T Poynard

BioPredictive, Lutetia Parisorum, Île-de-France, France

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Publications (623)3838.08 Total impact

  • Mona Munteanu, Marion Houot, Yen Ngo, Thierry Poynard
    The American journal of gastroenterology. 08/2014; 109(8):1287-8.
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    ABSTRACT: & Aims: Transient elastometry is a non-invasive procedure used to measure fibrosis when patients are diagnosed with liver disease; it might be used to monitor changes over time. We investigated whether there are short-term variations in stiffness measurements not attributable to changes in fibrosis by studying patients with stable liver disease.
    07/2014;
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    ABSTRACT: The first aim was to extend the validation of FibroTest (FT) and transient elastography (TE) as markers of occurrence of cirrhosis without complications (F4.1), esophageal varices (F4.2), and severe complications (F4.3) in patients with chronic hepatitis B (CHB). The second aim was to validate a previous definition of inactive carrier based on normal FT and ActiTest (normal-FTAT). The third aim was to assess the long-term dynamics of fibrosis in patients with sustained virological response.
    Journal of hepatology. 07/2014;
  • Mona Munteanu, Marion Houot, Yen Ngo, Thierry Poynard
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    ABSTRACT: We read with interest the comprehensive review article debating about the diagnostic accuracy of non-invasive markers for the prediction of hepatitis B-related fibrosis. [1] The author must be congratulated for the effort to review respective advantages and disadvantages of currently available non-invasive methods, such as serum biomarkers and TE. Even we acknowledge that the author deplored the lack of meta-analyses of data from individual patients, the review did not underlined few other important methodological limitations.This article is protected by copyright. All rights reserved.
    Liver international: official journal of the International Association for the Study of the Liver 05/2014; · 3.87 Impact Factor
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    ABSTRACT: The development of esophageal varices is a late complication of chronic liver disease in children. The diagnosis is currently limited to invasive procedures such as endoscopy. Noninvasive tools to diagnose presence and degree of esophageal varices would potentially alter management decisions and support indications for invasive procedures in affected children. AIM:: To test the feasibility of spleen stiffness measurement (SSM) by transient elastography (Fibroscan) in children and compare data on its potential diagnostic use with established markers of liver fibrosis and parameters of portal hypertension. 99 children (62 with chronic liver disease, 6 after LTx, 31 controls) underwent SSM by transient elastography. Fibrotest was determined in 37 children, 45 children had an additional liver stiffness measurement and 19 underwent upper endoscopy. Spleen stiffness measurement by Fibroscan is feasible. Spleen size significantly determined success rate (90.5% in patients with splenomegaly vs. 70.2% in patients without, p = 0.02). Spleen stiffness was significantly higher in patients with splenomegaly (62.96kPa vs. 18.4kPa, p < 0.001), in patients with varices (75kPa vs. 24kPa, p < 0.01) and in patients with a history of variceal haemorrhage (75kPa vs. 50.25kPa, p < 0.05). Variceal haemorrhage did not occur in patients with SSM results below 60 kPa. Spleen stiffness decreased after liver transplantation, but remained elevated compared to controls (27.5 kPa vs. 16.3 kPa). Liver stiffness measurements and Fibrotest did not reflect presence or degree of esophageal varices. Spleen stiffness measurement by transient elastography is feasible in children and results reflect the degree and occurrence of complications. A prospective follow-up study with larger patient numbers and performance of screening endoscopies appears justified and desirable.
    Journal of pediatric gastroenterology and nutrition 04/2014; · 2.18 Impact Factor
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    ABSTRACT: We investigated the effectiveness of the protease inhibitors peginterferon and ribavirin in treatment-experienced patients with hepatitis C virus (HCV) genotype 1 infection and cirrhosis. In the Compassionate Use of Protease Inhibitors in Viral C Cirrhosis study, 511 patients with HCV genotype 1 infection and compensated cirrhosis who did not respond to a prior course of peginterferon and ribavirin (44.3% relapsers or patients with viral breakthrough, 44.8% partial responders, and 8.0% null responders) were given either telaprevir (n=299) or boceprevir (n=212) for 48 weeks. We assessed percentages of patients with sustained viral responses 12 weeks after therapy (SVR12) and safety. This observational study did not allow for direct comparison of the 2 regimens. Among patients given telaprevir, 74.2% of relapsers, 40.0% of partial responders, and 19.4% of null responders achieved SVR12. Among those given boceprevir, 53.9% of relapsers, 38.3% of partial responders, and none of the null responders achieved SVR12. In multivariate analysis, factors associated with SVR12 included prior response to treatment response, no lead-in phase, HCV subtype 1b (vs 1a), and baseline platelet count >100,000/mm(3). Severe adverse events occurred in 49.9% of cases, including liver decompensation or severe infections in 10.4% and death in 2.2%. In multivariate analysis, baseline serum albumin <35 g/L and baseline platelet counts ≤100,000/mm(3) predicted severe side effects or death. Relatively high percentages of real-life, treatment-experienced, patients with HCV genotype 1 infection and cirrhosis respond to the combination of peginterferon and ribavirin with telaprevir or boceprevir. However, side effects are frequent and often severe side. Baseline levels of albumin and platelet counts can be used to guide treatment decisions. ClinicalTrials.gov number, NCT01514890.
    Gastroenterology 04/2014; · 12.82 Impact Factor
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    ABSTRACT: A complex interaction among metabolic factors, adipose tissue lipolysis, oxidative stress, and insulin resistance results in a deleterious process that may link nonalcoholic fatty liver disease (NAFLD) with severe cardiovascular (CV) outcomes. Patients with NAFLD are at higher risk of atherosclerosis, new onset of CV events, and overall mortality. The strong association between NAFLD and CV disease should affect clinical practice, with screening and surveillance of patients with NAFLD. This review discusses the data linking these major diseases.
    Clinics in liver disease 02/2014; 18(1):233-48.
  • Journal of hepatology. Supplement / EASL 01/2014; 60(1):S348.
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    ABSTRACT: Background The aspartate aminotransferase platelet ratio index (APRI) is a validated, non-patented blood test for diagnosing fibrosis or cirrhosis in patients with chronic hepatitis C. We assess the impact of two limitations, the variability of the upper limit of normal for aspartate aminotransferase (AST-ULN) and the risk of overestimating fibrosis stage due to necroinflammatory activity. Methods The variability of AST-ULN was assessed by an overview of the literature and an assessment of AST-ULN in 2 control populations 7521 healthy volunteers and 393 blood donors. We assessed the impact of AST-ULN variability on APRI performance for estimating fibrosis prevalence and on the Obuchowski measure using individual data of 1651 patients with APRI, FibroTest and biopsy. Results The overview, and the analysis of the control populations found that ULN-AST ranged from 26 to 49 IU/L according to gender, body mass index and serum cholesterol. When this AST-ULN variability was applied to the chronic hepatitis group, the prevalence of advanced fibrosis and cirrhosis as presumed by APRI varied (P < 0.001) from 34.7% to 68.5%, and from 11.4% to 32.3%, respectively. This spectrum effect induced variability in APRI performance, which could be similar 0.862 (if AST-ULN = 26 IU/L) or lower 0.820 (AST-ULN ≥ 30IU/L) than the stable FibroTest performance (0.867; P = 0.35 and P < 0.0001 respectively). When applied to 18 acute hepatitis C patients, the rate of false positives of APRI varied from 0% to 61% due to AST-ULN. Conclusion The AST-ULN variability is high highly associated with the variability of metabolic risk factors between the different control groups. This variability induces a spectrum effect, which could cause misleading interpretations of APRI performance for the staging of fibrosis, comparisons of APRI with other non-invasive tests, and estimates of false positive rate.
    Clinics and Research in Hepatology and Gastroenterology. 01/2014;
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    ABSTRACT: Emerging data indicate that all-oral antiviral treatments for chronic hepatitis C virus (HCV) will become a reality in the near future. In replacing interferon-based therapies, all-oral regimens are expected to be more tolerable, more effective, shorter in duration and simpler to administer. Coinciding with new treatment options are novel methodologies for disease screening and staging, which create the possibility of more timely care and treatment. Assessments of histologic damage typically are performed using liver biopsy, yet noninvasive assessments of histologic damage have become the norm in some European countries and are becoming more widespread in the United States. Also in place are new Centers for Disease Control and Prevention (CDC) initiatives to simplify testing, improve provider and patient awareness and expand recommendations for HCV screening beyond risk-based strategies. Issued in 2012, the CDC recommendations aim to increase HCV testing among those with the greatest HCV burden in the United States by recommending one-time testing for all persons born during 1945-1965. In 2013, the United States Preventive Services Task Force adopted similar recommendations for risk-based and birth-cohort-based testing. Taken together, the developments in screening, diagnosis and treatment will likely increase demand for therapy and stimulate a shift in delivery of care related to chronic HCV, with increased involvement of primary care and infectious disease specialists. Yet even in this new era of therapy, barriers to curing patients of HCV will exist. Overcoming such barriers will require novel, integrative strategies and investment of resources at local, regional and national levels.
    Journal of Viral Hepatitis 11/2013; 20(11):745-60. · 3.08 Impact Factor
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    ABSTRACT: Saliva sampling may provide an easier access to hepatitis C virus (HCV) screening test. HIV infection influence on specific salivary antibody detection has not been extensively studied. An anti-HCV antibodies (HCV-Ab) test was adapted for saliva specimens and its performances were analysed according to the patients' HIV status and related factors such as CD4 cell counts and HIV viral load. Four patients groups were selected: (i) HCV and HIV negative volunteers (n=28); (ii) HCV positive and HIV negative patients (n=30); (iii) HCV negative and HIV positive patients (n=30); (iv) HCV and HIV co-infected patients (n=30). Saliva samples were collected (Salivette system, Sarstedt) and an in-house adapted HCV-Ab detection assay was performed (MONOLISA anti-HCV PLUS Version 2, Biorad). HIV viral load, CD4 cells counts and HCV viremic status were reported. Sensitivity and specificity of saliva anti-HCV antibody tests in the HIV negative groups were 90% and 100%, respectively, compared to 73% and 93%, respectively in the HIV infected population. Compared to the HIV negative population, HIV mono-infected patients presented higher absorbance values (p=0.01) and HIV/HCV co-infected population presented lower HCV-Ab absorbance values (p<0.001). Sensitivity decline was associated with HIV replication (p=0.02), HCV replication (p=0.16) but not with CD4 cell counts (p=0.64). Performances of salivary HCV antibodies testing are strongly deteriorated in the HIV positive population, especially for patients with residual HIV replication. This serious limitation should prompt careful testing of non-invasive screening tests for hepatitis C in HIV-infected patients before use in real screening conditions.
    Journal of clinical virology: the official publication of the Pan American Society for Clinical Virology 08/2013; · 3.12 Impact Factor
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    ABSTRACT: Due to common routes of transmission, HIV and HBV are frequently found as concomitant infections. The dynamic of liver disease in co-infected patients is important to understand for appropriate clinical management. Conflicting data surround the role played by genotype-G HBV (HBV-G) during the course of HIV co-infection. This study aims to assess, using non-invasive methods, liver disease progression in HIV-HBV genotype-G co-infected patients. Co-infected patients with residual HBV replication (n=125) were screened for HBV-G infection by specific real-time PCR. The impact of HBV-G on liver fibrosis progression, as assessed by a non invasive biomarker (Fibrotest), was evaluated first, by a cross sectional analysis comparing fibrosis between HBV-G (n=23) and non-G (n=55) infected patients and second, by a longitudinal study performed over a 5 year period. Selected patients were mostly male (90%), with homogenous characteristics between the HBV-G and non-G infected groups, in terms of age, known duration of HIV disease, immune and virological status and duration of HIV/HBV treatment. HBV-G infected patients were exclusively from Western Europe with homosexual intercourses (83%) as principal risk of transmission. Cross sectional analysis revealed comparable liver disease severity distribution between HBV-G and non-G infected patients. Co-infection with other hepatitis viruses and low CD4-nadir, but not HBV-G co-infection, were associated with a 5-year risk of fibrosis progression. This study suggests that HBV-G infection is not significantly associated with a more severe liver disease and does not have a deleterious impact on fibrosis progression in efficiently treated HIV-HBV co-infected patients.
    Journal of clinical virology: the official publication of the Pan American Society for Clinical Virology 08/2013; · 3.12 Impact Factor
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    ABSTRACT: Sustained virologic response (SVR) is the standard measure for evaluating response to therapy in patients with chronic hepatitis C (CHC). The aim of this study was to prospectively assess the durability of SVR in the pivotal studies of peginterferon (PEG-IFN) α-2b or IFN α-2b. We conducted two phase 3b long-term follow-up studies of patients previously treated for CHC in eight prospective randomized studies of IFN α-2b and/or PEG-IFN α-2b. Patients who achieved SVR [undetectable hepatitis C virus (HCV) RNA 24 weeks after completion of treatment] were eligible for inclusion in these follow-up studies. In total, 636 patients with SVR following treatment with IFN α-2b and 366 with SVR following treatment with PEG-IFN α-2b were enrolled. Definite relapse (quantifiable serum HCV RNA with no subsequent undetectable HCV RNA) was reported in six patients treated with IFN α-2b and three patients treated with PEG-IFN α-2b. Based on these relapses, the point estimate for the likelihood of maintaining response after 5 years was 99.2% [95% confidence interval (CI), 98.1-99.7%] for IFN α-2b and 99.4% (95% CI, 97.7-99.9%) for PEG-IFN α-2b. Successful treatment of hepatitis C with PEG-IFN α-2b or IFN α-2b leads to clinical cure of hepatitis C in the vast majority of cases.
    Journal of Viral Hepatitis 08/2013; 20(8):524-9. · 3.08 Impact Factor
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    ABSTRACT: The use of non-invasive markers to diagnose liver allograft fibrosis is not well established in children after LTx. TE, FT, and ELF score were performed in 117 liver-transplanted children (60M, 8.9 [0.5-18.5] yr) and 336 healthy controls. Liver biopsy was available in 36 children. Results of histology and non-invasive markers were compared using correlation coefficient or Mann-Whitney U-test as appropriate. TE correlated best with histological degree of fibrosis (r = 0.85 vs. r = 0.04 [FT] or r = -0.38 [ELF]). Liver stiffness values for transplanted children without fibrosis were significantly higher than those of healthy controls (7.55 [5.4-20.4] kPa vs. 4.5 [2.5-8.9] kPa). Presence of rejection was a potent confounder for the performance of TE. Both TE and FT reflected clinical changes (acute rejection, cholestasis, increasing fibrosis) in a total of 16 patients who underwent serial measurements. TE correlates better with histological degree of fibrosis in liver-transplanted children than FT or ELF, but an individual baseline value needs to be determined for each patient. Normal or cutoff values for pathological degrees of fibrosis cannot be transferred from non-transplanted children. Follow-up studies, preferably with protocol biopsies, might help to improve the diagnostic quality of TE.
    Pediatric Transplantation 06/2013; · 1.50 Impact Factor
  • J Hepatol. 05/2013;
  • Marika Rudler, Thierry Poynard, Dominique Thabut
    Gastroenterology 03/2013; · 12.82 Impact Factor
  • M Munteanu, V Ratziu, T Poynard
    Alimentary Pharmacology & Therapeutics 03/2013; 37(6):655-6. · 4.55 Impact Factor
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    ABSTRACT: BACKGROUND: Patients with cystic fibrosis (CF) have a relevant morbidity and mortality caused by CF-related liver-disease. While transient elastography (TE) is an established elastography method in hepatology centers, Acoustic-Radiation-Force-Impulse (ARFI)-Imaging is a novel ultrasound-based elastography method which is integrated in a conventional ultrasound-system. The aim of the present study was to evaluate the prevalence of liver-fibrosis in patients with CF using TE, ARFI-imaging and fibrosis blood tests. METHODS: 106 patients with CF were prospectively included in the present study and received ARFI-imaging of the left and right liver-lobe, ARFI of the pancreas TE of the liver and laboratory evaluation. RESULTS: The prevalence of liver-fibrosis according to recently published best practice guidelines for CFLD was 22.6%. Prevalence of significant liver-fibrosis assessed by TE, ARFI-right-liver-lobe, ARFI-left-liver-lobe, Fibrotest, Fibrotest-corrected-by-haptoglobin was 17%, 24%, 40%, 7%, and 16%, respectively. The best agreement was found for TE, ARFI-right-liver-lobe and Fibrotest-corrected-by-haptoglobin. Patients with pancreatic-insufficiency had significantly lower pancreas-ARFI-values as compared to patients without. CONCLUSIONS: ARFI-imaging and TE seem to be promising non-invasive methods for detection of liver-fibrosis in patients with CF.
    Journal of cystic fibrosis: official journal of the European Cystic Fibrosis Society 01/2013; · 3.19 Impact Factor
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    ABSTRACT: BACKGROUND AND AIM: Real-time shear wave elastography (SWE) is a new two-dimensional transient elastography which had no assessment of factors associated with reliability, and has had limited comparisons with other validated fibrosis biomarkers. The aim was to assess the applicability and the performances of SWE for the diagnosis of fibrosis as compared with FibroTest (FT) and liver stiffness measurement (LSM) by transient elastography using two probes (TE-M and TE-XL). METHODS: without a gold standard were applied: the strength of concordance, discordance analysis and latent class analysis (LCM). RESULTS: 422 patients were included. The applicability of SWE (90.0%) was significantly lower than that of FT (97.9%; P<0.0001) and did not differ from those of TE-M (90.5%) and TE-XL (90.3%); it was higher though for SWE (86%) in 22 patients with ascites vs. 55% using TE-M (P=0.04). For the diagnosis of all fibrosis stages as presumed by FT, the performance of SWE was highly significant (Obuchowski measure 0.807 ± 0.013 [m ± se]), but lower than those of TE-M (0.852; P=0.0007) and TE-XL (0.834; P=0.046). SWE had a low performance for discrimination between F0 and F1. For the diagnosis of cirrhosis using LCM, the SWE specificities were all equal to 99%, and SWE sensitivities ranged from 0.47 to 0.64. For the diagnosis of non-cirrhotic stages, the results were heterogeneous. CONCLUSION: The performance of SWE for the diagnosis of cirrhosis was similar to those of FT and TE. The SWE applicability was lower than that of FT, but greater than that of TE in patients with ascites.
    Journal of Hepatology 01/2013; · 9.86 Impact Factor
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    ABSTRACT: Background and Aims FibroTest (FT) and Transient Elastography (TE) have been validated as noninvasive markers of METAVIR fibrosis stages from F0 to F4 using biopsy, and as prognostic markers of liver related mortality in patients with chronic hepatitis C. The aim was to extend the validation of FT and TE as markers of critical steps defined by occurrence of cirrhosis without complications (F4.1), esophageal varices (F4.2), and severe complications (F4.3): primary liver cancer, variceal bleeding, or decompensation (ascites, encephalopathy, or jaundice). Methods The updated individual data of 3927 patients (1046 cirrhotics) without complications at baseline were pooled from three prospective cohorts called “EPIC”, “Paris” and “Bordeaux” cohorts. Results At 5 years among 501 patients without varices at baseline (F4.1), varices occurred in 19 patients F4.2 incidence of 4.0% (95%CI 2.2-5.8). The predictive performance (AUROC) of FT was 0.77 (0.66-0.84; P<0.001). At 10 years severe complications occurred in 203 patients, F4.3 incidence of 13.4% (9.6-17.1), including primary liver cancer in 84 patients 6.4%(3.5-9.3). FT was predictive (Cox adjusted on treatment) of severe complications AUROC 0.79(76-82); P<0.0001, including primary liver cancer AUROC 0.84(80-87); P<0.0001. Similarly TE was predictive of severe complications AUROC 0.77(72-81); P<0.0001, including primary liver cancer AUROC 0.86(81-90); P<0.0001. Conclusion FibroTest and TE increase were associated with the occurrence of all severe complications including hepatocellular carcinoma, hepatic insufficiency and variceal bleeding. FibroTest increase was also associated with the occurrence of esophageal varices.
    Journal of Hepatology 01/2013; · 9.86 Impact Factor

Publication Stats

27k Citations
3,838.08 Total Impact Points

Institutions

  • 2008–2014
    • BioPredictive
      Lutetia Parisorum, Île-de-France, France
    • Hôpital d'Aix en Provence
      Aix, Provence-Alpes-Côte d'Azur, France
    • Université de Vincennes - Paris 8
      Saint-Denis, Île-de-France, France
    • Alphabio
      Marsiglia, Provence-Alpes-Côte d'Azur, France
  • 1994–2014
    • Hôpital La Pitié Salpêtrière (Groupe Hospitalier "La Pitié Salpêtrière - Charles Foix")
      • • Service d’Hépato - Gastro - Entérologie
      • • Service de Médecine Interne 1
      Lutetia Parisorum, Île-de-France, France
    • Yale-New Haven Hospital
      New Haven, Connecticut, United States
    • Centre Hospitalier Universitaire de Grenoble
      Grenoble, Rhône-Alpes, France
  • 2013
    • Hôpital Bichat - Claude-Bernard (Hôpitaux Universitaires Paris Nord Val de Seine)
      Lutetia Parisorum, Île-de-France, France
  • 2007–2013
    • Assistance Publique – Hôpitaux de Paris
      Lutetia Parisorum, Île-de-France, France
    • The University of Western Ontario
      London, Ontario, Canada
  • 2011–2012
    • UPMC
      Pittsburgh, Pennsylvania, United States
    • Université de Cergy-Pontoise
      95001 CEDEX, Ile-de-France, France
    • Hospital Clínic de Barcelona
      Barcino, Catalonia, Spain
  • 2010–2012
    • Polytech Paris-UPMC
      Lutetia Parisorum, Île-de-France, France
  • 2005–2012
    • Pierre and Marie Curie University - Paris 6
      Lutetia Parisorum, Île-de-France, France
  • 1994–2012
    • Hôpitaux Universitaires La Pitié salpêtrière - Charles Foix
      Lutetia Parisorum, Île-de-France, France
  • 2007–2010
    • Unité Inserm U1077
      Caen, Lower Normandy, France
  • 2004
    • Centre Hospitalier Régional et Universitaire de Besançon
      Becoinson, Franche-Comté, France
    • The University of Hong Kong
      • Department of Medicine
      Hong Kong, Hong Kong
  • 2002
    • Duke University Medical Center
      • Duke Clinical Research Institute
      Durham, NC, United States
  • 1994–2002
    • French National Centre for Scientific Research
      Lutetia Parisorum, Île-de-France, France
  • 1987–2002
    • Hôpital Antoine-Béclère – Hôpitaux universitaires Paris-Sud
      Clamart, Île-de-France, France
  • 2001
    • Université René Descartes - Paris 5
      • Faculty of Pharmaceutical Sciences and biology
      Lutetia Parisorum, Île-de-France, France
  • 2000
    • Tufts University
      • Department of Medicine
      Boston, GA, United States
  • 1999
    • University of Angers
      Angers, Pays de la Loire, France
  • 1998
    • French Institute of Health and Medical Research
      Lutetia Parisorum, Île-de-France, France
  • 1991–1997
    • Institut de Cancérologie Gustave Roussy
      • Department of Radiotherapy
      Île-de-France, France
  • 1989
    • National Institute of Immunology
      New Dilli, NCT, India
  • 1988
    • Harvard Medical School
      Boston, Massachusetts, United States