J Steinmetz

Unité Inserm U1077, Caen, Lower Normandy, France

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Publications (50)137.21 Total impact

  • Journal of Clinical Virology 07/2006; 36. DOI:10.1016/S1386-6532(06)80613-X · 3.47 Impact Factor
  • Journal of Hepatology 04/2006; 44. DOI:10.1016/S0168-8278(06)80047-4 · 10.40 Impact Factor
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    ABSTRACT: International guidelines emphasize the importance of LDL cholesterol (LDL-C) assay in the care and follow-up of patients with cardiovascular risk. Most studies and common practice use Friedewald's formula for LDL-C calculation. The accuracy of the result depends closely on the precision of the input parameters (total cholesterol, triglycerides (TG) and HDL cholesterol), and discrepancies between calculated LDL-C and measurement by reference methods appear when TG exceed 4.5 mmol/L, or in the presence of abnormal lipoproteins. These restrictions and uncertainties in calculations have prompted the recent development of direct and homogeneous methods that fit all analyzers. A multicenter evaluation of four direct assays of LDL-C (Daiichi, Denka Seiken, Kyowa, Wako) was carried out on 45 serum samples (TG below 3.1 mmol/L) in eight laboratories using different analyzers. For three methods (Daiichi, Kyowa, Wako), the interlaboratory reproducibility was markedly improved relative to that of calculation. A strong correlation was found for all new methods when compared with a beta-quantification assay. Average bias in Denka Seiken assays was greater than Kyowa's and Daiichi's (although less dispersed for the latter) and for Wako all bias were positive. The relationship between bias variations and the lipid parameters of the samples was studied. Three methods, Daiichi, Kyowa and Wako, revealed a significant positive correlation between bias and serum VLDL-C/TG ratio, clearly indicating that cholesterol enrichment of VLDL was a source of variability in these assays. Specificity of the four methods was tested in situation of dyslipidemia by spiking isolated lipoproteins (chylomicrons, VLDL and HDL). This experiment revealed differences in behavior, most evidently upon addition of VLDL. No method was truly specific, but up to 8 mmol/L of TG the variations were acceptable. In the presence of type III hyperlipoproteinemia, however, only the Denka Seiken method was reliable. Linearity up to 20 mmol/L (Daiichi, Denka Seiken) or 14 mmol/L (Kyowa, Wako) of LDL-C allows these tests to be used in main routine cases. New direct assays are an obvious technological advance in terms of analytical performance and conveniency. Their use for the diagnosis and follow-up of hyperlipidemic patients offers an alternative that overcomes the limitations of the Friedewald calculation.
    Annales de biologie clinique 01/2005; 63(1):27-41. · 0.42 Impact Factor
  • Revue d Épidémiologie et de Santé Publique 09/2004; 52:74-74. DOI:10.1016/S0398-7620(04)99235-8 · 0.66 Impact Factor
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    ABSTRACT: According to a recent French legislation (1995), retired people who have been exposed to an occupational carcinogen can benefit from a specific post-occupational medical follow-up program, supported by the "Caisse Primaire d'Assurance-Maladie" (CPAM), the French health insurance system. However, only very few people presently take access to this social measure. The ESPACES project developed and evaluated a procedure to identify retirees who have been exposed to asbestos during their career, and to inform them about the post-occupational medical follow-up program. This pilot study was performed within the health centers ("Centres d'examens de santé" (CES)) of the health insurance system in a random sample of men who have retired from the six main French administrative divisions between 1994 to 1996. A probability of exposure to asbestos was attributed through a job exposure matrix. Subjects were interviewed in the CES to validate their exposure data. Retired subjects with confirmed exposure to asbestos were referred to their CPAM, to apply for the medical follow-up. The whole process was evaluated through a comparison with control CPAMs, and simulations were performed to assess its sensitivity and specificity, as well as the total number of persons in France who could potentially benefit. Among the 737 persons classified as exposed by the matrix who came to the CES, the exposure was confirmed for 53.8%, and 143 benefited from the medical follow-up, 17 times more than in a sample of control CPAMs. Based on an annual number of about 250,000 new retirees, simulations showed that a low detection threshold, taking into account the probability and duration of exposure, would yield approximately 25,000 persons coming to the CES, more 6,000 of them benefiting from the follow-up. The proposed detection threshold would allow for a feasible and ethically acceptable generalization, due to the optimization of the false negative and false positive rate.
    Revue d Épidémiologie et de Santé Publique 03/2004; 52(1):7-17. · 0.66 Impact Factor
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    ABSTRACT: Position du problèmeLa réglementation française permet aux inactifs qui ont été exposés à une substance cancérogène dans leur vie professionnelle de bénéficier d’un suivi médical post-professionnel pris en charge par leur Caisse Primaire d’Assurance-Maladie (CPAM). Actuellement, très peu de personnes concernées bénéficient de cette mesure. Le projet ESPACES propose et évalue une méthode de repérage des retraités qui auraient été exposés professionnellement à l’amiante afin de les informer de leurs droits à ce suivi.MéthodesCette étude pilote a été réalisée dans les Centres d’Examens de Santé (CES) de la Sécurité sociale de six départements, sur un échantillon d’hommes retraités dans les années 1994-96 tirés au sort. La probabilité d’exposition à l’amiante a été évaluée grâce à une matrice emplois-exposition. Des entretiens de validation ont été réalisés dans les CES. Les retraités dont l’exposition a été confirmée ont été adressés pour une demande de prise en charge de suivi médical. Une évaluation de la procédure a été réalisée par comparaison avec des CPAM témoins, et des simulations ont permis d’évaluer la sensibilité et la spécificité de la procédure, ainsi que les effectifs potentiellement concernés.RésultatsParmi les 737 sujets classés exposés part la matrice et qui sont venus à l’entretien, 53,8 % ont vu leur exposition confirmée. Au total, 143 sujets ont été pris en charge, soit une proportion 17 fois supérieure à celle des CPAM témoins. Les simulations montrent que pour environ 250 000 nouveaux retraités chaque année, l’adoption d’un seuil bas de détection (prenant en compte la probabilité et la durée d’exposition) amènerait environ 25 000 personnes dans les CES, dont plus de 6 000 seraient pris en charge.ConclusionUne généralisation de la procédure qui aurait pour effet de réduire les inégalités d’information des personnes ayant été exposées à l’amiante a été proposée aux responsables de la Sécurité sociale. Le seuil de dépistage proposé permet une généralisation réalisable et éthiquement acceptable, en optimisant le nombre de faux positifs et de faux négatifs.Background According to a recent French legislation (1995), retired people who have been exposed to an occupational carcinogen can benefit from a specific post-occupational medical follow-up program, supported by the “Caisse Primaire d’Assurance-Maladie” (CPAM), the French health insurance system. However, only very few people presently take access to this social measure. The ESPACES project developed and evaluated a procedure to identify retirees who have been exposed to asbestos during their career, and to inform them about the post-occupational medical follow-up program.Methods This pilot study was performed within the health centers (“Centres d’examens de santé” (CES)) of the health insurance system in a random sample of men who have retired from the six main French administrative divisions between 1994 to 1996. A probability of exposure to asbestos was attributed through a job exposure matrix. Subjects were interviewed in the CES to validate their exposure data. Retired subjects with confirmed exposure to asbestos were referred to their CPAM, to apply for the medical follow-up. The whole process was evaluated through a comparison with control CPAMs, and simulations were performed to assess its sensitivity and specificity, as well as the total number of persons in France who could potentially benefit.ResultsAmong the 737 persons classified as exposed by the matrix who came to the CES, the exposure was confirmed for 53.8%, and 143 benefited from the medical follow-up, 17 times more than in a sample of control CPAMs. Based on an annual number of about 250,000 new retirees, simulations showed that a low detection threshold, taking into account the probability and duration of exposure, would yield approximately 25,000 persons coming to the CES, more 6,000 of them benefiting from the follow-up.Conclusion The proposed detection threshold would allow for a feasible and ethically acceptable generalization, due to the optimization of the false negative and false positive rate.
    Revue d Épidémiologie et de Santé Publique 02/2004; 52(1):7-17. DOI:10.1016/S0398-7620(04)99018-9 · 0.66 Impact Factor
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    ABSTRACT: Aim: To assess biennial screening for colorectal cancer in health examination centers (CES) after four years of follow-up in complement to a preliminary publication. Method: We offered a biennial screening test for occult blood in stools (Hemoccult II®) by mail to patients who had had a negative screening test for occult blood two years pre-viously. Patients who had a positive result were then offered the possibility of undergoing further tests. Data on the actual outcomes were obtained from the attending physicians. We offered subsequent biennial screening only to patients who tested negative for occult blood. We enrolled a total of 121,127 patients who had taken part in a first screening test during a health examination (point n° 1). A second test was performed two years later in 1999-2000 in patients who tested negative in the first screening test (n° 2) and a third test in 2001-2002 for those who tested negative in the second screening test (n° 3). Results: The participation rate in the screening tests, compared to the number of subjects included in the initial screening sample, was 58.3 % after four years of follow-up. The participation rate increased from 81.6 % at point n° 2 to 91.7 % at point n° 3. A total of 3.01 % of the tests were positive. Data concerning follow-up from positives tests was available in 64.8 % of the cases. 1,014 patients were diagnosed with adenomas (positive predictive value = 20.2 %); 352 of the adenomas were larger than 10 mm. 276 cancers were detected (positive predictive value = 5.5 %). 53 % of the cancers were discovered following the initial screening test. Conclusion: These results are similar to our preliminary findings and suggest that biennial screening in examination centers is a satisfactory screening method after four years of follow-up with respect to clearly-defined quality criteria.
  • J Steinmetz, J Henny, R Gueguen
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    ABSTRACT: The Sysmex UF-50 is an automated flow cytometer for urine sediments analysis. Interpretation of the results needs establishment of reference limits for the different constituents measured. First of all, we checked precision of measurements and stability of urines during transportation. Then, urine samples from 4 to 95 year old subjects were examined with the UF-50, by visual microscopy and test strips. Distributions of results for erythrocytes, leukocytes, epithelial cells, casts, bacteria and conductivity were described in a sample of 680 subjects (364 men and 316 women), with creatininemia below 140 micromol/L, consuming no drugs and for women without intra uterine device and apart from menstruation period. Then, the results were compared with those obtained in groups selected on microscopic analysis and test strip results. UF-50 sensitivity and specificity were 77.5% and 88% for 15 erythrocytes/microL in reference to microscopic urinalysis, they were 91.3% and 87.3% for 15 leucocytes/microL. The reference sample was defined with negative microscopic results. The upper reference limits (centile 97.5) were 16 red blood cells/microL for men 14.5 for women, 13.5 and 33 leucocytes/microL, 8 and 19 epithelial cells/microL, 1,3 and 0,4 casts/microL, 5 500 et 7 700 bacteria/microL, 36,2 et 34,6 conductivity mS/cm. The Sysmex UF-50 is a suitable analyser for urinary sediments. Reference limits may be different from usual reference limits due to variability in performances of other methods.
    Annales de biologie clinique 01/2004; 62(6):671-80. · 0.42 Impact Factor
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    ABSTRACT: and Aims: The ESPACES study was intended to identify retirees who may have been, according to their job descriptions, exposed to asbestos during their working lives. As part of this study, we analysed the quality of the occupation and activity sector coding as well as its effect on the subjects' exposure status. The occupation and activity sector for a sample of 450 retired men were coded twice (with the second coder blinded to the first result), according to the international codes for industries (ISIC-1975) and occupations (ISCO-1968). For each series, linking the information about a job episode (dates, ISIC code, ISCO code) with the matrix allowed attribution of a probability of asbestos exposure to each episode and each subject. The asbestos exposure in the two series was compared by the kappa reproducibility coefficient. The analysis concerned 425 questionnaires. There was at least one difference in the code for either activity sector (ISIC) or occupation (ISCO) in half the episodes (50.2%). The exposure status estimated by the job-exposure matrix did not change between the series for 84.7% of the subjects. The kappa coefficient was 0.64 for all questionnaires, 0.70 when the questionnaire was coded twice by the same coder, and 0.62 when coded by two different coders. Despite intra- and inter-differences between coders, the coding of job episodes for the ESPACES study appears satisfactory and hence indicates that the assessment of the subjects' asbestos exposure was assessed without major distortions. This study underlines the usefulness of employing coders specifically trained for this technique.
    Occupational and Environmental Medicine 07/2003; 60(6):438-43. DOI:10.1136/oem.60.6.438 · 3.23 Impact Factor
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    ABSTRACT: Infraclinical hypothyroidism is a recognized entity defined in terms of laboratory results which occurs more readily in women. The appropriateness of thyroid hormone multicentric prospective study initiated in 1997 has established that infraclinical hypothyroidism occurred in about 3% of women over 45 years of age undergoing routine check-ups at eleven health screening centers. Associated clinical signs and laboratory findings were reported. The purpose of the present study was to describe findings in a 3-year follow-up of these women with infraclinical hypothyroidism in order to assess natural history and appropriate care. Ninety-seven women of the 151 women with a TSH level between 4 and 12 mU/l in the 1997 survey were reviewed during the last three months of 2000. Forty-three of them had taken thyroid hormone replacement drugs since 1997. About 44% of the women examined still had infraclinical hypothyroidism or developing hypothyroidism. There was not significant difference between treated (33%) and non-treated (55%) patients. Clinical and biological signs associated with infraclinical hypothyroidism at the initial examination (elevated serum cholesterol, abnormal ECG, eyelid edema, recent weight gain) were unchanged at the second examination, both in treated and not treated women. A logistic model including all these factors demonstrated that the probability of prescription of thyroid hormone replacement therapy increased 5.4-fold when the starting TSH level was above 6 mU/l and 3.2-fold if ECG abnormalities were present. Using a statistical model with anti TPO antibodies, a level above 64 U/l increased the probability of treatment 7-fold, with ECG findings being related to probability of treatment. Age, cholesterol level, use to lipid lowering drugs, presence of eyelid edema or weight gain were not associated with replacement therapy in this model. No consistent conclusion concerning the appropriateness of screening for infraclinical hypothyroidism can be drawn from these three-year follow-up findings. Another examination scheduled for 2003 should provide further precision concerning the natural history of infraclinical hypothyroidism as well as long-term medical practices and therapeutic impact.
    Annales d Endocrinologie 01/2003; 63(6 Pt 1):505-10. · 0.66 Impact Factor
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    ABSTRACT: Aim: To determine the acceptability of colonoscopy and the results of Hemoccult II® testing for colorectal cancer screening in patients seen in the health fund’s health clinics (CES). Method: The study group consisted in 929 patients aged 50 to 75 years examined in the health clinics in 2000 who had Hemoccult II® positive stools, and who had no past or family history of risk for colorectal cancer. Results: Results were obtained in 88.7% of the enrolled patients who had undergone Hemoccult II® screening. The acceptability of diagnostic procedures, mainly colonoscopy, was 84.1%. Diagnostic procedures were obtained within 11.6 weeks on the average; in 30.7% of the cases, lower gastro-intestinal disease was present (adenomatous polyps or cancers) and included 31 cancers. Cancer of the sigmoid colon was found in 36 %. Conclusion: This study illustrates the important individual role played by health clinics in screening for colo-rectal cancer, in spite of the fact that only a small percentage of the French population is involved. The procedures’ high acceptability rate should not make us lose sight of the need for more complete information; improvement in the delay needed for obtaining required diagnostic procedures is also necessary.
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    ABSTRACT: Screening for colorectal cancer with fecal occult-blood test has been performed in health centers for several years. The aim of this study was to describe participation rate and results in a population attending the Center for preventive medicine at Vandoeuvre-lès-Nancy, France in 1996 and 1997. Among 19,325 people aged 50-75 years, the screening test was proposed to 17,917 and performed in 15,527. Participation rate was 86.7%. Overall positivity was 3.6% higher in men than in women (4.1% versus 3.0%). In the 440 colonoscopies performed, 22 cancers and 84 adenoma polyps were identified (PPV = 24%). These results show good participation rates in a screening program for colorectal cancer during periodic health check-ups. Follow-up for positive subjects was satisfactory but requires good cooperation between specialists and general practitioners to obtain complete information to evaluate the program.
    La Presse Médicale 11/2001; 30(28):1389-93. · 1.17 Impact Factor
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    ABSTRACT: Prevalance of subclinical hypothyroïdism in 4403 women.We performed to prospective multicentric study in eleven health centre to define the frequency of subclinical hypothyroïdism in 4403 females aged 45–70 years (mean 55,2 ± 6,9 years). TSH assays were performed using a microparticule sandwich immunoenzyme method on free serum with an IMX or an Axsym. In these study, the reference rage of serum TSH were : 0,43 – 3,71 mU L−1. 131 women (3 %) had subclinical hypothyroïdism defined as TSH between 4 and 12 mU L−1 and FT4 > 10 pmol L−1. Subtle cardial adnormalities and hypercholesterolemia 6,24 mmol L−1 vs. 6,06 mmol L−1 were been associated. Thirty-five women were treated with thyroxine, by their primary care physician. The study indicated that subclinical hypothyroïdism found in about 3 % of females aged 45–70 years, appears to be a risk factor for atherosclerosis and coronary heart disease, and might be diagnostied more frequently.
    Immuno-analyse & Biologie Spécialisée 01/2001; 16(1):34-39. DOI:10.1016/S0923-2532(01)80007-7 · 0.11 Impact Factor
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    ABSTRACT: Thyroid stimulating hormone (TSH) was measured in a sample of 4,403 women, aged 45-70 years in 11 Centers for health screening, to define the interest of this biological indicator for screening subclinical hypothyroidism. The aim of this work was to describe clinical signs, symptoms and medical history linked to TSH variations, to estimate the distribution of this hormone in a general population and reference limits in a selected subgroup. All the participating laboratories used the same third-generation immunoassay on fresh samples. In the general sample population (age mean: 55.2 6.9 yrs), 1.1% presented hyperthyroidism (TSH<0.3 mU/l) and 0.4% had hypothyroidism (TSH>12 mU/l). In the sub-sample of 151 women (3.4%) with TSH between 4-12 mU/l, 131 had subclinical hypothyroidism (FT4>8 ng/l). The TSH mean was significantly lower (- 10 to - 23%) in women presenting a nodular goiter. Inversely, TSH was higher in women with muscle cramps, asthenia, recent weight gain, morning eyelid edema and abnormal electrocardiogram. The reference limits for percentiles 2.5 and 97.5 were 0.43 and 3.71 mU/l on 1 348 subjects after excluding women having one of these symptoms or taking any drug treatment.
    Annales d Endocrinologie 12/2000; 61(6):501-507. · 0.66 Impact Factor
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    ABSTRACT: The aim of the study was to evaluate the frequency of iron deficiency with serum ferritin in elderly population, and to appreciate the opportunity of early screening according to digestive diseases. Data were collected from 3524 men and 3120 women aged 60 to 75 years during a health screening examination. Evaluation of diagnosis and treatment were obtained through questionnaire completed by treating physician. The frequency of hypoferritinemia was about 2.3% in our population (hypoferritinemia was defined by serum ferritin<20 microg/L or between 20-40 microg/L if C reactive protein was > 12 mg/L). Anemia was found in 3.3% of patients. Logistic regression model adjusting for multiple variables was used to examine factors associated with hypoferritinemia. The probability was greater among non-anemic patients with chronic digestive bleeding (odds-ratio: 2.3), or with positive occult blood testing (odds-ratio: 2.3). Information about the medical follow-up was obtained in 81% of patients with hypoferritinemia. A digestive exploration was made in 38 cases. Digestive disease was found among 24.3% patients with hypoferritinemia, and three colorectal cancers were observed. The screening of hypoferritinemia in elderly population examined in health screening centres could not be recommended as its frequency was low in this population, despite a strong correlation between hypoferritinemia and digestive diseases.
    Gastroentérologie Clinique et Biologique 01/2000; 24(8-9):709-13. · 1.14 Impact Factor
  • Atherosclerosis 10/1997; 134(1):91-91. DOI:10.1016/S0021-9150(97)88529-2 · 3.71 Impact Factor
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    ABSTRACT: The utilization of two WHO reference materials, liquid and lyophilized, permitted international standardization of apolipoprotein measurements. We report here the results of a collaborative study between Arcol, SFBC and SFRL in order to establish reference ranges for apo A1 and B on nine standardized systems. A population of 1027 men and women supposed healthy, 4 to 60 year old, have been selected in two Centers for Preventive Medicine. The serum samples were aliquoted frozen at -20 degrees C the day of sampling and analysed by the manufacturers with IFCC standardized calibrants. A specific quality control was performed using a frozen pool of sera. For apo A1, the centile 2.5 of the reference population varies from 1.04 to 1.16 g/l. The range values for the centile 97.5 varies from 1.87 to 2.24 g/l. For apoB, the centile 2.5 varies from 0.43 to 0.57 g/l, and the centile 97.5 from 1.30 to 1.39 g/l. Only one system has a problem of dispersion with an upper limit equal to 1.20 g/l. These results improve that international standardization allowed actually a good comparability of the results, especially for apoB.
    Annales de biologie clinique 01/1997; 55(5):451-4. · 0.42 Impact Factor
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    ABSTRACT: The effects of alcohol consumption on serum concentrations of apolipoproteins (apo) A-I, C-III, B, and E and of lipoproteins (Lp) A-I, A-I:A-II, C-III, C-III:B, and (a) were studied in 132 healthy subjects, including 55 low drinkers of alcohol (<20 g/day), 36 moderate drinkers (20-50 g/day), and 41 heavy drinkers (>50 g/day), and in 97 hospitalized alcoholic patients (> 100 g/day) without severe liver disease (especially functional insufficiency), before and after 21 days of withdrawal treatment. Serum concentrations of apo A-I, LpA-I, LpA-I:A-II, apo C-III, and LpC-III significantly (P </= 0.01) increased with alcohol intake (mean +/- SE in low drinkers vs in alcoholics)--1.45 +/- 0.03 vs 1.78 +/- 0.05 g/L; 0.45 +/- 0.02 vs 0.56 +/- 0.02 g/L; 0.99 +/- 0.02 vs 1.22 +/- 0.04 g/L; 27.6 +/- 1.5 vs 39.7 +/- 1.7 mg/L; and 8.4 +/- 0.9 vs 24.7 +/- 1.7 mg/L, respectively-whereas apo B and LpC-III:B concentrations tended to decrease--1.20 +/- 0.04 vs 1.06 +/- 0.04 g/L and 19.3 +/- 1.2 vs 14.9 +/- 1.0 mg/L, respectively. No significant difference between these four types of alcohol consumption was noticed for cholesterol, triglycerides, apo E, and Lp(a). After withdrawal, the concentrations of serum apo A-I, apo C-III, LpA-I, LpA-I:A-II, and LpC-III decreased significantly (P </= 0.01), reaching values comparable with those in low drinkers; concentrations of triglycerides, apo B, apo E, and Lp(a) rose; and cholesterol concentration was unaffected. In multiple regression analysis, after adjustment for serum concentrations of albumin, aspartate aminotransferase, and gamma-glutamyltransferase and for the Quetelet index, alcohol consumption remained positively correlated to apo A-I, LpA-I:A-II, apo C-III, and LpC-III concentrations. Study of other determinants of serum apo and lipoprotein concentrations suggests that alcohol-related variations in some of them, especially apo A-I, might depend on the metabolic ability of the liver to synthesize proteins and on induction phenomena. Finally, although the increase of antiatherogenic apo- and lipoproteins and the decrease of those known to be atherogenic were generally marked in alcoholics, alcohol-related modifications of these markers were very limited in our sample of French healthy men. We conclude, therefore, that moderate alcohol consumption (20-50 g/day) is unlikely to protect against ischemic heart disease through an effect on the proteins measured in this study.
    Clinical Chemistry 11/1996; 42(10):1666-75. · 7.77 Impact Factor
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    ABSTRACT: Allele frequencies of genetic polymorphisms were compared between supposedly healthy subjects and angiographically proven coronary artery disease patients. The polymorphic candidate loci investigated were the apolipoprotein (apo) B signal peptide and XbaI polymorphism, the apo E polymorphism and two polymorphism of lipoprotein lipase (LPL) gene: Hind/III and PvuII. Apo B signal peptide and HindIII/LPL polymorphisms showed significant differences in allele partition between cases and controls; the rare alleles of both polymorphisms were less frequent (p < 0.05) in cases. We looked for associations between the polymorphisms and lipid concentration variability in a supposedly healthy population (145 men and 144 women). Apo B signal peptide, apo E and PvuII/LPL polymorphisms seem to influence some lipid metabolism parameters significantly. Apo AI and LpCIII levels were significantly different among apo B signal peptide genotypes: Del homozygotes had the highest concentrations of both variables. The epsilon 4 allele of apo E polymorphism was associated with increased concentrations of total cholesterol, LDL cholesterol and apo B. Increased LpAI:AII levels observed in E3 homozygotes (p < 0.01) have not previously been reported. LpAI:AII concentration was also influenced by PvuII/LPL polymorphisms.
    Clinical Genetics 11/1996; 50(5):339-47. · 3.65 Impact Factor
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    ABSTRACT: The aim of this study was to evaluate the trends of indicators of cardiovascular risk (smoking, physical activity, cholesterol, triglycerides...) in adolescents between 14 and 18 years of age. The data was recensed at the Centre of Preventive Medicine of Vandoeuvre-lès-Nancy which was responsible for periodic Social Security health check-ups in 6,974 adolescents in 1980, 1984, 1988 and 1991. The analysis of the trends of the indicators of cardiovascular risk took into consideration the socio-economic changes of the population recruited during this period and the long-term analytical variations of biochemical parameters. Globally, between 1980 and 1991, there was a decrease in the percentage of smokers (21.8% to 13.5%) which was more marked in boys than in girls, an increase in physical activities (46.9% to 57.5%), a linear reduction in serum cholesterol (4.65 mmol/l to 4.33 mmol/l in boys, and 4.94 mmol/l to 4.72 mmol/l in girls), and no significant changes in serum triglycerides. These results confirm those reported by others and are encouraging for cardiovascular disease prevention and should be confirmed in adults groups.
    Archives des maladies du coeur et des vaisseaux 12/1995; 88(11):1561-7. · 0.40 Impact Factor

Publication Stats

644 Citations
137.21 Total Impact Points

Institutions

  • 2006
    • Unité Inserm U1077
      Caen, Lower Normandy, France
  • 1989–1994
    • University of Texas Health Science Center at Houston
      • Graduate School of Biomedical Sciences
      Houston, TX, United States
  • 1990
    • Agence de Médecine Préventive
      Lutetia Parisorum, Île-de-France, France