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Publications (4)5.36 Total impact

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    ABSTRACT: The first 5 years of life, the period called "early childhood", are characterized by a dynamic process of development and maturation of the central nervous system (CNS). This process is manifested by continuous changes in cognitive, motor, speech/language, psychological and sensory modulation skills and consequently, in the behavior of the developing child. It is a period of neuron-plasticity, in which the CNS structure and functioning are very sensitive to environmental influences. These influences could be positive or negative. On the one hand, early protective factors, like secure attachment, increase the resilience of the very young child against stressors and against the development of psychopathology; but on the other hand, there is a high vulnerability to early insults of any kind. It has been demonstrated that a high percentage of psychopathology in adult life has his roots in early childhood, and that early diagnosis, which leads to early therapeutic interventions, decreases morbidity and the later life consequences of the disorders. These findings have promoted the field of early childhood psychiatry during the last decade, to become one of the most promising challenges in the field of mental health. In our review, we present an update on the state of nosology, assessment and diagnosis in early childhood and provide clinical guidelines for the daily work of professionals involved in the mental health care of very young children.
    Harefuah 04/2011; 150(4):353-8, 419, 418.
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    ABSTRACT: Early repolarization (ER), considered a common and benign electrocardiographic pattern on the surface 12-lead electrocardiogram (ECG), was recently found to be prevalent among patients with idiopathic ventricular fibrillation. It is also highly predominant in physically active young males. Reports on sudden cardiac death (SCD) of children and adolescents treated with psychotropic agents have raised concerns regarding the need for cardiovascular monitoring and risk stratification schedules. The rate of ER pattern has not been estimated in children with attention deficit/hyperactivity disorder (ADHD). Thus, in the present retrospective chart review study, we estimated the rate of ER pattern, as well as RR, QT, and QTc intervals, from ECG tracings of physically healthy children with ADHD versus physically and mentally healthy controls. The ECG tracings of 50 children (aged 8.7 +/- 1.4 years; 12 girls, 44 boys) diagnosed as suffering from ADHD were compared to 55 physically and mentally healthy controls (aged 8.25 +/- 2.1 years; 20 girls, 35 boys). ER was defined as an elevation of the QRS-ST junction (J point) of at least 0.1 mV from baseline with slurring or notching of the QRS complex, and assessed separately by two senior cardiologists who were blind to all other data relating to the study participants. The rate of ER pattern was significantly higher in ADHD children compared to normal controls (32% vs. 13%, respectively, P = 0.012; relative risk [RR] = 1.68, 95% confidence interval [CI] 1.16-2.44), irrespective of stimulant treatment or gender. All other standard ECG measures (heart rate, QT and QTc intervals) were within normal range. The rate of ER in children with ADHD is significantly higher than in normal controls. Its clinical significance awaits further research.
    Journal of child and adolescent psychopharmacology 12/2009; 19(6):731-5. · 2.59 Impact Factor
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    ABSTRACT: QT dispersion (QTd) is a measure of interlead variations of the surface 12-lead electrocardiogram (ECG). Increased QTd, found in various cardiac diseases, reflects cardiac instability and risk for lethal cardiac arrhythmias. Research suggests a link between psychotropic treatment, ECG abnormalities (QT prolongation), and increased sudden cardiac mortality rates. Reports of sudden death in children treated with psychotropic drugs have raised concerns about cardiovascular monitoring and risk stratification. QTd analysis has not been investigated in very young children treated with antipsychotic drugs. In the present retrospective chart review study, we calculated QT interval, QTd, and their rate-corrected values in very young children treated with antipsychotics. The charts of 12 children (ages 5.8 +/- 0.98 yr; 4 girls, 8 boys) were examined before initiation of antipsychotic treatment [risperidone (n = 7), clotinapine (n = 1), and propericiazine (n = 4)] and during the maintenance period after achieving a positive clinical response. Three children were concomitantly maintained on methylphenidate. QT interval, QTd, and their rate-corrected values were calculated. QT interval, QTd, and their rate-corrected values were all within normal values both before and after successful drug treatment. This preliminary, naturalistic, small-scale study suggests that antipsychotic treatment, with or without methylphenidate, in very young children is not commonly associated with significant alterations of QT interval and dispersion, suggesting the relative safety of these agents in this unique age group.
    Journal of Child and Adolescent Psychopharmacology 05/2007; 17(2):187-94. · 2.77 Impact Factor
  • European Psychiatry - EUR PSYCHIAT. 01/2007; 22.