Asuman Ozkan

State Hospital of Ercis, Turkey, Arcis, Van, Turkey

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Publications (8)12.07 Total impact

  • [Show abstract] [Hide abstract]
    ABSTRACT: To investigate Helicobacter pylori seropositivity rate in preeclamptic and healthy pregnants. Additionally, we compared serum malondialdehyde (MDA) levels and lipid profile between H. pylori-positive and negative cases. This study included 53 preeclamptic and 30 healthy pregnants. Serum levels of total cholesterol (TC), triglyceride (TG), high-density lipoprotein (HDL-C) and low-density lipoprotein (LDL-C), MDA, and H. pylori Ig G antibodies were measured. Preeclampsia group had higher serum MDA levels compared with healthy pregnants (P<0.001). While the rate of H. pylori seropositivity was 43/53 (81%) in the preeclampsia group, this was 18/30 (% 60) in normal pregnants (odds ratio (OR), 2.86; 95% confidence interval (CI), 1.05-7.82; P=0.036). We further divided the preeclampsia group as H. pylori-positive and H. pylori-negative subgroups. In H. pylori-positive group, serum TC (P<0.01) and LDL-C (P<0.01) levels were significantly higher than those of H. pylori-negative group. Mean MDA concentration was higher in H. pylori-positive group than that of H. pylori-negative group (P<0.001). H. pylori-positive pregnants may have a high risk for preeclampsia and H. pylori may be one of the causes for high MDA levels in preeclampsia.
    Journal of Clinical Laboratory Analysis 03/2009; 23(4):219-22. DOI:10.1002/jcla.20330 · 1.14 Impact Factor
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    ABSTRACT: Turkey, especially its eastern part, has been accepted as endemic for vitamin D deficiency rickets (VDDR). In a study performed by our team in the region in 1998, the incidence of VDDR was 6.09% in children aged between 0–3 years. In 2005, the Ministry of Health initiated a free vitamin D supplementation campaign nationwide for every infant to eradicate VDDR. In this study, we aimed to investigate the prevalence of VDDR in children aged between 0–3 years in order to evaluate the effectiveness of this campaign. Between March 2007 and February 2008, 39,133 children aged between 0–3 years who were brought to different pediatric outpatient clinics in Erzurum, Turkey, were examined for VDDR. VDDR diagnosis was made by radiological and biochemical findings in the cases who were initially suspected of having clinical VDDR. During a one-year period, 39 (0.099%) of the 39,133 patients were diagnosed with VDDR. None of the cases with rickets was taking vitamin D supplementation. The most frequent physical findings were rachitic rosary, enlargement of the wrists, and craniotabes. The laboratory findings of the cases were compatible with VDDR; serum calcium (Ca) 7.5 ± 1.9 mg/dL, PO4 4.4 ± 1.3 mg/dL, alkaline phosphatase (ALP) 1,341 ± 823, 25-hydroxyvitamin D (25 (OH) D) 5.8 ± 2.9 ng/mL, intact parathyroid hormone (iPTH) 240 ± 106 pg/mL. It was concluded that, although VDDR has been a continuing childhood health problem, a nationwide free vitamin D supplementation campaign initiated by the government appeared to be effective in eliminating VDDR.
    European Journal of Pediatrics 02/2009; 168(1):101. DOI:10.1007/s00431-008-0846-3 · 1.98 Impact Factor
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    ABSTRACT: The aim of this study was to investigate lipid profile, paraoxonase 1 (PON1) activity, and oxidative stress status in the serum of hyperemesis gravidarum (HG) patients. Thirty-six HG cases and 36 normal pregnants were included in the study. Serum total cholesterol (TC), triglyceride (TG), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), apoproteins A1 (apo A1) and B (apo B), malondialdehyde (MDA), and total antioxidant activity (TAO) values and PON1 and arylesterase activities were determined. Although serum TC, TG, LDL-C, and apo B levels were not different among; the groups (P>0.05), HDL-C (P=0.01) and apo A1 (P=0.007) levels were lower in HG patients than in normal pregnants. HG group had significantly lower serum PON1 (P=0.03) and arylesterase activities (P=0.03) compared with the control group. Additionally, mean TAO values were lower (P=0.01) and MDA levels were higher (P=0.02) in HG group than in the healthy pregnants. A significant negative correlation between PON1 and MDA was found in HG group (r=-0.33, P<0.05). The findings of this study have revealed that HG may be one of the conditions in which oxidant and antioxidant balance is impaired.
    Journal of Clinical Laboratory Analysis 01/2009; 23(2):105-9. DOI:10.1002/jcla.20298 · 1.14 Impact Factor
  • [Show abstract] [Hide abstract]
    ABSTRACT: Turkey, especially its eastern part, has been accepted as endemic for vitamin D deficiency rickets (VDDR). In a study performed by our team in the region in 1998, the incidence of VDDR was 6.09% in children aged between 0–3 years. In 2005, the Ministry of Health initiated a free vitamin D supplementation campaign nationwide for every infant to eradicate VDDR. In this study, we aimed to investigate the prevalence of VDDR in children aged between 0–3 years in order to evaluate the effectiveness of this campaign. Between March 2007 and February 2008, 39,133 children aged between 0–3 years who were brought to different pediatric outpatient clinics in Erzurum, Turkey, were examined for VDDR. VDDR diagnosis was made by radiological and biochemical findings in the cases who were initially suspected of having clinical VDDR. During a one-year period, 39 (0.099%) of the 39,133 patients were diagnosed with VDDR. None of the cases with rickets was taking vitamin D supplementation. The most frequent physical findings were rachitic rosary, enlargement of the wrists, and craniotabes. The laboratory findings of the cases were compatible with VDDR; serum calcium (Ca) 7.5 ± 1.9mg/dL, PO4 4.4 ± 1.3mg/dL, alkaline phosphatase (ALP) 1,341 ± 823, 25-hydroxyvitamin D (25 (OH) D) 5.8 ± 2.9ng/mL, intact parathyroid hormone (iPTH) 240 ± 106pg/mL. It was concluded that, although VDDR has been a continuing childhood health problem, a nationwide free vitamin D supplementation campaign initiated by the government appeared to be effective in eliminating VDDR.
    European Journal of Pediatrics 12/2008; 168(1):95-100. DOI:10.1007/s00431-008-0821-z · 1.98 Impact Factor
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    ABSTRACT: In recent years, alendronate, an oral biphosphonate, has been added to therapy of hypercalcemia secondary to vitamin D intoxication in children. Alendronate may cause mucosal ulcerations in the mouth and esophagus. We report our experience in two infants with vitamin D intoxication to whom alendronate therapy was administered through nasogastric tube, an alternate route for alendronate administration.
    Clinical Toxicology 05/2008; 46(4):300-2. DOI:10.1080/15563650701455361 · 3.12 Impact Factor
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    ABSTRACT: The main function of hepatic lipase (HL) with respect to high-density lipoprotein (HDL) is hydrolysis of phospholipids and triglycerides. The -514C-->T polymorphism in the promoter region of the hepatic lipase gene affects HL activity. We aimed to investigate the association between the frequency of the -514C-->T polymorphism of hepatic lipase (PHL) and CAD in the East Anatolian region of Turkey. We conducted a case-control study in 302 unrelated subjects who were referred for coronary angiography. One hundred fifty-one patients with angiographically documented CAD and one hundred fifty-one subjects without angiographically documented CAD were studied to examine the association of the frequency of the -514C-->T polymorphism with CAD. Genotyping was determined by polymerase chain reaction. The PCR products were analysed for the -514C-->T polymorphism by enzyme digestion. The frequency of the -514C-->T polymorphism was found in 20 of 151 (13.2%) patients with CAD and in 9 of 151 (6%) of the control subjects (P < 0.05). There was a significant difference in terms of smoking (P = 0.001), gender (P < 0.05), total cholesterol levels (P < 0.05) and low-density lipoprotein (LDL) levels (P < 0.01) but there was no association with diabetes mellitus, hypertension, family history of CAD and HDL levels in the PHL (+) and PHL (-) patients with CAD. The results of this study suggest that the -514C-->T polymorphism of the hepatic lipase gene could act as a risk factor in the development of CAD in the East Anatolian region of Turkey as well as male gender, diabetes mellitus, hypertension, and a positive family history of CAD.
    Acta cardiologica 04/2008; 63(2):197-202. DOI:10.2143/AC.63.2.2029528 · 0.56 Impact Factor
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    ABSTRACT: Peripheral blood cultures were exposed to various doses (5 to 500 mg/L) of boron compounds. Sister-chromatid exchange, micronucleus and chromosomal aberration tests were applied to estimate the DNA damage, and biochemical parameters (superoxide dismutase, catalase, glutathione peroxidase, glutathione-S-transferase, glucose-6-phosphate dehydrogenase, total glutathione, malondialdehyde and total antioxidant capacity) were examined to determine oxidative stress. According to our findings, various boron compounds at low doses were useful in supporting antioxidant enzyme activities in human blood cultures. It was found that the boron compounds do not have genotoxic effects even in the highest concentrations, though in increasing doses they constitute oxidative stress. It is concluded that the tested boron compounds can be used safely, but it is necessary to consider the tissue damages which are likely to appear depending on the oxidative stress.
    Zeitschrift fur Naturforschung C 01/2007; 62(11-12):889-96. DOI:10.1515/znc-2007-11-1218 · 0.57 Impact Factor
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    ABSTRACT: To investigate the activities of the 2 isoforms of prostaglandin synthetic enzyme cyclo-oxygenase (COX), COX-1 and COX-2, in the placental tissue of women with pre-eclampsia and healthy pregnant women. The relationship between placental lipid peroxidation and the activities of COX-1 and COX-2 was also investigated. Tissue specimens were obtained from pre-eclamptic women (20 had severe pre-eclampsia and 38 had mild pre-eclampsia) and 27 healthy pregnant women who underwent cesarean section before the onset of labor. Malondialdehyde (MDA) levels and COX-1 and COX-2 activities were measured in placental tissue homogenates. Mean activities for COX-1 and COX-2 were significantly lower in women with severe pre-eclampsia than in healthy controls (P<0.05 and P<0.01, respectively). COX-1 and COX-2 activities were also lower in women with mild pre-eclampsia than in healthy controls, but the difference was of borderline significance (P=0.049 and P=0.059, respectively). The mean placental MDA level was significantly higher in pregnant women with severe and mild pre-eclampsia than in healthy pregnant women (P<0.01 for both). The correlation analysis showed significant negative correlations between MDA and COX-1 (r=-0.44, P<0.001) and MDA and COX-2 (r=-0.45, P<0.001) in the placental tissue of women with pre-eclampsia. These results suggest that COX-1 and COX-2 activities are decreased in the placental tissue of women with pre-eclampsia, probably by oxidative stress.
    International Journal of Gynecology & Obstetrics 12/2006; 95(2):127-31. DOI:10.1016/j.ijgo.2006.06.016 · 1.56 Impact Factor

Publication Stats

91 Citations
12.07 Total Impact Points

Institutions

  • 2009
    • State Hospital of Ercis, Turkey
      Arcis, Van, Turkey
  • 2006–2008
    • Ataturk University
      Kalikala, Erzurum, Turkey