Jee Young Kim

Dankook University, Eidō, Chungcheongbuk-do, South Korea

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Publications (64)118.81 Total impact

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    ABSTRACT: Diseases associated with immunoglobulin A (IgA) antibody include linear IgA dermatosis, IgA nephropathy, Celiac disease, Henoch-Schönlein purpura, etc. Although usually idiopathic, IgA antibody is occasionally induced by drugs (e.g., vancomycin, carbamazepine, ceftriaxone, and cyclosporine), malignancies, infections, and other causes. So far, only a few cases of IgA bullous dermatosis coexisting with IgA nephropathy have been reported. A 64-year-old female receiving intravenous ceftriaxone and metronidazole for liver abscess had purpuric macules and papules on her extremities. One week later, she had generalized edema and skin rash with bullae and was diagnosed with concurrent linear IgA dermatosis and IgA nephropathy. After steroid treatment, the skin lesion subsided within two weeks, and kidney function slowly returned to normal. As both diseases occurred after a common possible cause, we predict their pathogeneses are associated.
    Annals of Dermatology 06/2015; 27(3):315-8. DOI:10.5021/ad.2015.27.3.315 · 0.95 Impact Factor
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    Annals of Dermatology 06/2015; 27(3):326-8. DOI:10.5021/ad.2015.27.3.326 · 0.95 Impact Factor
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    ABSTRACT: Systemic lupus erythematosus (SLE) is an autoimmune disease that is a significant source of morbidity and mortality when it manifests in the central nervous system. The early detection and treatment of neuropsychiatric SLE (NPSLE) is very important, but a confirmative diagnostic tool has yet to be developed.
    01/2015; 14(1). DOI:10.12779/dnd.2015.14.1.48
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    Yonsei Medical Journal 01/2015; 56(1):307-8. DOI:10.3349/ymj.2015.56.1.307 · 1.26 Impact Factor
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    ABSTRACT: A 75-year-old man presented with multiple, scaly, erythematous, grouped papules, nodules and plaques with tenderness ranging from the right forearm to hand dorsum and the right lower leg for 2–3 months. Five months prior to presentation, the patient had received an antibiotic skin test on his right forearm. Lesions appeared approximately 2–3 months after the antibiotic skin test, slowly progressing without clinical improvement. Culture for fungus on the right forearm revealed growth of Scedosporium apiospermum. The tissue acid-fast bacilli (AFB) culture for the right forearm and right leg revealed growth of non-tuberculous mycobacteria which was Mycobacterium chelonae, and subsequent tissue polymerase chain reaction of both sites reported positive signs of M. chelonae. On diastase periodic acid-Schiff stain of the biopsy specimen of the right forearm, fungal hyphae were found while rod-shaped bacilli could be seen in AFB stain for the biopsy specimen of the right leg. The patient was treated with oral clarithromycin and ciprofloxacin along with an oral antifungal agent for 13 weeks. After the treatment, the lesions subsided and left a scar. We report a rare case of co-infection of S. apiospermum and M. chelonae in an immunocompetent host.
    The Journal of Dermatology 09/2014; 41(10). DOI:10.1111/1346-8138.12601 · 2.35 Impact Factor
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    ABSTRACT: A p-tert-octylcalix[4]arene derivative with four phenyl ketonic side arms has been synthesized as a solvent extraction reagent for precious metal ions in order to compare the extraction behavior with that of the corresponding methyl ketonic derivative of p-tert-octylcalix[4]arene in nitric acid media. The extraction efficiency of the phenyl ketonic derivative for palladium was superior to that of the methyl ketonic one over the whole nitric acid concentration range. Silver and platinum were also moderately extracted by the phenyl ketonic derivative in low nitric acid concentration. The results demonstrated that the extraction behavior of the ligands towards precious metals is related to several structural factors, such as the flexibility of the side arms, the electric charge on the carbonyl oxygen atoms and the lipophilic properties. This work also determined the extraction mechanism of palladium with the phenyl ketonic derivative of p-tert-octylcalix[4]arene based on slope analysis and the peak shift for the FT-IR spectra of the ligand before and after the metal loading. Stripping from the organic phase after forward extraction was performed to separate palladium and silver.
    Journal of inclusion phenomena and macrocyclic chemistry 06/2014; 82(1-2):25-32. DOI:10.1007/s10847-014-0467-6 · 1.43 Impact Factor
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    Annals of Dermatology 04/2014; 26(2):258-60. DOI:10.5021/ad.2014.26.2.258 · 0.95 Impact Factor
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    ABSTRACT: A bispidine-like ligand involving four pyridine-N and three aliphatic-N donor atoms forms a bimetallic species with CuCl2 in which all seven N-donors are bound and which aggregates in the crystal through double chloride-bridging to give a tetranuclear unit. The magnetism of this solid can be interpreted in terms of a relatively weak antiferromagnetic coupling between the two Cu(ii) centres of the dinuclear subunits and a strong ferromagnetic coupling of the Cu(ii) centres in different dinuclear units involved in the bis-chlorido bridge. In solution, the assembly decays into the dinuclear subunits and, in agreement with the solid state studies, the interaction between the corresponding Cu(II) centres is shown to be primarily due to dipole-dipole coupling.
    Dalton Transactions 03/2014; 43(15). DOI:10.1039/c4dt00305e · 4.10 Impact Factor
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    ABSTRACT: Background/Aims: Demonstrating the molecular mechanisms of human adipose tissue-derived mesenchymal stem cells (hADSCs) differentiation and proliferation could develop hADSCs-based cell therapy. Methods: The microRNA-137 (miR-137) and cell division control protein 42 homolog (CDC42) levels were regulated by oligonucleotides transfection. The adipogenic differentiation was induced for 10 days in an adipogenic medium and assessed by using an Oil Red O stain. The regulation of miR-137 on CDC42 expression was determined by western blot, real-time PCR and luciferase reporter assay. Results: We confirmed the roles of miR-137 on hADSCs proliferation and adipogenic differentiation. We showed that overexpression of miR-137 inhibited both hADSCs proliferation and adipogenic differentiation. Overexpression of miR-137 also downregulated protein and mRNA levels of CDC42, a predicted target of miR-137. In contrast, inhibition of miR-137 with 2'-O-methyl antisense RNA increased proliferation and adipogenic differentiation in hADSCs. Luciferase reporter activity in the miR-137 target site within the CDC42 3'UTR was lower in miR-137-transfected hADSCs than in control miRNA-transfected hADSCs. RNA interference-mediated downregulation of CDC42 in hADSCs inhibited their proliferation and adipogenic differentiation. Conclusion: Our results indicate that miR-137 regulates hADSCs adipogenic differentiation and proliferation by directly targeting CDC42. These findings improve our knowledge of the molecular mechanisms governing hADSCs differentiation and proliferation. © 2014 S. Karger AG, Basel.
    Cellular Physiology and Biochemistry 03/2014; 33(3):758-768. DOI:10.1159/000358650 · 3.55 Impact Factor
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    ABSTRACT: Background/Aims: The aim of this study was to analyze the effect of BMP2 on osteogenic differentiation of human adipose tissue-derived stromal cells (hADSCs). Methods: Cultured cells were differentiated into osteogenic lineage in the presence of BMP2. Gene expressions were determined by real time PCR. Results: BMP2 increased (2/8) or inhibited (6/8) osteogenic differentiation according to hADSCs batches. Regardless of the BMP2 action on osteogenic differentiation, BMP2 induced lipid droplet formation under an osteogenic differentiation condition in all batches of hADSCs, not hBMSCs, to be tested, which was confirmed by analysis of adipogenesis related genes expression. hADSCs expressed various BMP receptors. BMP2 increased expression of BMP2-responsive genes such as DLX3 and ID2, and induced SMAD1 phosphorylation in hADSCs and hBMSCs. BMP2 increased osteogenic differentiation of hADSCs in osteogenic medium in which dexamethasone was omitted. The addition of BMP2 in the control culture media containing dexamethasone alone lead to formation of lipid droplets and increased C/EBP-alpha expression in hADSCs. In the presence of TNF-alpha, BMP2 stimulated osteogenic differentiation of hADSCs even in hADSCs batches in which treatment of BMP2 alone inhibited osteogenic differentiation. Conclusion: These data indicate that the control of osteogenesis and adipogenesis in hADSCs is closely related, and that hADSCs have preferential commitment to adipogenic lineages. (C) 2014 S. Karger AG, Basel
    Cellular Physiology and Biochemistry 01/2014; 34(4):1339-50. DOI:10.1159/000366341 · 3.55 Impact Factor
  • The Journal of Dermatology 12/2013; 41(1). DOI:10.1111/1346-8138.12319 · 2.35 Impact Factor
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    ABSTRACT: Neuromyelitis optica (NMO) is an inflammatory demyelinating disorder of the central nervous system with a relapsing and remitting course. We aimed to identify factors associated with the time to next attack, including the effect of the natural disease course and the diverse treatment regimens, by applying a longitudinal statistical analysis to the individual attacks of each patient. In total, 184 acute attacks among 58 patients with either NMO or NMO spectrum disorder with anti-aquaporin-4 antibody were assessed retrospectively. Patient demographics, clinical characteristics at each attack, and type of treatment during inter-attack periods were assessed. The dependent variable was defined as the time from each attack to the next attack (inter-attack interval). An exponential accelerated failure time model with shared gamma frailty was adapted for statistical analysis. A multivariable analysis revealed that the time from each attack to the next attack in NMO increased independently by 1.31 times (95% confidence interval (CI), 1.02-1.67; p = 0.035) with each additional cumulative attack experienced, by 5.34 times (95% CI, 1.57-18.13; p = 0.007) with combined azathioprine treatment and continued oral prednisolone, and by 4.26 times (95% CI, 1.09-16.61; p = 0.037) with rituximab treatment. The time to next attack in NMO can increase naturally in the later stages of the disease as the number of cumulative attacks increases. Nevertheless, both combined azathioprine treatment with continued oral prednisolone and rituximab treatment were also associated with a longer time to next attack, independently of the natural disease course of NMO.
    PLoS ONE 12/2013; 8(12):e82325. DOI:10.1371/journal.pone.0082325 · 3.53 Impact Factor
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    ABSTRACT: For topical applications in wound healing, silver nanoparticles (AgNPs) have attracted much attention as antibacterial agents. Herein, we describe a green-synthetic route for the production of biocompatible and crystalline AgNPs using two glycosaminoglycans, chondroitin sulfate (CS) and acharan sulfate (AS), as reducing agents. The synthetic approach avoids the use of toxic chemicals, and the yield of AgNPs formation is found to be 98.1% and 91.1% for the chondroitin sulfate-reduced silver nanoparticles (CS-AgNPs) and the acharan sulfate-reduced silver nanoparticles (AS-AgNPs), respectively. Nanoparticles with mostly spherical and amorphous shapes were observed, with an average diameter of 6.16 ± 2.26 nm for CS-AgNPs and 5.79 ± 3.10 nm for AS-AgNPs. Images of the CS-AgNPs obtained from atomic force microscopy revealed the self-assembled structure of CS was similar to a densely packed woven mat with AgNPs sprinkled on the CS. These nanoparticles were stable under cell culture conditions without any noticeable aggregation. An approximately 128-fold enhancement of the antibacterial activities of the AgNPs was observed against Enterobacter cloacae and Escherichia coli when compared to CS and AS alone. In addition, an in vivo animal model of wound healing activity was tested using mice that were subjected to deep incision wounds. In comparison to the controls, the ointments containing CS-AgNPs and AS-AgNPs stimulated wound closure under histological examination and accelerated the deposition of granulation tissue and collagen in the wound area. The wound healing activity of the ointments containing CS-AgNPs and AS-AgNPs are comparable to that of a commercial formulation of silver sulfadiazine even though the newly prepared ointments contain a lower silver concentration. Therefore, the newly prepared AgNPs demonstrate potential for use as an attractive biocompatible nanocomposite for topical applications in the treatment of wounds.
    Nanotechnology 09/2013; 24(39):395102. DOI:10.1088/0957-4484/24/39/395102 · 3.67 Impact Factor
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    ABSTRACT: The natural course of cytologically benign thyroid nodules remains unclear. The aim of this study was to evaluate whether ultrasonographic (US) changes are associated with changes in nodule volume during follow-up. We retrospectively reviewed over 4 years of clinical records of patients with benign thyroid nodules as confirmed by fine needle aspiration (FNA). In total, 186 patients with 202 benign thyroid nodules were included for study. We assessed for changes in nodule volume and examined the cystic portion of the nodule as well as four US features (echogenicity, margin, calcification pattern, and shape). During follow-up (mean, 21.7±10.7 months) and using 50% as a cutoff value, nodule volumes increased in 11.8%, exhibited no change in 79.9%, and decreased in 8.3% of patients. Proportion of nodules demonstrating at least one US change was 20.8% (42/202). The most common US changes (in descending order of frequency) were cystic change, margin change, and calcification pattern change. Nodule shape and echogenicity rarely changed. Increased nodule volume was not significantly associated with any US features or with the number of FNAs but was associated with younger age at time of diagnosis. Although a portion of thyroid nodules confirmed as benign showed US changes or volume changes during the follow-up period, these findings may only represent the natural course of benign nodules. Frequent follow-up with US might be needed for only a small number of cases with suspicious US findings.
    06/2013; 28(2):110-8. DOI:10.3803/EnM.2013.28.2.110
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    ABSTRACT: Despite the increasing use of topical tacrolimus, there is little information about its effect on skin wound healing. To determine effects on acute cutaneous wound healing, two full-thickness skin wounds were imparted on the backs of 45 hairless mice, which were then divided into vehicle-, topical tacrolimus- and topical steroid-treated group. Each drug was topically applied once daily. The wound area was assessed by using dermoscopic images every two days after wounding. At 3, 7 and 11 days after wounding, 10 wounds in each group were collected for semi-quantitative analysis of histological features including re-epithelialization, polymorphonuclear leucocytes, fibroblasts and collagen. We also checked the mRNA expression levels of EGF, TGF-β, TNF-α and IL-1α. While topical application of clobetasol propionate was found to delay re-epithelialization and infiltration of polymorphonuclear leucocyte, topical treatment with tacrolimus showed patterns similar to that of the vehicle. In the tacrolimus-treated group, mRNA expression levels of IL-1α and TGF-β were slightly decreased, while the others were similar with the vehicle-treated group. Unlike steroid, topical tacrolimus, therefore, did not disturb the wound healing process in a murine skin wound model.
    Experimental Dermatology 05/2013; 22(5):369-71. DOI:10.1111/exd.12131 · 4.12 Impact Factor
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    ABSTRACT: BACKGROUND: Despite a few experimental studies showing a dose-dependent myocardial depressive effect of propofol anesthesia induction, few clinical data are available to determine its precise impact on myocardial function, probably because of its brevity and a lack of appropriate evaluation tools. The purpose of this study was to examine the impact of propofol-based anesthesia induction on left ventricular (LV) function using Doppler tissue and speckle-tracking imaging. METHODS: In 19 low-risk patients with normal LV systolic and diastolic function undergoing noncardiac surgery (all women; mean age, 42 years), propofol bolus (2.0 mg/kg) was administered intravenously for anesthesia induction. LV ejection fraction, global peak systolic longitudinal strain, and tissue Doppler-derived indices of mitral annular velocity during systole (S'), early diastole (e'), and atrial contraction (a') were determined by intraoperative transthoracic echocardiography before and 1, 3, and 5 min after propofol bolus (T0, T1, T2, and T3, respectively). RESULTS: The following at T1, T2, and T3 were significantly less in magnitude than at T0: septal S' (5.61, 5.61, and 5.51 vs 7.60 cm/sec, P < .001), lateral S' (5.75, 5.89, and 5.94 vs 8.12 cm/sec, P < .001), septal e' (10.10, 10.26, and 10.07 vs 11.4 cm/sec, P < .01), septal a' (6.70, 6.21, and 6.13 vs 8.58 cm/sec, P < .01), lateral a' (7.29, 6.81, and 6.85 vs 9.01 cm/sec, P < .01), and longitudinal strain (-19.36%, -19.71%, and -19.61% vs -22.28%, P < .001). LV ejection fraction was not significantly changed (P = .361). CONCLUSIONS: Propofol anesthesia induction diminished LV and atrial contraction in low-risk patients with prior normal LV function. Further studies are needed to understand the clinical implications, particularly for higher risk populations.
    Journal of the American Society of Echocardiography: official publication of the American Society of Echocardiography 04/2013; DOI:10.1016/j.echo.2013.03.016 · 3.99 Impact Factor
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    ABSTRACT: The crystal structures of one inert and six labile metal ion complexes have been analysed as a means of illustrating the refinements that X-ray crystallography has brought to the understanding of coordination chemistry so profoundly influenced by Alfred Werner. Contemporary interest in various weak interactions evident from structural studies can be related to the Wernerian concepts of «haupt-» and «neben-valenz».
    Polyhedron 03/2013; 52:1190-1198. DOI:10.1016/j.poly.2012.06.044 · 2.05 Impact Factor
  • Journal of Dermatological Science 02/2013; 69(2):e25. DOI:10.1016/j.jdermsci.2012.11.377 · 3.34 Impact Factor
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    ABSTRACT: Extramammary Paget's disease (EMPD) is an uncommon intraepithelial adenocarcinoma, primarily affecting the apocrine-bearing skin. Bowen disease is an intraepithelial squamous cell carcinoma having the potential to become invasive carcinoma. The histopathological concomitant features between EMPD and Bowen disease have been described. One theory is that primary EMPD arises multicentrically, within the epidermis from the pluripotent stem cells. Herein, we describe a case of EMPD that had bowenoid features, and review the previous cases associated with the origin of EMPD.
    Annals of Dermatology 02/2013; 25(1):88-91. DOI:10.5021/ad.2013.25.1.88 · 0.95 Impact Factor
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    ABSTRACT: X-linked bulbospinal muscular atrophy (X-BSMA) is characterized by bulbar and spinal muscular weakness and fasciculations. Although X-BSMA is a motor neuronopathy, there are several reports of myasthenic symptoms or decremental responses to repetitive nerve stimulation (RNS). We report the results of applying the RNS test to 15 patients among 41 with genetically confirmed X-BSMA; these 15 patients complained of fatigue, ease of becoming tired, or early muscular exhaustion. The 3-Hz RNS test was performed on the trapezius, nasalis, orbicularis oculi, flexor carpi ulnaris, and abductor digiti quinti muscles. A decrement greater than 10% was considered abnormal. Additionally, a pharmacologic response to neostigmine was identified in three patients. A significant decrement was observed in 67% of patients, and was most common in the trapezius muscle (nine cases). The decrement of the trapezius muscle response ranged from 15.9% to 36.9%. The decrement was inversely correlated with the amplitude of compound muscle action potentials at rest. Neostigmine injection markedly improved the decrement in three patients, who showed noticeable decremental responses to 3-Hz RNS. This study shows that myasthenic symptoms and abnormal decremental responses to low-rate RNS are common in X-BSMA.
    Journal of Clinical Neurology 01/2013; 9(1):32-5. DOI:10.3988/jcn.2013.9.1.32 · 1.81 Impact Factor

Publication Stats

370 Citations
118.81 Total Impact Points


  • 2011–2015
    • Dankook University
      • Department of Dermatology
      Eidō, Chungcheongbuk-do, South Korea
  • 2014
    • Dankook University Hospital
      Anjŏ, Gyeonggi Province, South Korea
    • Saga University
      • Department of Chemistry and Applied Chemistry
      Сага Япония, Saga Prefecture, Japan
  • 2009–2014
    • Pusan National University
      • • School of Medicine
      • • Department of Chemistry
      Tsau-liang-hai, Busan, South Korea
  • 2013
    • Kosin University
      Tsau-liang-hai, Busan, South Korea
    • Kangwon National University
      • Department of Veterinary Medicine
      Gangneung, Gangwon, South Korea
    • Seoul National University
      • Natural Products Research Institute
      Sŏul, Seoul, South Korea
  • 2011–2013
    • Myongji Hospital
      Kōyō, Gyeonggi Province, South Korea
  • 2002–2013
    • Catholic University of Korea
      • • Department of Radiology
      • • College of Medicine
      Sŏul, Seoul, South Korea
  • 2011–2012
    • Catholic Kwandong University
      • College of Medicine
      Gangneung, Gangwon-do, South Korea
  • 2010
    • Korea Food and Drug Administration
      Seishō-gun, North Gyeongsang, South Korea
  • 2007–2008
    • Ewha Womans University
      • Department of Neurology
      Sŏul, Seoul, South Korea
  • 2001
    • Sejong University
      • Faculty of Food Science and Technology
      Sŏul, Seoul, South Korea