Mihir M Desai

Keck School of Medicine USC, Los Ángeles, California, United States

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Publications (333)1310.92 Total impact

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    ABSTRACT: Clear cell renal cell carcinoma (ccRCC) is the most common subtype of renal cell cancer (RCC), followed by papillary RCC (pRCC). It is important to distinguish these two subtypes because of prognostic differences and possible changes in management, especially in cases undergoing active surveillance. The purpose of our study is to evaluate the use of voxel-based whole-lesion (WL) enhancement parameters on contrast enhanced computed tomography (CECT) to distinguish ccRCC from pRCC. In this institutional review board-approved study, we retrospectively queried the surgical database for post nephrectomy patients who had pathology proven ccRCC or pRCC and who had preoperative multiphase CECT of the abdomen between June 2009 and June 2011. A total of 61 patients (46 with ccRCC and 15 with pRCC) who underwent robotic assisted partial nephrectomy for clinically localized disease were included in the study. Multiphase CT acquisitions were transferred to a dedicated three-dimensional workstation, and WL regions of interest were manually segmented. Voxel-based contrast enhancement values were collected from the lesion segmentation and displayed as a histogram. Mean and median enhancement and histogram distribution parameters skewness, kurtosis, standard deviation, and interquartile range were calculated for each lesion. Comparison between ccRCC and pRCC was made using each imaging parameter. For mean and median enhancement, which had a normal distribution, independent t-test was used. For histogram distribution parameters, which were not normally distributed, Wilcoxon rank sum test was used. ccRCC had significantly higher mean and median whole WL enhancement (p < 0.01) compared to pRCC on arterial, nephrographic, and excretory phases. ccRCC had significantly higher interquartile range and standard deviation (p < 0.01) and significantly lower skewness (p < 0.01) compared to pRCC on arterial and nephrographic phases. ccRCC had significantly lower kurtosis compared to pRCC on only the arterial phase. Our study suggests that voxel-based WL enhancement parameters can be used as a quantitative tool to differentiate ccRCC from pRCC. Differentiating between the two main types of RCC would provide the patient and the treating physicians more information to formulate the initial approach to managing the patient's renal cancer.
    SpringerPlus 12/2015; 4(1). DOI:10.1186/s40064-015-0823-z
  • Raj Satkunasivam · Mihir Desai · Inderbir S Gill ·

    European Urology 09/2015; DOI:10.1016/j.eururo.2015.08.022 · 13.94 Impact Factor
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    ABSTRACT: Introduction and objectives: Following the recently published EAU Policy on Live Surgical Events (LSE’s), it is now assured that live surgery will be ongoing at conferences in the immediate future. However, the panel reached >80% consensus on the view that performing at a home institution may be safer. The committee also identified issues with a ‘‘travelling surgeon’’ performing complex surgery in an unfamiliar environment with a surgical team that is not experienced with the intricacies of the surgeon’s technique. LSE’s from a home institution remove or minimize these negative aspects. Furthermore, there are other important reasons why LSE’s are enhanced when performed at a high- volume home institution. The potential to optimise surgical performance comes from working with an experienced team. Consistency is a key measure of quality, and robotic surgery in particular epitomises teamwork. It is therefore likely that the natural evolution of LSE’s, is that a greater proportion are broadcast from home institutions. We aimed to highlight the benefits of this approach to surgical training with a global approach. Material and methods: On the 16-17th February 2015 ten robotic centers from 4 continents broadcast live surgery over a 24hr continuous period. The event was advised by and approved by the EAU live surgery committee. The live surgery was broadcast on a website www.wrse24.org which was accessible only to professionals, being password protected and requiring registration and approval. LiveArena provided the infrastructure and technological support. The event was promoted via social media including a BJUI blog and a poll carried out by the BJUI website posing the question “would you sign up for a surgical webinar, instead of travelling to the venue if you received the same Continuous Medical Education (CME) points?” Results: We had registrants from 61 countries in total (58 on the day). Accessing the live surgery included 469 registrants from Europe, 114 from the US, 267 from Asia, 114 from Australia and 12 from Africa. Unique viewers were classified as viewers using a unique IP address. We had 1390 unique viewers to the www.wrse24.org website over the live 24 hours and this number increased to 2277 over the next 6 days. 76% of respondents to the BJUI poll said that they would ‘attend’ a streamed virtual surgical conference instead of travelling to it, if they got the same CME accreditation. Conclusions: This was the largest global robotic webinar for live surgery. Indications are that it was well received by the worldwide audience. Planned improvements to future WRSE24 events include further integration of social media for direct real-time interaction between surgeons and the viewers, and increased functionality and interaction with the video library.
    European Urology Supplements 09/2015; 14(5):101. · 3.37 Impact Factor
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    ABSTRACT: Intracorporeal orthotopic neobladder (iONB) creation following robotic radical cystectomy is an emerging procedure and robust functional data are required. To evaluate urodynamic features of iONB and bladder cancer-specific and general health-related quality-of-life (HRQOL) outcomes. We retrospectively assessed 28 men who underwent iONB creation (January 2012 to October 2013) and compared results to a previously characterized cohort of 79 of open ONB procedures. OUTCOME MEASUREMENTS AND STATISTICAL ANALYSIS: iONB pressure-volume properties were characterized using multichannel urodynamics (UDS). The Bladder Cancer Index (BCI) questionnaire, modified with mucus- and pad-related questions, and the Short Form Health Survey (SF-36) were used to evaluate urinary function and HRQOL. ONB cohorts were compared for functional outcomes and BCI score. Multivariable linear regression was used to assess predictors of BCI score. The median follow-up was 9.4 mo for the iONB and 62.1 mo for the open ONB group (p<0.0001); ≥2-yr follow-up had been completed for one (4%) patient in the iONB group compared to 75 (95%) patients in the open ONB group (p<0.0001). In UDS tests, the iONB group had minimal postvoid residual volume, normal compliance, and a mean capacity of 514 cm(3) (range 339-1001). BCI mean scores for urinary function (p=0.58) and urinary bother (p=0.31) were comparable between the groups. The surgical approach was not associated with the BCI score on multivariable analysis. Rates of 24-h pad use were comparable between iONB and open ONB groups (pad-free 17% vs 19%; ≤2 pads 84% vs 79%), as reflected by total pad usage (p=0.1); pad size and daytime wetness were worse in the iONB group. The clean intermittent catheterization rate was 10.7% in the iONB and 6.3% in the open ONB group. Limitations include the retrospective comparison, small number of patients and short follow-up for the iONB group. iONB had adequate UDS characteristics and comparable bladder cancer-specific HRQOL scores to open ONB. However, pad size and daytime wetness were worse for iONB, albeit over significantly shorter follow-up. We demonstrate that the volumetric and pressure characteristics are acceptable for a neobladder created using an entirely robot-assisted laparoscopic technique after bladder removal for cancer. Urinary function and quality-of-life outcomes related to the robotic technique were compared to those for neobladders created via an open surgical technique. We found that urinary function and bother indices were comparable; however, the robotic group required larger incontinence pads that were wetter during the daytime. This may be explained by the significantly shorter duration of recovery after surgery in the robotic group. Copyright © 2015 European Association of Urology. Published by Elsevier B.V. All rights reserved.
    European Urology 07/2015; DOI:10.1016/j.eururo.2015.06.041 · 13.94 Impact Factor
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    ABSTRACT: To develop a robotic technique for exclusively trans-abdominal control of the supra-hepatic, infra-diaphragmatic inferior vena cava (IVC) to enable level 3 IVC tumor thrombectomy. Robotic technique was developed in 3 fresh, perfused-model cadavers. Pre-operatively, inflow (right jugular vein) and outflow (left femoral vein) cannulae were inserted and connected to a centrifugal pump to establish a 10 mmHg pressure in the IVC for the water-perfused cadaver model. Using a 5-port trans-peritoneal robotic approach, the falciform ligament was detached from the anterior abdominal wall towards its junction with the diaphragm, and tautly retracted caudally; this adequately retracted the liver caudally as well. Triangular and coronary ligaments were incised, allowing ready visualization of supra-hepatic/infra-diaphragmatic IVC and right/left main hepatic veins. Under direct robotic visualization, IVC was circumferentially mobilized, vessel-looped and controlled. All 3 robotic procedures were successfully completed trans-abdominally. Average robotic time to control the supra-hepatic IVC was 37min; in each case, the supra-hepatic IVC was circumferentially controlled with a vessel-loop. There were no intraoperative complications. Length of the mobilized supra-hepatic IVC measured between 2-3cm. Right and left supra-hepatic veins were clearly visualized in each case. Necropsy revealed no intra-abdominal/intra-thoracic visceral or vascular injuries to the supra-hepatic IVC, bilateral hepatic veins, or tributaries. We developed a novel robotic technique for trans-abdominal control of the supra-hepatic infra-diaphragmatic IVC in a perfused human cadaver model. This approach may extend the application of advanced robotic techniques for the performance of major vena caval, hepatic and level 3 IVC renal tumor thrombus surgery.
    Journal of endourology / Endourological Society 06/2015; 29(10). DOI:10.1089/end.2015.0081 · 1.71 Impact Factor
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    ABSTRACT: Anatomic partial nephrectomy (PN) techniques aim to decrease or eliminate global renal ischemia. To report the technical feasibility of completely unclamped "minimal-margin" robotic PN. We also illustrate the stepwise evolution of anatomic PN surgery with related outcomes data. This study was a retrospective analysis of 179 contemporary patients undergoing anatomic PN at a tertiary academic institution between October 2009 and February 2013. Consecutive consented patients were grouped into three cohorts: group 1, with superselective clamping and developmental-curve experience (n = 70); group 2, with superselective clamping and mature experience (n = 60); and group 3, which had completely unclamped, minimal-margin PN (n = 49). Patients in groups 1 and 2 underwent superselective tumor-specific devascularization, whereas patients in group 3 underwent completely unclamped minimal-margin PN adjacent to the tumor edge, a technique that takes advantage of the radially oriented intrarenal architecture and anatomy. Primary outcomes assessed the technical feasibility of robotic, completely unclamped, minimal-margin PN; short-term changes in estimated glomerular filtration rate (eGFR); and development of new-onset chronic kidney disease (CKD) stage >3. Secondary outcome measures included perioperative variables, 30-d complications, and histopathologic outcomes. Demographic data were similar among groups. For similarly sized tumors (p = 0.13), percentage of kidney preserved was greater (p = 0.047) and margin width was narrower (p = 0.0004) in group 3. In addition, group 3 had less blood loss (200, 225, and 150ml; p = 0.04), lower transfusion rates (21%, 23%, and 4%; p = 0.008), and shorter hospital stay (p = 0.006), whereas operative time and 30-d complication rates were similar. At 1-mo postoperatively, median percentage reduction in eGFR was similar (7.6%, 0%, and 3.0%; p = 0.53); however, new-onset CKD stage >3 occurred less frequently in group 3 (23%, 10%, and 2%; p = 0.003). Study limitations included retrospective analysis, small sample size, and short follow-up. We developed an anatomically based technique of robotic, unclamped, minimal-margin PN. This evolution from selective clamped to unclamped PN may further optimize functional outcomes but requires external validation and longer follow-up. The technical evolution of partial nephrectomy surgery is aimed at eliminating global renal damage from the cessation of blood flow. An unclamped minimal-margin technique is described and may offer renal functional advantage but requires long-term follow-up and validation at other institutions. Copyright © 2015 European Association of Urology. Published by Elsevier B.V. All rights reserved.
    European Urology 06/2015; 68(4). DOI:10.1016/j.eururo.2015.04.044 · 13.94 Impact Factor
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    ABSTRACT: To describe our approach for port placement and robot docking for pelvic and kidney surgery (KS). We utilize a four-arm robotic approach and a 5-6 port placement consisting of: 1- 12 mm camera port, 3- 8 mm robotic ports, and 1 to 2 assistant ports. For radical prostatectomy, the working robotic ports run parallel below the level of the umbilicus. Radical cystectomy ports are more cephalad and above the level of the umbilicus. For transperitoneal KS, two bariatric robotic ports are used, aiming for an equilateral triangle configuration. With retroperitoneal (RN) KS, a balloon dilator and balloon port create the RN space; bariatric ports comprise the most anterior and posterior ports. This technique has been utilized since 2010 on over 2,370 robotic urologic cases. To date, no procedure has required patient or robot positioning while maintaining 4th arm functionality with minimal robotic arm clashing. Our approach of port placement and robot docking is reproducible and feasible for pelvic and kidney surgery.
    Journal of endourology / Endourological Society 04/2015; DOI:10.1089/end.2015.0077 · 1.71 Impact Factor
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    ABSTRACT: Level III inferior vena cava (IVC) tumor thrombectomy for renal cancer is one of the most challenging open urologic oncologic surgeries. The initial series of completely intra-corporeal robotic level III IVC tumor thrombectomy is presented. Nine patients underwent robotic level III IVC thrombectomy; additionally, 7 patients underwent level II thrombectomy. The entire operation (high intra-hepatic IVC control, caval exclusion, tumor thrombectomy, IVC repair, radical nephrectomy, retroperitoneal lymphadenectomy) was performed exclusively robotically. To minimize chances of intra-operative IVC thrombus embolization, an 'IVC-first, kidney-last' robotic technique was developed. Data were accrued prospectively. All 16 robotic procedures were successful, without open conversion or mortality. For level III cases (n=9), median primary kidney (right=6, left=3) cancer size was 8.5 cm (5.3-10.8) and IVC thrombus length was 5.7 cm (4-7). Median operative time was 4.9 hours (4.5-6.3), estimated blood loss was 375 cc (200-7000) and hospital stay was 4.5 days. All surgical margins were negative. There was no intra- and 1 post-operative complication (Clavien 3b). Over median 7 months follow-up (1-18), all patients are alive. Compared to level II thrombi, the level III cohort trended towards greater IVC thrombus length (3.3 vs 5.7 cm), operative time (4.5 vs 4.9 hrs) and blood loss (290 vs 375 cc). With appropriate patient selection, surgical planning and robotic experience, completely intra-corporeal robotic level III IVC thrombectomy is feasible and can be performed efficiently. Larger experience, longer follow-up and comparison with open surgery are needed to confirm these initial outcomes. Copyright © 2015 American Urological Association Education and Research, Inc. Published by Elsevier Inc. All rights reserved.
    The Journal of urology 04/2015; 194(4). DOI:10.1016/j.juro.2015.03.119 · 4.47 Impact Factor
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    The Journal of Urology 04/2015; 193(4):e699. DOI:10.1016/j.juro.2015.02.2089 · 4.47 Impact Factor
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    The Journal of Urology 04/2015; 193(4):e734. DOI:10.1016/j.juro.2015.02.2172 · 4.47 Impact Factor
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    The Journal of Urology 04/2015; 193(4):e20. DOI:10.1016/j.juro.2015.02.106 · 4.47 Impact Factor
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    The Journal of Urology 04/2015; 193(4):e790. DOI:10.1016/j.juro.2015.02.2337 · 4.47 Impact Factor
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    The Journal of Urology 04/2015; 193(4):e1054. DOI:10.1016/j.juro.2015.02.1887 · 4.47 Impact Factor

  • The Journal of Urology 04/2015; 193(4):e875-e876. DOI:10.1016/j.juro.2015.02.2528 · 4.47 Impact Factor
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    The Journal of Urology 04/2015; 193(4):e197. DOI:10.1016/j.juro.2015.02.934 · 4.47 Impact Factor
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    ABSTRACT: Introduction: We present an updated version of our previously validated robotic partial nephrectomy (RPN) training model,1,2 which includes the reconstructive part of the procedure in addition to the tumor excision component. Material and Methods: For this pilot series, participants were recruited as novice (zero console cases), intermediate (1, but <100 cases), and expert (≥100 console cases). After parenchymal resection with opening of the collecting system, a 5-cm Styrofoam ball mimicking a lower pole tumor was glued on an ex vivo porcine kidney. Each participant performed an RPN using the da Vinci SI Surgical System to excise the Styrofoam tumor. For reconstruction and hemostasis, two horizontal mattress sutures were applied. Renal artery and collecting system were perfused respecting physiologic conditions to test hemostasis and watertightness. Participants completed a poststudy questionnaire assessing training model realism and utility and were anonymously judged by expert reviewers using a validated laparoscopic assessment tool.3 Focusing on expenses per kidney: the preparation time is around 10 min and the costs for disposables (tissue, Styrofoam ball, glue, and fixation) is ∼5 to 10 USD (without training instruments). Results: The 13 participants included 7 novices, 2 intermediates, and 4 experts. Overall, surgeons rated the training model as “very realistic” (median visual analogue score [VAS] 8/10) (face validity). Expert surgeons rated it as an “extremely useful” training tool for residents and attendings (median VAS 9/10) (content validity).4 Experts outscored all others on overall performance (p<0.05) (construct validity). Additionally, the video displays in a head-to-head manner the way an expert surgeon outscores a novice on individual metrics. Thereby, model validation and training potential are demonstrated. Conclusions: Our perfused RPN training model has demonstrated face, content, and construct validity. Herewith tumors of any complexity and reconstruction can be simulated without patients at risk. In addition, the easy to build up, reproducible, and cheap model can be used, for example, within a residency training program. It allows to evaluate individual learning curves and to differentiate distinct surgical skills. No competing financial interests exist. Runtime of video: 7 mins 52 secs
    04/2015; 193(4):e777. DOI:10.1016/j.juro.2015.02.2282
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    ABSTRACT: To assess survival following radical prostatectomy (RP), intensity modulated radiation therapy (IMRT) or conformal radiation therapy (CRT) versus no local therapy (NLT) for metastatic prostate cancer (MPCa), adjusting for patient comorbidity, androgen deprivation therapy (ADT) and other factors. Men ≥66 with MPCa undergoing treatment by RP, IMRT, CRT or NLT identified from SEER-Medicare linked database (2004-2009). Multivariable Cox proportional hazards models, before and after inverse propensity score weighting, were used to assess all cause and PCa specific mortality. Competing risk regression analysis was used to assess PCa specific mortality. Among 4069 men with MPCa, RP (n=47), IMRT (n=88), CRT (n=107) were selected as local therapy versus NLT (n=3827). RP was associated with a 52% (HR: 0.48, 95% CI: 0.27-0.85) reduction in the risk of PCa specific mortality, after adjusting for socio-demographic, primary tumour characteristics, comorbidity, ADT and bone radiation within 6 months of diagnosis. IMRT was associated with a 62% (HR: 0.38, 95% CI: 0.24-0.61) reduction in the risk of PCa specific mortality, respectively. CRT was not associated with improved survival compared to NLT. Propensity score weighting yielded comparable results. Competing risk analysis revealed a 42% (SHR: 0.58, 95% CI: 0.35-0.95) and 57% (SHR: 0.43, 95% CI: 0.27-0.68) reduction in the risk of PCa specific mortality for RP and IMRT. Local therapy with RP and IMRT, but not CRT, was associated with a survival benefit in MPC and warrants prospective evaluation in clinical trials. Copyright © 2015 American Urological Association Education and Research, Inc. Published by Elsevier Inc. All rights reserved.
    The Journal of Urology 02/2015; 194(2). DOI:10.1016/j.juro.2015.02.084 · 4.47 Impact Factor
  • Mihir M Desai · Inderbir S Gill ·

    European Urology 01/2015; 67(6). DOI:10.1016/j.eururo.2015.01.017 · 13.94 Impact Factor

Publication Stats

10k Citations
1,310.92 Total Impact Points


  • 2011-2015
    • Keck School of Medicine USC
      Los Ángeles, California, United States
    • University of Texas Southwestern Medical Center
      • Department of Urology
      Dallas, Texas, United States
  • 2009-2015
    • University of Southern California
      • Keck School of Medicine
      Los Ángeles, California, United States
    • University Hospital Of North Staffordshire NHS Trust
      • Department of Urology
      Stoke-upon-Trent, England, United Kingdom
    • Southwest Kidney Institute, PNC
      Tucson, Arizona, United States
  • 2002-2015
    • Muljibhai Patel Urological Hospital
      Aimand, Gujarat, India
  • 2014
    • Istituto Regina Elena - Istituti Fisioterapici Ospitalieri
      Roma, Latium, Italy
    • Michigan Institute of Urology
      Detroit, Michigan, United States
  • 2009-2014
    • University of California, Los Angeles
      Los Angeles, California, United States
  • 2010
    • Stanford University
      Palo Alto, California, United States
  • 2008-2009
    • Cleveland Clinic
      • Department of Urology
      Cleveland, Ohio, United States
    • University of Minnesota Duluth
      Duluth, Minnesota, United States
  • 2003
    • American Physical Society
      CGS, Maryland, United States