Ioana Dana Alexa

Universitatea de Medicina si Farmacie Grigore T. Popa Iasi, Iaşi, Judetul Iasi, Romania

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Publications (38)1.22 Total impact

  • [Show abstract] [Hide abstract]
    ABSTRACT: The present study aims to evaluate whether ascorbic acid (AA) and curcumin, two substances with redox properties, have similar effects on different models of pain in mice.
    04/2014; 118(2):346-51.
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    ABSTRACT: Schizophrenia as severe mental disorder is characterized by a disintegration of the process of thinking and of emotional responsiveness whereas the underlying mechanisms of schizophrenia are complex and still discussed. The objective of this study is to find out if patients with schizophrenia and their healthy first-degree relatives have abnormal autonomic nervous system (ANS) activity by measuring cardiac indices as QT variability index (QTVI). Moreover, it is useful to study if ANS dysfunction could play an important role in schizophrenia and if abnormal functioning could be retrieved by patients' healthy first degree relatives. Also, a parallel experiment monitored QTVI in healthy controls before, during and after a new complex stress test named Mannheim Multicomponent Stress Test (MMST). As QT variability analysis results were not significantly different during MMST versus normal state, we concluded that short-term stress has no fundamental impact on ECG morphology in healthy subjects. However, patients with schizophrenia revealed an increased QTVI that indicates structural changes of ECG morphology in those patients. These findings were obviously independent from the findings regarding to healthy subjects under stress and healthy subjects (basic measurement of 30min).
    IEEE 4th International Conference E-Health and Bioengineering – ”EHB 2013”, IASI, Romania; 11/2013
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    ABSTRACT: A complex goal in biomedical information technology today is the design and implementation of telemedicine and e-health solutions, which provide (chronic) patients and elderly people services that can enhance their quality of life. We used wireless sensor network technology, low-power integrated embedded systems and wireless communications, which have enabled us the design of low-cost, miniature, precise and intelligent physiological sensor modules. These modules are capable of measuring, processing, communicating one or more physiological parameters, and can be integrated into a wireless personal area network (WPAN). We have designed, deployed, produced and tested both hardware and software medical sensors for WPAN, dedicated to vital signs acquisition, processing and transmitting, as well as the whole telemedical system for these physiologic parameters monitoring in real time. This paper is dedicated to the most complex Romanian telemedical pilot project, TELEMON, that has as goals the design and implementation of a system for automatic and complex telemonitoring, everywhere and every time, in (almost) real time, of the vital signs of persons with chronic illnesses, of elderly people, of those having high medical risk and of those living in isolated regions. The final objective of this pilot project is to enable personalized telemedical services, and to act as a basis for a public service for telemedical procedures in Romania and abroad.
    Revista medico-chirurgicală̆ a Societă̆ţ̜ii de Medici ş̧i Naturaliş̧ti din Iaş̧i. 08/2013; 117(3):825-32.
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    ABSTRACT: This paper presents a Romanian telemedical project that has as goals researches, design and implementation of an electronic-informatics-telecom and scalable system, that allows the automatic and complex telemonitoring, everywhere and every time (at home, in hospitals, at work, of mobile subject, etc), in (almost) real time, of the vital signs of persons with chronic illnesses, of elderly people, of those having high medical risk and of those with neuro-locomotor disabilities. The main objective of this pilot project is to enable personalized medical teleservices delivery and patient safety enhancement based on an earlier diagnosis, and to act as basis for a public service for telemedical procedures. Keywordstelemedicine-biomedical equipment-biomedical signal analysis-wireless personal area network-falldetection
    01/2010: pages 92-95;
  • International Journal of Computers, Communications & Control (IJCCC) 01/2010; V(5):892-901. · 0.44 Impact Factor
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    ABSTRACT: The current common goal in medical information technology to-day is the design and implementation of telemedicine solutions, which provide to patients services that enhance their quality of life. Advances in wireless sensor network technology, the overall miniaturization of their associated hard-ware low-power integrated circuits and wireless communications have enabled the design of low-cost, miniature, and intelligent physiological sensor modules with applications in the medical industry. These modules are capable of mea-suring, processing, communicating one or more physiological parameters, and can be integrated into a wireless personal area network. This paper is dedi-cated to the most complex Romanian telemedical pilot project, TELEMON, which has as goals design and implementation of an electronic-informatics-telecommunications system, that allows the automatic and complex telemoni-toring, everywhere and every time, in (almost) real time, of the vital signs of persons with chronic illnesses, of elderly people, of those having high medical risk and of those living in isolated regions. The final objective of this pilot project is to enable personalized medical teleservices delivery, and to act as a basis for a public service for telemedical procedures in Romania and abroad.
    Int. J. of Computers. 01/2010; V:900-909.
  • H. Costin, C. Rotariu, Ioana Alexa, et al
    The World Congress on Medical Physics and Biomedical Engineering; 09/2009
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    ABSTRACT: This paper presents the most complex Romanian telemedical project, TELEMON, that has as goals researches, design and implementation of an electronic-informatics-telecom and scalable system, that allows the automatic and complex telemonitoring, everywhere and every time (at home, in hospitals, at work, of mobile subject, etc), in (almost) real time, of the vital signs of persons with chronic illnesses, of elderly people, of those having high medical risk and of those with neuro-locomotor disabilities. The main objective of this pilot project is to enable personalized medical teleservices delivery and patient safety enhancement based on an earlier diagnosis, and to act as basis for a public service for telemedical procedures.
    01/2009;
  • S Ardeleanu, Ioana Dana Alexa, O Prisadă, G Ungureanu
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    ABSTRACT: Right heart infective endocarditis in an elderly patient with no previous known risk factors is a very rare situation (even if subacute infective endocarditis has the same chance of occurrence at either a young person, or an elderly patient). We present the case of a 75-years old patient, with no previous cardiac history, addressed to our clinic with nonspecific septic symptoms associated with an edematous syndrome. The patient was treated for right heart valve infective endocarditis; a particularity may be the fact not all Duke criteria were respected. Iatrogeny was involved, our patient having administered a 7-day antibiotic treatment before hospital addressing. The therapeutic probe was positive: excellent evolution under treatment. Few cases of infective endocarditis of the tricuspid valve were reported worldwide, in which the source of infection was unknown in about 80% of cases. In two pediatric cases reported, tricuspid endocarditis was caused by Staphylococcus aureus septicemia following upper respiratory infection. This may also occur in adult cases. Further investigations should be carried out in the future to elucidate the source of infection. Isolated right-sided endocarditis should be included in the differential diagnosis of patients with febrile syndrome, respiratory symptoms and predisposing disease, even when they do not have a pacemaker and are not intravenous-drug users (IVDU).
    Revista medico-chirurgicală̆ a Societă̆ţ̜ii de Medici ş̧i Naturaliş̧ti din Iaş̧i. 01/2009; 113(3):762-5.
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    ABSTRACT: This paper presents a project that has as main goal researches, design and implementation of an electronicinformatics- telecom and scalable system, that allows the automatic, complex and real time telemonitoring, everywhere and every time (at home, in hospitals, at work, etc.), using several communication paths, of (mobile) persons with chronic illnesses, of elderly people, of those having high medical risk and of those with neuro-locomotor disabilities. The monitored features are electrophysiological (vital) signs, signals for domotics (home surveillance, access control in a certain area), and the systems also performs automatic image analysis of the movements of the subjects.
    12/2008: pages 1002-1005;
  • G Ungureanu, Ioana Dana Alexa, Ortansa Stoica
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    ABSTRACT: The 21st century's demographic and epidemiologic perspectives suggest an absolute and percentual increment of elderly population. In the same time the prevalence of heart insufficiency increases with advanced age, which transforms heart failure in a true challenge for health insurance system. This new dimension of the problem resides in the increment of heart insufficiency's prevalence and in the high costs of medical care of these patients. Heart failure's medical costs are high not only due to the necessity of compensating the cardiac function but also due to the necessity of treating the etiology, the risk factors and the co-morbidities with cardiac side effects. Elderly patients usually have a low therapeutic compliance and an important number of iatrogenic reactions mainly due to poly-medication, poly-pathology and cognitive and physical deficiencies, which need special measures of therapeutic education for the patient and family and medical survey, probably best in a nursing house; all these elements increase significantly the cost, which is almost double than the cost for cancer. The prophylaxis in heart insufficiency means an extremely efficient management of entire cardiac pathology in order to delay the moment of heart failure. In elderly patients, the treatment in heart insufficiency is difficult not due to hospital treatment of decompensation episodes but due to low therapeutic compliance at home. We need special programs to ensure medical education of the patient and the family/caregiver in order to avoid iatrogenic pathology and to ensure therapeutic efficiency.
    Revista medico-chirurgicală̆ a Societă̆ţ̜ii de Medici ş̧i Naturaliş̧ti din Iaş̧i. 01/2008; 112(2):293-8.
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    ABSTRACT: The paper presents a project that has as main goal researches, design and implementation of an electronic-informatics-telecom and scalable system, that allows the automatic and complex telemonitoring, everywhere and every time (at home, in hospitals, at work, of mobile subject etc, using several communication paths), in real time, of persons with chronic illnesses, of elderly people, of those having high medical risk and of those with neuro-locomotor disabilities.
    01/2008;
  • G Ungureanu, Ioana Dana Alexa, Ortansa Stoica
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    ABSTRACT: Discussions about the impact of iatrogeny over general health were avoided and neglected for a very long time. It was brought to medical interest due to recent studies concerning therapeutic compliance, patient's medical education and acute awareness of ethical implications of medical activities. Even if iatrogeny was always present in medicine, we realized but recently the dimensions and the necessity of a coherent and systematic approach of this problem. Iatrogenic pathology in elderly population has even a bigger impact due to conjugation of two major demographic phenomena: an absolute and percentage increase of elderly population parallel with an increase of prevalence of iatrogenic pathology with age. That's why iatrogeny in elderly becomes a major health problem, unfortunately often ignored, neglected and even obscured inspite of well-recognized impact over duration and quality of patient's life as well as over the cost of medical assistance.
    Revista medico-chirurgicală̆ a Societă̆ţ̜ii de Medici ş̧i Naturaliş̧ti din Iaş̧i. 01/2007; 111(4):803-10.
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    ABSTRACT: Neuropsychiatric systemic lupus erythematosus (NPSLE) has become a popular term designing all neurological and psychiatric complications in patients with systemic lupus erythematosus (SLE). It occurs in up to two thirds of all SLE patients and it covers a vast array of disorders ranging from peripheral neuropathy to stroke, psychosis, and dementia. Mechanisms associated with the pathogenesis of NPSLE include anti-neuronal antibodies, antiphospholipid antibody associated thrombosis, emboli from cardiac source and, rarely, vasculitis by immune complex depositions. Although the most common manifestations is cognitive dysfunction (50%), NPSLE may also present itself as peripheral neuropathy (15%), psychosis (10%), or other central nervous system abnormalities (stroke, organic brain syndrome, seizures). In lupus patients, one should always look for secondary causes of the neuropsychiatric manifestation, including infection, toxic metabolic abnormalities, and hypertension. We present two cases of SLE, which developed neuropsychiatric manifestations.
    Revista medico-chirurgicală̆ a Societă̆ţ̜ii de Medici ş̧i Naturaliş̧ti din Iaş̧i. 01/2006; 110(2):322-5.
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    ABSTRACT: Oxidative stress is the result of the imbalance between pro-oxidant and antioxidant factors. The participation of oxidative stress in atherosclerosis (ATS) is reflected by lipid peroxidation which is a process initiated and maintained by oxygen reactive species generated by the aterogenic cells themselves. The endothelial aggression in ATS is accompanied by endothelial dysfunction, which is due to the neutralization of nitric oxide by superoxid anion. The key role in the onset and the development of the ATS lesions belongs to oxidated LDL-cholesterol that influence at different levels and by several mechanisms the ATS process. The neutralization of the toxic effects of free radicals is due to the endo and exogen antioxidant systems. It appears that the individual antioxidant status is influenced by environmental factors as well as by a genetic determinant. The antioxidant therapy, which is controversial at the moment, represents an associated therapy in endothelial dysfunction from ATS.
    Revista medico-chirurgicală̆ a Societă̆ţ̜ii de Medici ş̧i Naturaliş̧ti din Iaş̧i. 01/2003; 107(3):502-11.
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    ABSTRACT: We present the case of a female patient with a chronic hypersideremic anemia associated with digestive and neurological symptoms, with a long time ignored toxic history. The diagnose was based on very high levels of lead in serum and urine, very high levels of D-aminolaevulinic acid in the urine, and the presence of basophilic stippling of erythrocytes in the smear of the patient. Lead intoxication was due to ingestion of home-made alcohol (domestic devices made from lead mixtures) and of yogurt preserved in lead-glazed mugs.
    Revista medico-chirurgicală̆ a Societă̆ţ̜ii de Medici ş̧i Naturaliş̧ti din Iaş̧i. 01/2002; 106(4):825-8.
  • G Ungureanu, I D Alexa
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    ABSTRACT: The paper presents a review of recent findings about cardiovascular risk factors in elderly. It becomes important to know that the cardiovascular risk factors we look for in adulthood change in elderly patients. However, we consider that the cardiovascular risk factors in elderly remain hypertension, smoking status, hypercholesterolemia, diabetes mellitus and obesity. Recent studies proved that in elderly high levels of cholesterol are much less found than in adults as well as smoking status. Elderly has specific risk factors: high levels of iron and basic tachycardia. Other possible risk factors are: high levels of homocysteine, low plasmatic levels of HDL-cholesterol, high levels of lipoprotein-A and some coagulation factors.
    Revista medico-chirurgicală̆ a Societă̆ţ̜ii de Medici ş̧i Naturaliş̧ti din Iaş̧i. 01/1998; 104(2):31-7.
  • I D Alexa, L Jerca
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    ABSTRACT: Several recent studies have reported that there is an imbalance of increased oxidant status and decreased antioxidant system in women with preeclampsia and that factor might contribute to the pathogenesis of the disease. The following study examined blood levels of some of the antioxidants (glutathione, glutathione-peroxidase and -SH groups) as markers of lipid peroxidation in women with preeclampsia compared with normal gestation. Blood levels of these antioxidants were found significantly decreased in women with preeclampsia, which allowed us to speculate that there were abnormally increased levels of lipid peroxides. We believe that lipid peroxides are toxic compounds that damage endothelial cells, increase peripheral vasoconstriction and increase thromboxane synthesis and decrease prostacyclin synthesis. We consider that lipid peroxides are not the cause but the effect of oxidative stress induced by ischaemic placenta and leukocytes activation, so the contribute but not induce pathogenesis in preeclampsia.
    Revista medico-chirurgicală̆ a Societă̆ţ̜ii de Medici ş̧i Naturaliş̧ti din Iaş̧i. 01/1996; 100(1-2):131-5.
  • I D Alexa, L Jerca, V Gheorghiţă
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    ABSTRACT: Several recent studies have reported that there is an imbalance between increased oxidant status and decreased antioxidant system in women with preeclampsia; this factor may contribute to endothelial lesion, one of the characteristics of the disease. Our studies has examined serum levels of lipid peroxides and of some of the antioxidants (glutathione and glutathione-peroxidase) in women with preeclampsia compared with normal pregnant women. The study was realised on two groups: Group A consisting of 34 normal pregnant women and group B consisting in 20 women with PEC. Serum levels of lipid peroxides have been found markedly increased and of antioxidants markedly decreased in preeclamptic serum compared with normal gestational serum. Lipid peroxides are toxic compounds that damage endothelial cells, increase peripheral vasoconstriction and increase thromboxane synthesis. Our study has pointed out that in PEC there is a deficiency in the antioxidant system which allow, together with the ischemic placenta and activated neutrophils, the enhancement of lipid peroxides. This deficiency in AO system contribute to the development and aggravation of the clinical manifestation in PEC.
    Revista medico-chirurgicală̆ a Societă̆ţ̜ii de Medici ş̧i Naturaliş̧ti din Iaş̧i. 01/1996; 100(3-4):84-9.
  • Ioana Dana Alexa, Larisa Panaghiu, G Ungureanu
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    ABSTRACT: To study the benefit of the therapy with hydroxymethylglutaryl coenzyme A reductase inhibitors (simvastatin) associated with diet in treating dyslipidemia in elderly patients, considering that they are more exposed to sudden death, myocardial infarction and stroke. Efficient and long-term serum cholesterol concentration lowering has beneficial effects on the risk for coronary heart disease as well as on other major cardiovascular risk factors such as hypertension and diabetes. A retrospective study of 84 patients aged > or = 65 years, admitted in the last 6 months in Medical Clinic IV, was conducted. Admission criteria in the study were: age > or = 65 years old and high serum levels of cholesterol, triglycerides and LDL-C/HDL-C ratio. The patient population was divided into two groups: Group I of 40 patients treated for dyslipidemia only with diet and Group II with 44 patients in which was associated treatment with hydroxymethylglutaryl coenzyme A reductase inhibitors, 10 mg/day. The patients were controlled when admitted in the study and then at 3 and 6 weeks afterwards. Serum cholesterol and triglycerides concentration lowering was modest in Group I at 3 and 6 weeks, maybe because we registered a progressively lowered compliance of patients to hypocholesterolemic diet. In Group II the results were much better as we obtained significant serum cholesterol and triglycerides levels lowering after 3 weeks of treatment, and in 32 cases (72%) we had a normal lipid profile after 6 weeks of treatment. The other 12 patients (28%) abandoned treatment after 4 weeks of therapy because of financial reasons. There were no side effects during the treatment with hydroxymethylglutaryl coenzyme A reductase inhibitors. The therapy with hydroxymethylglutaryl coenzyme A reductase inhibitors associated to hypocholesterolemic diet controlled efficiently dyslipidemia in elderly patients. Diet alone could not control cholesterol and triglycerides levels, mainly because of lack of adherence of the patients to the diet. Based on the fact that dyslipidemia is a major, independent cardiovascular risk factor, we consider that therapy with hydroxymethylglutaryl coenzyme-A-reductase inhibitors is beneficial in elderly patients because of their efficacity, minimal side effects and protection against sudden death, myocardial infarction and stroke.
    Revista medico-chirurgicală̆ a Societă̆ţ̜ii de Medici ş̧i Naturaliş̧ti din Iaş̧i. 109(4):721-6.

Publication Stats

94 Citations
1.22 Total Impact Points

Institutions

  • 1996–2009
    • Universitatea de Medicina si Farmacie Grigore T. Popa Iasi
      • Faculty of Medicine
      Iaşi, Judetul Iasi, Romania