Publications (42)120.28 Total impact
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Article: Reexpansion pulmonary edema after treatment of simultaneous bilateral spontaneous tension pneumothorax.
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ABSTRACT: We report a case of 46-year-old male with simultaneous bilateral spontaneous tension pneumothorax. Severe reexpansion pulmonary edema developed after bilateral tube thoracoscomy, but he was recovered after 2 days ventilator care. After bilateral wedge resection and talc pleurodesis, he was discharged without complications and had remained well and without recurrence during the 8-year follow-up.Journal of Cardiothoracic Surgery 04/2013; 8(1):62. · 1.19 Impact Factor -
Article: Detrimental effects of leptin on intracerebral hemorrhage via the STAT3 signal pathway.
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ABSTRACT: Leptin, one of the most important adipokines, is not only an energy regulator but also a regulator of innate immunity. Inflammation plays a key role in the tissue damage after intracerebral hemorrhage (ICH), and we sought to investigate whether leptin has a detrimental effect on ICH. After the injection of a high replacement dose (0.04 mg/kg) and two pharmacologic doses (4 and 8 mg/kg) of leptin, brain water contents increased significantly compared with that of control mice (P<0.05), which was confirmed when comparing the results with leptin-deficient ob/ob and wild-type (WT) mice (78.8%±0.6% versus 79.7%±0.6%, P<0.05). The number of Ox6-positive microglia/macrophages was increased in the leptin-injected group and decreased in ob/ob compared with WT mice. Among the candidate signal transducers, an increase in signal transduction and activator of transcription 3 (STAT3) levels was found after leptin injection. When we administered NSC74859, a specific inhibitor of phosphorylated STAT3 (pSTAT3), the water content became normalized. Activity of pSTAT3 was found mainly in Ox6-positive microglia/macrophages, but not in either neurons or astrocytes. We demonstrate that leptin plays a critical role in the secondary brain injury around a hematoma and is a novel mediator of the inflammation. This detrimental effect of leptin on ICH is mediated by the STAT3 signaling pathway in inflammatory cells.Journal of Cerebral Blood Flow & Metabolism advance online publication, 6 March 2013; doi:10.1038/jcbfm.2013.35.Journal of cerebral blood flow and metabolism: official journal of the International Society of Cerebral Blood Flow and Metabolism 03/2013; · 5.46 Impact Factor -
Article: Primary idiopathic silent chylopericardium.
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ABSTRACT: Chylopericardium usually occurs secondary to trauma, cardiothoracic surgery, radiation therapy, or neoplasm of the mediastinum. Idiopathic chylopericardium is extremely rare. We report a case of primary chylopericardium in a 79-year-old male patient. Although pericardial window and thoracic duct ligation are the treatment of choice, the patient has been doing well for six months since video-assisted thoracoscopic pericardial window.Journal of Cardiothoracic Surgery 02/2013; 8(1):28. · 1.19 Impact Factor -
Article: Video-assisted thoracoscopic surgery for primary spontaneous pneumothorax in children.
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ABSTRACT: PURPOSE: There is controversy regarding the best way to prevent recurrences of primary spontaneous pneumothorax (PSP) in children. The purpose of this study was to evaluate the efficacy of video-assisted thoracoscopic surgery (VATS) for pediatric PSP. METHODS: We retrospectively reviewed patients under 29 years of age who underwent VATS for PSP between March 2005 and February 2011. Patients were divided into 2 groups: children (under the age of 17 years) and young adults (over the age of 18 years). RESULTS: Two hundred eighty-one VATS procedures in 257 patients were included in this study. The mean follow-up was 47.1 ± 20.5 months. No mortality was observed. The mean duration of pleural drainage was 3.4 ± 2.2 days. The overall recurrence rate was 6.8 %. The operative outcomes did not differ significantly. However, the recurrence rate was significantly higher in the children's group than the young adult group (10.6 vs. 3.9 %, P = 0.032). Younger age and postoperative prolonged air leak had a significantly higher risk of postoperative recurrence. CONCLUSIONS: VATS is a safe and effective procedure for PSP in children. However, the risk of recurrence is increased in children and it is related to the formation of new bullae.Pediatric Surgery International 02/2013; · 1.25 Impact Factor -
Article: Extents of White Matter Lesions and Increased Intraventricular Extension of Intracerebral Hemorrhage.
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ABSTRACT: OBJECTIVES:: To determine whether the extent of white matter lesions on CT scan of acute intracerebral hemorrhage patients is associated with the prevalence and severity of intraventricular extension of hemorrhage. DESIGN AND SETTING:: A post hoc analysis of Acute Brain Bleeding Analysis-IntraCerebral Hemorrhage cohort, a nationwide prospective cohort of acute intracerebral hemorrhage patients (total number of cohort subjects, 1,604). PATIENTS:: Spontaneous intracerebral hemorrhage patients (n = 1,262). INTERVENTIONS:: None. MEASUREMENTS:: The authors analyzed CT scan images taken within 48 hrs after stroke onset. Extent of white matter lesions, volume of intracerebral hemorrhage, presence of intraventricular extension of hemorrhage, and intraventricular extension of hemorrhage score (approximation of intraventricular extension of hemorrhage volume) were measured using CT scans, and demographic, laboratory, clinical, and mortality data were also gathered through review of medical records and retrieval from the governmental statistical archive. MAIN RESULTS:: The frequency of intraventricular extension of hemorrhage in our population was 27.2% (343 subjects). The proportion of extensive white matter lesions in intraventricular extension of hemorrhage subjects (33.8%) was higher than that of non-intraventricular extension of hemorrhage cases (16.3%; p < 0.01). Multivariable analysis showed that mild (odds ratioo, 1.48; 95% confidence interval 1.05- .09; p < 0.01) and extensive (odds ratio, 2.73; 95% confidence interval 1.88-3.98; p < 0.01) white matter lesions were significantly associated with the presence of intraventricular extension of hemorrhage in spontaneous intracerebral hemorrhage patients. The estimated mean of the intraventricular extension of hemorrhage score from the extensive white matter lesions group (9.09 ± 0.76) was significantly higher than that of the no white matter lesions group (6.72 ± 0.78; p < 0.01 from analyses of covariances) after adjustment for relevant covariates. CONCLUSIONS:: We documented that the severity of white matter lesions is related to the occurrence and amount of intraventricular extension of hemorrhage in spontaneous intracerebral hemorrhage cases.Critical care medicine 02/2013; · 6.37 Impact Factor -
Article: Recurrent cervical esophageal stenosis after colon conduit failure: Use of myocutaneous flap.
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ABSTRACT: A 53-year-old male developed cervical esophageal stenosis after esophageal bypass surgery using a right colon conduit. The esophageal bypass surgery was performed to treat multiple esophageal strictures resulting from corrosive ingestion three years prior to presentation. Although the patient underwent several endoscopic stricture dilatations after surgery, he continued to suffer from recurrent esophageal stenosis. We planned cervical patch esophagoplasty with a pedicled skin flap of sternocleidomastoid (SCM) muscle. Postoperative recovery was successful, and the patient could eat a solid meal without difficulty and has been well for 18 mo. SCM flap esophagoplasty is an easier and safer method of managing complicated and recurrent cervical esophageal strictures than other operations.World Journal of Gastroenterology 01/2013; 19(2):307-10. · 2.47 Impact Factor -
Article: Successful Treatment of Catamenial Hemoptysis by Video-Assisted Thoracoscopic Surgery.
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ABSTRACT: We report a case of a 23-year-old woman with a 5-year history of recurrent hemoptysis during menstrual period. Catamenial hemoptysis was diagnosed using chest computed tomography and bronchoscopic examination during menstruation. The patient was managed successfully with wedge resection and has been free of recurrence for 5 years. We suggest that surgery is an effective treatment, and complete resection with accurate localization is important for the prevention of recurrence.The Thoracic and Cardiovascular Surgeon 01/2013; · 0.88 Impact Factor -
Article: Serum Uric Acid Levels and Cerebral Microbleeds in Patients with Acute Ischemic Stroke.
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ABSTRACT: Unlike experimental studies indicating a neuroprotective property of uric acid, clinical studies have shown that elevated levels of uric acid are associated with a risk of ischemic stroke. However, the association of uric acid with cerebral hemorrhage has seldom been tested. We aimed to elucidate the association between uric acid and cerebral microbleeds (CMBs), a hemorrhage-prone cerebral microangiopathy. Seven hundred twenty-four patients with ischemic stroke who were consecutively admitted to our hospital were included in this study. We collected demographic, clinical, and laboratory data, including uric acid level, and examined the presence of CMBs using T2*-weighted gradient-echo MRI. We used logistic regression analysis to examine an independent association between uric acid and CMBs. Two-hundred twenty-six patients had CMBs (31.2%). After adjusting for possible confounders, elevated uric acid was independently associated with the presence of CMBs (the highest quartile vs. lowest quartile, adjusted odd ratio [OR], 1.98; 95% confidence interval [CI], 1.16-3.39). This association retained in patients with deep or infratentorial CMBs (with or without lobar CMBs) but not among those with lobar CMBs. In addition, this association was robust among patients with hypertension (the highest quartile vs. lowest quartile, adjusted OR, 2.74; 95% CI, 1.43-5.24). In contrast, we did not find the association in patients without hypertension. We demonstrated that serum uric acid is independently associated with the presence of CMBs. In particular, the relation between uric acid and CMBs was robust in hypertensive patients.PLoS ONE 01/2013; 8(1):e55210. · 4.09 Impact Factor -
Article: Successful Management of a Mycotic Pseudoaneurysm Involving an Arch Branch Using an Endovascular Stent Graft.
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ABSTRACT: Mycotic aneurysms in the aortic arch are extremely rare and represent a challenging surgical problem. Although surgery is the standard treatment, application of endovascular repair has been extended, but this technique carries a concern regarding the interposition of an artificial graft in the infected lesion. We present the case of an infected pseudoaneurysm in the thoracic aorta which was successfully excluded by treatment with a stent graft.The Thoracic and Cardiovascular Surgeon 12/2012; · 0.88 Impact Factor -
Article: Excessive work and risk of haemorrhagic stroke: a nationwide case-control study.
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ABSTRACT: BACKGROUND: Adverse effect of excessive work on health has been suggested previously, but it was not documented in cerebrovascular diseases. AIM: The authors investigated whether excessive working conditions would associate with increased risk of haemorrhagic stroke. METHODS: A nationwide matched case-control study database, which contains 940 cases of incident haemorrhagic stroke (498 intracerebral haemorrhages and 442 sub-arachnoid haemorrhages) with 1880 gender- and age- (±5-year) matched controls, was analysed. Work-related information based on the regular job situation, including type of occupation, regular working time, duration of strenuous activity during regular work and shift work, was gathered through face-to-face interviews. Conditional logistic regression analyses were used for the multivariable analyses. RESULTS: Compared with white-collar workers, blue-collar workers had a higher risk for haemorrhagic stroke (odds ratio, 1·33 [95% confidence interval, 1·06-1·66]). Longer regular working time was associated with increased risk of haemorrhagic stroke [odds ratio, 1·38 (95% confidence interval, 1·05-1·81) for 8-12 h/day; odds ratio, 1·95 (95% confidence interval, 1·33-2·86) for ≥13 h/day; compared with ≤4 h/day]. Exposure to ≥8 h/week of strenuous activity also associated haemorrhagic stroke risk [odds ratio, 1·61 (95% confidence interval, 1·26-2·05); compared with no strenuous activity]. Shift work was not associated with haemorrhagic stroke (P = 0·98). Positive associations between working condition indices and haemorrhagic stroke risk were consistent regardless of haemorrhagic stroke sub-types and current employment status. CONCLUSIONS: Blue-collar occupation, longer regular working time and extended duration of strenuous activity during work may relate to an increased risk of haemorrhagic stroke.International Journal of Stroke 12/2012; · 2.38 Impact Factor -
Article: A Quantitative Comparison of the Vertebral Artery and Transverse Foramen Using CT Angiography.
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ABSTRACT: The vertebral artery (VA) is important for the development of the transverse foramen (TF). Most studies of these structures have focused on anatomical anomalies. Therefore, we investigated quantitatively the association between the relative sizes of the TF and VA. We recruited a consecutive series of subjects who underwent CT angiography to estimate the relative sizes of the VA and TF in axial source images. Two neurologists independently reviewed the axial CT images of 208 patients who had no history of transient ischemic attack or stroke. Averaged areas of the VA and TF were defined by the sum of the areas at each level from C3 to C6, divided by 4. Correlation analyses were adjusted for age, sex, and vascular risk factors. The mean age of the subjects was 53 years. The interobserver and intraobserver reliabilities of TF size were good. There was a linear relationship between the sizes of the VA and TF on each side (right side: r(2)=0.58, p<0.001; left side: r(2)=0.62, p<0.001). The area of the VA was significantly associated with that of the TF after adjusting for vascular risk factors. The size of the VA is strongly and linearly correlated with the size of the TF. These findings suggest that measurement of the TF and VA with CT angiography is a reliable method for evaluating VA diseases, and may provide new insight into the differentiation between VA hypoplasia and atherosclerosis of the VA.Journal of Clinical Neurology 12/2012; 8(4):259-64. · 1.69 Impact Factor -
Article: Impact of CHADS(2) Score on Neurological Severity and Long-Term Outcome in Atrial Fibrillation-Related Ischemic Stroke.
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ABSTRACT: The CHADS(2) (an acronym for congestive heart failure, hypertension, age ≥75 years, diabetes mellitus, and prior stroke or transient ischemic attack or thromboembolism) score is a widely used system for estimating the risk of stroke in patients with atrial fibrillation. However, how the CHADS(2) score is related to stroke severity and outcome in patients with strokes due to atrial fibrillation has not yet been elucidated. We enrolled patients with atrial fibrillation who visited our stroke center within 7 days after the onset of acute ischemic stroke between October 2002 and September 2008. CHADS(2) scores were categorized into three groups: 0 points, low risk; 1 or 2 points, intermediate risk; and 3-6 points, high risk. Poor neurological state was defined as follows: a National Institutes of Health Stroke Scale (NIHSS) score of ≥2, and a modified Rankin Scale (mRS) score of ≥3 at discharge. Mortality information was ascertained as at December 2008. A cohort of 298 patients with atrial-fibrillation-related stroke was included in this study. A high-risk CHADS(2) score at admission was a powerful predictor of poor neurological outcome [for NIHSS: odds ratio (OR), 4.17; 95% confidence interval (CI), 1.76-9.87; for mRS: OR, 2.97; 95% CI, 1.23-7.16] after controlling for all possible confounders. In addition, a high-risk CHADS(2) score was an independent predictor of all causes of death during the follow-up [hazard ratio (HR), 3.01; 95% CI, 1.18-7.65] and vascular death (HR, 12.25; 95% CI, 1.50-99.90). Although the CHADS(2) score was originally designed to distinguish patients with a future risk of stroke, our study shows that it may also be used to predict poor neurological outcome after atrial-fibrillation-related stroke.Journal of Clinical Neurology 12/2012; 8(4):251-8. · 1.69 Impact Factor -
Article: Occlusive vascular Ehlers-Danlos syndrome accompanying a congenital cystic adenomatoid malformation of the lung: report of a case.
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ABSTRACT: An 8-year-old male presented with a cystic lung lesion in the left lower lobe, which was initially detected during surgery for a spontaneous rupture of the sigmoid colon at the age of 6 years. Tissue fragility and a tendency to bleed easily were noted during the surgery, which strongly suggested vascular Ehlers-Danlos syndrome. Although there was no abnormality in the hemostasis screening test, or any suspicious hereditary problem in his pedigree, genetic gene testing for vascular Ehlers-Danlos syndrome was recommended, and showed a de novo mutation in the COL3A1 gene. This report presents the case of patient with occlusive vascular Ehlers-Danlos syndrome accompanying a congenital cystic adenomatoid malformation of lung, in addition to a duplicated infrarenal vena cava.Surgery Today 10/2012; · 1.22 Impact Factor -
Article: Ceria Nanoparticles that can Protect against Ischemic Stroke.
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ABSTRACT: Uniform 3 nm-sized ceria nanoparticles can protect against ischemic stroke by scavenging reactive oxygen species (ROS) and reducing apoptosis. PEGylated ceria nanoparticles showed protective effects against ROS-induced cell death in vitro. Optimal doses of ceria nanoparticles reduced infarct volumes and the rate of ischemic cell death in vivo.Angewandte Chemie International Edition 09/2012; 51(44):11039-43. · 13.45 Impact Factor -
Article: Impact of smoking cessation on the risk of subarachnoid haemorrhage: a nationwide multicentre case control study.
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ABSTRACT: Subarachnoid haemorrhage (SAH) is the most devastating cerebrovascular disease. Cigarette smoking is one of the established risk factors for SAH, but the risk of SAH has not been properly elucidated in relation to smoking cessation. We performed a nationwide multicentre case control study involving 33 hospitals in Korea. A total of 426 SAH cases and 426 age and sex matched controls were enrolled. We obtained detailed information on lifestyle, medical history and, in particular, smoking habits from participants using structured questionnaires. 148 SAH patients (37.4%) were current smokers compared with 103 (24.2%) controls, giving an adjusted OR of 2.84 (95% CI, 1.63 to 4.97) after controlling for possible confounders. Based on cumulative dose of smoking (pack years), the risk of SAH was found to increase in a dose-responsive fashion. Smoking cessation (≥5 years) caused a reduction in SAH to 59% (p<0.05). However, participants with a history of heavy smoking (≥20 cigarettes per day) had a 2.3 times increased risk of SAH compared with participants who had never smoked (p<0.05). We have demonstrated that cigarette smoking increases the risk of SAH, but smoking cessation decreases the risk in a time dependent manner, although this beneficial effect may be diminished in previous heavy smokers. To forestall tragic SAH events, our results call for more global and vigorous efforts for people to stop smoking.Journal of neurology, neurosurgery, and psychiatry 08/2012; 83(11):1100-3. · 4.87 Impact Factor -
Article: Spontaneous Rupture of Internal Iliac Artery Secondary to Anticoagulant Therapy.
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ABSTRACT: We present a case of spontaneous retroperitoneal hemorrhage secondary to anticoagulant therapy. A 41-year-old woman who underwent aortic valve replacement due to infective endocarditis 2 months ago was admitted for evaluation of dizziness and fatigue. Physical examination revealed the abdomen to be distended. Blood work showed a hemoglobin 4.5 and INR 3.5. Abdominal CT showed a huge intra-abdominal hematoma with right internal iliac artery rupture. In abdominal aortic angiography, rupture of right internal iliac artery was confirmed and treated with embolization. Bleeding stopped after embolization, but she developed acute renal failure secondary to a huge hematoma. On POD#4, she underwent a laparotomy and the hematoma was evacuated. The patient had an uneventful recovery and was discharged from the hospital with no further bleeding episodes.Annals of thoracic and cardiovascular surgery : official journal of the Association of Thoracic and Cardiovascular Surgeons of Asia. 08/2012; -
Article: No significant association of aspirin use with cerebral microbleeds in the asymptomatic elderly.
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ABSTRACT: Cerebral microbleeds (CMBs) may predict future risk for intracerebral hemorrhage (ICH). ICH is one of the most important complications of aspirin use. The association between aspirin use and CMBs is still controversial. In this context, we sought to investigate whether aspirin use is associated with CMBs in subjects without previous history of stroke. Asymptomatic elderly subjects (n=1452; age ≥ 65 years) who visited for routine health check-ups were included in this study. CMBs were evaluated through T2*-weighted gradient-recalled echo MRI. Information about aspirin or warfarin use was obtained using a structured questionnaire. A total of 138 subjects (9.5%) were found to have CMBs. In the group of aspirin use, 43 subjects (11.2%) had CMBs; among them 9 (2.3%) had strictly lobar microbleeds and 34 (8.9%) had deep or infratentorial microbleeds. Compared with the non-use group, the risk for CMBs did not increase in the group of aspirin use (adjusted odds ratio, 1.10; 95% confidence interval, 0.73-1.66). For the group of aspirin use above 5 years, the proportion of CMBs (11.1%) did not increase compared with the group of short-term use (≤ 5 years, 9.5%, p=0.99) and non-use group (8.9%, p=0.66). We found that the prevalence of CMBs did not increase in the group of aspirin use, and the presence of CMBs was not associated with the duration of aspirin use in asymptomatic elderly subjects without a history of stroke or transient ischemic attack.Journal of the neurological sciences 05/2012; 319(1-2):56-8. · 2.32 Impact Factor -
Article: Association of obesity with cerebral microbleeds in neurologically asymptomatic elderly subjects.
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ABSTRACT: Obesity is associated with an increased risk of cardiovascular disease, but few studies have investigated the effects of obesity on subclinical cerebrovascular disease. Cerebral microbleeds (CMBs) are radiological markers of cerebral small vessel disease and reflect underlying vasculopathy. In this context, we assessed whether obesity was related to CMBs and to CMB subtypes categorized by location. Neurologically asymptomatic elderly subjects (n = 1,251; age ≥ 65 years) who visited for routine health check-ups were included in this study. Cerebral microbleeds were evaluated through T2*-weighted gradient-recalled echo MRI. The subjects were categorized into two groups depending on CMB location: strictly lobar and deep or infratentorial microbleeds. Body mass index was calculated, and obesity was defined using the World Health Organization Western Pacific Regional Office criteria. A total of 120 (9.6 %) subjects were found to have CMBs. As the severity of obesity increased, the prevalence of CMBs increased. Compared with the normal weight group and after controlling possible confounders, the risk of deep or infratentorial microbleeds was significantly increased in the overweight group [odds ratio (OR) 2.32, 95 % confidence interval (CI) 1.19-4.53], and the obese group (OR 2.17, 95 % CI 1.14-4.13). However, the ORs for the strictly lobar microbleeds were not increased in either the overweight or obese groups. Obesity was associated with deep or infratentorial microbleeds. This finding suggests that obesity affects cerebral small vessels through arteriosclerotic vasculopathy. Based on our findings, we postulate that obesity is associated with the presence of subclinical and bleeding-prone cerebrovascular disease in the elderly.Journal of Neurology 05/2012; · 3.47 Impact Factor -
Article: The relation between chronic kidney disease and cerebral microbleeds: difference between patients with and without diabetes.
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ABSTRACT: BACKGROUND : Cerebral microbleeds are an important radiologic marker of bleeding-prone brain and have been reported to be associated with the increased risk of intracerebral haemorrhage. AIMS : We sought to examine the association of chronic kidney disease with cerebral microbleeds, and determine whether the association differs between patients with and without diabetes. METHODS : A total of 909 patients with ischemic stroke who were consecutively admitted to our hospital were included in this study. We collected demographic, clinical, and laboratory data (including serum creatinine levels) and documented the presence and numbers of microbleeds. Kidney function was estimated by using the Modification of Diet in Renal Disease formula. We categorized estimated glomerular filtration rates into moderate to severe, mild, and normal (<60, 60-90, and >90 ml/min/1·73 m(2) , respectively). RESULTS : Cerebral microbleeds is most frequent in the moderate-to-severe chronic kidney disease group (45·6%). In patients without diabetes, mild and moderate-to-severe chronic kidney disease was found to be independently associated with the presence of cerebral microbleeds (adjusted odds ratio, 1·68; 95% confidence interval, 1·04-2·71 and adjusted odds ratio, 3·74; 95% confidence interval, 1·87-7·47) compared with normal kidney function. In patients with diabetes, however, this relationship was not found. Furthermore, ordinal logistic regression analysis revealed that an increased serum creatinine level and a reduced kidney function were associated with the number of cerebral microbleeds. CONCLUSION : We found that chronic kidney disease is independently associated with cerebral microbleeds in patients without diabetes but not in patients with diabetes.International Journal of Stroke 01/2012; 7(7):551-7. · 2.38 Impact Factor -
Article: Pentraxin 3: a novel and independent prognostic marker in ischemic stroke.
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ABSTRACT: Pentraxin 3 (PTX3) is one of the pattern-recognition receptors related to the initial step of the immune response with C-reactive protein, but the physiologic and pathologic functions are not fully understood. The purpose of the current study was to determine the impact of PTX3 levels on mortality after ischemic stroke. We consecutively enrolled 376 patients who had ischemic stroke between September 2004 and September 2006. The patients were divided into tertiles according to PTX3 levels. Cox regression analysis was used to determine hazard ratios (HRs) and 95% confidence intervals (CIs) of the PTX3 tertiles for all-cause mortality with adjustment for traditional risk factors and laboratory variables, including C-reactive protein. During the follow-up, 19.4% of the patients were deceased. The median PTX3 levels were higher in the deceased patients (18.0 vs. 6.4 ng/mL, p<0.001). Based on Cox regression analysis, compared with the first tertile of PTX3, the adjusted HRs of the second and third tertiles for all-cause mortality were 1.24 (95% CI, 0.52-2.98) and 2.64 (95% CI, 1.19-5.85), respectively. When the log-transformed levels of PTX3 were incorporated as continuous variables, higher levels of PTX3 were also associated with an increased mortality (increase per log unit; HR, 1.60; 95% CI, 1.19-2.16). We showed that higher levels of PTX3 are independently associated with increased mortality after ischemic stroke. Our results suggest that PTX3 may be used as a new powerful prognostic biomarker in patients with ischemic stroke.Atherosclerosis 12/2011; 220(2):581-6. · 3.79 Impact Factor
Top co-authors
Top Journals
Institutions
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2012–2013
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Seoul National University Bundang Hospital
Seoul, Seoul, South Korea -
Seoul National University
- Department of Neurology
Seoul, Seoul, South Korea -
Hallym University Medical Center
Seoul, Seoul, South Korea
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2009–2013
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Seoul National University Hospital
Seoul, Seoul, South Korea
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2006–2013
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Catholic University of Korea
- Department of Thoracic and Cardiovascular Surgery
Seoul, Seoul, South Korea
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