Songsong Zhu

West China Hospital of Stomatology, Hua-yang, Sichuan, China

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Publications (48)88.21 Total impact

  • Songsong Zhu · Yangmei Jiang · Niraj Pokhrel · Jing Hu ·
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    ABSTRACT: Background: Temporomandibular joint (TMJ) ankylosis causes serious problems in oral functions. When it occurs in childhood, it can cause secondary dentofacial deformities. This study described our experience in the simultaneous correction of TMJ ankylosis and secondary dentofacial deformities performed in a single operation. Methods: Twenty-seven patients with TMJ ankylosis and secondary deformities were treated in a single surgery from January 2009 to December 2013. Clinical outcomes were assessed based on the oral function, radiography, and medical photography. Results: No relapse (of TMJ ankylosis) occurred in any of the patients during the follow-up period. Oral function and skeletal deformities had (were) significantly improved in all the patients. Most of the patients were satisfied with the final outcome. Conclusions: One-stage treatment permits the simultaneous correction of both the TMJ functional deficit and skeletal deformities in a single operation, which suggests that it is an effective approach for the treatment of patents with TMJ ankylosis and secondary dentofacial deformities.
    The Journal of craniofacial surgery 10/2015; DOI:10.1097/SCS.0000000000002085 · 0.68 Impact Factor
  • Yunfeng Li · Yangmei Jiang · Bin Ye · Jing Hu · Qianming Chen · Songsong Zhu ·
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    ABSTRACT: One-stage treatment for condylar osteochondroma and secondary facial deformities by resection and reconstruction of the mandibular condyle, orthognathic surgery, and mandibular contouring has been reported recently. This study investigated the clinical feasibility of treating osteochondroma of the mandibular condyle and secondary dento-maxillofacial deformities by virtual surgical planning and 3-dimensional (3D) printed surgical templates. A composite skull model with accurate dentition was obtained with data from spiral computed tomography (CT) and surface scanning of the dental arch. Virtual surgical simulation was performed using Dolphin Imaging 11.7 Premium and Mimics software after a comprehensive 3D diagnosis and surgery planning. Surgical templates were fabricated by 3D printing using data from virtual surgical simulation for guidance of excision of the mandibular condyle with osteochondroma, reconstruction of the mandibular condyle, mandibular contouring, and reconstruction of a normal occlusion. Le Fort I osteotomy of the upper jaw and genioplasty were performed when indicated. The linear difference between virtually simulated and postoperative skull models was evaluated. All surgeries were successfully simulated using virtual surgical planning, and the guiding templates were successfully applied for all patients. Successful reconstruction of condylar function, normal occlusion, and symmetry of the facial profile was achieved. Postoperative CT scans and quantitative analysis showed that virtual surgical plans provided acceptable accuracy in the operating room. The linear difference of the incisors and first molars was no more than 1.4 mm, and the greatest difference was found for the menton landmark, which was up to 2.4 mm. Results from this study suggested that virtual surgical planning and guiding templates facilitated accurate diagnosis, treatment planning, accurate osteotomy, repositioning of bony segments, and contouring of the mandibular border in the treatment of condylar osteochondroma and secondary facial asymmetry. Copyright © 2015 American Association of Oral and Maxillofacial Surgeons. Published by Elsevier Inc. All rights reserved.
    Journal of oral and maxillofacial surgery: official journal of the American Association of Oral and Maxillofacial Surgeons 06/2015; DOI:10.1016/j.joms.2015.06.169 · 1.43 Impact Factor
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    ABSTRACT: The aim of this study is to evaluate the effects of myrtol standardized on cartilage lesions in osteoarthritis (OA) rats. Fifty-six healthy Sprague-Dawley rats were randomly divided into sham group (13 rats) and OA model group (43 rats) with interior meniscus excision. Then serum estradiol (E2) and glycosaminoglycan (GAG) content in cartilage tissue were measured by radioimmunoassay and toluidine blue staining, respectively. After that, the model rats were randomly divided into low dose myrtol (LDM) group, middle dose myrtol (MDM) group and high dose myrtol (HDM) group (10 rats in each group) with treatment of 450 mg/kg, 300 mg/kg and 150 mg/kg myrtol, respectively. Then, Mankin scores were used to evaluate lesion extent of knee joint cartilage. Expression of tumor necrosis factor α (TNF-α), transforming growth factor β1 (TGF-β1), interleukin (IL)-6, Bax and Bcl-2 were investigated using PCR gel electrophoresis method. Mankin cores were lower in sham group and myrtol group than in model group. There were statistically significant differences (P < 0.01) between sham group and model group in expression of TNF-α, TGF-β1, IL-6, Bax and Bcl-2 in the cartilage tissue. Myrtol significantly reduced the expression of TNF-α, IL-6 and Bax, and increased the expression of TGF-β1 and Bcl-2 in myrtol group, comparing with those in model group (P < 0.01). Myrtol could down-regulate the expression of TNF-α, IL-6 and Bax, and up-regulate the expression of TGF-β1 and Bcl-2. Myrtol standardized is a promising drug to ameliorate knee cartilage lesions in the OA rat model.
    International journal of clinical and experimental pathology 05/2015; 8(2):1435-42. · 1.89 Impact Factor
  • Xuemei Wang · Songsong Zhu · Xiaowen Jiang · Yunfeng Li · Donghui Song · Jing Hu ·
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    ABSTRACT: Lithium, popular in psychology field, has been recognized as an activator component of the canonical Wnt signaling pathway. The effect of lithium on osteogenesis or on the human fracture risk has been widely reported. However, little is known on its role in distraction osteogenesis to date. In this study, the effect of systematic administrated lithium on distraction osteogenesis in a rat model was investigated. The osteotomy was performed on the right tibia in 40 adult male Sprague-Dawley rats. Then they were randomly assigned into two equal groups (n = 20/group), which underwent Lithium or saline treatment through gastric gavage until the day they were killed. One week after the osteotomy, the tibias were distracted for 14 days (rate 0.6 mm/day). Following 8 weeks consolidation period, the distracted tibias in both groups were harvested and examined by X-ray plain radiography, histology, dual-energy X-ray absorptiometry, Micro-CT, and biomechanical tests. The results showed that lithium group possessed higher bone mineral density, more mature new bone tissue, and better regenerated bone mass continuity in the distraction gaps without any local or systemic adverse effects was encountered. This study suggested lithium could increase bony callus ossification volume and accelerate distracted tissue mineralization to facilitate bone regeneration in distraction gap.
    Calcified Tissue International 04/2015; 96(6). DOI:10.1007/s00223-015-0004-7 · 3.27 Impact Factor
  • Wenyang Li · Songsong Zhu · Jing Hu ·
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    ABSTRACT: Lactoferrin, an iron-binding glycoprotein which belongs to the transferrin family, has been shown to promote bone growth. However, reports regarding effects of lactoferrin on bone regeneration during distraction osteogenesis are limited. Our study was designed to investigate the effect of bovine lactoferrin treatment on bone formation of the distracted callus. We asked whether bovine lactoferrin enhances bone formation of the distraction callus as determined by (1) radiographic and histologic appearances; (2) dual-energy x-ray absorptiometry (DXA) analysis of bone mineral composition and bone mineral density; (3) micro-CT measures of trabecular architecture; and (4) biomechanical strength of the healing bone. Additionally, serology, reverse transcription (RT)-PCR, and immunohistochemistry were used to explore the possible mechanisms of bovine lactoferrin use on bone formation during distraction osteogenesis. Unilateral tibial osteodistraction was performed on 80 New Zealand White rabbits with a distraction rate of 1 mm per day for 10 days. Animals then were divided randomly into two groups: (1) vehicle and (2) bovine lactoferrin. At 4 and 8 weeks after completion of distraction, the animals were sacrificed. Lengthened tibias and serum samples were obtained and subjected to radiologic, DXA, micro-CT, histologic, and biomechanical examinations, and serum, RT-PCR and immunohistochemical analyses. Radiologic, DXA, micro-CT, histologic, and biomechanical examinations indicated that bovine lactoferrin treatment not only accelerated bone formation at early stages of distraction osteogenesis but also promoted bone consolidation at late stages. The ultimate force of the distracted calluses was increased by 37% (118.8 ± 6.65 N in the lactoferrin group and 86.5 ± 5.47 N in the vehicle group; p < 0.001) and 84% (384.8 ± 18.4 N in the lactoferrin group and 209.0 ± 15.2 N in the vehicle group; p < 0.001) at 4 and 8 weeks, respectively. Moreover, serum analysis showed that bovine lactoferrin treatment significantly increased serum levels of bone alkaline phosphatase and decreased serum levels of tartrate resistant acid phosphatase 5b. In addition, RT-PCR and immunohistochemical analyses suggested that bovine lactoferrin treatment induced a lower receptor activator of nuclear factor-kappaB (RANK) ligand/osteoprotegerin (RANKL/OPG) ratio in the distracted callus. The results of our study suggest that bovine lactoferrin treatment could promote bone regeneration during distraction osteogenesis in the rabbit. The results indicate that the OPG/RANKL/RANK system might be a major mechanism for increased bone formation and decreased bone resorption in distraction osteogenesis with bovine lactoferrin treatment. Oral administration of bovine lactoferrin may provide a feasible approach for promoting osteogenesis during distraction osteogenesis.
    Clinical Orthopaedics and Related Research 03/2015; 473(7). DOI:10.1007/s11999-015-4270-5 · 2.77 Impact Factor
  • Yunfeng Li · Yangmei Jiang · Nan Zhang · Rui Xu · Jing Hu · Songsong Zhu ·
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    ABSTRACT: Computer-aided jaw surgery has been extensively studied recently. The purpose of this study was to determine the clinical feasibility of performing bimaxillary orthognathic surgery without intermediate splint using virtual surgical planning and rapid prototyping technology. Twelve consecutive patients who underwent bimaxillary orthognathic surgery were included. The presented treatment plan here mainly consists of 6 procedures: (1) data acquisition from computed tomography (CT) of the skull and laser scanning of the dentition; (2) reconstruction and fusion of a virtual skull model with accurate dentition; (3) virtual surgery simulation including osteotomy and movement and repositioning of bony segments; (4) final surgical splint fabrication (no intermediate splint) using computer-aided design and rapid prototyping technology; (5) transfer of the virtual surgical plan to the operating room; and (6) comparison of the actual surgical outcome to the virtual surgical plan. All procedures of the treatment were successfully performed on all 12 patients. In quantification of differences between simulated and actual postoperative outcome, we found that the mean linear difference was less than 1.8 mm, and the mean angular difference was less than 2.5 degrees in all evaluated patients. Results from this study suggested that it was feasible to perform bimaxillary orthognathic surgery without intermediate splint. Virtual surgical planning and the guiding splints facilitated the diagnosis, treatment planning, accurate osteotomy, and bony segments repositioning in orthognathic surgery.
    Journal of Craniofacial Surgery 02/2015; 26(2). DOI:10.1097/SCS.0000000000001530 · 0.68 Impact Factor
  • Niansong Ye · Hu Long · Songsong Zhu · Yunqiang Yang · Wenli Lai · Jing Hu ·
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    ABSTRACT: Mandibular angle ostectomy (MAO) is commonly used to correct prominent mandibular angles through an intraoral approach. However, limited vision in the operative site may lead to difficulties or complications during surgery. Therefore, it is necessary to develop an effective method for helping surgeons to perform MAO more precisely and safely. In this study, we report a novel method of a computer image-guided surgical template for navigation of MAO, and evaluate its accuracy and clinical outcomes. Nine patients with a prominent mandibular angle were enrolled in this study. A pair of stereolithographic templates was fabricated by computer-aided image design and 3D printing. In all cases, bilateral MAO was performed under the guide of these templates. Post-operative effects were evaluated by 3D curve functions and maximal shell-to-shell deviations. All patients were satisfied with their cosmetic outcomes. The mean and SD of ICC between R-Sim and R-Post were 0.958 ± 0.011; between L-Sim and L-Post, 0.965 ± 0.014; and between R-Post and L-Post, 0.964 ± 0.013. The maximal shell-to-shell deviations between the simulated mandibular contour and post-operative mandibular contour on the right and left sides were 2.02 ± 0.32 and 1.97 ± 0.41 mm, respectively. The results of this study suggest that this new technique could assist surgeons in making better pre-surgical plans and ensure more accurate and safer manipulation for completion of this procedure. This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors .
    Aesthetic Plastic Surgery 12/2014; 39(1). DOI:10.1007/s00266-014-0424-1 · 0.96 Impact Factor
  • Hui Li · Jing Hu · En Luo · Songsong Zhu · Jihua Li ·
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    ABSTRACT: Purpose Osteochondroma is a benign tumor that is rare in the craniofacial region. When it does occur, the condyle and coronoid process have been the most commonly affected sites. The secondary progressive malocclusion and facial asymmetry will be common physical signs in most cases. The traditional surgical treatment of osteochondroma of the mandibular condyle has been condylectomy, with or without reconstruction of the condyle. We believe more attention should be paid to restoring joint function, improving the facial appearance, correcting malocclusion, and re-establishing harmony among them.
    Journal of Oral and Maxillofacial Surgery 11/2014; 72(11). DOI:10.1016/j.joms.2014.03.021 · 1.43 Impact Factor
  • Wei Lin · Weina Zhang · Jing Zhang · Jing Hu · Songsong Zhu ·
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    ABSTRACT: This study was to investigate whether surgically created incisions in discs at different sizes would heal spontaneously. Thirty mature goats were randomly divided into group A (1mm), group B (3mm) and group C (5mm) according to the length of incision on the discs. Five animals in each group were sacrificed at 3 and 6 months postoperatively. The disc and condyle were evaluated by gross, histological and immunohistochemistry examinations. 1-mm discal incisions healed spontaneously with nearly normal gross and histological appearance at 6 months postoperatively, while 3-mm and 5-mm discal incisions failed to heal. Degenerative changes were observed in the fibrocartilage in both 3-mm and 5-mm incision groups, with a greater extent in the 5-mm group. Our results suggested that the TMJ disc of goat has limited self-repair capability to damage, which will be useful for making pre-surgical decisions related to the size and healing period of TMJ disc perforations.
    Journal of Cranio-Maxillofacial Surgery 10/2014; 42(7). DOI:10.1016/j.jcms.2014.03.023 · 2.93 Impact Factor
  • Weina Zhang · Bin Gu · Jing Hu · Bin Guo · Ge Feng · Songsong Zhu ·
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    ABSTRACT: We retrospectively compared the clinical outcomes of autogenous coronoid process grafts (n=32) and costochondral grafts (n=28) in condylar reconstruction for the treatment of unilateral ankylosis of the temporomandibular joint (TMJ) in adults. Preoperative and postoperative assessments included diet scores, cone-beam computed tomography (CT), maximal interincisal opening, lateral excursion, and mandibular deviation on opening the mouth. There were no significant differences between the 2 groups in the measurements before and after the operation with respect to incisal opening, lateral excursion, mandibular deviation, diet scores, or recurrence rate, but in both the postoperative incisal opening, lateral excursion, and diet scores had improved significantly compared with preoperatively. After costochondral graft 3 patients developed intraoperative plural tears, and 6 had temporary pain at the donor site. The frontal branch of the facial nerve was temporarily affected in 5 patients after costochondral graft and 3 after coronoid process grafts, all of which recovered in 3-6 months. There was no recurrence after coronoid process grafting, and one after costochondral grafting. The clinical outcomes in both groups were satisfactory and comparable. Autogenous coronoid process grafting may therefore be a good alternative for condylar reconstruction in patients with ankylosis of the TMJ.
    British Journal of Oral and Maxillofacial Surgery 09/2014; 52(10). DOI:10.1016/j.bjoms.2014.08.018 · 1.08 Impact Factor
  • Jian Song · Songsong Zhu · En Luo · Jing Hu · Ge Feng ·
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    ABSTRACT: Purpose: This study was designed to investigate the stress and the displacement distributions of the mandible after mandibular angle ostectomy (MAO) by means of three-dimensional finite element analysis. Methods: On the basis of a female patient with a prominent angle of the mandible, the finite element models were generated by helical computed tomography and related software and were analyzed under muscle forces and 3 kinds of biting conditions, including intercuspal position (ICP), incisal clenching (INC), and right unilateral molar clenching (RMOL). The mandibular stress and displacement distributions were analyzed by Abaqus software. Results: In the model of MAO, the increased stress and the decreased displacement was found in ICP, INC, and RMOL at the area of mandibular angle. The stress and the displacement increased in ICP and RMOL, whereas the others remained unchanged in INC at the area of mandibular condylar neck. Conclusions: The results of this study have shown that MAO could alter biomechanical characteristics in the operated mandible, which suggested that a greater hit on face may lead to a higher incidence rate of condyle fracture and a lower incidence rate of angle fracture after MAO.
    Journal of Craniofacial Surgery 07/2014; 25(4):e375-e378. DOI:10.1097/SCS.0000000000000868 · 0.68 Impact Factor
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    Songsong Zhu · Bi Zhang · Cheng Man · Yongqing Ma · Xianwen Liu · Jing Hu ·
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    ABSTRACT: In cartilage tissue engineering using stem cells, it is important to stimulate proliferation and control the differentiation of stem cells to specific lineages. Here we reported a combined technique for articular cartilage repair, consisting of bone marrow mesenchymal stem cells (BMMSCs) transfected with connective tissue growth factor (CTGF) gene and NaOH-treated poly(lactic-co-glycolic) acid (PLGA) scaffolds. In the present study, BMMSCs or CTGF-modified BMMSCs seeded on PLGA or NaOH-treated PLGA scaffolds were incubated in vitro and NaOH-treated PLGA significantly stimulated proliferation of BMMSCs, while CTGF gene transfer promoted chondrogenic differentiation. The effects of the composite on the repair of cartilage defects were evaluated in rabbit knee joints in vivo. Full-thickness cartilage defects (diameter: 5 mm; depth: 3 mm) were created unilaterally in the patellar groove. Defects were either left empty (n = 18) or implanted with BMMSCs/PLGA (n = 18), BMMSCs/NaOH-treated PLGA (n = 18), or CTGF-modified BMMSCs/NaOH-treated PLGA (n = 18). The defect area was examined grossly, histologically, and mechanically at 6, 12, and 24 weeks postoperatively. Implanted cells were tracked using adeno-LacZ labeling at 6 weeks after implantation. Overall, the CTGF-modified BMMSCs/NaOH-treated PLGA group showed successful hyaline-like cartilage regeneration similar to normal cartilage, which was superior to the other groups using gross examination, qualitative and quantitative histology, and mechanical assessment. The in vivo viability of the implanted cells was demonstrated by their retention for 6 weeks after implantation. These findings suggested that a combination of CTGF-modified BMMSCs and NaOH-treated PLGA may be an alternative treatment for large osteochondral defects in high-loading sites.
    Cell Transplantation 04/2014; 23(6):715-27. DOI:10.3727/096368913X669770 · 3.13 Impact Factor
  • Yunfeng Li · En Luo · Songsong Zhu · Jihua Li · Li Zhang · Jing Hu ·
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    ABSTRACT: Purpose: The objective of this study was to investigate cancellous bone response to strontium-doped hydroxyapatite (SrHA) in ovariectomized (OVX) rats. Methods: Hydroxyapatite (HA) and 10%SrHA (HA with 10 mol% calcium substituted by strontium) implants were prepared and characterized by scanning electronic microscopy (SEM), energy dispersive microanalysis (EDX) and X-ray diffraction (XRD). Twelve weeks after bilateral ovariectomy, 20 rats randomly received HA or 10%SrHA implants in the right distal femur, with 10 animals in each group. Eight weeks after implantation, specimens were harvested and analyzed by micro-computed tomography (micro-CT) and histology. Results: Compared with HA, 10%SrHA raised the percentage bone volume by 42.6%, bone-to-implant contact by 47.1%, mean trabecular number by 27.3%, mean trabecular thickness by 31.5% and mean connectivity density by 37.4%, while it decreased mean trabecular separation by 20.1% in micro-CT evaluation. 10%SrHA also increased the bone area density by 47.6% in histological analysis. Conclusions: With the HA implants as controls, the 10%SrHA implants were shown to increase bone density and bone-to-implant contact, and improve trabecular architecture in the vicinity of implant surfaces.
    Journal of Applied Biomaterials and Fundamental Materials 04/2014; 13(1). DOI:10.5301/jabfm.5000168 · 1.50 Impact Factor
  • Xianwen Liu · Songsong Zhu · Jing Hu ·
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    ABSTRACT: The purpose of this systematic review is to evaluate the efficacy of a new modified alar base cinch suture by comparing it with the commonly used classic alar base suture after LeFort I osteotomy. A comprehensive search strategy was performed to include interventional studies involving the comparisons of alar base suturing methods after LeFort I osteotomy. Data analyses were conducted using the random-effects model. Three studies with 146 participants undergoing LeFort I maxillary osteotomy were included in this review. The results showed that, compared with the classic method, both modified transseptal alar base suture and modified reinsertion sutures significantly decreased postoperative alar and alar base widening. The modified alar base cinch suture was more effective than the classic alar base suture in maintaining preoperative alar and alar base width after LeFort I osteotomy.
    01/2014; 117(1):37-44. DOI:10.1016/j.oooo.2013.09.002
  • Yanshan Liu · Na Bai · Guodong Song · Xiaohui Zhang · Jing Hu · Songsong Zhu · En Luo ·
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    ABSTRACT: Purpose: To compare the efficacy of operative and conservative treatment of displaced condylar fractures of the mandible, a meta-analysis was performed. Study design: PubMed, Cochrane Controlled Trials Register, EMBASE electronic databases were searched until 10 December 2012. English studies were restricted in randomized controlled trials (RCT). Results: Four RCT with 177 patients were included. No significant difference was found between the 2 groups in the maximal interincisal opening (P = .32). However a statistically significant difference was seen that operative treatment statistically got better efficacy in lateral excursion movement, protrusion, malocclusion, and temporomandibular joint pain (P < .05). Conclusions: This meta-analysis confirms that both treatment options for unilateral displaced condylar fractures of the mandible yielded acceptable results. However, operative treatment was superior in most objective and subjective functional parameters.
    05/2013; 116(2). DOI:10.1016/j.oooo.2013.02.023
  • Binbin Ying · Jing Hu · Songsong Zhu ·
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    ABSTRACT: This study introduced the modified Leclerc blocking procedure with miniplate and temporal fascial flap for recurrent temporomandibular joint (TMJ) dislocation and evaluated its clinical effects. Seven patients were treated by the modified Leclerc blocking procedure with miniplate and temporal fascial flap. The postoperative follow-up period ranged from half a year to 2 years to access the maximal mouth opening, TMJ disorder symptoms (pain and sound), and incidence of recurrence. No recurrence was observed in all of the 7 patients postoperatively. The mean preoperative and postoperative MMOs were 49.7 mm and 40.1 mm, respectively. There were 3 patients who reported the alleviation of pain and/or sound postoperatively. Two older patients with long-term course of disease reported no improvement of the TMJ symptoms in terms of pain and sound postoperatively. Our results showed that the modified Leclerc blocking procedure with miniplates and temporal fascial flap provided a more stable support for the condylar movement with less recurrence, suggesting that this operation could be a good alternative for the treatment of recurrent TMJ dislocation.
    The Journal of craniofacial surgery 05/2013; 24(3):740-742. DOI:10.1097/SCS.0b013e3182802441 · 0.68 Impact Factor
  • Guodong Song · Ping Yang · Songsong Zhu · En Luo · Ge Feng · Jing Hu · Jihua Li · Yunfeng Li ·
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    ABSTRACT: Surgical correction of craniosynostosis in children is associated with substantial intraoperative bleeding. Intraoperatively administered tranexamic acid (TXA) can lessen blood loss during orthopedic and cardiovascular surgery, but its efficacy in craniosynostosis surgery is uncertain. Therefore, a meta-analysis performed with published comparative studies was to determine whether TXA could reduce packed red blood cells (or erythrocytes) (PRBCs) transfused and blood loss during pediatric craniosynostosis surgery. Two PubMed and EMBASE electronic databases were searched until June 2012. Eligible studies were restricted in comparative controlled trials. Four studies in 3 articles with 138 patients were included. The results showed that intraoperative administration of TXA can significantly reduce transfusion of PRBCs (weighed mean difference [WMD] = -10.81, 95% confidence interval [CI] = -16.84 to -4.78, P < 0.00001). In the level of blood loss, the meta-analysis on 4 studies showed that the difference was statistically significant (WMD = -20.53, 95% CI = -32.26 to -8.80, P = 0.0006) between the TXA groups and the control groups. However, the subgroup analysis on randomized controlled trials showed that TXA did not significantly reduce blood loss during surgery compared with the placebo group (WMD = -30.79, 95% CIs = -71.72 to 10.14, P = 0.14). Tranexamic acid can significantly reduce the transfusion of PRBCs in children undergoing craniosynostosis surgery. However, there is a controversy on the efficacy of TXA in reducing blood loss. Therefore, new randomized controlled trials to assess the effects of TXA in children with craniosynostosis surgery should be conducted.
    The Journal of craniofacial surgery 01/2013; 24(1):299-303. DOI:10.1097/SCS.0b013e3182710232 · 0.68 Impact Factor
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    ABSTRACT: Schwannomas (neurilemmomas) are benign nerve sheath tumor originating from Schwann cells. They are well circumscribed and rarely infiltrate and metastasize. Schwannomas of the head and neck commonly occur in the tongue followed by the palate, floor of mouth, buccal mucosa, and mandible. Tongue base schwannomas could extend to the pharyngeal cavity or the floor of the mouse, and it is difficult to differentiate between tumors of the lingual, hypoglossal, and glossopharyngeal nerves.Surgical treatment of tongue base schwannomas is difficult because of limited operative exposure. Although mandibulotomy with lip splitting could obtain good exposure, surgeons might strike a balance between exposure obtaining and morbidity following because there are intricate neurovascular anatomical relationships in this region, and mandibulotomy with lip splitting would cause significant morbidity. Surgical approach options are important for tongue base schwannoma removal. From March 2008 to March 2010, 8 patients were clinically and pathologically diagnosed with tongue base schwannomas in our department, and all underwent surgical treatment. In our experience, transoral approach was used for tongue base schwannomas extending to the floor of the mouse and suprahyroid pharyngotomy approach for those extending to the pharyngeal cavity. Follow-up was made until now. One patient who experienced transoral excision still experienced numbness in the region of the lateral tongue tip, and the other 7 patients had no postoperative long-term complications.
    The Journal of craniofacial surgery 01/2013; 24(1):e9-e11. DOI:10.1097/SCS.0b013e3182668867 · 0.68 Impact Factor
  • Songsong Zhu · Dazhang Wang · Qiudan Yin · Jing Hu ·
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    ABSTRACT: Temporomandibular joint (TMJ) ankylosis with secondary dentofacial deformities in adult patients is a severely disfiguring condition and surgical treatment of this disease remains a great clinical challenge. Treatment goals are to restore the joint function, to improve facial appearances and to correct malocclusion, as well as to re-establishing harmony among them. Currently, various surgical techniques, such as arthroplasty with or without interpositional material, orthognathic surgery, distraction osteogenesis, autologous bone or bone replacement materials graft and plastic surgery, have been described in the literature. In most cases these techniques should be used in combination to achieve satisfactory outcomes. The biggest difficulty for most clinicians is to determine the proper sequence of these procedures because no uniform treatment protocol has been established. Based on the published literature and our own clinical experiences, we have prepared this review article to provide some guidelines for the surgical management of TMJ ankylosis with dentofacial deformities in adults, which will be modified and updated periodically to provide the best treatment options to benefit our patients.
    Journal of cranio-maxillo-facial surgery: official publication of the European Association for Cranio-Maxillo-Facial Surgery 01/2013; 41(7). DOI:10.1016/j.jcms.2012.11.038 · 2.93 Impact Factor
  • Songsong Zhu · Kan Chen · Yu Lan · Nan Zhang · Rulang Jiang · Jing Hu ·
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    ABSTRACT: Osteoporosis (OP) and osteoarthritis (OA) are major health problems in the increasing elderly population, particularly in postmenopausal women, but their relationship remains unclear. The present study investigated whether alendronate (ALN), a potent inhibitor of bone resorption, could protect articular cartilage from degeneration in a combined animal model of OP and OA induced by ovariectomy (OVX). Seventy-eight seven-month-old female Sprague-Dawley rats were assigned into five experimental groups: (1) sham-operated with vehicle treatment, (2) sham-operated with ALN treatment, (3) OVX with vehicle treatment, (4) ALN treatment starting at OVX, and (5) ALN treatment starting at eight weeks after OVX. Histological and micro-CT analyses, together with urine collagen degradation markers, indicated that early ALN treatment completely prevented both subchondral bone loss and cartilage surface erosion induced by OVX. Although late ALN treatment also inhibited subchondral bone loss and significantly reduced cartilage erosion in the OVX rats, these tissues did not completely recover even after 10-weeks of ALN treatment. Quantitative RT-PCR analyses showed that the protective effect of ALN correlated with increased ratio of OPG/RANKL in both subchondral bone and cartilage. Moreover, whereas OVX caused upregulation of expression of matrix metalloproteinases MMP-13 and MMP-9 in the articular cartilage and chondrocytes in the interface between the articular cartilage and subchondral bone, respectively, early ALN treatment blocked whereas late ALN treatment attenuated the upregulation of these catabolic enzymes in the corresponding tissues. Together, these data indicate that the subchondral bone loss plays an important role in OA pathogenesis in the combined OP and OA model and suggest that treatment timing is an important factor for the effectiveness of anti-resorptive drugs therapy of combined OP and OA.
    Bone 01/2013; 53(2). DOI:10.1016/j.bone.2012.12.044 · 3.97 Impact Factor

Publication Stats

459 Citations
88.21 Total Impact Points


  • 2013-2015
    • West China Hospital of Stomatology
      Hua-yang, Sichuan, China
  • 2006-2014
    • Sichuan University
      • • State Key Laboratory of Oral Diseases
      • • Department of Oral and Maxillofacial Surgery
      Hua-yang, Sichuan, China
  • 2011
    • Center For Oral & Maxillofacial Surgery
      Georgia, United States
  • 2009
    • The University of Winchester
      Winchester, England, United Kingdom