Geming Li

The Children's Hospital of Philadelphia, Filadelfia, Pennsylvania, United States

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Publications (9)20.75 Total impact

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    ABSTRACT: The aim of this study was to determine whether tube feeding affects the rate of gastric emptying determined by gastroesophageal reflux scintigraphy in pediatric patients. Gastroesophageal reflux scintigraphy studies of 700 pediatric patients aged 1 week to 16 years were retrospectively analyzed. From these, 350 subjects received their study meal via a feeding tube, and 350 subjects received their meal as oral feeding. Gastric-emptying rate at 60 minutes was calculated, and the results compared. Stratification analysis for age, sex, and type and volume of administered meal was also performed. The average rate of the gastric emptying was higher in the tube feeding compared with oral feeding group (52.9% ± 17.9% vs 44.2% ± 15.1% gastric emptying at 1 hour, P < 0.01). The prevalence of fast gastric emptying, defined as greater than 50% emptying at 60 minutes, was also higher in the tube feeding group, being registered in 59.7% (209/350 cases) versus only 31.4% (110/350 cases) in the oral feeding group, P < 0.01. The difference persisted following stratification analysis for sex, age, and type and volume of ingested meal. Our findings show that tube feeding increases the rate of gastric emptying determined by gastroesophageal reflux scintigraphy in pediatric patients. The effect proved independent on such factors as sex, age, and type or volume of ingested meal.
    Clinical nuclear medicine 10/2013; 38(12). DOI:10.1097/RLU.0000000000000268 · 3.93 Impact Factor
  • Sandip Basu · Geming Li · Abass Alavi ·
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    ABSTRACT: In this article, we have reviewed the current role of PET/PET-computed tomography (CT) in the management of gynecological malignancies. The promise of this technique is becoming increasingly evident, based upon several studies conducted in these malignancies. 2-fluoro-2-deoxy-D-glucose-PET appears to have a potential role in assessing response to treatment and forecasting prognosis. For cervical carcinoma, the modality has proven useful in both the staging of untreated advanced cervical cancer and restaging of the disease. Its role in prognostication of the disease and in detecting lesions in the setting of post-treatment unexplained tumor-marker elevation appears promising. PET is of great benefit as a diagnostic tool in ovarian carcinoma when there is an increase in serum CA-125 and CT/MRI or conventional imaging are inconclusive or negative. With regard to its role in endometrial carcinoma, its benefit is particularly emphasized in the setting of post-therapy surveillance of the disease, although, in a limited series, it also appears to give additional information in the pretreatment states. PET may be of value in detecting the extra-uterine lesions that are not visualized with CT/MRI. Data on the role of 2-fluoro-2-deoxy-D-glucose-PET imaging in the management of vulvar and vaginal cancer are relatively sparse at this time but the modality appears to be of value in staging disease and is more effective than conventional diagnostic modalities with respect to detecting nodal metastasis in both malignancies.
    Expert Review of Anti-infective Therapy 02/2009; 9(1):75-96. DOI:10.1586/14737140.9.1.75 · 2.25 Impact Factor
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    ABSTRACT: A 17-month-old boy presented with fever and lethargy for 2 days. A complete physical examination rendered no results to explain the source of the fever. Laboratory tests only showed leukocytosis, whereas CT scans of the chest, abdomen, and pelvis were unrevealing. Because the patient refused to walk, possible osteomyelitis of the lower extremities was suspected by referring physicians, and 3-phase bone scintigraphy of the lower extremities was acquired to confirm the suspicion. The bone-scan images showed no abnormal activity in the lower extremities. However, there was increased activity in the region of the mastoid of the right temporal bone. This finding prompted subsequent head CT scan that showed opacification of the middle ear cavity and mastoid air cells with destruction of mastoid bone, suggestive of otomastoiditis and possible osteomyelitis as a complication. In addition, CT showed a large right cerebellar abscess.
    Clinical nuclear medicine 11/2008; 33(10):711-2. DOI:10.1097/RLU.0b013e318184bf30 · 3.93 Impact Factor
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    ABSTRACT: PET and PET/CT imaging are increasingly used in pediatric oncology; however, their role is still evolving. Studies have shown an incremental impact of PET imaging on the management of childhood malignancies. Gastrointestinal tumors have low incidence in children and PET has proved useful in many of them. Overall, the published data support the exceptional diagnostic capability of PET and PET-CT imaging. This article presents insight through the available literature on pediatric gastrointestinal oncology.
    PET Clinics 04/2008; 3(2):227-238. DOI:10.1016/j.cpet.2008.10.004
  • Yifan Zhang · Geming Li · Hongming Zhuang ·
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    ABSTRACT: A 68-year-old man with a history of non-Hodgkin lymphoma presented with fatigue, weight loss, and coughing. Recurrent lymphoma was suspected and the patient then underwent an FDG PET scan, which revealed multiple foci of hypermetabolism in the mediastinum and bilateral hilar regions of the lungs. Two follow-up FDG PET scans were performed during and after chemotherapy to monitor the effectiveness of the therapy. There was diminished activity in most lesions during and after chemotherapy. However, 1 lesion in the region of the right hilum continued to grow during chemotherapy, which was later proven to be squamous cell carcinoma of the lung.
    Clinical Nuclear Medicine 03/2008; 33(2):109-10. DOI:10.1097/RLU.0b013e31815f2440 · 3.93 Impact Factor
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    ABSTRACT: The present study was undertaken to investigate the significance of 2-deoxy-2-[F-18]fluoro-D-glucose (FDG) uptake in the intercostal muscles (ICM) and prominent visualization of right ventricle (RV) in FDG-positron emission tomography (PET) scans and its implications. Patients identified to have FDG uptake in the ICM with or without prominent visualization of the RV either incidentally or in the background of an existing explanatory cause at the time of FDG-PET studies were included in this retrospective study. These patients had undergone FDG-PET either for ruling out malignancy or for disease monitoring purposes in setting a proven malignancy. We reviewed the clinical and investigational records (including computed tomography [CT] thorax, chest X-ray, 2-D echo and pulmonary function tests, and arterial blood gas analysis) of the group with incidental FDG uptake for revelation of a pathology explaining such uptake. A total of 14 cases with 16 FDG-PET studies were identified from the retrospective examination of case records. One patient had three FDG-PET at different time points of his disease course. The patient population included 13 males and one female with age range 46-88 years. The patients were classified into two groups: (1) cases with isolated ICM uptake (n=10); (2) cases with both ICM and RV uptake (n=4). Among 10 patients with isolated ICM uptake, in six patients it was a serendipitous observation, whereas four patients had existing explanatory cause at the time of FDG-PET. The causes found to be associated included COPD, asthma, recent heart failure, interstitial lung disease (post external radiotherapy) and pulmonary embolism, atelectasis with pleural effusion. In all four cases with associated RV uptake, there was evidence of pulmonary hypertension (PH). Among these, in one patient this was a serendipitous observation. He had evidence of interstitial lung disease (ILD) in CT thorax, and 2-D echo showed moderate PH. The remaining three patients had cor pulmonale secondary to COPD, pneumoconiosis, and Swyer James Syndrome with associated severe PH. The SUVmax ratio of the RV-to-LV free wall ranged from 0.53 to 1.04 in the cases with prominent RV uptake. One patient had multiple FDG-PET studies and have shown reduction of RV uptake in the last scan consistent with the clinical impression of improvement of cor pulmonale. Both intercostal muscle and prominent RV uptake in FDG-PET can be associated with a spectrum of causes (including both obstructive and restrictive airway diseases) that lead to breathing exertion. These are important markers, which could signify underlying pulmonary disease and pulmonary hypertension, respectively. Associated prominent RV uptake strongly indicates presence of pulmonary hypertension and the uptake in the right heart can subserve a valuable surrogate marker in the treatment-monitoring scenario of a known PH.
    Molecular Imaging & Biology 10/2007; 9(6):333-9. DOI:10.1007/s11307-007-0102-7 · 2.77 Impact Factor
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    ABSTRACT: Diffuse and uniform FDG uptake in the ribs and the intercostal muscles might appear similar on FDG-PET images and a reliable differentiation between the two is important for accurately identifying the underlying process. The former usually suggests excessive contraction of intercostal muscles mostly due to chronic obstructive pulmonary disease, whereas the latter signifies either bone marrow stimulation or involvement by a pathologic process. At times, images may appear confusing and may be misinterpreted. However, in both clinical settings, there are additional ancillary signs, which are helpful in making a correct diagnosis. We herein present 2 case vignettes from each category in which other ancillary signs helped to distinguish FDG rib uptake from intercostal muscle uptake.
    Clinical Nuclear Medicine 10/2007; 32(9):739-40. DOI:10.1097/RLU.0b013e318126c00a · 3.93 Impact Factor
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    ABSTRACT: The number of incidentally detected thyroid lesions found with 18F-fluorodeoxyglucose positron emission tomography is increasing. Malignant cases incidentally found with this technique are mainly primary thyroid cancers, particularly papillary thyroid carcinoma, which tend to harbor a higher rate of unfavorable prognostic features than routinely diagnosed primary thyroid cancers. The significance of standardized uptake values in predicting malignancy of incidental thyroid fluorodeoxyglucose uptake is controversial, and more studies are needed to establish its role in differentiating benign and malignant incidental thyroid fluorodeoxyglucose uptake. In this article, we review recent publications regarding incidental thyroid lesions found on fluorodeoxyglucose positron emission tomography and their differential diagnosis, including the risk for malignancy.
    PET Clinics 07/2007; 2(3):321-329. DOI:10.1016/j.cpet.2008.04.001
  • Drew A. Torigian · Geming Li · Abass Alavi ·
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    ABSTRACT: Many disorders commonly affect various organs of the endocrine system. The nuclear medicine physician and radiologist must be aware of the manifestations of these disorders that may be detected on structural imaging modalities. In this article, we provide a brief review of the advantages and disadvantages of CT, MR imaging, and ultrasonography. We then discuss the role of these structural imaging modalities in the evaluation of disorders affecting the endocrine organs. In particular, we focus our review on imaging evaluation of the pituitary gland, the thyroid gland, the parathyroid glands, and the adrenal gland. Specific examples of some of the disease entities affecting these organs are also reviewed.
    PET Clinics 07/2007; 2(3):395-408. DOI:10.1016/j.cpet.2008.05.002

Publication Stats

82 Citations
20.75 Total Impact Points


  • 2008-2013
    • The Children's Hospital of Philadelphia
      • Department of Radiology
      Filadelfia, Pennsylvania, United States
    • William Penn University
      Filadelfia, Pennsylvania, United States
  • 2007
    • Hospital of the University of Pennsylvania
      • Department of Radiology
      Filadelfia, Pennsylvania, United States