D F Anderson

Oregon Health and Science University, Portland, Oregon, United States

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Publications (22)73.18 Total impact

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    ABSTRACT: Two to eight days after surgery, we determined biventricular cardiac output with the microsphere-dilution method and individual ventricular output with an electromagnetic flow sensor in 12 fetal lambs. Mean biventricular output was 462 ml.min-1.kg-1. Right ventricular output was 60%, pulmonary blood flow was 6%, blood flow in the ductus arteriosus was 54%, flow through the foramen ovale was 34%, and flow in the descending thoracic aorta above the ductus arteriosus was 12% of the biventricular cardiac output. Foramen ovale flow did not correlate with the pressure difference between the atria. The flow though the foramen ovale correlated positively with the flow in the inferior caval vein. It was concluded the shunt flow through the foramen ovale is mainly determined by the kinetic energy of the blood in the "lower atrial inflow tract." Fetal systemic somatic blood flow showed a reliable negative correlation with the oxygen tension in the fetal arterial blood. This was taken as presumptive evidence for long-term autoregulation of flow in the peripheral tissues.
    The American journal of physiology 08/1981; 241(1):H60-6. · 3.28 Impact Factor
  • D F Anderson, K L Thornburg, J J Faber
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    ABSTRACT: We placed capsules in fetal guinea-pigs for measuring the hydrostatic pressure of the interstitial fluid and for collecting samples of interstitial fluid. The vitelline artery and vein were cannulated to measure blood pressures. Plasma colloid osmotic pressure (mmHg) and total protein concentration (g/100 ml) were measured in samples taken from other adult and fetal guinea-pigs and were found to be related by colloid osmotic pressure = 0.16 + 2.32 X protein concentration. The colloid osmotic pressures of fetal plasma and fetal interstitial fluid, calculated from measured protein concentrations, were 10.6 +/- 0.4 mmHg and 9.1 +/- 0.6 mmHg (mean +/- SEM). The hydrostatic pressure of the interstitial fluid was 0.2+/- 0.3 mmHg below intra-uterine pressure and the mean capillary blood pressure was calculated to be 1.3 +/- 0.8 mmHg above intra-uterine pressure. Arterial and venous blood pressures in the vitelline vessels were 29.0 +/- 0.9 and 3.8 +/- 0.6 mmHg above intra-uterine pressure. The ratio of pre- to -post-capillary resistance was, therefore, greater than 10.
    Journal of developmental physiology 05/1981; 3(2):123-32.