Sundus Aslan

Mustafa Kemal University, Antalya, Antalya, Turkey

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Publications (14)10.72 Total impact

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    ABSTRACT: To investigate hearing loss in patients with vitiligo. Case-control study. University hospital. Conventional pure-tone and high-frequency audiometric tests were obtained, and pure-tone average hearing thresholds were calculated for 22 consecutive cases with vitiligo and 22 sex- and age-matched controls. Transient evoked otoacoustic emission testing was also performed. There was sensorineural hearing loss on pure-tone audiogram in 16 (36.4%) ears in patients with vitiligo. The hearing thresholds (in dB) were 16.02 +/- 6.61 versus 12.39 +/- 6.05, 15.68 +/- 6.34 versus 13.18 +/- 3.75, 15.80 +/- 13.93 versus 7.39 +/- 6.95, 25.11 +/- 17.40 versus 15.91 +/- 12.91, 29.89 +/- 18.57 versus 17.84 +/- 12.36, and 45.91 +/- 23.31 versus 33.86 +/- 15.99 in the patient and control groups at 0.25, 1, 4, 8, 10, and 12.5 kHz, respectively, and were statistically significantly different. Reduction of transient evoked otoacoustic emission amplitude was statistically significant at 4 kHz in patients with vitiligo (6.34 +/- 3.98 dB vs 8.63 +/- 5.15 dB, P = 0.023). There was no significant difference in reproducibility, stimulus intensity, stability, and average transient evoked otoacoustic emission amplitudes in patients with vitiligo. Hearing thresholds at pure-tone and high-frequency audiometry were higher in patients with vitiligo. Also, significantly lower high-frequency amplitudes were recorded during transient evoked otoacoustic emission testing in the disease group.
    Otolaryngology Head and Neck Surgery 03/2010; 142(3):409-14. · 1.73 Impact Factor
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    ABSTRACT: To investigate hearing loss in patients with Behçet's disease. Twenty-four consecutive cases of Behçet's disease and 24 sex- and age-matched controls were included in this study. Pure tone and high frequency audiometric tests were performed and pure tone average hearing thresholds calculated for both groups. Transient evoked otoacoustic emission testing was also performed. Pure tone audiometry showed a sensorineural hearing loss in 15 of the Behçet's disease ears. Hearing thresholds were significantly higher in the study group than in the control group, on both pure tone frequency (except 0.5 kHz) and high frequency audiometry. Significant reductions in transient evoked otoacoustic emission amplitude were found at 1.4 and 2 kHz in the Behçet's disease patients. There were no significant differences in reproducibility, stimulus intensity or stability, comparing the Behçet's disease patients and controls. Significantly lower mid-frequency amplitudes were found in Behçet's patients on transient evoked otoacoustic emission testing.
    The Journal of Laryngology & Otology 09/2009; 124(1):10-5. · 0.68 Impact Factor
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    ABSTRACT: Despite the fact that this was a study done with fascia other than the temporalis, we found that non-formaldehyde-formed and formaldehyde-formed fascia graft shrunk by a mean value of 26.5% and 16.7%, respectively, which was statistically significant. This finding might be the explanation for the consistently reported successful outcomes in tympanoplasty carried out with formaldehyde-formed temporalis fascia. However, this study should be validated with autologous human temporalis fascia graft. To determine whether there is any difference in the dimensional stability of free fascia grafts when formed with formaldehyde or not. In a total of 22 rats, free fascias were prepared with 4% buffered formaldehyde solution in 11 and without formaldehyde in the other 11 rats. All fascia grafts of 1 x 1 cm were implanted under the insicion site of the same rat (autograft). All rats were re-operated after 5 days to measure the dimensions of the grafts. The postoperative changes in the dimensions were calculated. By the 5th day, the mean non-formaldehyde-formed graft surface area was 73.51+/-13.43 mm(2) and the mean formaldehyde-formed graft surface area was 83.28+/-10.50 mm(2) respectively. After 5 days there was a mean decrease in surface area of the non-formaldehyde-formed and formaldehyde-formed grafts of 26.49+/-13.43 mm(2) and 16.72+/-10.50 mm(2), respectively. It was found that formaldehyde-formed fascia exhibited significantly superior dimensional stability when compared with non-fixed fascia during the 5 days of the early healing phase (p=0.031).
    Acta oto-laryngologica 06/2009; 130(1):52-6. · 0.98 Impact Factor
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    ABSTRACT: To determine if any difference exists between a set of nasal dimension measurements in choanal atresia patients and in a control group. A retrospective study was undertaken to define the variation of values for a series of nasal dimension measurements through axial computed tomography in 9 patients with bilateral choanal atresia and compare the same dimensions with a control group 104 patients of similar gender and age distribution. The statistical significance of the differences in these dimensions was examined. Nine of 17 variables showed a significant difference between normal and choanal atresia group. The result showed that the growth of the nasal complex can be influenced by nasal obstruction. These findings might serve in understanding the differential growth patterns of nasal structures in the face of the nasal breathing obstruction. Computed tomography is valuable in defining the exact anatomical extent of the disease and also in preoperative evaluation of the patient.
    International Journal of Pediatric Otorhinolaryngology 02/2009; 73(2):329-35. · 1.35 Impact Factor
  • European Urology Supplements - EUR UROL SUPPL. 01/2009; 8(8):588-589.
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    ABSTRACT: Prolene is cheap, effective, and readily available in almost all operating theaters. It might be used successfully in endoscopic dacryocystorhinostomy and is promising as an alternative to silicone stent intubations, especially in settings with limited resources. To evaluate the clinical efficacy and results of stenting with polypropylene (Prolene; Ethicon, Inc.) suture material instead of silicone tube in endoscopic dacryocystorhinostomy. Forty-two endoscopic dacryocystorhinostomy operations were performed in 36 patients (11 men and 25 women; mean age 34.7 + or - 9.5 years, range 16-60 years) between 2007 and 2008. After creating an aperture in the medial wall of the lacrimal sac, 2/0 Prolene was inserted through the canaliculi into the sac. The Prolene was left in the lacrimal sac for 3 months. The patients were followed up for between 6 and 18 months (mean 8.1 + or - 3.6 months). The improvement in the complaint of epiphora was grouped as very good, good, or no change. The improvement in 34 eyes (81%) was reported as very good, whereas improvement was noted as good in 5 eyes (11.9%), and there was no change in 3 eyes (7.1%). We observed granulation tissue formation around the Prolene in two patients.
    Acta oto-laryngologica 10/2008; 129(7):755-9. · 0.98 Impact Factor
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    ABSTRACT: To report the case of a spontaneous arteriovenous malformation involving the auricula, external auditory meatus, middle ear and part of the petrous apex, and also to provide updated information about its management. A 33-year-old woman presented complaining of accelerated growth of a retro-auricular swelling during her latest pregnancy, together with pain, pulsatile tinnitus and ear discharge. An arteriovenous malformation occupying the right auricula, external auditory canal, mastoid process of the temporal bone and the lateral half of the petrous segment was diagnosed, using temporal computerised tomography and magnetic resonance imaging. The lesion was embolised with polyvinyl alcohol particles at angiography. Excision of the arteriovenous malformation nidus was performed. Three years post-operatively, magnetic resonance imaging showed no residual lesion or recurrence at the temporal bone and petrous apex, although a few scanty, serpiginous, vascular remnants had persisted. In the head and neck, arteriovenous malformations usually occur intracranially; they are rare outside the cranium. To our knowledge, there have been no previously published cases of such an extensive arteriovenous malformation involving the temporal region. Apropos of our case, the definition, clinical findings, diagnostic approaches and therapeutic management of arteriovenous malformations are discussed.
    The Journal of Laryngology & Otology 08/2008; 122(7):737-40. · 0.68 Impact Factor
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    ABSTRACT: Epidermoid carcinoma (also known as squamous cell carcinoma) of the parotid gland is more prevalent among the elderly, as are other head and neck tumors. In most cases it is observed either as a nodal metastasis of a primary tumor that drains into the parotid area or as a direct extension of a tumor that has originated in the upper dermis. Primary epidermoid carcinomas arising directly from the parotid gland are extremely rare. Similarly, secondary invasion of the orbital region by a neighboring tumor is more common than primary epidermoid carcinoma of the orbit, which is also rare. In this article, we discuss the diagnosis and treatment of a rare case of epidermoid carcinoma simultaneously invading the parotid gland and the orbit.
    Ear, nose, & throat journal 07/2008; 87(7):394-8. · 1.03 Impact Factor
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    ABSTRACT: The objectives of this clinical study were to identify, by means of the Pronto Dry test and pathologic examination, Helicobacter pylori (HP) in tonsillary tissue and to establish the role of HP in tonsillary microbiology by identifying that bacterium in the tonsillary mucosa or within the tonsil core. The subjects consisted of 52 patients (25 men and 27 women; age range, 3-65 years; mean age, 15.1+/-14.5 years) who were scheduled to undergo tonsillectomy for the treatment of chronic tonsillitis and who had not been treated with an antibiotic or a bismuth-containing compound for 6 months before the initiation of the study. In each patient, two specimens (one 4 mm x 4 mm tissue sample from the nonmucosal tonsil core and one 4 mm x 4 mm sample of mucosal tissue) were excised from both tonsils immediately after tonsillectomy. The specimens were placed in the Pronto Dry test kit, and the test results were obtained 1 h later. The remaining tonsillary tissues were submitted for pathologic analysis via hematoxylin-eosin stain, Giemsa stain, Warthin-Starry silver stain, and staining for inducible nitric oxide synthase (iNOS). The results of the Pronto Dry test were positive for HP in 42% (n=22) of the excised mucosal tissue and in 47% (n=24) of the excised core tissue. In 27% (n=14) of the patients, both the core and the mucosal tissues tested positive for HP. There was no significant difference between the positive Pronto Dry test ratios of the biopsies obtained from the mucosa and those obtained from the core (P=0.693). iNOS staining showed that macrophage iNOS activity was significantly higher (P=0.025) in biopsied mucosal tissues with a positive Pronto Dry test result than in those with a negative result. Light microscopy revealed no HP in samples stained with hematoxylin-eosin stain, Giemsa stain, or Warthin-Starry silver stain. Positive Pronto Dry test results and the results of iNOS staining showed that HP contributes to chronic tonsillitis, especially at the mucosal layer. Although HP does not colonize, it contributes to the chronic tonsillary inflammatory process as a triggering agent by affecting macrophages in the tonsil and thus increasing iNOS expression.
    Auris Nasus Larynx 10/2007; 34(3):339-42. · 0.95 Impact Factor
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    ABSTRACT: Objectives: To evaluate parotidectomy cases with masses in the parotid gland and present our experience. Methods: Clinical records of 68 patients who underwent parotidec-tomy with a diagnosis of parotid mass at Baflkent University Hospital between January 2000 and December 2005 were retro-spectively reviewed. All patients who were operated by parotidec-tomy due to neoplastic and non-neoplastic parotid gland diseases were included in the study. ENT examinations, the results of com-puted tomography and magnetic resonance imaging, fine needle aspiration biopsy and pathology were evaluated and discussed. Results: The age of the cases ranged between 12 months and 85 years (mean=52.4 years); 57 cases were operated on because of benign masses whereas 11 cases were operated on due to malign masses. The cases who were operated on because of benign mass-es were treated by superficial parotidectomy or total parotidecto-my. Those operated on with diagnosis of malign masses were treated by superficial, total or radical parotidectomy according to the kind of pathology. The facial nerve was included in the speci-men in cases with nerve invasion. For some cases neck dissection was performed if needed. As additional treatment radiotherapy, chemotheraphy, or chemoradiotherapy were performed. The patients' follow up span ranged between two months and five years (mean=3.5 years). There were no recurrences among the cases operated for benign masses. Follow up examination of the three patients with malign masses of epidermoid carcinoma revealed that one had lung metastasis and other two had neck metastasis. There were no recurrences and no metastasis among the other malign cases. Conclusion: Our surgical approaches were appropriate in benign masses despite of short follow up period of theirs, and it has not been detected any recurrence until now. However, we thought that particularly approach to neck in malign tumors should have been done radical.
    Turkish Archives of Otolaryngology. 01/2007; 45(2):91-99.
  • Acta Oto-Laryngologica 11/2006; 126(10):1110-1. · 1.11 Impact Factor
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    ABSTRACT: To investigate the effects of intratympanic dexamethasone injection, which is done because of tinnitus, on transient evoked otoacoustic emission (TEOAE) and so determine whether given dexamethasone cause any damage in the inner ear. Twenty-six patients, aged between 32 and 75, with subjective tinnitus, were randomly selected. The selected patients were the ones whose improvement had not been achieved through minimum 6 months' medical therapy (eg, Ginkgo biloba extract EGb 761, betahistidine, and trimetazidin) and who were free of systemic or otolaryngologic disease (hypertension, diabetes mellitus, hypo/hypertyroidi, hypercholesterolemia, Meniere disease, and otosclerosis). Before and after the injections, audiometry including high-frequency tinnitus matching and TEOAE tests were done. The injections of 4 mg/mL dexamethasone were done 5 times in fixed protocols on days 0, 2, 4, 6, and 8. After each injection, the patients were kept supine for 60 minutes with the head turned 45 degrees to opposite ear. Paired t test was used to compare the beginning and final measurements. Temporary pain and vertigo attacks which lasted at most for 15 minutes occurred in some patients only during injections. Neither infection nor persistent perforation occurred in any patients. After the management, there was no significant difference on patient's pure tone averages ( P = .067) and high-frequency averages ( P = .592). When the obtained TEOAE results before and after management were compared, the only significant increase was detected in the reproducibility values ( P = .042). There was no significant difference in other TEOAE parameters which are stimulus stability, stimulus intensity, and overall signal-to-noise ratio ( P > .05). There is no fixed criteria for rejecting a response solely on the reproducibility. However, a high value of the reproducibility (or increase in reproducibility) is always meaningful. Intratympanic dexamethasone used for management in many indications, primarily in Meniere and tinnitus patients, was found to increase the reproducibility values of otoacoustic emission. Despite the fact that there was not a reasonable increase in the responses coming from the outer hair cells, the result was considered positive for the study as the responses did not decrease. It is found out that 4 mg/mL dexamethasone given intratympanically does not adversely affect the outer hair cell function as measured by otoacoustic emission. Within the limits of this study, dexamethasone appears to be safe when given intratympanically.
    American Journal of Otolaryngology 01/2005; 26(2):113-7. · 1.23 Impact Factor
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    ABSTRACT: Bacteriology of tonsil core: a clinical study Objectives: The purpose of the study was to investigate the core specimens of the tonsil tissue without surface mucosa, and deter- mine the bacteriology of tonsil tissue. Methods: This study was conducted in the Baflkent University Adana Research and Teaching Medical Center. One hundred-twen- ty patients who underwent tonsillectomy with the diagnosis of chronic tonsillitis were included in the study. Hot tonsillectomy was not performed in any of the patients. Core specimens without sur- face mucosa were obtained from the removed tonsils under the sterile conditions and were examined microbiologically. The statis- tical analysis was performed by using χ2 method. p values
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    ABSTRACT: Results: The age of the cases ranged between 12 months and 85 years (mean=52.4 years); 57 cases were operated on because of benign masses whereas 11 cases were operated on due to malign masses. The cases who were operated on because of benign mass- es were treated by superficial parotidectomy or total parotidecto- my. Those operated on with diagnosis of malign masses were treated by superficial, total or radical parotidectomy according to the kind of pathology. The facial nerve was included in the speci- men in cases with nerve invasion. For some cases neck dissection was performed if needed. As additional treatment radiotherapy, chemotheraphy, or chemoradiotherapy were performed. The patients' follow up span ranged between two months and five years (mean=3.5 years). There were no recurrences among the cases operated for benign masses. Follow up examination of the three patients with malign masses of epidermoid carcinoma revealed that one had lung metastasis and other two had neck metastasis. There were no recurrences and no metastasis among the other malign cases. Conclusion: Our surgical approaches were appropriate in benign masses despite of short follow up period of theirs, and it has not been detected any recurrence until now. However, we thought that particularly approach to neck in malign tumors should have been done radical.