Eyal Sheiner

Ben-Gurion University of the Negev, Be'er Sheva`, Southern District, Israel

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Publications (483)1069.88 Total impact

  • [Show abstract] [Hide abstract]
    ABSTRACT: Placental growth factor (PlGF) has been suggested as a possible biomarker for major placenta-related disorders such as preeclampsia and intrauterine growth restriction. However, experimental findings suggest that PlGF concentrations may be influenced by other factors besides the placenta. In the present study, we examined how acute fetal injury affects PlGF concentrations in maternal circulation. We therefore monitored PlGF concentrations in maternal circulation before and after feticide. A prospective comparative study was performed. Blood samples were drawn prospectively between January and July 2012, before and after feticide at predetermined time points in relation to the procedure (0, 30, 60, and 120 min). The levels of lactate dehydrogenase (LDH) in the maternal circulation were measured to detect acute tissue damage. PlGF concentrations were measured by standard human ELISA. Following feticide (60 and 120 min), PlGF concentrations decreased significantly compared to the concentrations before feticide. LDH concentrations did not change before and after feticide. Our finding, along with the detailed review of the literature described in our work, supports a new concept in which primary fetal distress can affect PlGF concentration in maternal circulation. A large-scale study is required to strengthen our finding.
    Archives of Gynecology 05/2015; DOI:10.1007/s00404-015-3729-7 · 1.28 Impact Factor
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    ABSTRACT: To determine whether women with a previous uterine rupture have a higher risk of adverse perinatal outcome in subsequent births. A retrospective study comparing all subsequent singleton cesarean deliveries (CD) of women with a previous uterine rupture, with CD of women with no such history, during the years 1988-2011 was conducted. Out of 34,601 singleton CD that occurred during the study period, 0.1 % (n = 46) were of women with a previous uterine rupture. Previous uterine rupture was significantly associated with preterm delivery (<37 weeks), low birth weight (<2500 g), cervical tears, and dehiscence of the uterine scar. Pregnancies following a previous uterine rupture were associated with lower Apgar scores at 5 min. However, the perinatal mortality rate did not differ between the two groups. A recurrent uterine rupture occurred in 15.2 % of patients with a previous uterine rupture. Previous uterine rupture is a risk factor for adverse maternal and perinatal outcome and specifically recurrent uterine rupture. Appropriate consultation regarding these risks is needed for patients with a previous uterine rupture.
    Archives of Gynecology 04/2015; DOI:10.1007/s00404-015-3715-0 · 1.28 Impact Factor
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    ABSTRACT: Objective: The present study was aimed to determine whether high potassium level during pregnancy is an independent risk factor for future atherosclerotic morbidity. Patients and methods: A case–control study was conducted including women who delivered between the years 2000–2012 and subsequently developed atherosclerotic morbidity after their last delivery (n = 653) and matched controls (n = 4101). The mean follow-up duration was 57.7 ± 36.5 and 78.5 ± 42.3 months, respectively. The cases were further divided into: major events (severe atherosclerotic morbidity; n = 363), minor events (i.e. cardiovascular risk factors; n = 201) and cardiovascular evaluation tests (n = 89). The Cox proportional hazards models were used to estimate the adjusted hazard ratios (HR) for hospitalizations while controlling for confounders. Results: A Cox proportional hazard model, controlling for confounders such as gestational hypertension, gestational diabetes mellitus, obesity, maternal age, creatinine level and gestational week at index pregnancy showed that K+ ≥ 5.0 mEq/L during pregnancy was significantly associated with hospitalizations due to severe atherosclerotic morbidity (adjusted HR = 1.55; 95% CI 1.02–2.35; p = 0.039). A non-significant trend was also noted with long-term total hospitalizations for atherosclerotic (adjusted HR = 1.39; 95% CI 0.99–1.94; p = 0.052). Conclusion: High potassium level during pregnancy is associated with a significant risk for severe atherosclerotic morbidity, as it might be an indication for occult metabolic and renal dysfunction.
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    ABSTRACT: The present study was aimed to determine whether high potassium level during pregnancy is an independent risk factor for future atherosclerotic morbidity. A case-control study was conducted including women who delivered between the years 2000-2012 and subsequently developed atherosclerotic morbidity after their last delivery (n = 653) and matched controls (n = 4101). The mean follow-up duration was 57.7 ± 36.5 and 78.5 ± 42.3 months, respectively. The cases were further divided into: major events (severe atherosclerotic morbidity; n = 363), minor events (i.e. cardiovascular risk factors; n = 201) and cardiovascular evaluation tests (n = 89). The Cox proportional hazards models were used to estimate the adjusted hazard ratios (HR) for hospitalizations while controlling for confounders. A Cox proportional hazard model, controlling for confounders such as gestational hypertension, gestational diabetes mellitus, obesity, maternal age, creatinine level and gestational week at index pregnancy showed that K(+ )≥ 5.0 mEq/L during pregnancy was significantly associated with hospitalizations due to severe atherosclerotic morbidity (adjusted HR = 1.55; 95% CI 1.02-2.35; p = 0.039). A non-significant trend was also noted with long-term total hospitalizations for atherosclerotic (adjusted HR = 1.39; 95% CI 0.99-1.94; p = 0.052). High potassium level during pregnancy is associated with a significant risk for severe atherosclerotic morbidity, as it might be an indication for occult metabolic and renal dysfunction.
    The journal of maternal-fetal & neonatal medicine: the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians 04/2015; DOI:10.3109/14767058.2015.1032238 · 1.21 Impact Factor
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    ABSTRACT: To evaluate the effect of non-obstetric invasive procedure during pregnancy on perinatal outcome. The present retrospective study investigated perinatal outcome in women that underwent an invasive procedure during one of their pregnancies (n = 61); perinatal outcome was compared to other pregnancies (without an invasive procedure) of the same patients (n = 122). Women with a non-obstetric invasive procedure during pregnancy delivered earlier than those in the comparison group (38.5 vs. 40.0 weeks; p = 0.01) and had a significantly higher rate of cesarean sections (18 vs. 5 cases; p < 0.01). In addition, birth weight was significantly lower in patients undergoing invasive procedures during pregnancy (2908.65 vs. 3185.84 gr; p = 0.02). The absolute rate of prematurity (<37 weeks) was non-significantly higher in the study group (18.3 vs. 10.0 %; p = 0.28). Non-obstetric invasive procedures are associated with an increased rate of cesarean sections and lower birth weight. Nevertheless, no significant differences in early perinatal outcome were found in comparison to other pregnancies of the same patients. More studies are needed to evaluate the outcome following specific procedures.
    Archives of Gynecology 03/2015; DOI:10.1007/s00404-015-3689-y · 1.28 Impact Factor
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    ABSTRACT: To examine whether a pre-gestational diagnosis of depression is a risk factor for adverse obstetric and neonatal outcome. A retrospective cohort study investigating maternal characteristics, obstetrical and perinatal outcomes in singleton pregnancies of women with and without a diagnosis of depression was conducted. A pre-gestational diagnosis of depression was made by a psychiatrist or family physician and was recorded in the patients' chart. Multiple logistic regression models were used to control for possible confounders. During the study period, 256312 deliveries occurred. Out of which, 221 women (0.1%) had a pre-gestational diagnosis of depression. When examining obstetric outcomes, women with a diagnosis of depression were older (32.05±5.772 VS 28.56±5.851) and smokers (7.2% VS 1.1%), had a higher rate of preterm deliveries (37.99±2.989 VS 39.02±2.249) and cesarean sections (28.5% VS 13.6%) in comparison to the control group. When examining neonatal outcomes, neonates of women diagnosed with depression had a lower birth mean weight (3.038.47±649.6 VS 3183.44±551.8) and increased rates of perinatal mortality (3.2% VS 1.3%). Using a multiple logistic regression model, with perinatal mortality as the outcome variable to control for cofounders such as maternal age, preterm birth, chronic hypertension and gestational diabetes mellitus, a diagnosis of depression was not found to be an independent risk factor for perinatal mortality. Another multiple logistic regression model found advanced maternal age, smoking, preterm birth and labor induction to be associated with a diagnosis of depression. Pregnant women diagnosed with depression are at an increased risk for preterm birth, low birth weight, and cesarean sections. However, it was not associated with increased rates of perinatal mortality.
    Journal of Maternal-Fetal and Neonatal Medicine 03/2015; DOI:10.3109/14767058.2015.1023708 · 1.21 Impact Factor
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    ABSTRACT: To evaluate whether vanishing twin syndrome (VTS) is associated with adverse perinatal outcome. A retrospective cohort study investigating the impact of VTS on perinatal outcome was conducted. Parturients were classified into three groups: those pregnancies that started with double fetal sacs and spontaneously reduced into one (VTS), those with dichorionic twins, and those with singleton pregnancies. Statistical analysis included multiple logistic regression models to control for possible confounders. Tertiary university medical center. The study involved 252,994 singleton deliveries between the years 1988 and 2012. None. The impact of VTS on perinatal outcome. During the study period, 278 pregnancies with VTS were compared with 1,801 pregnancies of dichorionic twins and 252,994 pregnancies of singletons. A significant linear association was documented among the three groups and various adverse outcomes, including gestational diabetes mellitus (GDM), intrauterine growth restriction (IUGR), very low birth weight (VLBW), and perinatal mortality. The higher risk was noted in the VTS group, and the lowest in singletons. Using multivariable logistic regression models, while controlling for confounders such as fertility treatment and maternal age, VTS (as compared with singletons) was found to be an independent risk factor for several adverse perinatal outcomes including GDM, IUGR, VLBW, low Apgar scores, and perinatal mortality (adjusted odds ratios with their respective 95% confidence intervals, 1.4 [1.01-2.0], 2.7 [1.7-4.3], 6.9 [4.7-10.2], 1.9 [1.1-3.3], 2.4 [1.2-4.5]). Pregnancies with VTS are associated with an adverse perinatal outcome, even after controlling for confounders such as fertility treatment and maternal age. Copyright © 2015 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.
    Fertility and Sterility 03/2015; DOI:10.1016/j.fertnstert.2015.02.009 · 4.30 Impact Factor
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    ABSTRACT: Abstract Objective: To investigate whether obesity during pregnancy poses a risk for subsequent maternal long-term cardiovascular morbidity, after controlling for diabetes and hypertensive disorders. Study design: Data were analyzed from consecutive pregnant women who delivered between 1988 and 1999, and were followed-up until 2010. Long-term cardiovascular morbidity was compared among women with and without obesity in pregnancy (maternal pre-pregnancy body mass index (BMI) of 30 kg/m(2) or more). Kaplan-Meier survival curves were used to compare cumulative incidence of cardiovascular hospitalizations. Cox proportional hazards models were used to estimate the adjusted hazard ratios (HRs) and 95% confidence intervals (CIs) for long-term cardiovascular hospitalizations. Results: During the study period 46 688 women met the inclusion criteria, 1221 (2.6%) had a BMI ≥30 kg/m(2). During a follow-up period of more than 10 years, patients with obesity had higher rates of simple cardiovascular events and total number of cardiovascular hospitalizations. These complications tended to occur at a shorter interval (mean 4871 days ± 950 versus 5060 days ± 1140; p = 0.001). In a Cox proportional hazards model that adjusted for diabetes mellitus, preeclampsia and maternal age, obesity was independently associated with cardiovascular hospitalizations (adjusted HR 2.6, 95% CI 2.0-3.4). Conclusion: Obesity during pregnancy is an independent risk factor for long-term cardiovascular morbidity, and these complications tend to occur earlier. Pregnancy should be considered as a window of opportunity to predict future health problems and as an opportunity to promote women's health. Obese parturients might benefit from cardiovascular risk screening that could lead to early detection and secondary prevention of cardiovascular morbidity.
    Journal of Maternal-Fetal and Neonatal Medicine 03/2015; DOI:10.3109/14767058.2015.1013932 · 1.21 Impact Factor
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    ABSTRACT: The aim of this study was to examine the association between uric acid (UA) level during pregnancy and future maternal hospitalization for atherosclerotic-related morbidity. A case-control study was conducted including women who delivered between the years 2000 to 2012 and subsequently developed atherosclerotic morbidity at least 1 year after their last delivery (n=588) and controls (n=3645). The mean follow-up duration was 57.8±35.6 months and 77±43.4 months, respectively. Cox proportional hazards models were used to estimate the adjusted hazard ratios for hospitalizations. A significant linear association was documented between UA during pregnancy and long-term maternal-related atherosclerotic morbidity. A Cox proportional hazard model, controlling for the confounders gestational hypertension, gestational diabetes mellitus, obesity, maternal age, creatinine level, and gestational week at index pregnancy showed that UA ≥5.6 mg/dL during pregnancy remained independently associated with long-term total hospitalization (adjusted hazard ratio, 1.47; 95% confidence interval, 1.16-1.86; P<.001). High UA level during pregnancy may predict maternal atherosclerotic morbidity. ©2015 Wiley Periodicals, Inc.
    Journal of Clinical Hypertension 03/2015; DOI:10.1111/jch.12535 · 2.96 Impact Factor
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    ABSTRACT: To investigate obstetrical risk factors predicting failure of vaginal delivery and an emergency cesarean section (CS) for the second twin after vaginal delivery of the first twin. In addition, the study was aimed to define perinatal outcomes of the second twin. A retrospective study was conducted, comparing all deliveries of twins in which CS was performed for the second twin to those in which both twins were delivered vaginally during the years 1988-2010. Women with multiple gestations in which a CS was performed for both twins were excluded from the study. During the study period, 1966 vaginal deliveries of the first twin were recorded; 192 involved emergency CS for the second twin. Risk factors for emergency CS of the second twin were preterm delivery, previous CS, placental abruption and breech presentation of the second twin. Perinatal outcomes did not differ between the groups. Risk factors for emergency cesarean section of the second twin are preterm delivery, previous CS, placental abruption and breech presentation. Nevertheless, short-term perinatal outcomes are comparable to twins delivered vaginally.
    Archives of Gynecology and Obstetrics 02/2015; 208(1). DOI:10.1007/s00404-015-3667-4 · 1.28 Impact Factor
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    ABSTRACT: To investigate whether severe and recurrent pre-eclampsia increase the risk for long-term maternal atherosclerotic disease. A population-based study compared the incidence of long-term atherosclerotic morbidity in a cohort of women who delivered in the years 1988-2012. The exposure variable was pre-eclampsia. Mean follow-up duration was 11.2 years. Kaplan-Meier survival curves were used to estimate cumulative incidence of simple, complex (ie, angina pectoris and congestive heart failure, respectively) cardiovascular-related and renal-related hospitalisations. Cox proportional hazards models were used to estimate the adjusted HRs for cardiovascular and renal morbidity. During the study, 96 370 patients met the inclusion criteria; 7824 (8.1%) in patients who were diagnosed at least once with pre-eclampsia. Patients with pre-eclampsia had higher rates of cardiovascular morbidity including cardiac non-invasive (OR 1.4; 95% CI 1.1 to 1.7; p=0.005) and invasive diagnostic procedures (OR 1.7; 95% CI 1.2 to 2.3; p=0.001), simple (OR 1.5; 95% CI 1.2 to 1.8; p=0.001), as well as complex cardiovascular events (OR 2.4; 95% CI 2.2 to 2.8; p=0.001) and renal (OR 3.7; 95% CI 2.2 to 6.0; p=0.001) hospitalisations. A significant linear association was noted between the severity of pre-eclampsia (no pre-eclampsia, mild pre-eclampsia, severe pre-eclampsia and eclampsia) and cardiovascular (2.7% vs 4.5% vs 5.2% vs 5.7%, respectively; p=0.001), as well as renal disease (0.1% vs 0.2% vs 0.5% vs 1.1%, respectively; p=0.001). Likewise, a linear association was found between the number of previous pregnancies with pre-eclampsia (no pre-eclampsia, one event and ≥2 events of pre-eclampsia) and risk for future simple cardiovascular disease (1.2% vs 1.6% vs 2.2%, respectively; p=0.001), complex cardiovascular disease (1.3% vs 2.7% vs 4.6%, respectively; p=0.001) and total cardiovascular hospitalisations (2.7% vs 4.4% vs 6.0%, respectively; p=0.001). Using a Kaplan-Meier survival curve, patients with pre-eclampsia had significantly higher cumulative incidence of atherosclerotic-related hospitalisations. In a Cox proportional hazards model, adjusted for confounders such as maternal age, parity, diabetes mellitus and obesity, pre-eclampsia remained independently associated with atherosclerotic hospitalisations. Previous pregnancy with pre-eclampsia is an independent risk factor for long-term maternal atherosclerotic morbidity. The risk is more substantial for patients with severe and recurrent episodes of pre-eclampsia. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.
    Heart (British Cardiac Society) 01/2015; 101(6). DOI:10.1136/heartjnl-2014-306571 · 6.02 Impact Factor
  • American Journal of Obstetrics and Gynecology 01/2015; 212(1):S342. DOI:10.1016/j.ajog.2014.10.906 · 3.97 Impact Factor
  • American Journal of Obstetrics and Gynecology 01/2015; 212(1):S34. DOI:10.1016/j.ajog.2014.10.093 · 3.97 Impact Factor
  • American Journal of Obstetrics and Gynecology 01/2015; 212(1):S381-S382. DOI:10.1016/j.ajog.2014.10.994 · 3.97 Impact Factor
  • American Journal of Obstetrics and Gynecology 01/2015; 212(1):S387. DOI:10.1016/j.ajog.2014.10.1006 · 3.97 Impact Factor
  • American Journal of Obstetrics and Gynecology 01/2015; 212(1):S268. DOI:10.1016/j.ajog.2014.10.582 · 3.97 Impact Factor
  • American Journal of Obstetrics and Gynecology 01/2015; 212(1):S119. DOI:10.1016/j.ajog.2014.10.257 · 3.97 Impact Factor
  • Eli Kabakov, Eyal Sheiner, Michael Friger
    American Journal of Obstetrics and Gynecology 01/2015; 212(1):S383. DOI:10.1016/j.ajog.2014.10.997 · 3.97 Impact Factor
  • American Journal of Obstetrics and Gynecology 01/2015; 212(1):S338. DOI:10.1016/j.ajog.2014.10.897 · 3.97 Impact Factor
  • Jamie Klein, Ron Charach, Eyal Sheiner
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    ABSTRACT: Introduction: Gestational diabetes mellitus (GDM), defined as glucose intolerance with first recognition or onset during pregnancy, is steadily rising in prevalence. GDM affects ∼ 3 - 5% of pregnancies in the US and is associated with significant adverse perinatal and maternal outcomes. Diagnosing and treating GDM early in pregnancy is of utmost importance as it can prevent poor outcomes such as macrosomia, shoulder dystocia and obstetric complications. Areas covered: This review describes the importance of treating GDM and the various available interventions for glycemic control in women with GDM, including the latest evidence regarding pharmacological treatments and specifically anti-hyperglycemic agents. It deals with timing of pharmacological treatments, recommended doses and what pharmacological agent should be used. Expert opinion: Unless diagnosed late during pregnancy, a stepwise approach is the best way to treat GDM, beginning with diet and exercise and proceeding to pharmacological interventions if failure occurred. Although insulin is the dominant treatment, the use of anti-hyperglycemic agents such as glyburide and metformin in treating GDM has gained popularity and consideration should be made using these agents as first-line pharmacological treatment. Anti-hyperglycemic agents do not require frequent monitoring or injections and may therefore appeal more to patients. Further studies are needed regarding long-acting insulin and other anti-hyperglycemic agents such as thiazolidinediones, as well as identifying treatment options more specific to an individual based on risk factors and other variables predicting treatment outcomes in GDM.
    Expert Opinion on Pharmacotherapy 11/2014; 16(3):1-12. DOI:10.1517/14656566.2015.988140 · 3.09 Impact Factor

Publication Stats

4k Citations
1,069.88 Total Impact Points

Institutions

  • 1998–2015
    • Ben-Gurion University of the Negev
      • • Division of Obstetrics and Gynecology
      • • Faculty of Health Sciences
      Be'er Sheva`, Southern District, Israel
  • 1999–2014
    • Soroka Medical Center
      • Division of Obstetrics and Gynecology
      Be'er Sheva`, Southern District, Israel
  • 2011
    • Royal College of Surgeons in Ireland
      Dublin, Leinster, Ireland
  • 2005–2009
    • Rush University Medical Center
      • Department of Obstetrics and Gynecology
      Chicago, Illinois, United States
    • Hadassah Medical Center
      • Department of Obstetrics and Gynaecology
      Yerushalayim, Jerusalem, Israel
  • 2008
    • University of Maryland, Baltimore
      • Department of Medicine
      Baltimore, Maryland, United States
    • University of North Carolina at Chapel Hill
      • Center for Functional GI and Motility Disorders
      North Carolina, United States
  • 2007
    • University of Cambridge
      • Department of Obstetrics & Gynaecology
      Cambridge, England, United Kingdom
    • Society for Maternal-Fetal Medicine
      Rochester, New York, United States
  • 2006
    • University of Chicago
      • Department of Obstetrics & Gynecology
      Chicago, IL, United States
    • University of Ulsan
      • College of Medicine
      Urusan, Ulsan, South Korea
  • 2003
    • McGill University
      • Department of Obstetrics and Gynecology
      Montréal, Quebec, Canada