A J Timperley

401 GSNA, Athens, Attiki, Greece

Are you A J Timperley?

Claim your profile

Publications (24)57.36 Total impact

  • Article: Benefits of using modern cementing techniques in the acetabulum: the Rim Cutter.
    [show abstract] [hide abstract]
    ABSTRACT: PURPOSE. To compare radiological records of 90 consecutive patients who underwent cemented total hip arthroplasty (THA) with or without use of the Rim Cutter to prepare the acetabulum. METHODS. The acetabulum of 45 patients was prepared using the Rim Cutter, whereas the device was not used in the other 45 patients. Postoperative radiographs were evaluated using a digital templating system to measure (1) the positions of the operated hips with respect to the normal, contralateral hips (the centre of rotation of the socket, the height of the centre of rotation from the teardrop, and lateralisation of the centre of rotation from the teardrop) and (2) the uniformity and width of the cement mantle in the 3 DeLee Charnley acetabular zones, and the number of radiolucencies in these zones. RESULTS. The study group showed improved radiological parameters and were closer to the anatomic centre of rotation both vertically (1.5 vs. 3.7 mm, p<0.001) and horizontally (1.8 vs. 4.4 mm, p<0.001) and had consistently thicker and more uniform cement mantles (p<0.001). There were 2 radiolucent lines in the control group but none in the study group. CONCLUSION. The Rim Cutter resulted in more accurate placement of the centre of rotation of a cemented prosthetic socket, and produced a thicker, more congruent cement mantle with fewer radiolucent lines.
    Journal of orthopaedic surgery (Hong Kong) 12/2012; 20(3):316-21.
  • Article: Revision total hip replacement using the cement-in-cement technique for the acetabular component: Technique and results for 60 hips.
    [show abstract] [hide abstract]
    ABSTRACT: The technique of femoral cement-in-cement revision is well established, but there are no previous series reporting its use on the acetabular side at the time of revision total hip replacement. We describe the technique and report the outcome of 60 consecutive acetabular cement-in-cement revisions in 59 patients at a mean follow-up of 8.5 years (5 to 12). All had a radiologically and clinically well-fixed acetabular cement mantle at the time of revision. During the follow-up 29 patients died, but no hips were lost to follow-up. The two most common indications for acetabular revision were recurrent dislocation (46, 77%) and to complement femoral revision (12, 20%). Of the 60 hips, there were two cases of aseptic loosening of the acetabular component (3.3%) requiring re-revision. No other hip was clinically or radiologically loose (96.7%) at the latest follow-up. One hip was re-revised for infection, four for recurrent dislocation and one for disarticulation of a constrained component. At five years the Kaplan-Meier survival rate was 100% for aseptic loosening and 92.2% (95% CI 84.8 to 99.6), with revision for any cause as the endpoint. These results support the use of cement-in-cement revision on the acetabular side in appropriate cases. Theoretical advantages include preservation of bone stock, reduced operating time, reduced risk of complications and durable fixation.
    Journal of Bone and Joint Surgery - British Volume 11/2012; 94(11):1482-6. · 2.83 Impact Factor
  • Article: Preservation of the original femoral cement mantle during the management of infected cemented total hip replacement by two-stage revision.
    [show abstract] [hide abstract]
    ABSTRACT: The removal of all prosthetic material and a two-stage revision procedure is the established standard management of an infected total hip replacement (THR). However, the removal of well-fixed femoral cement is time-consuming and can result in significant loss of bone stock and femoral shaft perforation or fracture. We report our results of two-stage revision THR for treating infection, with retention of the original well-fixed femoral cement mantle in 15 patients, who were treated between 1989 and 2002. Following partial excision arthroplasty, patients received local and systemic antibiotics and underwent reconstruction and re-implantation at a second-stage procedure, when the infection had resolved. The mean follow-up of these 15 patients was 82 months (60 to 192). Two patients had positive microbiology at the second stage and were treated with six weeks of appropriate antibiotics; one of these developed recurrent infection requiring further revision. Successful eradication of infection was achieved in the remaining 14 patients. We conclude that when two-stage revision is used for the treatment of peri-prosthetic infection involving a THR, a well-fixed femoral cement mantle can be safely left in situ, without compromising the treatment of infection. Advantages of this technique include a shorter operating time, reduced loss of bone stock and a technically more straightforward second-stage procedure.
    Journal of Bone and Joint Surgery - British Volume 03/2012; 94(3):322-7. · 2.83 Impact Factor
  • Article: Treatment of Crowe IV high hip dysplasia with total hip replacement using the Exeter stem and shortening derotational subtrochanteric osteotomy.
    [show abstract] [hide abstract]
    ABSTRACT: We evaluated all cases involving the combined use of a subtrochanteric derotational femoral shortening osteotomy with a cemented Exeter stem performed at our institution. With severe developmental dysplasia of the hip an osteotomy is often necessary to achieve shortening and derotation of the proximal femur. Reduction can be maintained with a 3.5 mm compression plate while the implant is cemented into place. Such a plate was used to stabilise the osteotomy in all cases. Intramedullary autograft helps to prevent cement interposition at the osteotomy site and promotes healing. There were 15 female patients (18 hips) with a mean age of 51 years (33 to 75) who had a Crowe IV dysplasia of the hip and were followed up for a mean of 114 months (52 to 168). None was lost to follow-up. All clinical scores were collected prospectively. The Charnley modification of the Merle D'Aubigné-Postel scores for pain, function and range of movement showed a statistically significant improvement from a mean of 2.4 (1 to 4), 2.3 (1 to 4), 3.4 (1 to 6) to 5.2 (3 to 6), 4.4 (3 to 6), 5.2 (4 to 6), respectively. Three acetabular revisions were required for aseptic loosening; one required femoral revision for access. One osteotomy failed to unite at 14 months and was revised successfully. No other case required a femoral revision. No postoperative sciatic nerve palsy was observed. Cemented Exeter femoral components perform well in the treatment of Crowe IV dysplasia with this procedure.
    Journal of Bone and Joint Surgery - British Volume 01/2011; 93(1):34-8. · 2.83 Impact Factor
  • Article: Properties of composite specimens of old and new bone cement.
    A Acharya, A J Timperley, A J C Lee
    [show abstract] [hide abstract]
    ABSTRACT: The most common cause of failure of a total hip replacement is aseptic loosening of an implant. In a number of cases, the cement-bone interface of at least one component is not compromised. In cases of aseptic cup loosening, removal of a well-fixed femoral stem may be undertaken to facilitate exposure of the acetabulum for cup revision, and the surgeon may choose to leave the functional cement-bone interfaces in the femur undisturbed. After cup revision, new cement is pressurized within the old cement mantle and a stem is cemented into this 'old-new cement' composite. Retaining the old cement mantle is an attractive option as it reduces the duration of surgery, minimizes bleeding, and preserves the bone stock. Excellent results have been shown with this technique of 'in-cement femoral revision' using a double-tapered polished stem. While considerable literature is available on the short- and long-term properties of PMMA bone cement, very little is known about the mechanical properties of old-new composite cement specimens where the old cement is more than a few days old. This paper tests the properties of such old-new composite specimens where the 'old' cement is aged between 3.3 and 17.7 years, better reflecting clinical situations.
    Proceedings of the Institution of Mechanical Engineers Part H Journal of Engineering in Medicine 01/2011; 225(1):86-93. · 1.21 Impact Factor
  • Source
    Article: The concentric all-polyethylene Exeter acetabular component in primary total hip replacement.
    [show abstract] [hide abstract]
    ABSTRACT: We report the outcome of the flangeless, cemented all-polyethylene Exeter acetabular component at a mean of 14.6 years (10 to 17) after operation. Of the 263 hips in 243 patients, 122 prostheses are still in situ; 112 patients (119 hips) have died, 18 hips have been revised, and three patients (four hips) were lost to follow-up. Radiographs at the final review were available for 110 of the 122 surviving hips. There were acetabular radiolucent lines in 54 hips (49%). Two acetabular components had migrated but neither patient required revision. The Kaplan-Meier survivorship at 15 years with 61 hips at risk with revision for any cause as the endpoint was 89.9% (95% confidence interval (CI) 84.6 to 95.2) and for aseptic loosening of the acetabular component or lysis 91.7% (95% CI 86.6 to 96.8). In 210 hips with a diagnosis of primary osteoarthritis, survivorship with revision for any cause as the endpoint was 93.2% (95% CI 88.1 to 98.3), and for aseptic loosening of the acetabular component 95.0% (95% CI 90.3 to 99.7). The cemented all-polyethylene Exeter acetabular component has an excellent long-term survivorship.
    Journal of Bone and Joint Surgery - British Volume 10/2010; 92(10):1351-5. · 2.83 Impact Factor
  • Source
    Article: The effect of the Rim Cutter on cement pressurization and penetration on cemented acetabular fixation in total hip arthroplasty: an in vitro study.
    [show abstract] [hide abstract]
    ABSTRACT: The Rim Cutter (Stryker Orthopedics, Mahwah, New Jersey) is a tool designed to cut a ledge inside the rim of the acetabulum, onto which a precisely trimmed, cemented, flanged cup can be fitted. The aim was to investigate the effect of the Rim Cutter on the intra-acetabular cement mantle pressure and the depth of cement penetration during cup insertion. The study had two parts. In the first part, hemi-pelvis models were fitted with pressure sensors. Pressure in the acetabulum was measured on insertion of a conventional cemented flanged cup with and without the use of a Rim Cutter to prepare the rim of the acetabulum. The second part assessed cement penetration when the same cups were inserted into a foam shell model. The shell was mounted in a jig and had holes drilled in it; the distance that cement penetrated into the holes was measured. A significant increase in cement pressure at the apex (p = 0.04) and the rim (p = 0.004) is seen when the Rim Cutter is used. Cement penetration in the Rim Cutter group was significantly increased at the rim of the acetabulum (p = 0.003). Insertion of a flanged cup after the acetabulum is prepared with the Rim Cutter leads to a significant increase in cement pressure and penetration during cup insertion in vitro when compared with conventional flanged cups.
    Proceedings of the Institution of Mechanical Engineers Part H Journal of Engineering in Medicine 01/2010; 224(9):1133-40. · 1.21 Impact Factor
  • Article: Mitigating surgical risk in patients undergoing hip arthroplasty for fractures of the proximal femur.
    A J Timperley, S L Whitehouse
    [show abstract] [hide abstract]
    ABSTRACT: Recently the National Patient Safety Agency in the United Kingdom published a report entitled "Mitigating surgical risk in patients undergoing hip arthroplasty for fractures of the proximal femur". A total of 26 deaths had been reported to them when cement was used at hemiarthroplasty between October 2003 and October 2008. This paper considers the evidence for using cement fixation of a hemiarthroplasty in the treatment of hip fractures.
    Journal of Bone and Joint Surgery - British Volume 08/2009; 91(7):851-4. · 2.83 Impact Factor
  • Article: The Exeter Universal cemented femoral component at 15 to 17 years: an update on the first 325 hips.
    [show abstract] [hide abstract]
    ABSTRACT: The first 325 Exeter Universal stems (309 patients) implanted at the originating centre were inserted between March 1988 and February 1990 by a group of surgeons with differing experience. In this report we describe the clinical and radiological results at a mean of 15.7 years (14.7 to 17.3) after operation with no loss to follow-up. There were 97 patients (108 hips) with replacements still in situ and 31 (31 hips) who had undergone a further procedure. With an endpoint of revision for aseptic loosening, the survivorship at 17 years was 100% and 90.4% for the femoral and acetabular component, respectively. The mean Merle D'Aubigné and Postel scores at review were 5.4 (SD 0.97) for pain and 4.5 (SD 1.72) for function. The mean Oxford score was 38.4 (SD 9.8) (0 to 48 worst-to-best scale) and the mean combined Harris pain and function score was 73.2 (SD 16.9). Radiological review showed excellent preservation of bone stock in the proximal femur and no failures of the femoral component.
    Journal of Bone and Joint Surgery - British Volume 07/2009; 91(6):730-7. · 2.83 Impact Factor
  • Article: Revision of the cemented femoral stem using a cement-in-cement technique: a five- to 15-year review.
    [show abstract] [hide abstract]
    ABSTRACT: The removal of well-fixed bone cement from the femoral canal during revision of a total hip replacement (THR) can be difficult and risks the loss of excessive bone stock and perforation or fracture of the femoral shaft. Retaining the cement mantle is attractive, yet the technique of cement-in-cement revision is not widely practised. We have used this procedure at our hospital since 1989. The stems were removed to gain a better exposure for acetabular revision, to alter version or leg length, or for component incompatibility. We studied 136 hips in 134 patients and followed them up for a mean of eight years (5 to 15). A further revision was required in 35 hips (25.7%), for acetabular loosening in 26 (19.1%), sepsis in four, instability in three, femoral fracture in one and stem fracture in one. No femoral stem needed to be re-revised for aseptic loosening. A cement-in-cement revision of the femoral stem is a reliable technique in the medium term. It also reduces the risk of perforation or fracture of the femoral shaft.
    Journal of Bone and Joint Surgery - British Volume 06/2009; 91(5):577-82. · 2.83 Impact Factor
  • Source
    Article: Femoral impaction grafting with cement in revision total hip replacement. Evolution of the technique and results.
    [show abstract] [hide abstract]
    ABSTRACT: We report the results of cancellous femoral impaction grafting with cement in revision hip arthroplasty in all patients from one centre who had undergone surgery more than five years previously. A total of 32 surgeons undertook femoral impaction grafting in 207 patients (226 hips). There were no deaths attributable to the revision surgery; 33 patients with 35 functioning hips died with less than five years' follow-up. One patient was lost to follow-up. Two hips (1%) developed early postoperative infection. Of the 12 stems which underwent a further surgical procedure for aseptic failure, ten were for femoral fracture and two for loosening. Survivorship with any further femoral operation as the endpoint was 90.5% (confidence intervals, 82 to 98) and using femoral reoperation for symptomatic aseptic loosening as the endpoint, the survivorship was 99.1% (confidence intervals, 96 to 100) at 10 to 11 years. As a consequence of the experience in this series, we have modified our technique with an increased use of longer stems with impacted allograft. Long stems are indicated when the host bone around the tip of a short stem is compromised, in patients with major loss of bone stock, or when a femoral fracture occurs.
    Journal of Bone and Joint Surgery - British Volume 09/2003; 85(6):809-17. · 2.83 Impact Factor
  • Source
    Article: The Johnson-Elloy (Accord) total knee replacement. Poor results at 8 to 12 years.
    M R Norton, R K Vhadra, A J Timperley
    [show abstract] [hide abstract]
    ABSTRACT: We have found poor mid-term results in a multisurgeon series of 94 Johnson-Elloy (Accord) total knee replacements. A total of 27 knees (29%) has required revision, in 26 for aseptic loosening. Only 18 (19%) remain in situ, and these give poor function, are painful and most show radiological evidence of early failure. At 12 to 13 years the survival rate is 43% (confidence interval 29 to 57) with failure requiring revision as the endpoint. Proximal migration of the femoral component is associated with considerable loss of bone stock. We believe that all patients who have this implant should be recalled for regular review in order to anticipate this problem.
    Journal of Bone and Joint Surgery - British Volume 09/2002; 84(6):852-5. · 2.83 Impact Factor
  • Article: Block allografts in revision total hip arthroplasty.
    [show abstract] [hide abstract]
    ABSTRACT: We report on 61 consecutive cemented acetabular revisions in which block allografts were used to reconstruct large defects. After a mean follow-up of 6.5 years, we observed satisfactory results when grafts had been rigidly fixed. Additional buttress-plates can improve the outcome. Paprosky type 3B defects had a double risk of failure. Cup migration had a 56% predictive value for failure. Several metal-backed cups failed, although the graft remained intact. There was a good improvement in functional outcome, which did not deteriorate up to a maximum follow-up of 11 years. Cemented revision total hip arthroplasty with the use of block allografts can give acceptable results in the medium to long term.
    The Journal of Arthroplasty 09/2002; 17(5):562-8. · 2.38 Impact Factor
  • Source
    Article: Impaction grafting of the femur in two-stage revision for infected total hip replacement.
    H English, A J Timperley, D Dunlop, G Gie
    [show abstract] [hide abstract]
    ABSTRACT: We report the mid-term results of femoral impaction grafting which was used in 53 patients during the second stage of a two-stage revision for an infected total hip replacement. We reviewed all cases performed between 1989 and 1998. All patients underwent a Girdlestone excision arthroplasty, received local and systemic antibiotics and subsequently underwent reconstruction, using femoral impaction grafting. Four patients had further infection (7.5%), and four died within 24 months of surgery. One patient underwent revision of the stem for a fracture below its tip at ten months. This left 44 patients with a mean follow-up of 53 months (24 to 122). All had improved clinical scores and a satisfactory radiological outcome.
    Journal of Bone and Joint Surgery - British Volume 08/2002; 84(5):700-5. · 2.83 Impact Factor
  • Article: Cup removal in revision hip arthroplasty.
    W J Farrington, D G Dunlop, A J Timperley
    [show abstract] [hide abstract]
    ABSTRACT: When revision hip surgery is undertaken to remove a cemented cup from the pelvis the preservation of bone stock and structural integrity of the acetabulum is a major concern. We describe a safe technique for cup removal, which helps avoid a rim fracture occurring during this procedure. This should ensure the defect remains a cavitatory defect and does not become a segmental one with a more uncertain prognosis.
    Journal of the Royal College of Surgeons of Edinburgh 05/2002; 47(2):500-1.
  • Source
    Article: The Exeter universal cemented femoral component at 8 to 12 years. A study of the first 325 hips.
    [show abstract] [hide abstract]
    ABSTRACT: We describe our experience with the implantation of 325 Exeter Universal hips. The fate of every implant was known. The procedures were undertaken by surgeons of widely differing experience. At follow-up at 12 years, survivorship with revision of the femoral component for aseptic loosening as the endpoint was 100% (95% CI 98 to 100). Survivorship with revision of the acetabular component for aseptic loosening as the endpoint was 96.86% (95% CI 93.1 to 98.9) and that with any reoperation as the endpoint 91.74% (95% CI 87.7 to 95.8). No adverse features have emerged as a consequence of the modular connection between the head and neck of the implant.
    Journal of Bone and Joint Surgery - British Volume 05/2002; 84(3):324-34. · 2.83 Impact Factor
  • Source
    Article: Impaction grafting for acetabular deficiency in total hip arthroplasty for developmental hip dysplasia.
    B Berghs, N Wendover, A J Timperley, G A Gie
    [show abstract] [hide abstract]
    ABSTRACT: The pathological anatomy in neglected developmental dysplasia of the hip often demands some sort of reconstructive surgery to augment the acetabular bone stock during total hip arthroplasty. We have reviewed 11 hips in 10 patients with osteoarthritis secondary to developmental hip dysplasia who underwent cemented total hip arthroplasty using impaction grafting of the acetabulum with a morselized femoral head autograft, to bring the socket down to the anatomical hip center. The mean age at the index procedure was 43.4 years (ranging from 29 to 60 years) and the mean follow-up period was 3.8 years (ranging from 2 to 7 years). Postoperative functional evaluation according to the Merle d'Aubigné and Postel score modified by Charnley revealed very satisfactory results. Radiographic review showed incorporation of all grafts. One socket is radiographically loose. No major complications have been encountered. There have been no reoperations. We believe that acetabular impaction grafting is a valuable alternative in dealing with osteoarthritic hips secondary to developmental hip dysplasia.
    Acta orthopaedica Belgica 01/2001; 66(5):461-71. · 0.40 Impact Factor
  • Article: Stem fracture with the Exeter prosthesis.
    G A Gie, R S Ling, A J Timperley
    Acta Orthopaedica Scandinavica 05/1996; 67(2):206-7.
  • Article: Contained morselized allograft in revision total hip arthroplasty. Surgical technique.
    [show abstract] [hide abstract]
    ABSTRACT: The current technique and instrumentation for contained morselized allograft with cement in dealing with femoral loosening associated with loss of bone stock is described. With a follow-up extending to 6 years, this method has proved effective in the management of these difficult problems.
    Orthopedic Clinics of North America 11/1993; 24(4):717-25. · 1.25 Impact Factor
  • Source
    Article: Histology of cancellous impaction grafting in the femur. A case report.
    R S Ling, A J Timperley, L Linder
    [show abstract] [hide abstract]
    ABSTRACT: We report the histology of a femur retrieved 3.5 years after a cemented revision of a hip replacement in which impaction allografting had been used to fill two large cortical defects. The allograft chips had largely been replaced by viable cortical bone, and the interface between cement and tissue resembled that seen after primary cemented arthroplasty.
    Journal of Bone and Joint Surgery - British Volume 10/1993; 75(5):693-6. · 2.83 Impact Factor