Publications (61)14.23 Total impact
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Article: [Sweet's syndrome: Retrospective case series of 47 patients.]
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ABSTRACT: PURPOSE: Also called acute febrile neutrophilic dermatosis, Sweet's syndrome is an inflammatory disorder with a prominent cutaneous expression. It is characterized by a variety of manifestations, clinical and histological findings. The objective of this study was to describe their clinical, pathological and therapeutic characteristics. METHODS: We report on a series of 47 patients who presented a Sweet's syndrome, collected in our institution in Tunis between 1997 and 2011. RESULTS: The patient population consisted of 11 men and 36 women. The mean age was 47 years with extreme ranging from 28 to 74 years. An associated disorder was observed in ten patients: inflammatory disease (three cases), inflammatory bowel disease (two cases), tuberculosis (three cases) and diabetes (three cases). One case of pregnancy was observed. Cutaneous lesions consisted of erythematous plaques or nodules. Lesions were located mainly on the upper or lower extremities. All biopsy specimens demonstrated a dermal infiltrate composed predominantly of neutrophils. Fibrinoid necrosis and intramural inflammation were observed in eight cases. CONCLUSION: The skin disorder can precede, follow, or appear concurrent with the diagnosis of an associated disease which requires careful surveillance.La Revue de Médecine Interne 11/2012; · 0.61 Impact Factor -
Article: Tuberculosis of the breast: a rare often unrecognized diagnosis.
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ABSTRACT: Tuberculosis of the breast (BT) is a rare extrapulmonary localization for tuberculosis that mainly affects young women during their child-bearing years. Objective: We report eight cases of BT and describe its clinical characteristics, outcomes, and differential diagnoses. Patients and methods: This retrospective study collected all cases of BT diagnosed at our hospital's infectious disease department in Tunisia from 2000 through 2009. We assessed the epidemiologic and clinical findings and reviewed the laboratory, histology, and radiology results, treatment data, and outcomes. Results: Eight women (mean age: 52.5 years, range: 31-75) had BT. Clinical features included retracted erythematous lesions in four cases, a fluctuating abscess in two, and a well-defined nodule in two. The biopsy culture was positive in two cases. Histology results showed a tuberculoid granuloma with caseous necrosis in all cases. Antituberculosis drugs were administered for 8 to 12 months. Two patients underwent surgery. Outcome included total regression of BT for all women. Conclusion: Clinical features of BT are often misleading and can easily be mistaken for those of breast cancer. Identification of the Koch bacillus or the presence of a tuberculoid granuloma with caseous necrosis on histology facilitates diagnosis. The treatment consists essentially of antituberculosis drugs. Despite its rarity, BT must not be misjudged, especially in countries where tuberculosis is endemic.Medecine et sante tropicales. 11/2012; -
Article: [Rosai-Dorfman disease: therapeutic issues in 2 cases].
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ABSTRACT: Rosai-Dorfman disease (RDD) is a benign lymphoproliferative disorder characterized by cervical lymph node enlargement with a consistent risk of airway compression and esthetic damage. Extranodal localizations are also described. There is no therapeutic consensus for pediatric forms of RDD. Through 2 pediatric cases with nodal involvement in 1 patient and a sinonasal and soft tissue localization in the other, we focus on the management problems of both nodal and extranodal RDD.Archives de Pédiatrie 11/2011; 18(11):1205-9. · 0.30 Impact Factor -
Article: [Tuberculous gumma in sporotrichoid pattern].
Médecine tropicale: revue du Corps de santé colonial 02/2011; 71(1):16. -
Article: Spindle cell oncocytoma of the adenohypophysis in a woman: a case report and review of the literature.
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ABSTRACT: Spindle cell oncocytoma of the adenohypophysis is a rare tumour recently reported by Roncaroli et al. in 2002. This tumour is considered a grade I tumour by the World Health Organization. We describe what is, to the best of our knowledge, the 14th case of its kind in the literature. A 45-year-old African woman presented clinical and radiological findings related to a nonfunctioning pituitary adenoma. The diagnosis was made on the basis of histological and immunohistochemical findings. The purpose of this work is to report a rare pituitary tumour and to describe its histological and immunohistochemical features, which were characterized by the expression of thyroid transcription factor 1 antigen by tumour cells. This fact could support the theory of a possible common origin of these tumours in pituicytomas. In fact, thyroid transcription factor 1 is considered to be a specific marker of pituicytes.Journal of Medical Case Reports 02/2011; 5:64. -
Article: Angiolymphoid hyperplasia with eosinophilia: a study of 7 cases.
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ABSTRACT: Angiolymphoid hyperplasia with eosinophilia (ALHE) is a benign vasoproliferative disease of undetermined origin. It is characterized by the presence of nodular pseudo-tumors corresponding microscopically to a vascular proliferation within an inflammatory infiltrate made up of lymphocytes, macrophages, and eosinophils. The authors describe 7 cases of ALHE. The 7 cases were diagnosed over a period of 19 years (1990-2008). Clinical data and histological slides were brought from the departments of dermatology and pathology of the Rabta Hospital. The 7 patients were 4 women and 3 men with an average age of 34.5 years. The cephalic localization was the most frequent. Lesions were solitary or multiple and formed papules or plaques of variable color. The diagnosis was based in all cases on histological findings. The main disease in the differential diagnosis of ALHE is Kimura disease, but the 2 entities have several clinical and histological differences. The pathogenesis remains unclear and there is no consensus on the best treatment.Dermatology online journal 01/2011; 17(2):1. -
Article: Pemphigus vegetans: a clinical, histological, immunopathological and prognostic study.
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ABSTRACT: Pemphigus vegetans (P Veg) is a rare clinical form of pemphigus. Studies on P Veg are rare in the literature and none has so far evaluated the prognostic parameters. In this retrospective study of P Veg, we aimed to analyse epidemiological, clinical, immunopathological and therapeutic data. Study of prognostic factors with accuracy of patient survival was also carried out. This is a retrospective study (1981-2009) including 17 cases of P Veg. Statistical analysis was performed with chi-square and Fisher tests looking for a possible relationship between clinical data and prognostic factors. Follow-up time and disease-free survival time were estimated using Kaplan-Meier methods. Clinical data were evaluated in univariate analysis looking for a significant association with survival. Equality of survival distribution was studied using log rank test. The hospital prevalence of P Veg was 0.084‰ with a frequency of 9.1% among pemphigus. The mean age at onset was 47.6 years, with a sex-ratio (F/M) about 4.66. Neumann P Veg was the predominant clinical form (11/17). Clinically, the lesions were multifocal (16/17), prevailed on folds and mucous membranes. Under corticosteroids the mean period for healing was 24 ± 9 days. During the follow-up time, three patients died and 11 patients relapsed. Median of overall relapse-free survival was 13 ± 1.7 months. No significant association between clinical data and prognostic factors was found. This study was a retrospective chart analysis and the number of patients was small. The P Veg seems to be more frequent in Tunisia with high rate of mortality.Journal of the European Academy of Dermatology and Venereology 12/2010; 25(10):1160-7. · 2.98 Impact Factor -
Article: [Profuse subcutaneous nodules in a Tunisian patient: Kaposi sarcoma revealing AIDS].
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ABSTRACT: The purpose of this report is to describe a case involving Kaposi sarcoma as the inaugural manifestation of HIV infection at the full-blown AIDS stage. The patient was a 59-year-old Tunisian man who presented with profuse subcutaneous nodules and multiple lymph nodes. Treatment was based on antiretroviral therapy in association with radiotherapy.Médecine tropicale: revue du Corps de santé colonial 08/2010; 70(4):403-5. -
Article: [Erythematous type scaly papule on the abdomen: chromoblastomycosis due to Fonsecaea pedrosoi].
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ABSTRACT: Chromoblastomycosis is a chronic subcutaneous fungal infection caused by dematiaceous saprophytic moulds. We report a case of chromoblastomycosis due to Fonsecaea pedrosoi observed in man from the Baja region of Tunis. He presented since one year an erythemato-squamous atrophic plaque localised at the abdomen area. Clinical remission was obtained after cryotherapy and terbinafine.Médecine tropicale: revue du Corps de santé colonial 02/2010; 70(1):81-3. -
Article: [Paraparesis and fever in a Tunisian woman: cryptococcal spondylitis with spinal involvement].
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ABSTRACT: Cryptococcus neoformans is a ubiquitous yeast that causes opportunistic infections mainly involving the central nervous system. Cryptococcoma is a rare entity characterized by a solid, tumor-like mass that is usually located in the cerebral hemispheres or cerebellum. Spinal involvement is rare with only 6 cases reported in literature. Bony involvement is also a rare occurrence that has been observed in only 5 to 10% of reported cases of infection by Cryptococcus neofomans. The purpose of this report is to describe a case of paraplegia due to cryptococcal spondylitis with spinal cord involvement in an HIV-seronegative patient with a history of systemic sarcoidosis. Diagnosis was achieved by histological examination of the surgical specimen.Médecine tropicale: revue du Corps de santé colonial 02/2010; 70(1):85-7. -
Article: [Pilocytic astrocytoma: unusual feature].
La Tunisie médicale 01/2010; 88(1):66-7. -
Article: [White plaque of oral mucosa].
Annales de Dermatologie et de Vénéréologie 06/2009; 136(5):453-5. · 0.72 Impact Factor -
Article: [Epidemiology of extrapulmonary hydatid cysts: 265 Tunisian cases].
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ABSTRACT: The authors wanted to analyze the epidemiological features of extrapulmonary hydatid cysts and compare their results with those reported in literature. Two hundred and sixty-five cases of extrapulmonary hydatid cysts collected from 1990 to 2007 were retrospectively studied. One hundred and one male and 164 female patients (sex ratio M/F=0.61 mean age 38.7 years) were included. In our series, hydatid cysts involved mainly the kidney (24.1%), the central nervous system (22.6%), the liver (19.6%) and the spleen (11.3%). Contrary to published data, our results show that hydatid cysts of the kidney and of the central nervous system are more frequent than hepatic location which ranks 3rd. Such unusual results may be due to a selection bias.Médecine et Maladies Infectieuses 05/2009; 39(5):341-3. · 0.72 Impact Factor -
Article: Extraventricular neurocytoma in a child mimicking oligodendroglioma: a diagnostic pitfall.
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ABSTRACT: Extraventricular neurocytomas are rare neuronal tumours that have been included in the 2007 WHO classification as a variant of central neurocytoma. They arise outside the ventricles, usually within the cerebral hemisphere,s but also in other regions throughout the neuraxis. The morphological overlap of these tumours with oligodendroglioma often poses diagnostic difficulty. Herein, a case of extraventricular neurocytoma in a 4-year-old girl is reported that mimicked histologically oligodendroglioma. The authors describe the clinicopathological features of this rare entity with special emphasis on differential diagnosis.Pathologica 04/2009; 101(2):105-7. -
Article: Paratesticular angiomyofibroblastoma: case report and review of the literature.
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ABSTRACT: Angiomyofibroblastoma is a rare, benign, mesenchymal tumour occurring mainly in the female genital tract, and more rarely, in males. We present a new case of angiomyofibroblastoma arising in the left inguinal region of an 83-year-old man. The tumour was well circumscribed and measured 60 mm in maximum dimension. On microscopic examination, the tumour was composed of small spindle cells without atypia within a fibrous and myxoid stroma where scattered mononuclear inflammatory cells were found around the capillaries of the stroma. Immunohistochemical studies showed positive staining of tumour cells for vimentin, desmin, smooth muscle actin and CD34, and negative staining for PS100 and oestrogen and progesterone receptors. These histological findings are consistent with angiomyofibroblastoma. The patient was followed up for 4 years without recurrence.Pathologica 01/2009; 100(6):489-91. -
Article: Subependymomas: a clinicopathological study of 6 symptomatic cases.
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ABSTRACT: Subependymomas are rare, slow-growing, ependymal neoplasms that commonly occur in the fourth or lateral ventricles. A retrospective study of 6 histologically proven subependymomas was undertaken to analyse their clinicopathological characteristics. There were five male and one female patients ranging in age from 11 to 50 years (mean 35.8 years). All patients were symptomatic at diagnosis. The most common clinical presentations included headache (n=6) and vomiting (n=3). Tumours were located in the lateral ventricle in five cases and in the fourth ventricle in one case. Magnetic resonance imaging detected obstructive hydrocephalus in all cases. Five patients underwent gross total resection and one patient had subtotal excision of the tumour. Histologically, all tumours were characterised by clustering of isomorphic cells arranged against a fibrillary background. Focal cystic degeneration was seen in 5 tumours. During the follow-up period, which ranged between 2 months and 10 years, all patients were symptom-free with no evidence of recurrence.Pathologica 11/2008; 100(5):401-4. -
Article: Une tumeur maligne primitive rarissime de la vésicule biliaire. Le carcinome épidermoïde
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ABSTRACT: Les carcinomes primitifs de la vésicule biliaire sont des tumeurs peu fréquentes. Ils sont essentiellement représentés par l’adénocarcinome. Le carcinome épidermoïde représente un type histologique rare caractérisé par une croissance rapide avec infiltration locorégionale et un pronostic sombre. Nous rapportons l’observation d’un homme âgé de 63 ans exploré pour douleur de l’hypochondre droit évoluant depuis deux mois. La tomodensitométrie abdominale a objectivé une masse tissulaire du fond vésiculaire envahissant le foie. Une cholécystectomie a été réalisée. À l’examen histologique, il s’agissait d’un carcinome épidermoïde bien différencié et kératinisant. Carcinomas of the gallbladder are rare malignancies. They are mostly represented by adenocarcinoma. Pure squamous cell carcinoma is a rare histologic subtype characterized by a rapid growth, with local extension and a poor prognosis. We present a recent case of a 63-years-old man admitted with the complaints of pain in right hypochondrium. Computed tomography revealed a tumour in the gallbladder fossa region with infiltration of the liver. Cholecystectomy was achieved. Pathologic examination of the surgical specimen revealed a well differentiated squamous cell carcinoma.Oncologie 10/2008; 10(11):677-680. · 0.17 Impact Factor -
Article: Cutaneous gamma-delta T-cell lymphoma arising in the setting of Behcet's disease.
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ABSTRACT: Cutaneous gamma-delta T-cell lymphoma (CGD-TCL) is an uncommon lymphoma composed of a clonal proliferation of mature activated gamma-delta T-cells expressing a cytotoxic phenotype. Malignant lymphoma is rarely associated with Behcet's disease, as only 12 cases have been reported in the literature, including a case of cutaneous T-cell lymphoma. In this report, the authors present a new case of CGD-TCL emerging in the course of Behcet's disease in a 40-year-old man. Diagnosis of CGD-TCL was established based on the combination of clinical, histological, immunophenotypical and molecular findings. Through a review of the current literature, the authors analyse the unique clinicopathological, molecular and immunohistochemical features of this rare cutaneous lymphoma.Pathologica 07/2008; 100(3):166-9. -
Article: Extragastrointestinal stromal tumor of the urinary wall bladder: case report and review of the literature.
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ABSTRACT: Most mesenchymal tumours of the gastrointestinal tract are now referred to as gastrointestinal stromal tumours (GISTs). These tumours typically express c-kit (CD117) and CD34; 30-50% are (often focally) positive for alpha-smooth muscle actin, and all are negative for desmin and S100 protein. Recently, mutations in exon 11 of the c-kit gene have been identified as a molecular genetic marker for the subset of GISTs. In this report, we describe a mesenchymal tumour removed from the pelvic cavity of a 34-year-old man. The tumour was strongly attached to the external wall of the urinary bladder. The neoplasm grossly resembled a leiomyoma, and was histologically composed of sheets of spindle cells with a dense collagenous background. The mitotic activity was low (less then 1 per 50 high-power fields). Immunohistochemically, tumour cells were negative for alpha-smooth muscle actin and desmin and positive for CD117 and CD34. This case illustrates that tumours which are phenotypically and genotypically similar to GISTs may present in sites other than the tubular gastrointestinal tract.Pathologica 07/2008; 100(3):173-5. -
Article: [Pseudomyxoma peritonei].
La Tunisie médicale 06/2008; 86(5):507-9.
