Jong Min Kim

Chonnam National University Hospital, Sŏul, Seoul, South Korea

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Publications (314)1204.19 Total impact

  • Jong Min Kim, Jin Chul Yang, Jin Young Park
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    ABSTRACT: In this paper, we developed a novel molecularly imprinted conducting polymer (MICP) system consisting of porous poly(pyrrole-co-pyrrole-3-carboxylic acid) copolymer matrices for the recognition of theophylline (THEO), a drug molecule. Various porous MICP (p-MICP) films were made using colloidal lithography and examined via gravimetric technique [e.g. gold quartz crystal microbalances (QCMs)]. They showed faster sensing response than a planar MICP film due to the increased THEO binding sites obtained from porous structures. Thus, this lithographical approach to MICP sensors can enable the rebind of a specific template to be increased to achieve improved sensor capacity.
    Sensors and Actuators B Chemical 01/2015; 206:50–55. · 3.84 Impact Factor
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    ABSTRACT: The directed self-assembly (DSA) of block copolymers (BCPs) has been suggested as a promising nanofabrication solution. However, further improvements of both the pattern quality and manufacturability remain as critical challenges. Although the use of BCPs with a high Flory-Huggins interaction parameter (χ) has been suggested as a potential solution, this practical self-assembly route has yet to be developed due to their extremely slow self-assembly kinetics. In this study, it is reported that warm solvent annealing (WSA) in a controlled environment can markedly improve both the self-assembly kinetics and pattern quality. A means of avoiding the undesirable trade-off between the quality and formation throughput of the self-assembled patterns, which is a dilemma which arises when using the conventional solvent vapor treatment, is suggested. As a demonstration, the formation of well-defined 13-nm-wide self-assembled patterns (3σ line edge roughness of ≈2.50 nm) in treatment times of 0.5 min (for 360-nm-wide templates) is shown. Self-consistent field theory (SCFT) simulation results are provided to elucidate the mechanism of the pattern quality improvement realized by WSA.
    Advanced Functional Materials 11/2014; · 10.44 Impact Factor
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    ABSTRACT: The directed self-assembly (DSA) of block copolymers (BCPs) is expected to complement conventional optical lithography due to its excellent pattern resolution and cost-effectiveness. Recent studies have shown that BCPs with a large Flory-Huggins interaction parameter (χ) are critical for a reduction of the thermodynamic defect density as well as an increase in pattern density. However, due to their slower self-assembly kinetics, high-χ BCPs typically necessitate solvent vapor annealing, which requires complex facilities and procedures compared to simple thermal annealing. Here, we introduce an immersion-triggered directed self-assembly (iDSA) process and demonstrate the combined advantages of excellent simplicity, productivity, large-area capability, and tunability. We show that the vapor-free, simple immersion of high-χ BCPs in a composition-optimized mixture of nonswelling and swelling solvents can induce the ultrafast (≤5 min) formation of nanoscale patterns with a pattern size ranging from 8-18 nm. Moreover, iDSA enables the reversible formation of seven different nanostructures from one sphere-forming BCP, demonstrating the outstanding controllability of this self-assembly route.
    ACS Nano 10/2014; · 12.03 Impact Factor
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    ABSTRACT: We present the science and technology roadmap (STR) for graphene, related two-dimensional (2d) crystals, and hybrid systems, targeting an evolution in technology, with impacts and benefits reaching into most areas of society. The roadmap was developed within the framework of the European Graphene Flagship and outlines the main targets and research areas as best understood at the start of this ambitious project. In this document we provide an overview of the key aspects of graphene and related materials (GRMs), ranging from fundamental research challenges to a variety of applications in a large number of sectors, highlithing the roadmap to take GRMs from a state of raw potential to a point where they might revolutionize multiple industries: from flexible, wearable and transparent electronics to high performance computing and spintronics.
    Nanoscale 09/2014; · 6.73 Impact Factor
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    ABSTRACT: Resistive random access memory (ReRAM) is a promising candidate for future nonvolatile memories (NVM). Resistive switching (RS) in a metal-insulator-metal (MIM) structure is generally assumed to be caused by the formation/rupture of nanoscale conductive filaments (CFs) under an applied electric field. The critical issue of ReRAM for practical memory applications, however, is insufficient repeatability of the operating voltage and resistance ratio. Here, we present an innovative approach to reliably and reproducibly control the CF growth in unipolar NiO resistive memory by exploiting uniform formation of insulating SiOx nanostructures from the self-assembly of a Si-containing block copolymer (BCP). In this way, the standard deviation (SD) of set and reset voltages was markedly reduced by 76.9% and 59.4%, respectively. The SD of high resistance state (HRS) also decreased significantly, from 6.3 x 10(7) Ω to 5.4 x 10(4) Ω. Moreover, we report direct observations of localized metallic Ni CF formation and their controllable growth using electron microscopy and discuss electro-thermal simulation results based on the finite element method (FEM) supporting our analysis results.
    ACS Nano 09/2014; · 12.03 Impact Factor
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    ABSTRACT: We sought to investigate the effect of ward-to-cath lab blood pressure (BP) differences on long-term clinical outcomes in patients undergoing percutaneous coronary intervention (PCI) with drug-eluting stent (DES). There are limited data available on the association between PCI with DES and BP differences on long-term clinical outcomes. This study enrolled 994 patients who underwent PCI with DES from March 2003 to August 2007. Resting BP was measured in a ward environment before transfer to the cardiac catheterization lab (cath lab), and again when the patient was laid down on the cath lab table. Patients were divided into two groups according to the difference in ward-to-cath lab systolic BP. Large difference group (n = 383) was defined as the absolute systolic difference of >20 mmHg and small difference group (n = 424) as the absolute systolic difference of ≤20 mmHg. The primary endpoints were all-cause mortality, cardiac death, nonfatal myocardial infarction and stroke. A total of 807 patients (mean age 60 ± 10 years, 522 males) received follow-up for 5.1 ± 2.4 years. The rate of all-cause mortality was significantly higher in the large difference group compared to the small difference group (6.6 vs. 2.8 %; adjusted hazard ratio (HR) 2.43; 95 % confidence interval (CI) 1.22-4.83; p = 0.012). There were higher cardiac deaths seen in the large difference group compared to the small difference group (3.9 vs. 1.4 %; adjusted HR 2.84; 95 % CI 1.1-7.31; p = 0.031). Stroke (2.4 vs. 1.2 %, p = 0.125) and TVR (3.7 vs. 1.7 %, p = 0.051) had higher trends in the large difference group compared to the small difference group. The composite of primary endpoints (all-cause mortality, cardiac death, nonfatal MI and stroke) occurred more frequently in the large difference group compared to the small difference group (10.0 vs. 6.4 %; adjusted HR 1.71; 95 % CI 1.04-2.81; p = 0.033). A difference in ward-to-cath lab systolic BP of >20 mmHg may contribute to increased adverse outcomes in the form of all-cause mortality and cardiac deaths in patients undergoing PCI with DES.
    Heart and vessels. 07/2014;
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    ABSTRACT: The six-minute walk test has been widely used in people with chronic cardiopulmonary disorders as an outcome assessment with regards to therapeutic or prognostic determinants. This study was undertaken to determine the six-minute walk distance (6MWD) in a sample of healthy Koreans and to create a reference equation. We also compared the 6MWD of our cohort with previously published equations.
    Tuberculosis and Respiratory Diseases 06/2014; 76(6):269-75.
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    ABSTRACT: Polymer-free drug-eluting stents (DES) may overcome the shortcomings of polymer-based DES. The aim of this study was to examine the effect of the polymer-free TiO2 film-coated stent with abciximab or alpha lipoic acid in a porcine coronary overstretch restenosis model.
    Journal of cardiology. 05/2014;
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    ABSTRACT: The present study presents a new dielectrophoresis (DEP) manipulation technique using a movable liquid electrode, which allows manipulation of particles by actively controlling the locations of electrodes and applying on-off electric input signals. This DEP system consists of mercury as a movable liquid electrode, indium tin oxide (ITO)-coated glass, SU-8-based micro-channels for electrode passages, and a polydimethylsiloxane (PDMS) medium chamber. A simple squeezing method was introduced to build a thin PDMS layer at the bottom of the medium chamber to create a contactless DEP system. To determine the operating conditions, the DEP force and the friction force were analytically compared for a single cell. In addition, an appropriate frequency range for effective DEP manipulation was chosen based on an estimation of the Clausius-Mossotti (CM) factor and the effective complex permittivity of the yeast cell using the concentric shell model. With this system, we demonstrated the active manipulation of yeast cells, and measured the collection efficiency and the dielectrophoretic velocity of cells for different AC electric field strengths and applied frequencies. The experimental results showed that the maximum collection efficiency reached was approximately 90%, and the dielectrophoretic velocity increased with increasing frequency and attained the maximum value of 10.85±0.95 μm/s at 100 kHz, above which it decreased.This article is protected by copyright. All rights reserved
    Electrophoresis 04/2014; · 3.26 Impact Factor
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    ABSTRACT: Many demineralized bone matrix (DBM) products are available with different formulation, bone composition or carrier molecules. Here we compared bone healing capacity of three different DBM products with either different carrier molecules (hyaluronic acid (HA) vs carboxymethylcellulose (CMC)) or different bone composition (cortical bone vs cortical bone and cancellous bone) in a rabbit segmental defect model. Each 15-mm segmental defect in both left and right radiuses was created in 36 New Zealand White rabbits and filled either with HA-based demineralized cortical bone matrix (DBX), CMC-based demineralized cortical bone matrix (DB) or CMC-based demineralized cortical bone with cancellous bone (NDDB) in random order. Additional two rabbits as control were used to no treatment and they were used to radiographic examination only during 12 weeks post-operation. Four rabbits from each group were sacrificed at 4, 8, and 12 weeks post-implantation. The wound area was evaluated by X-ray radiology, micro-computerized tomography (CT) and histopathology. DBX has significantly lower radiopacity, bone volume fraction, and bone mineral density compared to DB and NDDB before implantation. However, there were no significant differences in bone healing capacity as revealed by similar bone healing score, bone volume fraction, bone mineral density, and residual bone area in radiographic assessment, micro-CT, and histological evaluation at 4, 8, and 12 weeks post-implantation. In conclusion, three DBM products with different carrier molecules or bone composition showed similar bone healing capacity in a segmental bone defect model in rabbits.
    Journal of veterinary science (Suwŏn-si, Korea) 03/2014; · 0.89 Impact Factor
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    ABSTRACT: We tried to determine the effect of stent balloon inflation time on stent expansion and apposition using optical coherence tomography. Second-generation drug-eluting stents (DES) have thin struts; however, inflation times for optimal stent expansion and apposition are unknown in vivo. Subjects included 17 patients (18 de novo coronary artery lesions), in whom Resolute Integrity → (n = 9) and Xience Prime → (n = 9) DES were deployed. All stents were inflated 3 times to the nominal inflation pressure (8.9 ± 0.6 atm) using the stent delivery balloon. The first inflation continued until the stent was angiographically fully expanded; the other 2 lasted 15 and 30 seconds, respectively. After the first, second, and third inflation of stent balloon, stent area (5.94 ± 1.7, 6.69 ± 1.8, 7.05 ± 1.8 mm(2) , P < 0.001) and stent volume (146.94 ± 59.40, 166.78 ± 69.55, 177.25 ± 69.19 mm(3) , P < 0.001) increased significantly. The number of malapposed struts (18.0 ± 17.0, 7.9 ± 10.2, 7.4 ± 10.8, P < 0.001) and the mean depth of malapposed struts (188.9 ± 75.6, 120.3 ± 101.4, 95.4 ± 86.8 µm, P < 0.001) decreased. Malapposed stent area (0.62 ± 0.32, 0.52 ± 0.21 mm(2) , P < 0.05) and the malapposed stent volume (15.03 ± 7.78, 12.64 ± 5.16 mm(3) , P < 0.05) decreased significantly following the second inflation; the third inflation gave no additional benefits to these parameters. There was no adverse clinical outcome after each stent balloon inflation. Additional 15 seconds of inflation after the angiographically full expansion of the stent balloon allows better stent expansion and apposition even though the inflation pressure is nominal pressure.
    Journal of Interventional Cardiology 03/2014; · 1.50 Impact Factor
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    ABSTRACT: It is well known that the hippocampus plays a role in spatial and contextual memory, and that spatial information is tightly regulated by the hippocampus. However, it is still highly controversial whether the hippocampus plays a role in object recognition memory. In a pilot study, the administration of bicuculline, a GABAA receptor antagonist, enhanced memory in the passive avoidance task, but not in the novel object recognition task. In the present study, we hypothesized that these different results are related to the characteristics of each task and the different roles of hippocampus and perirhinal cortex. A region-specific drug-treatment model was employed to clarify the role of the hippocampus and perirhinal cortex in object recognition memory. After a single habituation in the novel object recognition task, intra-perirhinal cortical injection of bicuculline increased and intra-hippocampal injection decreased the exploration time ratio to novel object. In addition, when animals were repeatedly habituated to the context, intra-perirhinal cortical administration of bicuculline still increased exploration time ratio to novel object, but the effect of intra-hippocampal administration disappeared. Concurrent increases of c-Fos expression and ERK phosphorylation were observed in the perirhinal cortex of the object with context-exposed group either after single or repeated habituation to the context, but no changes were noted in the hippocampus. Altogether, these results suggest that object recognition memory formation requires the perirhinal cortex but not the hippocampus, and that hippocampal activation interferes with object recognition memory by the information encoding of unfamiliar environment.
    Brain research 01/2014; · 2.46 Impact Factor
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    ABSTRACT: Restriction fragment length polymorphism (RFLP) analysis is one of the oldest, most convenient and least expensive methods of genotyping, but is limited by the availability of restriction endonuclease sites. Here we present a novel method of employing CRISPR/Cas-derived RNA-guided engineered nucleases (RGENs) in RFLP analysis. We prepare RGENs by complexing recombinant Cas9 protein derived from Streptococcus pyogenes with in vitro transcribed guide RNAs that are complementary to the DNA sequences of interest. Then, we genotype recurrent mutations found in cancer and small insertions or deletions (indels) induced in cultured cells and animals by RGENs and other engineered nucleases such as transcription activator-like effector nucleases (TALENs). Unlike T7 endonuclease I or Surveyor assays that are widely used for genotyping engineered nuclease-induced mutations, RGEN-mediated RFLP analysis can detect homozygous mutant clones that contain identical biallelic indel sequences and is not limited by sequence polymorphisms near the nuclease target sites.
    Nature Communications 01/2014; 5:3157. · 10.74 Impact Factor
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    ABSTRACT: A multi-level microstructure is proposed for terahertz slow-wave circuits, with dispersion relation retrieved by scattering parameter measurements. The measured return loss shows strong resonances above the cutoff with negligible phase shifts compared with finite element analysis. Splitting the circuit into multi levels enables a low aspect ratio configuration that alleviates the loading effect of deep-reactive-ion etching on silicon wafers. This makes it easier to achieve flat-etched bottom and smooth sidewall profiles. The dispersion retrieved from the measurement, therefore, corresponds well to the theoretical estimation. The result provides a straightforward way to the precise determination of dispersions in terahertz vacuum electronics.
    Applied Physics Letters 01/2014; 104(2):021118. · 3.52 Impact Factor
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    ABSTRACT: •Presynaptic dopaminergic depletions have been reported in one case each of sCJD and variant CJD by image of presynaptic dopaminergic system.•This report is a CJD case which show relatively preserved presynaptic dopaminergic system despite the existence of rapidly progressive severe parkinsonism•Mechanism of parkinsonism in early CJD can be assumed to be involved post-synaptic dopaminergic system or non-dopaminergic system as well as presynaptic dopaminergic system.
    Journal of the Neurological Sciences. 01/2014;
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    ABSTRACT: Cu foils of 2 × 2 cm2 have been implanted with 70 keV C− ions to nominal fluences of (2–10) × 1015 cm−2 at room temperature (RT) and subsequently annealed at 900–1100 °C for 15 min, before being cooled to RT to form graphene layers on the Cu surfaces. Analyses with Raman spectroscopy and atomic force microscopy demonstrate that a continuous film of bi-layer graphene (BG) is produced for implant fluences as low as 2 × 1015 cm−2, much less than the carbon content of the BG films. This suggests that the implanted carbon facilitates the nucleation and growth of graphene, with additional carbon supplied by the Cu substrate (0.515 ppm carbon content). No graphene was observed on unimplanted Cu foils subjected to the same thermal treatment. This implantation method provides a novel technique for the selective growth of graphene on Cu surfaces.
    Carbon 01/2014; 66:267–271. · 6.16 Impact Factor
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    ABSTRACT: We demonstrate the fabrication of solution based low temperature-processed p-type ZnO NRs doped with phosphorous by using a spin-on-dopant method coupled with a hydrothermal process. We confirmed the incorporation of phosphorous dopants into a ZnO crystal by analyzing SIMS profiles, together with the evolution of the photoluminescence spectra. It is further revealed that the electrical properties of the p-type ZnO/n-type Si heterojunction diode exhibited good rectifying behavior, confirming that p-type ZnO NRs were successfully formed. In addition, we demonstrate that a piezoelectric nanogenerator with p-type ZnO NRs made on a glass substrate shows large enough power to drive polymer dispersed liquid crystal displays.
    Nanoscale 12/2013; · 6.73 Impact Factor
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    ABSTRACT: We report a systematic and reliable approach to fabricate ZnO nanocone or nanoneedle arrays on various substrates including fibers. Our approach employs wet chemical etching of ZnO nanowire arrays using an aqueous solution of HCl. Using this simple chemical etching technique, nanowire arrays were transformed to nanocone arrays on Si substrates and Kevlar fibers. Significant enhancement of light emission intensities at UV peak (∼387 nm) was observed when the ZnO nanowire arrays are converted to ZnO nanocone arrays. The photoluminescence intensities at the UV peaks from the nanocones are found to be ∼3–4 times larger than those from the nanowires.
    Physica Status Solidi (A) Applications and Materials 12/2013; 210(12). · 1.53 Impact Factor
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    ABSTRACT: Statins have pleiotropic effects, which include the inhibition of neointima hyperplasia, the inhibition of vascular inflammation, and platelet inhibition. The aim of this study was to examine the effect of an atorvastatin-eluting stent (AES) in a rabbit iliac artery overstretch restenosis model. Ten rabbits were used in this study (10 rabbits, 10 iliac arteries for each stent). An AES and paclitaxel-eluting stent (PES) were implanted in the left and right iliac arteries in a rabbit (2 stents in each rabbit). The stents were deployed with oversizing (stent/artery ratio 1.3:1), and histopathologic analysis was assessed at 28 days after stenting. There were no significant differences in the injury score, lumen area, or inflammation score. There were significant differences in the neointimal area (0.7±0.18 mm(2) in the AES group vs. 0.4±0.25 mm(2) in the PES group, p<0.01), in the percentage stenosis area (14.8±5.06% in the AES group vs. 10.5±6.80% in the PES group, p<0.05), and in the fibrin score (0.4±0.51 in the AES group vs. 2.7±0.48 in the PES group, p<0.001). Although the AES did not suppress neointimal hyperplasia compared with the PES, it showed a superior arterial healing effect in a rabbit iliac artery overstretch restenosis model.
    Chonnam medical journal. 12/2013; 49(3):118-24.
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    ABSTRACT: Danggui-Jakyak-San (DJS), a traditional herbal prescription, has been used to treat insufficient blood supplies. Recently, regenerative medication for the treatment of cerebral ischemia has drawn the attention of many researchers. In this study, we examined whether DJS exerts a neuronal regenerative effect in the hippocampus of a transient forebrain ischemia mice model. Transient forebrain ischemia was induced by bilateral common carotid artery occlusion (BCCAO). Animals were divided into three groups (sham, BCCAO + vehicle, and BCCAO + DJS). To test the effect of DJS on learning and memory, Morris water maze or passive avoidance test was conducted. To test neuroprotective and neurogenic effect, immunohistochemistry and Western blot analysis were used. Statistical significance was analyzed with Student t-test, one-way or two-way analysis of variance. We found that the administration of DJS ameliorated ischemia-induced spatial memory impairment in the Morris water maze task. Moreover, Akt/glycogen synthase kinase-3beta (GSK3beta)/beta-catenin signaling was increased by DJS, which would be one possible mechanism of DJS for neurogenesis in the hippocampal dentate gyrus region. These results suggest that DJS is a possible candidate for the treatment of ischemia-induced neuronal degeneration.
    BMC Complementary and Alternative Medicine 11/2013; 13(1):324. · 2.08 Impact Factor

Publication Stats

4k Citations
1,204.19 Total Impact Points

Institutions

  • 2014
    • Chonnam National University Hospital
      Sŏul, Seoul, South Korea
    • Daegu Fatima Hospital
      Yeoncheon Gun, South Korea
    • Chung-Ang University
      • School of Mechanical Engineering
      Sŏul, Seoul, South Korea
  • 2012–2014
    • Seoul National University Bundang Hospital
      • Department of Neurology
      Sŏul, Seoul, South Korea
    • Kyonggi University
      • Department of Convergence Security
      Sŏul, Seoul, South Korea
  • 2009–2014
    • Kyung Hee University
      • • Department of Applied Physics
      • • Department of Life and Nanopharmaceutical Science
      Sŏul, Seoul, South Korea
  • 1999–2014
    • Samsung Advanced Institute of Technology
      Usan-ri, Gyeonggi Province, South Korea
  • 1997–2014
    • Seoul National University
      • • Department of Chemistry
      • • School of Computer Science and Engineering
      • • Department of Computer Science and Engineering
      Sŏul, Seoul, South Korea
  • 2013
    • Hyundai Motor Company
      Sŏul, Seoul, South Korea
    • University of Oxford
      Oxford, England, United Kingdom
  • 2012–2013
    • Korea Advanced Nano Fab Center
      Whasung-Gun, Gyeonggi Province, South Korea
  • 2009–2013
    • Yonsei University
      • Department of Mechanical Engineering
      Sŏul, Seoul, South Korea
  • 2002–2013
    • Korea Advanced Institute of Science and Technology
      • • Department of Materials Science and Engineering
      • • Department of Bio and Brain Engineering
      • • Department of Mechanical Engineering
      Sŏul, Seoul, South Korea
  • 1995–2013
    • Dong-A University
      • • Department of Chemical Engineering
      • • Department of Obstetrics and Gynecology
      • • College of Medicine
      Pusan, Busan, South Korea
  • 2011–2012
    • Georgia Institute of Technology
      • School of Materials Science and Engineering
      Atlanta, GA, United States
    • Kyungpook National University Hospital
      Sŏul, Seoul, South Korea
    • Chungbuk National University
      • College of Veterinary Medicine
      South Korea
  • 2008–2012
    • Stanford University
      • Department of Chemical Engineering
      Stanford, CA, United States
  • 2005–2012
    • Pusan National University
      • • Department of Microbiology
      • • College of Medicine
      Pusan, Busan, South Korea
    • Chonbuk National University
      • Department of Organic Materials and Fiber Engineering
      Seoul, Seoul, South Korea
  • 2003–2012
    • Sungkyunkwan University
      • • Institute of Basic Science
      • • School of Advanced Materials Science and Engineering (AMSE)
      • • School of Mechanical Engineering
      • • Department of Physics
      Sŏul, Seoul, South Korea
  • 2010–2011
    • Sejong University
      • Faculty of Bioscience and Biotechnology
      Seoul, Seoul, South Korea
    • Yeungnam University
      • Department of Urology
      Daikyū, Daegu, South Korea
    • National Institute of Environmental Research
      Sŏul, Seoul, South Korea
  • 2006–2011
    • Korea Institute of Oriental Medicine
      Bucheon, Gyeonggi Province, South Korea
  • 2009–2010
    • Peking University
      • • College of Chemistry and Molecular Engineering
      • • State Key Laboratory for Structural Chemistry of Unstable and Stable Species
      Beijing, Beijing Shi, China
  • 2008–2010
    • Gyeongsang National University
      • Division of Applied Life Science
      Chinju, South Gyeongsang, South Korea
  • 2004–2008
    • Osaka University
      • The Institute of Scientific and Industrial Research (ISIR)
      Ibaraki, Osaka-fu, Japan
  • 2006–2007
    • Yonsei University Hospital
      • Department of Internal Medicine
      Seoul, Seoul, South Korea
  • 2002–2004
    • Gwangju Institute of Science and Technology
      • School of Information and Communications
      Kwangju, Gwangju, South Korea
  • 1998–1999
    • Hanyang University
      • Division of Chemical Engineering and Bioengineering
      Sŏul, Seoul, South Korea
  • 1996
    • Korea Atomic Energy Research Institute (KAERI)
      Daiden, Daejeon, South Korea
  • 1987
    • Kyoto University
      • Division of Applied Life Sciences
      Kyoto, Kyoto-fu, Japan