L Balus

Istituto Dermatologico San Gallicano - Istituti Fisioterapici Ospitalieri, Roma, Latium, Italy

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Publications (35)54.7 Total impact

  • L M Muscardin · F Poggiali · L Balus · A Venuti
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    ABSTRACT: Epidermodysplasia verruciformis (EV) can be defined as a genetic disorder that determines a lifelong infection of the skin by human Papillomaviruses (HPV). The benign lesions contain different HPVs; whereas in the tumors HPV types 5, 8, and, much less frequently, types 14, 17, 20 and 47 can be detected. Variants of HPV5 have been recognized on the basis of the genetic heterogeneity of the E6 open reading frame. We report a typical case of EV in which the presence and expression of the HPV type 5 were clearly detectable. Direct sequence analysis demonstrated a perfect homology with the sequence of the HPV5b variant. This variant was first isolated in a Japanese patient and thereafter in a Polish one. Its presence in the Italian patient indicates that the same variant can be detected in different geographic areas and therefore that some cellular genes may exert a selection pressure so strong as to induce the emergence of this stable HPV5b infectious variant.
    European journal of dermatology: EJD 01/2001; 11(6):572-5. · 1.95 Impact Factor
  • L M Muscardin · M Bellocci · L Balus
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    ABSTRACT: We report a case of adult colloid milium in a 47-year-old mechanic with a long history of professional contact with lubricating oils and of sun exposure. In addition to the typical translucent papules seen on the forehead, there were warty papules on the backs of both hands with unusual histological and ultrastructural features: marked hyperplasia of the epidermis with orthokeratotic hyperkeratosis and papillary deposits of colloid material that were contiguous with the basal layer of the epidermis. The hand lesions caused by occupational exposure to mineral oils and solar radiation represent an occupational variant of adult colloid milium.
    British Journal of Dermatology 11/2000; 143(4):884-7. DOI:10.1046/j.1365-2133.2000.03798.x · 4.10 Impact Factor
  • P. Donati · L. Manente · L. Balus
    American Journal of Dermatopathology 12/1998; 20(6):598. DOI:10.1097/00000372-199812000-00056 · 1.43 Impact Factor
  • American Journal of Dermatopathology 12/1998; 20(6):600. DOI:10.1097/00000372-199812000-00065 · 1.43 Impact Factor
  • Ada Amantea · M. C. Giuliano · L. Balus
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    ABSTRACT: The association of porokeratosis with dermal amyloid deposits is extremely rare, only three cases are reported in the literature. We describe a case of disseminated superficial porokeratosis (DSP) with clear histologic evidence of amyloid deposition in the upper dermis. The amyloid was typed with an original immunohistochemical assay based on three anticytokeratin antibodies (MNF 116, CK1, KER B). The epidermal origin of the substance (K amyloid) was demonstrated by its strong positivity for MNF 116 and KER B.
    American Journal of Dermatopathology 02/1998; 20(1):86-88. DOI:10.1097/00000372-199802000-00017 · 1.43 Impact Factor
  • A Amantea · M C Giuliano · L Balus
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    ABSTRACT: The association of porokeratosis with dermal amyloid deposits is extremely rare, only three cases are reported in the literature. We describe a case of disseminated superficial porokeratosis (DSP) with clear histologic evidence of amyloid deposition in the upper dermis. The amyloid was typed with an original immunohistochemical assay based on three anticytokeratin antibodies (MNF 116, CK1, KER B). The epidermal origin of the substance (K amyloid) was demonstrated by its strong positivity for MNF 116 and KER B.
    American Journal of Dermatopathology 02/1998; 20(1):86-8. · 1.43 Impact Factor
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    ABSTRACT: The clinical and histological features of the entities known as 'white fibrous papulosis of the neck' (WFPN) and 'acquired elastolysis of the papillary dermis simulating pseudoxanthoma elasticum' (PDE) are not clearly defined. This study was conducted to compare our experience of WFPN/PDE with those described in the literature. Twenty patients presented at our institution with papular eruptions involving the neck. The asymptomatic lesions, which ranged in colour from normal skin tones to yellowish, were isolated or coalescent. Microscopically, the papules showed elastolysis and fibrosis of the upper reticular and papillary dermis. A review of the literature shows similar characteristics in cases reported as WFPN and PDE. This study indicates that WFPN and PDE are variants of a single disorder that can be more precisely defined as 'fibroelastolytic papulosis of the neck' and which appears to be a manifestation of intrinsic skin ageing.
    British Journal of Dermatology 10/1997; 137(3):461-6. DOI:10.1046/j.1365-2133.1997.18711957.x · 4.10 Impact Factor
  • Clinical and Experimental Dermatology 08/1996; 21(4):321-3. · 1.23 Impact Factor
  • Clinical and Experimental Dermatology 07/1996; 21(4):321-323. DOI:10.1111/j.1365-2230.1996.tb00111.x · 1.23 Impact Factor
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    ABSTRACT: We describe a patient with granulomatous slack skin (GSS) who has been followed for 15 years and present clinical, histological, immunohistochemical, ultrastructural, cytogenetic, and molecular findings. The clinical and pathological aspects of the 20 cases of GSS reported in the recent literature are reviewed and compared with those of the present case.
    American Journal of Dermatopathology 05/1996; 18(2):199-206. · 1.43 Impact Factor
  • [Show abstract] [Hide abstract]
    ABSTRACT: We describe a patient with granulomatous slack skin (GSS) who has been followed for 15 years and present clinical, histological, immunohistochemical, ultrastructural, cytogenetic, and molecular findings. The clinical and pathological aspects of the 20 cases of GSS reported in the recent literature are reviewed and compared with those of the present case.
    American Journal of Dermatopathology 04/1996; 18(2):199-206. DOI:10.1097/00000372-199604000-00015 · 1.43 Impact Factor
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    ABSTRACT: Hereditary sclerosing poikiloderma is a genodermatosis with dominant autosomal transmission and variable penetration. The first case was described by Weary in 1969 in 7 members of two black families. A 10-year-old girl had localized regional poikiloderma of the fingers and club toes. These lesions were associated secondarily with linear symmetric bands of sclerotic tissue in the axiallary regions. On the X-ray examinations of the distal phalanges of the fingers and the toes showed a proximal growth foyer and absent ungueal phalanges, excepting in the fourth finger of the left hand. Capillaroscopy of the supra-ungueal fold of the fingers showed abnormal capillary circulation. Histology and ultrastructural examinations did not reveal any pathognomonic alterations. This case is the first reported in a white patient. The radiological aspect and the results of the capillaroscopy of the fingers and the toes have not been reported previously in this rare genodermatosis. Inheritance of this genodermatosis is poorly defined.
    Annales de Dermatologie et de Vénéréologie 02/1995; 122(9):618-20. · 0.67 Impact Factor
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    ABSTRACT: Granulomatous slack skin (GSS) is a rare disorder which is considered a slowly evolving T-cell lymphoma associated with granulomatous inflammation that mediates clastolysis. A combined cytogenetic, molecular, and cellular analysis was conducted on a clinically and histologically defined case of GSS. Cell cultures obtained from the skin biopsy showed trisomy of chromosome 8, and the DNA sample extracted from the skin biopsy showed a T-cell receptor beta-chain rearrangement.
    Cancer Genetics and Cytogenetics 03/1994; 72(2):96-100. DOI:10.1016/0165-4608(94)90122-8 · 1.93 Impact Factor
  • L Balus · A Amantea · P Donati
    American Journal of Dermatopathology 02/1994; 16(1):106. DOI:10.1097/00000372-199402000-00071 · 1.43 Impact Factor
  • P Donati · L Balus
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    ABSTRACT: The clinical and histological features of a recently recognized entity, folliculosebaceous cystic hamartoma, are reported. The peculiarity of our case is a previously unreported neural proliferation in the stroma.
    American Journal of Dermatopathology 07/1993; 15(3):277-9. · 1.43 Impact Factor
  • L Balus · M Fazio · A Amantea · G Menaguale
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    ABSTRACT: In 8 out of a series of 21 cases Dowling-Degos disease was associated with Verneuil's disease (chronic hidradenitis suppurativa). This association might be more common, since both diseases are characterized by a single defect (follicular occlusion) and occur in similar cutaneous areas.
    Annales de Dermatologie et de Vénéréologie 02/1993; 120(10):705-8. · 0.67 Impact Factor
  • L Balus · M Fazio · G Sacerdoti
    Annales de Dermatologie et de Vénéréologie 02/1993; 120(11):820-2. · 0.67 Impact Factor
  • A S Breathnach · L Balus · A Amantea
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    ABSTRACT: This study on five patients has revealed more extensive alterations to melanocytes than previously reported, and emphasizes the fact that depigmentation is an essential element of the condition. In hyperpigmented areas, melanocytes were increased in number along the basal layer of the epithelium, were hyperactive, and in some cases contained bizarre melanosomes. In two cases there was suggestion of a defect in melanosome transfer to keratinocytes. Lymphocytes were closely apposed to melanocytes, and, in hypopigmented areas, were clearly involved in their disintegration. In depigmented areas, there was complete absence of melanocytes and of melanosomes in keratinocytes, and lymphocytes were present in the basal layer. In general, the appearances did not resemble melanoma in situ with spontaneous regression, although a second biopsy of one patient after one year did reveal features of melanocytes suggestive of an early stage of this condition. The study has provided no clear information as to the initial cause of the condition, but the manner of destruction of melanocytes suggests an immune reaction. Neither has it been of assistance in suggesting a more precise name for it.
    Pigment Cell Research 01/1993; 5(6):404-13. DOI:10.1111/j.1600-0749.1992.tb00571.x · 4.29 Impact Factor
  • P Donati · A Amantea · M Carducci · L Balus
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    ABSTRACT: No abstract is available for this article.
    British Journal of Dermatology 05/1991; 124(4):395-6. DOI:10.1111/j.1365-2133.1991.tb00612.x · 4.10 Impact Factor
  • P Donati · C Catricalà · A Amantea · L Balus
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    ABSTRACT: The Authors report 3 cases of "Congenital Smooth Muscle Hamartoma" (CSMH). CSMH presents as congenital patches or slightly indurated plaques with prominent overlying hair, often hyperpigmented. Histopathologic examination showed increased numbers of well-defined smooth muscle bundles in the superficial and deep dermis. CSMH and Becker's nevus should be considered in the differential diagnosis of any congenital hairy hamartoma.
    Giornale Italiano di Dermatologia e Venereologia 11/1990; 125(10):453-5. · 0.49 Impact Factor