Gabriella Spiridon

Publications (4)13.56 Total impact

• Article: Efavirenz in plasma from HIV-infected patients does not directly block reverse transcriptase activity in cell-free assays but inhibits HIV replication in cellular assays.

  Renaud Burrer, Gabriella Spiridon, Sandrine Einius-Haessig, Sophie Richert, Dominique Salmon-Ceron, Gianfranco Pancino, Anne Marie Aubertin, Christiane Moog
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  ABSTRACT: The aim of this study was to characterize the potent nonimmunoglobulin (Ig) inhibitory activity defected in plasma from some HIV-infected, efavirenz (EFV)-treated patients. Concentration of EFV in plasma was measured by HPLC and correlation with reverse transcriptase (RT) inhibition or decrease in virus replication in cellular assays was searched. After plasma protein elimination by ethanol extraction, an inhibitory activity is measurable on RT in vitro that correlates with EFV concentration determined by HPLC. However, total plasma-containing EFV does not inhibit RT activity in cell-free assay, but it does efficiently inhibit virus replication in cell culture assays. Thus, despite being bound to plasma proteins (retention of EFV after extensive dialysis), EFV in plasma conserves its antiviral activity on infected cells. This observation precludes the use of crude sera and plasmas from EFV-treated patients for the study of antibody-mediated neutralizing activity.
  AIDS Research and Human Retroviruses 10/2006; 22(9):865-9. · 2.25 Impact Factor
• Article: Nodular regenerative hyperplasia of the liver after IL-2 therapy in an HIV-infected patient.

  Philippe Podevin, Gabriella Spiridon, Benoit Terris, Laurence Chauvelot-Moachon, Loic Guillevin, Stanislas Chaussade, Philippe Sogni, Dominique Salmon-Ceron
  AIDS 02/2006; 20(2):313-5. · 6.24 Impact Factor
• Source

  Available from: oxfordjournals.org

  Article: Bacterial prostatitis due to Pseudomonas aeruginosa harbouring the blaVIM-2 metallo-{beta}-lactamase gene from Saudi Arabia.

  François Guerin, Corneliu Henegar, Gabriella Spiridon, Odile Launay, Dominique Salmon-Ceron, Claire Poyart
  Journal of Antimicrobial Chemotherapy 10/2005; 56(3):601-2. · 5.07 Impact Factor
• Article: Immunoglobulin G (IgG) and IgA, but also Nonantibody Factors, Account for In Vitro Neutralization of Human Immunodeficiency Virus (HIV) Type 1 Primary Isolates by Serum and Plasma of HIV-Infected Patients

  Renaud Burrer, Dominique Salmon-Ceron, Sophie Richert, Gianfranco Pancino, Gabriella Spiridon, Sandrine Haessig, Virginie Roques, Francoise Barre-Sinoussi, Anne-Marie Aubertin, Christiane Moog