Jin-A Park

Publications (3)10.66 Total impact

• Source

  Available from: Choong-Gu Lee

  Article: Cinnamon extract suppresses tumor progression by modulating angiogenesis and the effector function of CD8+ T cells.

  Ho-Keun Kwon, Won Kyung Jeon, Ji-Sun Hwang, Choong-Gu Lee, Jae-Seon So, Jin-A Park, Byoung Seob Ko, Sin-Hyeog Im
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  ABSTRACT: Cinnamon is one of the most widely used herbal medicines with diverse bioactive effects. However, little evidence has been reported about the potential anti-tumor effects of cinnamon. In vitro and in vivo system, cinnamon treatment strongly inhibited the expression of pro-angiogenic factors and master regulators of tumor progression not only in melanoma cell lines but also in experimental melanoma model. In addition, cinnamon treatment increased the anti-tumor activities of CD8(+) T cells by increasing the levels of cytolytic molecules and their cytotoxic activity. In conclusion, cinnamon extract has the potential to be an alternative medicine for tumor treatment.
  Cancer letters 03/2009; 278(2):174-82. · 4.86 Impact Factor
• Article: Lactobacillus casei potentiates induction of oral tolerance in experimental arthritis.

  Jae-Seon So, Choong-Gu Lee, Ho-Keun Kwon, Hwa-Jung Yi, Chang-Suk Chae, Jin-A Park, Ki-Chul Hwang, Sin-Hyeog Im
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  ABSTRACT: Probiotics have been shown to exert beneficial effects on modulation of diverse diseases. However, no information is available for the effect of probiotics in the induction of oral tolerance in autoimmune diseases. The main purpose of this study was to elucidate whether Lactobacillus casei (L. casei) affect the induction of oral tolerance in experimental rheumatoid arthritis (RA). Type II collagen (CII) alone or together with L. casei was orally administered into collagen-induced arthritis (CIA) rats, and its effects on the clinical and histopathological aspects of RA were investigated. Co-administration of L. casei with CII more effectively suppressed clinical symptoms, paw swelling, lymphocyte infiltration and destruction of cartilage tissues of experimental arthritis than the rats treated with CII alone. The enhanced therapeutic efficacy was associated with an increase in anti-inflammatory cytokines (IL-10 and TGF-beta) while decreasing pro-inflammatory cytokines (IL-1beta, IL-2, IL-6, IL-12, IL-17, IFN-gamma and TNF-alpha). Co-administration of L. casei with CII more effectively suppressed CII-reactive T cell proliferation and the levels of Th1-type IgG isotypes (IgG2a and IgG2b), while up-regulating Foxp3 expression levels and the population of Foxp3(+) CD4(+) T cells. Our study provides evidence that L. casei could potentiate antigen-specific oral tolerance and suppress Th1-type immune responses of arthritic inflammation.
  Molecular Immunology 10/2008; 46(1):172-80. · 2.90 Impact Factor
• Article: Lactobacillus casei suppresses experimental arthritis by down-regulating T helper 1 effector functions.

  Jae-Seon So, Ho-Keun Kwon, Choong-Gu Lee, Hwa-Jung Yi, Jin-A Park, So-Yeon Lim, Ki-Chul Hwang, Young Ho Jeon, Sin-Hyeog Im
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  ABSTRACT: Although the beneficial effects of probiotics on wide variety of diseases have been shown, little is known about how probiotics modulate the immune system. In this study we elucidated the underlying mechanisms how Lactobacillus casei (L. casei) protects against rheumatoid arthritis (RA) progression by investigating the effector functions of CD4(+) T cells. Oral administration of L. casei suppressed collagen-induced arthritis (CIA) and reduced paw swelling, lymphocyte infiltration and destruction of cartilage tissue. L. casei administration reduced type II collagen (CII)-reactive proinflammatory molecules (IL-1beta, IL-2, IL-6, IL-12, IL-17, IFN-gamma, TNF-alpha and Cox-2) by CD4(+) T cells. L. casei administration also reduced translocation of NF-kappaB into nucleus and CII-reactive Th1-type IgG isotypes IgG2a and IgG2b, while up-regulating immunoregulatory IL-10 levels. Our results suggest that oral administration of L. casei suppresses the type II collagen-reactive effector function of Th1-type cellular and humoral immune responses in arthritic inflammation.
  Molecular Immunology 06/2008; 45(9):2690-9. · 2.90 Impact Factor