndrome by Corynebacterium jeikeium post hypophyseal macroadenoma resection.
  Recenti progressi in medicina 07/2005; 96(6):291-2.
• Article: Thoracic aortic graft infection after disseminated tuberculosis.

  Massimo Marroni, Piergiorgio Cao, Fabio Verzini, Paolo Corneli, Rosanna Mazzola, Giuliano Stagni
  The Lancet Infectious Diseases 05/2005; 5(4):251. · 17.39 Impact Factor
• Article: Pulsed field gel electrophoresis and random amplified polymorphic DNA molecular characterization of Ralstonia pickettii isolates from patients with nosocomial central venous catheter related bacteremia.

  Maria Bruna Pasticci, Franco Baldelli, Romina Camilli, Gianluigi Cardinali, Antonietta Colozza, Massimo Marroni, Sabrina Morosi, Annalisa Pantosti, Lucia Pitzurra, Antonella Repettos, Francesco Bistoni, Giuliano Stagni
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  ABSTRACT: Over a period of 18 months 3 clusters of central venous catheter-related Ralstonia pickettii bacteremia occurred in 3 different units of the same hospital. In order to investigate the relatedness of the clinical isolates we studied 15 strains using pulsed-field gel electrophoresis (PFGE) and randomly amplified polymorphic DNA (RAPD) techniques. The combined analysis of the results obtained by these two methods led us to conclude that all the patients except one were infected by a single clone comprising two variants circulating in the units. Only one case was due to a different strain, probably originating outside the ward. PFGE and RAPD appear to be discriminatory techniques to study the clonal relationship among the isolates and can represent a good tool to perform the epidemiological investigation of an outbreak.
  The new microbiologica: official journal of the Italian Society for Medical, Odontoiatric, and Clinical Microbiology (SIMMOC) 05/2005; 28(2):145-9. · 1.00 Impact Factor
• Article: Acute transverse myelitis and hepatitis C virus.

  Pasquale Annunziata, Massimo Marroni, Daniela Francisci, Giuliano Stagni
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  ABSTRACT: In the last few years, substantial evidence has been provided on peripheral nervous involvement in infection by hepatitis C virus (HCV), whilst central nervous involvement is rare. Here, we report a case of acute transverse myelitis in a woman developing 4 years after documented HCV seropositivity, associated with intrathecal anti-HCV protein IgG. Isoelectrofocusing of all CSF samples before and after immunoabsorption with recombinant structural HCV proteins revealed disappearance or marked decrease of some oligoclonal IgG bands suggesting binding to HCV proteins. To our knowledge, this is the first report of acute myelitis associated with intrathecal immune response against HCV proteins. This finding suggests that in acute myelitis of unknown aetiology, testing CSF for HCV RNA and related antibodies is warranted.
  Le infezioni in medicina: rivista periodica di eziologia, epidemiologia, diagnostica, clinica e terapia delle patologie infettive 04/2005; 13(1):45-7.
• Article: Nosocomial Aspergillus flavus wound infections following cardiac surgery.

  Maurizio Florio, Massimo Marroni, Sabrina Morosi, Giuliano Stagni
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  ABSTRACT: In this report we describe three cases of Aspergillus flavus sternal wound infection following cardiac surgery. All three cases occurred in a 3-month period coinciding with hospital renovation activities. The patients were successfully treated with combined surgical and medical therapy.
  Le infezioni in medicina: rivista periodica di eziologia, epidemiologia, diagnostica, clinica e terapia delle patologie infettive 01/2005; 12(4):270-3.
• Article: [Nosocomial infections in a general surgical ward].

  Maurizio Fiorio, Massimo Marroni, Benedetto Tristaino, Loredana Capitanucci, Sandro Serafini, Giuseppe De Socio, Giuliano Stagni
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  ABSTRACT: According to the National Nosocomial Infection Surveillance system we analysed the post-surgical nosocomial infections in a surgery ward of Perugia University. Between May 2000 and April 2001, 677 patients were enrolled mean age 51.5 years: 355 (52%) male, 462 (68%) ASA score 1, "clean" surgery in 355 cases (52%), cephazolin prophylaxis in 256 (38%); 11 (2%) patients deceased perioperatively. A total of 37 nosocomial infections, in 33 patients, were detected: 18 pneumonia (48.6%), 10 surgical site infections (27%) with 18 isolated: 12 gram-negative (E. coli 3, Acinetobacter baumannii 2, Providencia stuartii 2, Pseudomonas aeruginosa 2, Achromobacter spp. 1, Citrobacter freundii 1, Morganella morgani 1) and 6 gram-positive (Staphylococcus aureus meticillin resistant 3, Enterococcus faecalis 2, Streptococcus salivarius 1); 7 sepsis (19%) due to 7 gram-positive (S. aureus meticillin resistant 4, S. aureus meticillin susceptible 1, Staphylococcus coagulase negative 1, Clostridium spp 1), 2 urinary tract infections (5.4%). Patients without infections and with nosocomial infections spent in hospital 6.3 and 16.6 days respectively. We can image that in one year 53 surgical procedure were lost, with a lost gain of 79.500-291.500 euro/year.
  Recenti progressi in medicina 02/2004; 95(1):11-4.
• Article: [Nosocomial infections in vascular surgery: 1-year surveillance].

  Massimo Marroni, Maurizio Fiorio, Piergiorgio Cao, Gianbattista Parlani, Sabrina Morosi, Giuliano Stagni
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  ABSTRACT: Among the hospital related complications the nosocomial infections are a major source of problems, especially in the Intensive Care and in the Surgery Units. It has been clearly demonstrated that infection control programs, in Surgery Units, have a large benefit in the reduction of surgical site infections (SSIs) rates. The surveillance method, sponsored by the Centers for Diseases Control of Atlanta, is the most consolidated system and it is active since '70 years. We used this method in the Vascular Surgery Unit of Perugia Hospital. During a 12-month period, 668 consecutive patients were enrolled and followed, after surgery, for 30 days (without implantable devices) or 1 year (with prosthesis). A total of 14 (2.1%) patients had SSIs: 4 superficial, 4 deep, 6 organ-space. We isolated 13 pathogens: 8 gram-positive, 4 gram-negative, and one Candida albicians. The most prevalent pathogen isolated was Staphylococcus aureus methicillin-susceptible. This first positive experience will be used for further more generalized work involving the principal surgical Unit of the Umbria Region.
  Recenti progressi in medicina 11/2003; 94(10):430-3.
• Article: Primary brain abscess with Nocardia farcinica in an immunocompetent patient.

  Lisa Malincarne, Massimo Marroni, Claudio Farina, Guido Camanni, Marina Valente, Barbara Belfiori, Stefano Fiorucci, Piero Floridi, Angela Cardaccia, Giuliano Stagni
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  ABSTRACT: In this paper, we describe a case of an immunocompetent patient with cerebral nocardiosis. The onset was with loss of strength, paresthesia and focal epilepsy of the left arm. MRI showed on T2-weighted sequences a hyperintense central area of pus surrounded by a well-defined hypointense capsule and surrounding edema; on T1-weighted sequences a hypointense necrotic cavity with ring enhancement following administration of intravenous gadolinium. The patient underwent surgical excision of the abscess but culture from the specimen was negative. After 40 days of empirical antimicrobial therapy he developed neurological deterioration with focal epilepsy. A new MRI documented an enlargement of the hypointense lesion in the right frontal-parietal region. A second craniotomy with drainage of the abscess was performed; cultures yielded Nocardia farcinica. Therapy with trimethoprim/sulfamethoxazole, amikacin and meropenem was given for 35 days, and clinical and radiological improvement was observed. Home therapy was done with oral trimethoprim/sulfamethoxazole. Currently, 5 months from the second surgery, the patient can walk with support and no new episodes of epilepsy occurred. Side effects were absent from therapy. The MRI appearance of the brain lesion has improved, with a decrease in size, surrounding edema and ring enhancement.
  Clinical Neurology and Neurosurgery 06/2002; 104(2):132-5. · 1.58 Impact Factor
• Article: Outbreak of infusion-related septicemia by Ralstonia pickettii in the Oncology Department.

  Massimo Marroni, Maria Bruna Pasticci, Annalisa Pantosti, Maria Antonietta Colozza, Giuliano Stagni, Maurizio Tonato
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  ABSTRACT: Hospital acquired blood stream infection by Ralstonia pickettii in 9 cancer patients related to the heparin solution contamination used to flush the central venous catheter.
  Tumori 89(5):575-6. · 0.86 Impact Factor
• Article: Leishmaniasis in patients with chronic renal failure: a diagnostic and therapeutic challenge for the clinician.

  Paolo Maggi, Vito Gaudiano, Marina Valente, Angela Latorraca, Rocco L Cavaliere, Massimo Marroni, Angela M V Larocca, Giuliano Stagni, Teodoro Lopez, Giuseppe Pastore
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  ABSTRACT: The role of leishmaniasis in dialyzed or transplanted patients for chronic renal failure is generally neglected. In this study, the authors present a series of three cases of leishmaniasis (one visceral, one mucous and one muco-visceral) in patients with end-stage renal failure characterized by an atypical presentation and/or resistance to therapy. Two patients had an atypical infection: the first patient demonstrated a mucosal form, while the second had visceral and mucosal involvement. These two presentations are very rare and, to the best of our knowledge, other autoctonous disease cases have never been described in Italy. In the first patient, a cycle of oral itraconazole was scarcely effective and poorly tolerated, while treatment with 15% topical paromomycin sulfate was successful. Patients two and three failed to respond to meglumine antimonate and amphotericin B lipid complex. A second cycle with liposomal amphotericin B was effective in both cases. In addition, a superior safety profile for liposomal amphotericin B in comparison with the lipid complex amphotericin B was observed. These three cases highlight the problem of leishmaniasis in both renal transplanted and dialyzed patients and suggest that this infection could be far from infrequent in addition to being resistant to therapies. Leishmaniasis should be considered in the differential diagnosis of fevers of unknown origin and mucosal lesions in these patients, even in countries not at risk for mucosal leishmaniasis.
  Journal of nephrology 17(2):296-301. · 1.65 Impact Factor