Hisashi Doi

Tokyo Medical and Dental University, Edo, Tōkyō, Japan

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Publications (84)136.82 Total impact

  • [Show abstract] [Hide abstract]
    ABSTRACT: This study aimed to develop a novel abutment material with good esthetic and mechanical properties by producing a white oxide layer on a zirconium-14 mass%niobium (Zr-14Nb) alloy substrate using a thermal oxidation process. Oxidation temperatures ranged 700-1000°C and oxidation time ranged 30-180 min. The color of the oxide layer varied depending on temperature and time. A white oxide layer was obtained under appropriate conditions. The oxide layer thickness increased with increased temperature and time, as revealed by scanning electron microscopy with energy-dispersive X-ray spectroscopy. Moreover, X-ray diffraction and X-ray photoelectron spectroscopy revealed that the oxide layer was predominantly monoclinic ZrO2, tetragonal ZrO2, and Nb2O5. The oxide layer revealed good abrasion resistance and high adhesion to the substrate. This novel process for producing white materials with good mechanical properties will be useful for abutments and prostheses in dental implant treatment.
    Dental Materials Journal 07/2014; · 0.81 Impact Factor
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    ABSTRACT: Although the reported percentage of bone-implant contact is far lower than 100%, the cause of such low levels of bone formation has rarely been investigated. This study tested the negative biological effect of hydrocarbon deposition onto titanium surfaces, which has been reported to be inevitable. Osteogenic MC3T3-E1 cells were cultured on titanium disks on which the carbon concentration was experimentally regulated to achieve carbon/titanium (C/Ti) ratios of 0.3, 0.7, and 1.0. Initial cellular activities such as cell attachment and cell spreading were concentration-dependently suppressed by the amount of carbon on the titanium surface. The osteoblastic functions of alkaline phosphatase activity and calcium mineralization were also reduced by more than 40% on the C/Ti (1.0) surface. These results indicate that osteoblast activity is influenced by the degree of hydrocarbon contamination on titanium implants and suggest that hydrocarbon decomposition before implant placement may increase the biocompatibility of titanium.
    Journal of dental research. 05/2014;
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    ABSTRACT: Objective: Most orthodontic equipment have been made of alloys because of its excellent elastic properties. However, the non-metallic orthodontic equipment have been desired from the viewpoint of the esthetics and the prevention of metal allergy. In this study, three types of the super engineering plastics (Poly Ether Ether Ketone: PEEK; Poly Ether Sulfone: PES; Poly Vinylidene Difluoride: PVDF), which have high mechanical and thermal properties, were applied for the orthodontic wires. Our objective is to estimate the mechanical properties of these new wires. Methods: The trial square (1.0×1.0 mm) wires of PEEK, PES and PVDF were prepared and applied for the mechanical test. The rectangular metal wires (0.40×0.55 mm) of SS (3M Unitek, USA), Co-Cr (TOMY, Japan), Ti-Mo (ORMCO, USA) and Ni-Ti (TOMY, Japan) wires were also tested. Three-point bending test was carried with the universal testing machine (AG-IS 500N, Shimadzu, Kyoto, Japan) under 14 mm span. Torsional properties of the PEEK, PES, PVDF, SS and Ni-Ti wires were also estimated (RTC-1210A, ORIENTEC, Tokyo, Japan) with measuring the torsional moment as a function of torsional angle. Results: The wire made with PEEK showed good flexural and torsion strength and those properties were similar to those of Ni-Ti wire. Although the wires made with PES and PVDF showed lower mechanical properties than PEEK, their transparency and esthetics were higher. In addition, those plastic wires all showed lower permanent deformation after 2mm bending test. Conclusion: The super engineering plastics could be applicable for the esthetic orthodontic wires.
    IADR Asia/Pacific Region (APR) Regional Meeting and Co-Annual Scientific Meeting of IADR Divisions 2013; 08/2013
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    ABSTRACT: Susceptibility artifacts generated in magnetic resonance (MR) images were quantitatively evaluated for various metals using a three-dimensional (3D) artifact rendering to demonstrate the correlation between magnetic susceptibility and artifact volume. Ten metals (stainless steel, cobalt-chromium alloy, niobium, titanium, zirconium, molybdenum, aluminum, tin (Sn), copper (Cu) and silver (Ag)) were prepared, and their magnetic susceptibilities measured using a magnetic balance. Each metal was embedded in a nickel-doped agarose gel phantom and the MR images of the metal-containing phantoms were taken using 1.5 and 3.0 Tesla MR scanners under both fast spin echo and gradient echo conditions. 3D renderings of the artifacts were constructed from the images and the artifact volumes were calculated for each metal. The artifact volumes of metals decreased with decreasing magnetic susceptibility, with the exception of Ag. Although Sn possesses the lowest absolute magnetic susceptibility (1.8×10(-6)), the artifact volume from Cu (-7.8×10(-6)) was smaller than that of Sn. This is because the magnetic susceptibility of Cu was close to that of the agarose gel phantom (-7.3×10(-6)). Since the difference in magnetic susceptibility between the agarose and Sn is close to that between the agarose and Ag (-17.5×10(-6)), their artifact volumes were almost the same, although they formed artifacts that were reversed in all three dimensions.
    Acta biomaterialia 05/2013; · 5.09 Impact Factor
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    ABSTRACT: The selective laser melting (SLM) process was applied to a Co-29Cr-6Mo alloy, and its microstructure, mechanical properties, and metal elution were investigated to determine whether the fabrication process is suitable for dental applications. The microstructure was evaluated using scanning electron microscopy with energy-dispersed X-ray spectroscopy (SEM-EDS), X-ray diffractometry (XRD), and electron back-scattered diffraction pattern analysis. The mechanical properties were evaluated using a tensile test. Dense builds were obtained when the input energy of the laser scan was higher than 400Jmm(-3), whereas porous builds were formed when the input energy was lower than 150Jmm(-3). The microstructure obtained was unique with fine cellular dendrites in the elongated grains parallel to the building direction. The γ phase was dominant in the build and its preferential 〈001〉 orientation was confirmed along the building direction, which was clearly observed for the builds fabricated at lower input energy. Although the mechanical anisotropy was confirmed in the SLM builds due to the unique microstructure, the yield strength, UTS, and elongation were higher than those of the as-cast alloy and satisfied the type 5 criteria in ISO22764. Metal elution from the SLM build was smaller than that of the as-cast alloy, and thus, the SLM process for the Co-29Cr-6Mo alloy is a promising candidate for fabricating dental devices.
    Journal of the mechanical behavior of biomedical materials. 02/2013; 21C:67-76.
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    ABSTRACT: Micro-arc oxidation (MAO) was performed on a β-type Ti–29Nb–13Ta–4.6Zr alloy (TNTZ) in this study to improve its bioactivity in a body fluid and its hard-tissue compatibility. The surface oxide layer formed on TNTZ by MAO treatment in a mixture of calcium glycerophosphate and magnesium acetate was characterized using various surface analyses. The oxide layer was mainly composed of two types of TiO2 (rutile and anatase), and it also contained Ca, P, and Mg, which were incorporated from the electrolyte during the treatment. The calcium phosphate formation on the surface of the specimens after immersion in Hanks’ solution was evaluated to determine the bioactivity of TNTZ with and without MAO treatment. As a result, thick calcium phosphate layers formed on the TNTZ specimen that underwent MAO treatment, whereas only a small amount of precipitate was observed on TNTZ without treatment. Thus, the MAO treatment is a promising method to improve the bioactivity and hard-tissue compatibility of TNTZ.
    Applied Surface Science 12/2012; 262:34–38. · 2.54 Impact Factor
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    ABSTRACT: The magnetic susceptibility of cold-rolled Zr-14Nb was evaluated to apply a new metallic medical device used for magnetic resonance imaging (MRI). The magnetic susceptibility of cold-rolled Zr-14Nb decreased up to the reduction ratio of 30%, followed by a gradual decrease up to the ratio of 90%. The TEM observation revealed the strain-induced ω phase formation after cold rolling at the reduction ratio of 5%, indicating that the initial decrease of magnetic susceptibility was caused by the formation of the ω phase. The formation of the ω phase was saturated at the reduction ratio of 30%. The formation of the ω phase was explicable on the basis of the increase of the Young's modulus and Vickers hardness of cold-rolled Zr-14Nb. The effect of texture formation was not obvious for these properties in cold-rolled Zr-14Nb. The magnetic susceptibility of Zr-14Nb can be reduced by applying cold rolling, because of the formation of the strain-induced ω phase, to as low as that of as-cast Zr-9Nb, which is one-third that of Ti and Ti alloys. Therefore, the cold-workable Zr-14Nb with low magnetic susceptibility could be a promising alloy for medical devices under MRI.
    Acta biomaterialia 11/2012; · 5.09 Impact Factor
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    ABSTRACT: The microstructure and mechanical properties of as-cast Co-(20-33)Cr-5Mo-N alloys were investigated to develop ductile Co-Cr-Mo alloys without Ni addition for dental applications that satisfy the requirements of the type 5 criteria in ISO 22674. The effects of the Cr and N contents on the microstructure and mechanical properties are discussed. The microstructures were evaluated using scanning electron microscopy with energy-dispersive X-ray spectroscopy (EDS), X-ray diffractometry (XRD), and electron back-scattered diffraction pattern analysis. The mechanical properties were evaluated using tensile testing. The proof strength and elongation of N-containing 33Cr satisfied the type 5 criteria in ISO 22674. ε-phase with striations was formed in the N-free (20-29)Cr alloys, while there was slight formation of ε-phase in the N-containing (20-29)Cr alloys, which disappeared in N-containing 33Cr. The lattice parameter of the γ-phase increased with increasing Cr content (i.e. N content) in the N-containing alloys, although the lattice parameter remained almost the same in the N-free alloys because of the small atomic radius difference between Co and Cr. Compositional analyses by EDS and XRD revealed that in the N-containing alloys Cr and Mo were concentrated in the cell boundary, which became enriched in N, stabilizing the γ-phase. The mechanical properties of the N-free alloys were independent of the Cr content and showed low strength and limited elongation. Strain-induced martensite was formed in all the N-free alloys after tensile testing. On the other hand, the proof strength, ultimate tensile strength, and elongation of the N-containing alloys increased with increasing Cr content (i.e. N content). Since formation of ε-phase after tensile testing was confirmed in the N-containing alloys the deformation mechanism may change from strain-induced martensite transformation to another form, such as twinning or dislocation slip, as the N content increases. Thus the N-containing 33Cr alloy with large elongation is promising for use in dentures with adjustable clasps through one piece casting.
    Acta biomaterialia 03/2012; 8(7):2856-62. · 5.09 Impact Factor
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    ABSTRACT: Surface modification techniques affect phase transformation which in turn influences strength of zirconia biomaterial. The study aimed at evaluating the tetragonal to monoclinic (t-m) phase transition of zirconia occurring after sandblasting three different ceramic abrasive materials and its subsequent effect on the strength. Zirconia bars (n=24) were sandblasted using silicon carbide (SiC), alumina (Al2O3) and zirconia (ZrO2) particles. After surface characterization by a scanning electron microscope (SEM) and a laser profilometer, the relative amount of transformed monoclinic (m) phase was analyzed by X-ray diffractometry (XRD) and its corresponding effect on the flexural strength and fatigue strength were determined. Data were analyzed using one-way analysis of variance ANOVA (p<0.05). Furthermore, Weibull statistics was used to analyze the variability of flexural strength. The highest amount of monoclinic content was found after sandblasting with SiC consequently resulting in an increased flexural strength and fracture resistance under cyclic load conditions. Weibull modulus was reduced in all the groups with SiC blasting showing the least degradation of m values. The strengthening mechanism that is attributed to sandblasting procedure is influenced by the abrasive material used.
    Bio-medical materials and engineering 01/2012; 22(6):383-98. · 1.09 Impact Factor
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    ABSTRACT: A novel coating technique of thin ceramic layer resembling teeth color on titanium (Ti) surface was developed by combination of sputter deposition of metal zirconium (Zr) and subsequent micro-arc oxidation (MAO) treatment. The oxide layer grown by MAO treatment had a porous structure with a thickness of approximately 6 micrometers and was mainly composed of zirconium dioxide (ZrO(2)) with both tetragonal and monoclinic crystal structures. The surface of the specimen was hardened by this technique, and the hardness of the specimen was significantly larger than that of untreated Ti and MAO-treated Ti without Zr layer. The bonding strength test revealed that fracture occurred inside the oxide layer, indicating that adhesion between the oxide layer and the Ti substrate was sufficiently strong. From these results, this technique has an advantage for the development of novel dental materials with excellent mechanical and aesthetic properties.
    Dental Materials Journal 09/2011; 30(5):754-61. · 0.81 Impact Factor
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    ABSTRACT: On the basis of the microstructures and mechanical properties of as-cast Zr-(0-24)Nb alloys the effects of phase constitution on the mechanical properties and magnetic susceptibility are discussed in order to develop Zr alloys for use in magnetic resonance imaging (MRI). The microstructures were evaluated using an X-ray diffractometer, an optical microscope, and a transmission electron microscope; the mechanical properties were evaluated by a tensile test. The α' phase was dominantly formed with less than 6 mass% Nb content. The ω phase was formed in Zr-(6-20)Nb alloys, but disappeared from Zr-22Nb. The β phase dominantly existed in Zr-(9-24)Nb alloys. The mechanical properties as well as the magnetic susceptibility of the Zr-Nb alloys varied depending on the phase constitution. The Zr-Nb alloys consisting of mainly α' phase showed high strength, moderate ductility, and a high Young's modulus, retaining low magnetic susceptibility. Zr-Nb alloys containing a larger volume of ω phase were found to be brittle and, thus, should be avoided, despite their low magnetic susceptibility. When the Zr-Nb alloys consisted primarily of β phase the effect of ω phase weakened the mechanical properties, thereby leading to an increase in ductility, even with an increase in magnetic susceptibility. The minimum value of Young's modulus was obtained for Zr-20Nb, because this composition was the phase boundary between the β and ω phases. However, the magnetic susceptibility of the alloy was half that of Ti-6Al-4V alloys. Zr-Nb alloys consisting of α' or β phase have excellent mechanical properties with low magnetic susceptibility and, thus, these alloys could be useful for medical devices used in MRI.
    Acta biomaterialia 07/2011; 7(12):4278-84. · 5.09 Impact Factor
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    ABSTRACT: The effects of Pt and Pd addition to a Zr-20Nb alloy on its microstructure and mechanical property, as well as the elution of metals from the alloys in lactic acid solution, were investigated. The microstructure was characterized with an X-ray diffractometer (XRD), an optical microscope (OM), and a transmission electron microscope (TEM). The mechanical properties were evaluated by a tensile test. The β phase is dominantly observed in the Zr-20Nb as well as in the Pt-added and Pd-added Zr-20Nb alloys. Needle-like microstructures are observed in equiaxed grains in all alloys. Pd addition to the Zr-20Nb alloy suppresses ω phase formation more than Pt addition does. The 0.2% offset yield strength and the ultimate tensile strength of the Pt-added and Pd-added Zr-20Nb alloys increase with the Pt and Pd concentrations. XRD analysis revealed that the lattice parameter of β-Zr in the Pt-added and Pd-added Zr-20Nb alloys decreases with the Pt and Pd concentrations. Pt and Pd solute in β-Zr as a substitutional element and contribute to the increase in the strength by solid solution hardening. The addition of 2Pt and 2Pd to the Zr-20Nb alloy also improves metal elution from the alloys in lactic acid solution.
    Materials Science and Engineering: C. 07/2011; 31(5):900–905.
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    ABSTRACT: The effects of the microstructures and phases of Zr-rich Mo alloys on their magnetic susceptibilities and mechanical properties were investigated in order to develop a Zr alloy with low magnetic susceptibility for use in magnetic resonance imaging (MRI). The magnetic susceptibility was measured with a magnetic susceptibility balance, while mechanical properties were evaluated by a tensile test. The microstructure was evaluated with an X-ray diffractometer, an optical microscope, and a transmission electron microscope. Evaluation of the microstructures revealed that the α' phase was the dominant form at less than 2% Mo content in the as-cast alloy. The ω phase was formed in as-cast Zr-3Mo but disappeared with aging at 973 K. Magnetic susceptibility was reflected in the phase constitution: the susceptibility showed a local minimum at Zr-(0.5-1)Mo with mostly α' phase and a minimum at Zr-3Mo with mostly β and ω phases. The magnetic susceptibility of as-cast Zr-3Mo increased at 973 K due to disappearance of the ω phase. However, the susceptibility was still as low as that of as-cast Zr-1Mo. The ultimate tensile strength of α'-based Zr-Mo alloys was tailored from 674 to 970 MPa, and the corresponding elongation varied from 11.1% to 2.9%. Because Zr-Mo alloys containing ω phase were found, through tensile tests, to be brittle this phase should be avoided, irrespective of the low magnetic susceptibility, in order to maintain mechanical reliability. Elongation of the Zr-3Mo alloy was dramatically improved when the phase constitution was changed to α and β phases by aging at 973 K for 86.4 ks. The magnetic susceptibilities of the α'-based Zr-Mo alloys are one-third those of Ti-6Al-4V and Ti-6Al-7Nb, and thus these Zr alloys are useful for medical devices under MRI.
    Acta biomaterialia 07/2011; 7(12):4259-66. · 5.09 Impact Factor
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    ABSTRACT: Immobilization of RGD peptides on titanium (Ti) surfaces enhances implant bone healing by promoting early osteoblastic cell attachment and subsequent differentiation by facilitating integrin binding. Our previous studies have demonstrated the efficacy of RGD peptide immobilization on Ti surfaces through the electrodeposition of poly(ethylene glycol) (PEG) (RGD/PEG/Ti), which exhibited good chemical stability and bonding. The RGD/PEG/Ti surface promoted differentiation and mineralization of pre-osteoblasts. This study investigated the in vivo bone healing capacity of the RGD/PEG/Ti surface for biomedical application as a more osteoconductive implant surface in dentistry. The RGD/PEG/Ti surface was produced on an osteoconductive implant surface, i.e. the grit blasted micro-rough surface of a commercial oral implant. The osteoconductivity of the RGD/PEG/Ti surface was compared by histomorphometric evaluation with an RGD peptide-coated surface obtained by simple adsorption in rabbit cancellous bone after 2 and 4 weeks healing. The RGD/PEG/Ti implants displayed a high degree of direct bone apposition in cancellous bone and achieved greater active bone apposition, even in areas of poor surrounding bone. Significant increases in the bone to implant contact percentage were observed for RGD/PEG/Ti implants compared with RGD-coated Ti implants obtained by simple adsorption both after 2 and 4 weeks healing (P<0.05). These results demonstrate that RGD peptide immobilization on a Ti surface through electrodeposited PEG may be an effective method for enhancing bone healing with commercial micro-rough surface oral implants in cancellous bone by achieving rapid bone apposition on the implant surface.
    Acta biomaterialia 04/2011; 7(8):3222-9. · 5.09 Impact Factor
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    ABSTRACT: Surface treatments with various combinations of micro-arc oxidation (MAO) and chemical treatments were performed on zirconium (Zr) disks in this study to enhance the bioactivity of Zr. The surface oxide layers formed with MAO and chemical treatments on Zr disks were characterized using surface analyses; the calcium phosphate formation on the specimens after immersion in Hanks' solution was evaluated. As a result, thick calcium phosphate layers formed on Zr specimens that underwent MAO treatment with a mixture of calcium glycerophosphate and magnesium acetate and subsequent chemical treatment with sulfuric acid or sodium hydroxide solutions, while no precipitate was observed without treatment. The surface analyses revealed that the porous oxide layer formed by MAO treatment contained Ca, P, and Mg, which were incorporated from the electrolytes during the treatments. In addition, both the composition and crystal structure of the oxide layers uniquely changed as a result of the various chemical treatments.
    Surface & Coatings Technology - SURF COAT TECH. 01/2011; 205(21):4948-4955.
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    ABSTRACT: This study investigated the surface characteristics and in vitro biocompatibility of a titanium (Ti) oxide layer incorporating calcium ions (Ca) obtained by hydrothermal treatment with or without post heat-treatment in the Ti–13Nb–13Zr alloy. The surface characteristics were evaluated by scanning electron microscopy, thin-film X-ray diffractometry, X-ray photoelectron spectroscopy, atomic force microscopy and contact angle measurements. In vitro biocompatibility of the Ca-containing surfaces was assessed in comparison with untreated surfaces using a pre-osteoblast cell line. Hydrothermal treatment produced a crystalline CaTiO3 layer. Post heat-treatment at 400°C for 2h in air significantly decreased water contact angles in the CaTiO3 layer (p
    Applied Surface Science 01/2011; 257(17):7856-7863. · 2.54 Impact Factor
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    ABSTRACT: Protein-resistant coatings have been studied for inhibiting biofilm formation on implant devices. In this study, titanium (Ti) surfaces were biofunctionalized with poly(ethylene glycol) (PEG) by electrodeposition and were evaluated as biofilm substrates under an oral simulated environment. Streptococcus gordonii, an early colonizer of oral biofilms, was inoculated on Ti and PEG-electrodeposited Ti (PEG-Ti) surfaces and was analyzed quantitatively and topographically. Streptococcus mutans supplemented with sucrose, a late colonizer mainly found in dental plaque, was also used to form biofilms on the surfaces of Ti and PEG-Ti for 20 h followed by sonication as a means of detaching the biofilms. The results indicated that the attachment of S. gordonii on PEG-Ti surfaces was inhibited compared with Ti, and the S. mutans biofilm was easier to be detached from the surface of PEG-Ti than that of Ti. Moreover, the presence of PEG electrodeposited on Ti surface inhibited salivary protein adsorption. The degree of detachment of biofilms from PEG-Ti was associated with the inhibition of the salivary protein adsorption, suggesting weak basal attachment of the biofilms to the electrodeposited surfaces. Therefore, controlling protein adsorption at the initial stage of biofilm formation may be an effective strategy to protect metal surfaces from bacterial contamination not only in dental manipulations but also in orthopedic applications.
    Journal of Biomedical Materials Research Part A 09/2010; 95(4):1105-13. · 2.83 Impact Factor
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    ABSTRACT: The cathodic polarization technique to form an alkaline environment on a zirconium (Zr) surface, discussed in the present study, is unique, and gives the ability to form calcium phosphate in a simulated body fluid to Zr; on the other hand, many previous studies have been conducted using immersion in alkaline solutions. In this study, two discrete techniques were investigated. Zr was cathodically polarized in an electrolyte without calcium and phosphate ions, and Zr was cathodically polarized in another electrolyte containing calcium and phosphate ions, Hanks' solution, to directly form a calcium phosphate layer. The surface was characterized using X-ray photoelectron spectroscopy, and the performance of the material was evaluated by immersion in Hanks' solution. As a result, the ability to form calcium phosphate in Hanks' solution was given by cathodic polarization in the Na(2)SO(4) solution containing H(2)O(2). In addition, a cathodic potential under -1.5 V(SCE) is required to form hydroxyapatite directly in Hanks' solution. This research clearly reveals useful surface modification techniques giving the ability to form calcium phosphate in a simulated body fluid by cathodic polarization.
    Acta biomaterialia 05/2010; 6(10):4161-6. · 5.09 Impact Factor
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    ABSTRACT: The roughness and cleanness of a titanium surface must be controlled in order to investigate the expression mechanism of hard tissue compatibility on titanium. In this study, osteogenic MC3T3-E1 cells were cultured and differentiation-induced on bulk and sputter-deposited titanium specimens, and the osteogenesis were investigated. For the preparation of bulk specimens, titanium discs were mirror-polished. On the other hand, titanium was sputter-deposited on smooth and clean cover glasses as sputter-deposited specimens. As a result, no significant difference was observed in the cell morphology and attached number. On the other hand, the time showing maximum activity in the alkaline phosphatase and gene expressions, which are related to bone differentiation on the bulk titanium, were superior to those on the sputter-deposited titanium. From the surface observation of the specimens with a scanning electron microscope and a scanning probe microscope, the surface on the sputter-deposited titanium was more uniform and cleaner than that on the bulk titanium. According to X-ray photoelectron spectroscopy, the thickness of surface oxide film on the sputter-deposited titanium was smaller than that on the bulk titanium. In addition, the proportions of TiO and Ti(2)O(3) in the surface oxide film on the sputter-deposited titanium were larger than those on the bulk titanium. These differences might influence the differentiation of osteoblastic cells.
    Journal of Biomedical Materials Research Part A 03/2010; 94(2):611-8. · 2.83 Impact Factor
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    ABSTRACT: Biological apatite (AP) is the main component of human bones, and it is a highly bioactive and biocompatible inorganic material. However, it has insufficient mechanical parameters and adhesion to surfaces. Carbon-based coatings, such as diamond-like carbon, carbon nanotubes and amorphous carbon are found to significantly improve the mechanical properties of AP, increase its adhesion, prevent metal ion release from metal implants and inhibit the formation of fibrous tissue and blood clotting upon implantation.In this study, nanodiamond (ND)-reinforced AP composite coating was prepared by electrodeposition on austenitic stainless steel from simulated body fluid (SBF) containing ND particles. Results revealed the formation of dense and homogeneous AP coating, containing CO3 and HPO4 groups similar to the biological AP. The composite coating was characterized by ductility, improved hardness and adhesion to the steel surface in comparison to pure AP. Mineralization experiment in a simulated body fluid revealed that the composite coating is potentially biologically active. Copyright © 2010 John Wiley & Sons, Ltd.
    Surface and Interface Analysis 02/2010; 42(6‐7):475 - 480. · 1.39 Impact Factor

Publication Stats

484 Citations
136.82 Total Impact Points


  • 1992–2014
    • Tokyo Medical and Dental University
      • • Institute of Biomaterials and Bioengineering
      • • Graduate School of Medical and Dental Sciences
      • • Department of Metals
      • • Department of Maxillofacial Orthognathics
      • • Institute for Medical and Dental Engineering
      Edo, Tōkyō, Japan
  • 2011
    • Kyungpook National University
      • Department of Periodontology
      Daikyū, Daegu, South Korea
  • 2008
    • Chulalongkorn University
      • Department of Prosthodontics
      Bangkok, Bangkok, Thailand