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ABSTRACT: Four new sesquiterpenes (1-4), together with four known compounds (5-8), were isolated from the stems of Pogostemon cablin (Blanco.) Benth. Their chemical structures were elucidated by means of spectroscopic methods, including 1D and 2D NMR, HRESIMS, IR, and UV. Hepatoprotective activities of these compounds were investigated, by studying the protective effect on HL-7702 cellular injury induced by DL-galactosamine.
Fitoterapia 03/2013; · 1.85 Impact Factor
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ABSTRACT: Twelve new dihydroagarofuran sesquiterpene polyol esters, triptersinines A-L (1-12), and eight known sesquiterpene pyridine alkaloids were isolated from the leaves of Tripterygium wilfordii. Their structures were elucidated on the basis of spectroscopic analyses, including UV, IR, and NMR experiments ((1)H-(1)H COSY, NOESY, HSQC, and HMBC). Furthermore, in an in vitro bioassay, compounds 1, 9, 11, 13, 14, and 18 showed moderate inhibitory effects on nitric oxide production in LPS-induced macrophages at 5 μM; all compounds were inactive when tested against five human cancer cell lines (IC(50) values >1 μM).
Journal of Natural Products 12/2012; · 3.13 Impact Factor
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ABSTRACT: Five new coumarin glycosides, umbelliferone 7-O-sophoroside (1), umbelliferone 7-O-β-D-glucopyranosyl(1 → 3)-β-D-glucopyranoside (2), umbelliferone 7-O-β-D-glucopyranosyl(1 → 3)-[β-D-apiofuranosyl(1 → 6)]-β-D-glucopyranoside (3), umbelliferone 7-O-β-D-glucopyranosyl(1 → 2)-β-D-apiofuranosyl(1 → 6)-β-D-glucopyranoside (4), and umbelliferone 7-O-β-D-glucopyranosyl(1 → 5)-β-D-apiofuranosyl(1 → 6)-β-D-glucopyranoside (5), and two new iridoid glucosides, 7-O-E-isoferuloyl loganic acid (6) and 7-O-β-D-glucopyranosyl loganin (7), together with eight known compounds (8-15) were isolated from the stems of Hydrangea paniculata. Their structures were established by spectroscopic analysis and chemical methods. At 10 µM, compounds 1, 3, 5, 6, 8, 9, and 13 showed neuroprotective effects against serum deprivation-induced PC12 cell damage.
Planta Medica 10/2012; · 2.15 Impact Factor
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ABSTRACT: Two new sesquiterpene pyridine alkaloids hypoglaunines E (1) and F (2) and a new triterpenoid saponin hypoglaside A (3), together with a known diterpenoid glucoside 11-O-β-d-glucopyranosyl neotriptophenolide (4) and two known triterpenoids 23-nor-oxopristimerol (5) and 2,3-dihydroxy-6-oxo-D:A-froedo-24 nor-1,3,5(10),7-oleanatetraen-29-oic acid (6), have been isolated from the root barks of Tripterygium hypoglaucum. Their structures were elucidated by NMR spectroscopy and MS analysis. Compounds 1-3 were screened for their cytotoxic activities against five cancer cell lines, but all of them were inactive.
Journal of Asian natural products research 10/2012; 14(10):973-80. · 0.61 Impact Factor
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ABSTRACT: Eleven oleanane-type triterpenoid glycosides, named gordonsaponins A-K, were isolated from the stems of Gordonia kwangsiensis. Their structures were elucidated by spectroscopic and chemical methods. The cytotoxic activities of all eleven were evaluated against five human tumor cell lines (HCT-8, Bel-7402, BGC-823, A549, and A2780), with only one having activity against all tested cell lines, with IC(50) values ranging from 0.1 to 2.41μM.
Phytochemistry 09/2012; · 3.35 Impact Factor
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ABSTRACT: To study the chemical constituents of the root bark of Tripterygium hypoglaucum.
Column chromatography was used to separate the chemical constituents. The structures were determined by application of spectroscopic (NMR, MS) and chemical methods.
Eleven compounds were isolated and identified as 4'-0-(-) methylepigallocatechin (1),3,4-dimethoxyphenyl-beta-D-glucopyranoside (2), 3,4,5-trimethoxyphenyl-f-D-glucopyranoside (3), (2R,3R)-3,5,7,3',5'-pentahydroxyflavan (4), 2-O-deacetyleuonine (5), tripfordine C (6), peritassine A (7) hypoglaunine C (8), wilfortrine (9), wilforgine (10) and wilfordine (11).
Compounds 1-6 are isolated from this plant for the first time.
Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 07/2012; 35(7):1083-7.
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ABSTRACT: Two new neolignans, (+)-(7R,8R)-4-hydroxy-3,3',5'-trimethoxy-8',9'-dinor-8,4'- oxyneoligna-7,9-diol-7'-aldehyde (1) and (-)-(7S,8R)-4-hydroxy-3,3',5'-trimethoxy-8', 9'-dinor-8,4'-oxyneoligna-7,9-diol-7'-aldehyde (2), were isolated from the stems of Euonymus oblongifolius. Their chemical structures were determined according to HR-ESI-MS, CD, 1D and 2D NMR spectroscopic analyses.
Journal of Asian natural products research 06/2012; 14(8):755-8. · 0.61 Impact Factor
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ABSTRACT: Ten new carbazole alkaloids, claulansines A-J (1-10), and seven known analogues (11-17) were isolated from the stems of Clausena lansium. Their structures were established on the basis of extensive spectroscopic analyses, and their absolute configurations were determined by CD experiments and computational methods. Screening results indicated that compounds 1, 6, 8-10, 13, 14, and 17 showed selective neuroprotective effects at the concentration of 10 μM.
Journal of Natural Products 02/2012; 75(4):677-82. · 3.13 Impact Factor
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ABSTRACT: Four new neolignans, wilfordiols A-D (1-4), together with five known compounds (5-9), were isolated from an aqueous extract of the dried leaves of Tripterygium wilfordii. Their structures were determined by spectroscopic methods, including 1D and 2D NMR, HRESIMS, and CD experiments. The anti-inflammation activities of compounds 1-9 were evaluated by the inhibitory effect on NO production, in vitro.
Fitoterapia 12/2011; 83(2):343-7. · 1.85 Impact Factor
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ABSTRACT: Eight new oleanane-type triterpenoid glycosides, gordonosides I-P (1-8), and two new phenolic glycosides (9 and 10) were isolated from the stems of Gordonia chrysandra. Their structures were elucidated by spectroscopic and chemical methods. In an in vitro bioassay, compound 1 showed a strong inhibitory effect on nitric oxide production in LPS-activated macrophages with an IC50 value of 0.14 μM.
Journal of Natural Products 05/2011; 74(5):1066-72. · 3.13 Impact Factor
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ABSTRACT: A new megastigmane glucoside (6S,7E,9S)-6,9,10-trihydroxy-4,7-megastigmadien-3-one 9-O-β-d-glucopyranoside (1) and a new amide alkaloid (E)-N-(4-methoxyphenethyl)-2-methylbut-2-enamide (2), together with three known amide alkaloids (3-5), were isolated from the leaves of Clausena lansium (Lour.) Skeels. Their structures were elucidated by their physicochemical properties and analysis of their spectral data.
Journal of Asian natural products research 04/2011; 13(4):361-6. · 0.61 Impact Factor
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ABSTRACT: Three novel sesquiterpenoid-based meroterpenoids of psidials A-C (1-3) have been isolated from the leaves of Psidium guajava L. Their complete structures were elucidated by spectral and chemical methods, and that of 1 was confirmed by single-crystal X-ray diffraction analysis. Psidial B (2) and C (3) represented the new skeleton of the 3,5-diformylbenzyl phloroglucinol-coupled sesquiterpenoid. A possible biosynthetic pathway for 2-3 was postulated. 2-3 showed activity to enzyme PTP1B in 10 microM.
Organic Letters 02/2010; 12(4):656-9. · 5.86 Impact Factor
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ABSTRACT: To study the chemical constituents of the fruits of Paliurus ramosissimus, various chromatographic techniques were used to separate and purify the chemical constituents. Three triterpenes have been isolated and purified by using various column chromatography. Their structures were elucidated by their physico-chemical properties and spectroscopic data. These compounds were determined as: 22S, 23R-epoxy-tirucalla-7-ene-3alpha,24, 25-triol (1), 21S, 23R-epoxy-21, 24S, 25-trihydroxy-apotirucalla-7-ene-3-one (2), 21R, 23R-epoxy-21-ethoxy-24S, 25-dihydroxy-apotirucalla-7-ene-3-one (3), separately. Compound 1 is a new compound, and the others were obtained from this genus for the first time.
Yao xue xue bao = Acta pharmaceutica Sinica 06/2009; 44(6):625-7.
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ABSTRACT: Eight new oleanane triterpenoid glycosides, gordonosides A-H (1-8), were isolated from a 50% EtOH extract of the roots of Gordonia chrysandra. Their structures were determined by spectroscopic analysis, including 1D and 2D NMR and ESIMS, and by chemical methods. Among these substances, compounds 1, 3, 5, and 6 exhibited cytotoxic activity against several human cancer cell lines, with 3 being the most potent.
Journal of Natural Products 05/2009; 72(5):866-70. · 3.13 Impact Factor
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ABSTRACT: Three new xanthones, 1,3-dihydroxy-2,5,6,7-tetramethoxyxanthone (1), 3-hydroxy-1,2,5,6,7-pentamethoxyxanthone (2), and 3,8-dihydroxy-1,2,6-trimethoxyxanthone (3), together with two known compounds were isolated from the roots of Polygala japonica Houtt. Their structures were determined on the basis of spectroscopic data.
Journal of Asian natural products research 02/2009; 11(5):465-9. · 0.61 Impact Factor
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ABSTRACT: To study the chemical constituents in the root of Isatis indigotica.
The constituents root were separated through various chromatographic techniques and their structures were elucidated by means of physicochemical properties and the analysis of their spectral data.
Eleven compounds were isolated and identified as (+) -isolariciresinol (1), lariciresinol (2), lariciresinol-9-O-beta-D-glucopyranoside (3), lariciresinol-4'-O-beta-D-glucopyranoside (4), lariciresinol-4,4'-bis-O-beta-D-glucopyranoside (5), 3-formylindole (6), 1-methoxy-3-indolecarbaldehyde (7), 1-methoxy-3-indoleacetonitrile (8), deoxyvasicinone (9), epigoitrin (10), adenosine (11).
Compounds 4-8 were isolated from I. indigotica for the first time.
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 05/2007; 32(8):688-91.
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ABSTRACT: To study chemical constituents of Solanum lyratum.
The constituens were isolated by polystyrene resin RA, sephadex LH-20 and silica gel column chormatography, their structures were identified by spectroscopic analysis.
Four compounds were identified as The constituens were caffeic acid, vanillic acid, rutin and N(p-hydropheneethyl) p-coumaramide.
These compounds were isolated from this plant for the first time.
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 02/2002; 27(1):42-3.
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ABSTRACT: Two new sesquiterpene lactones (1) and (2), along with three known sesquiterpenes, atractylenolide beta (3), chloranthalactone E (4), and ( - )-istanbulin A (5), were isolated from the whole plant of Sarcandra glabra. The structures of two new compounds were established as 8beta,9alpha-dihydroxyeudesman-4(15),7(11)-dien-8alpha,12-olide (1) and 8beta,9alpha-dihydroxylindan-4(5),7 (11)-dien-8alpha,12-olide (2) on the basis of spectroscopic analysis. Compound 3 was isolated from this genus for the first time.
Journal of Asian Natural Products Research 10(5-6):541-5. · 0.94 Impact Factor
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ABSTRACT: Three new dibenz[b,f]oxepins: 6-methoxy-7-methyl-8-hydroxydibenz[b, f]oxepin (1), 1,8-dimethoxy-6-hydroxy-7-methyldibenz[b, f]oxepin (2), and 1-hydroxy-6,8-dimethoxy-7-methyldibenz[b,f]oxepin (3), along with two known dibenz[b,f]oxepins pacharin (4) and bauhiniastatin 4 (5), were isolated from Cercis chinensis Bunge (Leguminosae). Their structures were elucidated on the basis of spectroscopic evidence (EI-MS, UV, IR, (1)H, (13)C and 2D NMR). Compounds 1-5 were isolated from the Cercis genus for the first time.
Journal of Asian Natural Products Research 9(6-8):649-53. · 0.94 Impact Factor
