Richard A. Glennon

Virginia Commonwealth University, Ричмонд, Virginia, United States

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Publications (411)1357.51 Total impact

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    ABSTRACT: Background and purpose: Methcathinone (MCAT) is a potent monoamine releaser and parent compound to emerging drugs of abuse including mephedrone (4-CH3 MCAT), the para-methyl analogue of MCAT. This study examined quantitative structure-activity relationships (QSAR) for MCAT and six para-substituted MCAT analogues on (a) in vitro potency to promote monoamine release via dopamine and serotonin transporters (DAT and SERT, respectively), and (b) in vivo modulation of intracranial self-stimulation (ICSS), a behavioural procedure used to evaluate abuse potential. Neurochemical and behavioural effects were correlated with steric (Es ), electronic (σp ) and lipophilic (πp ) parameters of the para substituents. Experimental approach: For neurochemical studies, drug effects on monoamine release through DAT and SERT were evaluated in rat brain synaptosomes. For behavioural studies, drug effects were tested in male Sprague-Dawley rats implanted with electrodes targeting the medial forebrain bundle and trained to lever-press for electrical brain stimulation. Key results: MCAT and all six para-substituted analogues increased monoamine release via DAT and SERT and dose- and time-dependently modulated ICSS. In vitro selectivity for DAT versus SERT correlated with in vivo efficacy to produce abuse-related ICSS facilitation. In addition, the Es values of the para substituents correlated with both selectivity for DAT versus SERT and magnitude of ICSS facilitation. Conclusions and implications: Selectivity for DAT versus SERT in vitro is a key determinant of abuse-related ICSS facilitation by these MCAT analogues, and steric aspects of the para substituent of the MCAT scaffold (indicated by Es ) are key determinants of this selectivity.
    British Journal of Pharmacology 05/2015; 172(10):2433-2444. DOI:10.1111/bph.13030 · 4.84 Impact Factor
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    ABSTRACT: Desformylflustrabromine (dFBr) is a positive allosteric modulator (PAM) of α4β2 and α2β2 nicotinic acetylcholine receptors (nAChRs) that, at concentrations >1 μM, also inhibits these receptors and α7 nAChRs. However, its interactions with muscle-type nAChRs have not been characterized, and the locations of its binding site(s) in any nAChR are not known. We report here that dFBr inhibits human muscle (αβϵδ) and Torpedo (αβγδ) nAChR expressed in Xenopus oocytes with IC50 values of ~1 μM. dFBr also inhibited the equilibrium binding of ion channel blockers to Torpedo nAChRs with higher affinity in the nAChR desensitized state ([(3)H]phencyclidine; IC50 = 4 μM) than in the resting state ([(3)H]tetracaine; IC50 = 60 μM), whereas it bound with only very low affinity to the ACh binding sites ([(3)H]ACh, IC50 = 1 mM). Upon irradiation at 312 nm, [3H]dFBr photoincorporated into amino acids within the Torpedo nAChR ion channel with the efficiency of photoincorporation enhanced in the presence of agonist and the agonist-enhanced photolabeling inhibitable by phencyclidine. In the presence of agonist, [(3)H]dFBr also photolabeled amino acids in the nAChR extracellular domain within binding pockets identified previously for the non-selective nAChR PAMs galantamine and physostigmine at the "canonical" α-γ interface containing the transmitter binding sites and at the "non-canonical" δ-β subunit interface. These results establish that dFBr inhibits muscle-type nAChR by binding in the ion channel and that [(3)H]dFBr is a photoaffinity probe with broad amino acid side chain reactivity. The American Society for Pharmacology and Experimental Therapeutics.
    Molecular pharmacology 04/2015; 88(1). DOI:10.1124/mol.115.098913 · 4.13 Impact Factor
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    ABSTRACT: The designer stimulant methylenedioxypyrovalerone (MDPV) is a potent reuptake inhibitor at transporters for dopamine (DAT) and norepinephrine (NET) that produces a constellation of abuse-related behavioral effects. MDPV possesses a chiral center, and the abused formulation of the drug is a racemic mixture, but no data are available on the pharmacology of its isomers. Here, the individual optical isomers of MDPV were prepared and examined with respect to their neurochemical actions on neurotransmitter reuptake and behavioral effects in an assay of intracranial self-stimulation (ICSS) in rats. In assays of DAT uptake inhibition, S(+)MDPV (EC50 = 2.13 nM) was more potent than either ()MDPV (EC50 = 4.85 nM) or R(-)MDPV (EC50 = 382.80 nM); the three drugs were less potent at NET uptake inhibition, with the same rank order of potency. Neither racemic MDPV, nor its optical isomers, inhibited the reuptake of serotonin at concentrations up to 10 µM. S(+)MDPV produced an abuse-related and dose-dependent facilitation of ICSS, and the potency of S(+)MDPV (significant facilitation at doses ≥0.1 mg/kg) was greater than that of the racemate (significant facilitation at doses ≥0.32 mg/kg). R(-)-MDPV failed to alter ICSS at doses up to 100 times greater than the lowest effective dose of S(+)MDPV. The results indicate that abuse-related neurochemical and behavioral effects of racemic MDPV reside primarily with its S(+)-isomer.
    ACS Chemical Neuroscience 02/2015; 6(5). DOI:10.1021/acschemneuro.5b00006 · 4.36 Impact Factor
  • Biophysical Journal 01/2015; 108(2):462a. DOI:10.1016/j.bpj.2014.11.2521 · 3.97 Impact Factor
  • QiongYao Tang · Renata Kolanos · Louis J DeFelice · Richard A Glennon
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    ABSTRACT: Amphetamine (AMPH) induces depolarizing currents through the human dopamine transporter (hDAT). Recently we discovered that the S(+) enantiomer of AMPH induces a current through hDAT that persists long after its removal from the external milieu. The persistent current is less prominent for R(-)AMPH and essentially absent for dopamine (DA)-induced currents. Related agents such as methamphetamine also exhibit persis-tent currents, which are present in both frog oocyte and mammalian HEK expression systems. Here, we study hDAT-expressing Xenopus laevis oocytes voltage-clamped and exposed from outside to DA, S(+)AMPH, R(-)AMPH, and related synthesized com-pounds, including stereoisomers. The goal of the study was to determine how structural transitioning from dopamine to amphetamine influences hDAT potency and action. At saturating concentrations, S(+)AMPH or R(-)AMPH induce a sharply rising, depolarizing current from -60 mV that is comparable in amplitude to DA-induced currents. The magnitude and duration of the currents and the presence or absence of persistent currents depend on the concentration, duration of exposure, and the chemical structure and enantiomeric versions of the agents.
    ACS Chemical Neuroscience 01/2015; 6(4). DOI:10.1021/cn500282f · 4.36 Impact Factor
  • Richard A Glennon
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    ABSTRACT: The term "synthetic cathinones" is fairly new, but, although the abuse of synthetic cathinones is a recent problem, research on cathinone analogs dates back >100 years. One structural element cathinone analogs have in common is an α-aminophenone moiety. Introduction of amine and/or aryl substituents affords a large number of agents. Today, >40 synthetic cathinones have been identified on the clandestine market and many have multiple "street names." Many cathinone analogs, although not referred to as such until the late 1970s, were initially prepared as intermediates in the synthesis of ephedrine analogs. The cathinones do not represent a pharmacologically or mechanistically homogeneous class of agents. Currently abused synthetic cathinones are derived from earlier agents and seem to produce their actions primarily via the dopamine, norepinephrine, and/or serotonin transporter; that is, they either release and/or inhibit the reuptake of one or more of these neurotransmitters. The actions of these agents can resemble those of central stimulants such as methamphetamine, cocaine, and/or empathogens such as 1-(3,4-methylenedioxyphenyl)-2-aminopropane (Ecstasy) and/or produce other effects. Side effects are primarily of a neurological and/or cardiovascular nature. The use of the "and/or" term is emphasized because synthetic cathinones represent a broad class of agents that produce a variety of actions; the agents cannot be viewed as being pharmacologically equivalent. Until valid structure-activity relationships are formulated for each behavioral/mechanistic action, individual synthetic cathinones remain to be evaluated on a case-by-case basis. Treatment of synthetic cathinone intoxication requires more "basic science" research. At this time, treatment is mostly palliative.
    Advances in pharmacology (San Diego, Calif.) 12/2014; 69:581-620. DOI:10.1016/B978-0-12-420118-7.00015-9
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    ABSTRACT: Background and PurposeCertain methcathinone (MCAT) analogs are psychostimulants of growing drug-abuse concern. This study extends an initial quantitative structure-activity relationship (QSAR) investigation that demonstrated important steric considerations of seven 4- (or para-)substituted analogs of MCAT. Specifically, the steric character (Taft's steric ES) of the 4-position substituent influenced in vitro potency to promote monoamine release via dopamine and serotonin transporters (DAT and SERT) and in vivo modulation of intracranial self-stimulation (ICSS). Here, we delve farther into this QSAR analysis by examining other steric properties of the 4-position substituents.Experimental ApproachDefinitive steric parameters that more explicitly focus on the volume, width, and length of the MCAT 4-position substituents were examined. In addition, homology models of hDAT and hSERT based on the crystallized Drosophila DAT were constructed and docking studies were performed, followed by HINT analysis of the docking results.Key ResultsThe potency of seven MCAT analogs at DAT was found to be negatively correlated with the volume and maximal width of their 4-position substituents, whereas potency at SERT increased as substituent volume and length increased. SERT/DAT selectivity, as well as abuse-related drug effects in the ICSS procedure, also correlated with the same parameters. Docking solutions offered a means of visualizing these findings.Conclusions and ImplicationsThese results suggest that steric aspects of the 4-position substituents of MCAT analogs are key determinants of their action and selectivity, and that the hydrophobic nature of these substituents is involved in their potency at SERT.
    British Journal of Pharmacology 12/2014; DOI:10.1111/bph.13043 · 4.84 Impact Factor
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    ABSTRACT: Neuropeptide S (NPS) is a neurotransmitter that activates the NPS receptor to modulate biological functions including anxiety-like behaviors, feeding, and drug reinforcement. RTI-118 is a novel NPS receptor antagonist that decreased cocaine self-administration in rats at doses that had little or no effect on food-maintained responding. To build on these previous findings, this study examined effects of RTI-118 on cocaine-induced facilitation of intracranial self-stimulation (ICSS) in rats. To provide a context for data interpretation, effects of RTI-118 were compared to effects of the kappa opioid receptor agonist U69,593, because the kappa opioid receptor is another peptide neurotransmitter receptor reported to modulate abuse-related cocaine effects. RTI-118 effects were also examined on ICSS facilitation produced by methylenedioxypyrovalerone (MDPV), a novel designer drug of abuse with some cocaine-like effects. Male Sprague-Dawley rats (n=12) with electrodes targeting the medial forebrain bundle responded under a fixed-ratio 1 schedule for range of brain stimulation frequencies. Under control conditions, brain stimulation maintained a frequency-dependent increase in ICSS rates. Cocaine (1.0-10mg/kg) and MDPV (3.2mg/kg) facilitated ICSS. RTI-118 (3.2-32mg/kg) alone produced little effect on ICSS but dose dependently blocked cocaine-induced ICSS facilitation. U69,593 (0.25-0.5mg/kg) also attenuated cocaine effects, but blockade of cocaine effects was incomplete even at a U69,593 dose that alone depressed ICSS. RTI-118 (32mg/kg) failed to block MDPV-induced ICSS facilitation. These results support further consideration of NPS receptor antagonists as candidate treatments for cocaine abuse and provide evidence for differential effects of a candidate treatment on abuse-related effects of cocaine and MDPV.
    European Journal of Pharmacology 09/2014; 743. DOI:10.1016/j.ejphar.2014.09.006 · 2.53 Impact Factor
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    ABSTRACT: Monoamine transporters have been implicated in dopamine or serotonin release in response to abused drugs such as methamphetamine or ecstasy (MDMA). In addition, monoamine transporters show substrate-induced inward currents that may modulate excitability and Ca(2+) mobilization, which could also contribute to neurotransmitter release. How monoamine transporters modulate Ca(2+) permeability is currently unknown. We investigate the functional interaction between the human serotonin transporter (hSERT) and voltage-gated Ca(2+) channels (CaV). We introduce an excitable expression system consisting of cultured muscle cells genetically engineered to express hSERT. Both 5HT and S(+)MDMA depolarize these cells and activate the excitation-contraction (EC)-coupling mechanism. However, hSERT substrates fail to activate EC-coupling in CaV1.1-null muscle cells, thus implicating Ca(2+) channels. CaV1.3 and CaV2.2 channels are natively expressed in neurons. When these channels are co-expressed with hSERT in HEK293T cells, only cells expressing the lower-threshold L-type CaV1.3 channel show Ca(2+) transients evoked by 5HT or S(+)MDMA. In addition, the electrical coupling between hSERT and CaV1.3 takes place at physiological 5HT concentrations. The electrical coupling between monoamine neurotransmitter transporters and Ca(2+) channels such as CaV1.3 is a novel mechanism by which endogenous substrates (neurotransmitters) or exogenous substrates (like ecstasy) could modulate Ca(2+)-driven signals in excitable cells.
    Cell calcium 07/2014; 56(1):25-33. DOI:10.1016/j.ceca.2014.04.003 · 3.51 Impact Factor
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    ABSTRACT: A fundamental understanding of the interaction of ligands with biological receptors is important since many drugs exert their influence via receptors. Using a cluster approach, we have studied the role of structural and electronic parameters on receptor-ligand binding by carrying out density functional theory based calculations. As model systems, we have studied substituted arylguanidines, which activate 5-HT3 receptors in a manner similar to that of serotonin. The geometries of the aryl guanidine derivatives were fully optimized to obtain the lowest energy structures. Electronic properties such as binding energies, dipole moments, polarizabilities, and electron affinities, as well as geometric properties, such as molecular volume and dihedral angles were calculated, and their relationship with binding affinity was evaluated. Results obtained were compared to experimental ligand-receptor binding affinity data available. These fundamental studies show that while both electronic and geometric properties of the ligands are important for binding, the electron affinities of the substituent species play a dominant role. Potential new fundamental indices for ligand-receptor affinity are also discussed.
    The Journal of Physical Chemistry A 05/2014; 118(37). DOI:10.1021/jp5017906 · 2.69 Impact Factor
  • Louis J De Felice · Richard A Glennon · Sidney S Negus
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    ABSTRACT: This mini-review summarizes the history of cathinone and its synthesized derivatives from early records to the present day, including the appearance of synthetic cathinones in the drug combination known as bath salts. Bath salts may consist of one compound (MDPV) or combinations of MDPV and one or more other synthetic cathinones, which may also appear alone without MDPV. We briefly review recent in vitro studies of bath salts components alone or in combination, focusing on pharmacological and biophysical studies. Finally we summarize new data from in vivo procedures that characterize the abuse-related neurochemical and behavioral effects of synthetic cathinones in rats.
    Life sciences 11/2013; 97(1). DOI:10.1016/j.lfs.2013.10.029 · 2.70 Impact Factor
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    ABSTRACT: Synthetic cathinones, beta-keto analogs of amphetamine (or, more correctly, of phenylalkylamines), represent a new and growing class of abused substances. Several such analogs have been demonstrated to act as dopamine (DA) releasing agents. Methylenedioxypyrovalerone (MDPV) was the first synthetic cathinone shown to act as a cocaine-like DA reuptake inhibitor. MDPV and seven deconstructed analogs were examined to determine which of MDPV's structural features account(s) for uptake inhibition. In voltage-clamped (-60 mV) Xenopus oocytes transfected with the human DA transporter (hDAT), all analogs elicited inhibitor-like behavior shown as hDAT-mediated outward currents. Using hDAT-expressing mammalian cells we determined the affinities of MDPV and its analogs to inhibit uptake of [3H]DA by hDAT that varied over a broad range (IC50 values ca 135 to >25,000 nM). The methylenedioxy group of MDPV made a minimal contribution to affinity, the carbonyl group and a tertiary amine are more important, and the extended beta-alkyl group seems most important. Either a tertiary amine, or the extended beta-alkyl group (but not both), are required for the potent nature of MDPV as an hDAT inhibitor.
    ACS Chemical Neuroscience 10/2013; 4(12). DOI:10.1021/cn4001236 · 4.36 Impact Factor
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    J S Bonano · R A Glennon · L J De Felice · M L Banks · S S Negus
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    ABSTRACT: Abuse of synthetic cathinones, popularized as "bath salts," has increased dramatically in the USA since their debut in 2010. Preclinical behavioral studies may clarify determinants of the abuse-related effects produced by these compounds. This study examined behavioral effects of (±)-methcathinone, (±)-3,4-methylenedioxypyrovalerone (MDPV), (±)-3,4-methylenedioxymethcathinone (methylone), and (±)-4-methylmethcathinone (mephedrone) in rats using intracranial self-stimulation (ICSS). Male Sprague-Dawley rats (n = 18) with electrodes targeting the medial forebrain bundle responded for multiple frequencies of brain stimulation and were tested in two phases. First, dose-effect curves for methcathinone (0.1-1.0 mg/kg), MDPV (0.32-3.2 mg/kg), methylone (1.0-10 mg/kg), and mephedrone (1.0-10 mg/kg) were determined. Second, time courses were determined for effects produced by the highest dose of each compound. Methcathinone produced dose- and time-dependent facilitation of ICSS. MDPV, methylone, and mephedrone produced dose- and time-dependent increases in low rates of ICSS maintained by low brain stimulation frequencies, but also produced abuse-limiting depression of high ICSS rates maintained by high brain stimulation frequencies. Efficacies to facilitate ICSS were methcathinone ≥ MDPV ≥ methylone > mephedrone. Methcathinone was the most potent compound, and MDPV was the longest acting compound. All compounds facilitated ICSS at some doses and pretreatment times, which is consistent with abuse liability for each of these compounds. However, efficacies of compounds to facilitate ICSS varied, with methcathinone displaying the highest efficacy and mephedrone displaying the lowest efficacy to facilitate ICSS.
    Psychopharmacology 08/2013; 231(1). DOI:10.1007/s00213-013-3223-5 · 3.88 Impact Factor
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    ABSTRACT: Rationale: Psychoactive "bath salts" represent a relatively new drug of abuse combination that was placed in Schedule I in October 2011. Two common ingredients of bath salts include the cathinone analogs: mephedrone and methylenedioxypyrovalerone (MDPV). The mechanism of action of these synthetic cathinone analogs has not been well investigated. Materials and methods: Because cathinone and methcathinone are known to act as releasing agents at the human dopamine transporter (hDAT), mephedrone and MDPV were investigated at hDAT expressed in Xenopus oocytes. Results: Whereas mephedrone was found to have the signature of a dopamine-releasing agent similar to methamphetamine or methcathinone, MDPV behaved as a cocaine-like reuptake inhibitor of dopamine. Conclusions: Mephedrone and MDPV produce opposite electrophysiological signatures through hDAT expressed in oocytes. Implications are that the combination (as found in bath salts) might produce effects similar to a combination of methamphetamine and cocaine.
    Psychopharmacology 01/2013; 227(3). DOI:10.1007/s00213-013-2967-2 · 3.88 Impact Factor
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    Biophysical Journal 01/2013; 104(2):110-. DOI:10.1016/j.bpj.2012.11.637 · 3.97 Impact Factor
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    ABSTRACT: Background and purpose: Bath salts is the street name for drug combinations that contain synthetic cathinone analogues, among them possibly mephedrone (MEPH) and certainly methylenedioxypyrovalerone (MDPV). In animal studies, cathinone and certain cathinone analogues release dopamine (DA), similar to the action of amphetamine (AMPH) and methamphetamine (METH). AMPH and METH act on the human DA transporter (hDAT); thus, we investigated MEPH and MDPV acting at hDAT. Experimental approach: We recorded electrical currents mediated by hDAT expressed in Xenopus laevis oocytes and exposed to: DA, METH, a known hDAT stimulant and DA releaser, MEPH, MDPV, MEPH + MDPV, or cocaine, a known hDAT inhibitor. Key results: DA, METH and MEPH induce an inward current (depolarizing) when the oocyte is held near the resting potential (-60 mV), therefore acting as excitatory hDAT substrates. Structurally analogous MDPV induces an outward (hyperpolarizing) current similar to cocaine, therefore acting as an inhibitory non-substrate blocker. Conclusions and implications: Two components of bath salts, MEPH and MDPV, produce opposite effects at hDAT that are comparable with METH and cocaine, respectively. In our assay, MEPH is nearly as potent as METH; however, MDPV is much more potent than cocaine and its effect is longer lasting. When applied in combination, MEPH exhibits faster kinetics than MDPV, viz., the MEPH depolarizing current occurs seconds before the slower MDPV hyperpolarizing current. Bath salts containing MEPH (or a similar drug) and MDPV might then be expected initially to release DA and subsequently prevent its reuptake via hDAT. Such combined action possibly underlies some of the reported effects of bath salts abuse.
    British Journal of Pharmacology 11/2012; 168(7). DOI:10.1111/bph.12061 · 4.84 Impact Factor
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    Bioorganic & Medicinal Chemistry Letters 10/2012; 22(20):6526. DOI:10.1016/j.bmcl.2012.08.076 · 2.42 Impact Factor
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    Biophysical Journal 01/2012; 102(3):215-. DOI:10.1016/j.bpj.2011.11.1178 · 3.97 Impact Factor
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    ABSTRACT: Desformylflustrabromine (dFBr; 1), perhaps the first selective positive allosteric modulator of α4β2 neuronal nicotinic acetylcholine (nACh) receptors, was deconstructed to determine which structural features contribute to its actions on receptors expressed in Xenopus ooycytes using two-electrode voltage clamp techniques. Although the intact structure of 1 was found to be optimal, several deconstructed analogs retained activity. Neither the 6-bromo substituent nor the entire 2-position chain is required for activity. In particular, reduction of the olefinic side chain of 1, as seen with 6, not only resulted in retention of activity/potency but in enhanced selectivity for α4β2 versus α7 nACh receptors. Pharmacophoric features for the allosteric modulation of α4β2 nACh receptors by 1 were identified.
    Journal of Medicinal Chemistry 09/2011; 54(20):7259-67. DOI:10.1021/jm200834x · 5.45 Impact Factor
  • Xiaoqun Zhang · Per E Andren · Richard A Glennon · Per Svenningsson
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    ABSTRACT: Serotonin 5-HT(6) receptors have been implicated in the regulation of cognition, locomotion, and mood, but the elucidation of their functions is complicated by conflicting data using various animal models. Here, a systematic evaluation showed that autoradiographic binding with the selective 5-HT(6) receptor antagonist [(125) I]SB-258585 was similar in marmosets and rats. In both species, [(125) I]SB-258585 binding was enriched in the caudate-putamen. Various recently developed agonists and antagonists toward 5-HT(6) receptors exhibited similarities in their abilities to displace [(125) I]SB-258585 binding in marmosets and rats. The rank order of pEC50 values were as follows: (+)EMDT-CR = EMD386088>MS-245 = 5-HT>EMDT>(-)EMDT-CR; and (+)EMDT-CR = EMD386088>5-HT = MS-245 = EMDT>(-)EMDT-CR, in marmosets and rats, respectively. Unilateral 6-hydroxydopamine lesioning of dopaminergic axons caused a significant decrease of [(125) I]SB-258585 binding in the caudate-putamen of both marmosets and rats. Nonetheless, acute administration of the 5-HT(6) receptor agonist EMDT to unilaterally 6-hydroxydopamine-lesioned rats, caused an induction of egr-1, homer, and enkephalin mRNAs in the dopamine-depleted hemisphere, indicating a supersensitization of 5-HT(6) receptors following dopamine depletion. In conclusion, this study provides evidence for significant similarities in the distribution, level, pharmacology, and regulation of 5-HT(6) receptors between rats and marmosets.
    The Journal of Comparative Neurology 06/2011; 519(9):1816-27. DOI:10.1002/cne.22605 · 3.23 Impact Factor

Publication Stats

11k Citations
1,357.51 Total Impact Points


  • 1978–2015
    • Virginia Commonwealth University
      • • Department of Medicinal Chemistry
      • • Department of Pharmacology and Toxicology
      • • School of Pharmacy
      Ричмонд, Virginia, United States
  • 1983–2013
    • Julphar School of Pharmacy
      United States
  • 1985–2011
    • Albany Medical College
      • Center for Neuropharmacology and Neuroscience
      Albany, New York, United States
  • 2010
    • Richmond VA Medical Center
      Ричмонд, Virginia, United States
  • 2003
    • University of Oxford
      • Department of Pharmacology
      Oxford, England, United Kingdom
  • 2001
    • University of Camerino
      • Dipartimento di Scienze Chimiche
      Camerino, The Marches, Italy
  • 1990
    • Union University
      Джексон, Alabama, United States
  • 1989
    • Johns Hopkins University
      • Department of Neuroscience
      Baltimore, MD, United States
  • 1986
    • Hackensack University Medical Center
      Hackensack, New Jersey, United States
  • 1973
    • University at Buffalo, The State University of New York
      Buffalo, New York, United States