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Publications (15)2.86 Total impact

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    ABSTRACT: To determine the frequency of neuron specific enolase (NSE) tissue expression and its possible influence on survival of patients treated for advanced non small cell lung cancer (NSCLC). We studied 158 patients with histological diagnosis of NSCLC (stage III/IV). Combined chemoradiotherapy was used in stage III disease (without pleural effusion), whereas chemotherapy only was used in stage III (with pleural effusion) as well as in stage IV disease. Immunohistochemical analysis of NSE expression was determined using antibodies to NSE (DAKO, Den). One- and 2-year overall survival were assessed. 45 (28.5%) patients had positive NSE expression. The most frequent NSE expression was seen in 6/9 (66.7%) patients with large cell carcinoma and in 23/50 (46%) with adenocarcinoma. One- and 2-year survival rates were 70% and 30% in the group of patients with positive NSE expression compared to 26% and 3% in the group with negative NSE expression (p=0.000). The median survival time was 16.4 vs. 11.4 months in the groups of patients with and without NSE expression, respectively (p < 0.001). One-and 2-year survival rate was higher in NSCLC patients with more than 50% of NSE positive cancer cells (p=0.0004 and 0.000, respectively). A total of 28.5% of advanced NSCLC patients had positive NSE expression. Median 1- and 2-year survival time was significantly longer in patients with positive NSE expression.
    Journal of B.U.ON.: official journal of the Balkan Union of Oncology 01/2008; 13(1):93-6. · 0.76 Impact Factor
  • G Plavec, V Dangubić, V Tatić
    Vojnosanitetski pregled. Military-medical and pharmaceutical review 01/2000; 44(3):206-8. · 0.21 Impact Factor
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    ABSTRACT: In 47 patients with pleural effusions of different etiology concentrations of the tissue polypeptide antigen (TPA) and tumour trypsin inhibitor (TATI) were measured. Malignant disease was found in 24 patients and benign one in 23 patients. In a group of patients with malignant pleural effusion the average concentration of TPA was 3102 U/L and of TATI 76.8 ug/L. In a group of patients with nonmalignant effusion these concentrations of TPA were 2381.8 U/L and of TATI 28.3 ug/L. Higher concentration of TPA was found in pleural effusion of malignant nature with specificity of 96% but with a small sensitivity of 12.5% and positive predictive value of 43%. TATI concentrations were also higher in malignant pleural effusion with good sensitivity and specificity (78%, 50% respectively) and positive predictive value of 66%.
    Vojnosanitetski pregled. Military-medical and pharmaceutical review 01/1992; 49(4):325-9. · 0.21 Impact Factor
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    ABSTRACT: In 105 patients with chronic obstructive pulmonary disease the bronchodilator response to salbutamol aerosol (ventolin) has been studied. According to the initial values of FEV1 (forced expiratory volume in one second) the patients were divided into four groups. Patients with bronchitis in the first group had the initial FEV1 between 600 and 1000 ml and in the second group between 100 and 2000 ml, while asthmatics in the third group had between 100 and 2000 ml and in the fourth group more than 2000 ml. The largest bronchodilator response was obtained in the groups of asthmatics (mean FEV1 increase was 473 +/- 258 ml in the third group and 609 +/- 334 ml in the fourth group). For evaluation of reversibility of obstruction of the respiratory ways after bronchodilatator tests and for better differentiation of chronic obstructive bronchitis and asthma the criteria have been proposed depending on the initial FEV1 values.
    Vojnosanitetski pregled. Military-medical and pharmaceutical review 01/1991; 48(1):19-22. · 0.21 Impact Factor
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    ABSTRACT: The concentration of neuron-specific enolase (NSE) was measured in the serum and pleural fluid of 42 patients with pleural effusions of different etiology. High levels (above 13.0 micrograms/l) of NSE in pleural fluid of 9 patients with malignant disease were observed (sensitivity 57%). However, pleural fluid NSE levels were also increased in 14 with non-malignant diseases (specificity 45%). Increased pleural fluid NSE activity is not specific for malignancy.
    Plućne bolesti: casopis Udruzenja pneumoftiziologa Jugoslavije = the journal of Yugoslav Association of Phthisiology and Pneumology 01/1990; 42(1-2):88-91.
  • V Dangubić, S Kamenica, G Plavec
    Plućne bolesti: casopis Udruzenja pneumoftiziologa Jugoslavije = the journal of Yugoslav Association of Phthisiology and Pneumology 37(1-2):97-101.
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    ABSTRACT: 178 new cases of tuberculosis of the lungs and pleura have been treated within the period of four years (1985-1988) in military medical institutions of the Y.P.A. The patients were classified by random selection in two therapeutical groups. Two six-month regimens were applied with the same drugs except for the fourth one which was used in the initial period only (EHRZ and SHRZ). Both applied therapeutical combinations were equally successful. All patients achieved negative cultures at least three months after onset of chemotherapy. Relapses occurred in 4 (2.3%) of patients during the period of follow-up for at least 2 and the most 5.5 years after the end of therapy. The toxic effects were tolerable. The drug resistance was found in 25 of 134 (18.6%) patients, the most common to one drug.
    Vojnosanitetski pregled. Military-medical and pharmaceutical review 49(1):3-7. · 0.21 Impact Factor
  • Vojnosanitetski pregled. Military-medical and pharmaceutical review 45(2):109-13. · 0.21 Impact Factor
  • Plućne bolesti: casopis Udruzenja pneumoftiziologa Jugoslavije = the journal of Yugoslav Association of Phthisiology and Pneumology 40(1-2):18-21.
  • Vojnosanitetski pregled. Military-medical and pharmaceutical review 45(3):183-7. · 0.21 Impact Factor
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    ABSTRACT: In 20 patients with pulmonary sarcoidosis bronchoalveolar lavage (BAL) was performed. The cellular content was analysed and lymphocyte subpopulation was determined using monoclonal antibodies. The patients with more than 28% of BAL T lymphocytes are classified as patients with high intensity alveolitis (n = 8) and those with less than 28% of T lymphocytes as low intensity alveolitis (n = 12). Of the total number of BAL T lymphocytes in high intensity alveolitis CD 3+ T cells were 88.8 +/- 8.4% and in low intensity alveolitis 68.2 +/- 13.8% (p < 0.001). In high intensity alveolitis the number of CD 4+ T cells was increased and the number of CD 8+ T cells was decreased which caused the increased index CD 4:CD 8; 9.8 +/- 8.7. In low intensity alveolitis this ratio was 2.2 +/- 1.2. Effects of smoking were also analysed. In smokers the total number of BAL cells was higher 184.0 +/- 47.2 x 10(4) ml of BAL, and in nonsmokers 101.3 +/- 65.1 x 10(4) ml of BAL (p < 0.001). Smoking has no effects on the characteristics of the cellular elements and subpopulation of BAL lymphocytes in patients with sarcoidosis. In 7 patients T lymphocyte subpopulation in the peripheral blood were determined too. Patients with high intensity alveolitis had the increased index CD 4:CD 8 in the peripheral blood compared with low intensity alveolitis.
    Vojnosanitetski pregled. Military-medical and pharmaceutical review 49(6):547-51. · 0.21 Impact Factor
  • V Dangubić, G Plavec, S Berger
    Plućne bolesti: casopis Udruzenja pneumoftiziologa Jugoslavije = the journal of Yugoslav Association of Phthisiology and Pneumology 36(3-4):223-5.
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    ABSTRACT: In 12 men, atopic asthmatics, the bronchodilator effects have been studied after inhalation of 400 micrograms of salbutamol cyclocaps and bronchodilators in aerosol (40 micrograms of ipratropium bromide, 400 micrograms of fenoterol, 100 micrograms of fenoterol + 40 micrograms of ipratropium bromide and 200 micrograms of salbutamol). Bronchodilators were inhaled in different days at the same time. FEV1 measurements were repeated after 30, 60, 120 and 360 minutes and the values were compared with those obtained prior to inhalation of the drug. Although a better bronchodilator response to salbutamol cyclocaps is statistically insignificant, its longest maintenance make it suitable for the long-term therapy.
    Vojnosanitetski pregled. Military-medical and pharmaceutical review 50(6):589-92. · 0.21 Impact Factor
  • G Plavec
    Vojnosanitetski pregled. Military-medical and pharmaceutical review 47(1):35-9. · 0.21 Impact Factor
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    ABSTRACT: The results of small spirometry, airway resistance and flow volume loop were compared in 10 patients with upper airway obstruction, 11 patients with chronic pulmonary obstructive disease and 15 healthy examinees. Our results have shown that for detection and differentiation of upper airway obstruction and chronic obstructive pulmonary disease the most reliable values give the following parameters and relations: MIF 50% less than or equal to 100 l/min, MEF 50% greater than or equal to 1, FEV1/ /PEF greater than or equal to 10 ml/l/min, FEV1/FEV0.5 greater than or equal to 1.5 and FEV1/ /FEV1 greater than or equal to 1.
    Vojnosanitetski pregled. Military-medical and pharmaceutical review 49(3):207-10. · 0.21 Impact Factor