Guowei Pan

Shenyang Medical College, Feng-t’ien, Liaoning, China

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Publications (29)88.95 Total impact

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    ABSTRACT: Polycyclic aromatic hydrocarbons (PAHs) are multiple compounds that include many carcinogens. We conducted a cross-sectional study in steel plant workers in Anshan, China, to identify biomarkers that reflect the carcinogenicity of PAHs. Subjects were 57 workers and 20 controls. Level of personal exposure to PAHs was measured using GC-MS. In accordance with the assessment methods defined by the United States Environmental Protection Agency (US EPA), 15 PAHs were selected for the analysis. For the measurement of urinary metabolites, urine samples were treated with β-glucuronidase and analyzed using HPLC with a fluorescence detector. The mean range of personal exposure to 15 PAHs (total PAHs) was 178.85, 47.08-1,329.45 (geometric mean, 5th and 95th percentile) μg/m(3). Ten known urinary metabolites (1-hydroxynaphthalene, 2-hydroxynaphthalene, 2-hydroxyfluorene, 1-hydroxyphenanthrene, 3-hydroxyphenanthrene, 9-hydroxyphenanthrene, 1-hydroxypyrene, 3-hydroxybenz[a]anthracene, 6-hydroxychrysene, and 3-hydroxybenzo[a]pyrene) and four unknown peaks were detected. The highest correlation was between total PAHs and urinary 2-hydroxynaphthalene (Spearman r = 0.716, P < 0.01). Among the detected urinary metabolites, 2-hydroxyfluorene, 1-hydroxyphenanthrene, 3-hydroxyphenanthrene, and 1-hydroxypyrene were found to correlate significantly with the "Σ carcinogenic potency of PAHs" (sum of seven carcinogenic PAHs calculated from the levels of personal PAHs and relative potency factors), and with the greatest correlation found for 1-hydroxypyrene (Spearman r = 0.630, P < 0.01). The analysis of personal exposure to 15 PAHs and 10 urinary metabolites, and calculation of Σ carcinogenic potency, indicated that urinary 1-hydroxypyrene was the most comprehensive carcinogenic biomarker of exposure to PAHs.
    International Archives of Occupational and Environmental Health 10/2013; 87(7). DOI:10.1007/s00420-013-0913-6 · 2.20 Impact Factor
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    ABSTRACT: This study aimed to assess whether Chinese men who have sex with men (MSM) had a significantly elevated prevalence of psychiatric disorders compared to urban males in China. 807 MSM were recruited using a respondent-driven sampling (RDS) method in urban area of northeast China. Psychiatric disorders were assessed employing the Composite International Diagnostic Interview (CIDI. Version 1.0) according to the criteria of the DSM-III-R. Chinese MSM had a significantly elevated standardized prevalence ratios (SPR) for lifetime prevalence of any disorder (SPR = 2.8; 95%CI: 2.5-3.2), mood disorder (SPR = 3.0; 95%CI: 2.3-3.7), anxiety disorder (SPR = 5.5; 95% CI: 4.6-6.5), alcohol use disorder (SPR = 2.4, 95%CI: 2.0-2.8), and combination of disorders (SPR = 4.2; 95%CI: 3.4-5.1). Chinese MSM had significantly elevated prevalence and comorbidity of psychiatric disorders. RDS is a suitable sampling method for psychiatric epidemiological survey in MSM population.
    PLoS ONE 04/2013; 8(4):e50762. DOI:10.1371/journal.pone.0050762 · 3.53 Impact Factor
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    ABSTRACT: China is one of the few countries with some of the highest particulate matter levels in the world. However, only a small number of particulate matter health studies have been conducted in China. The study objective was to examine the association of particulate matter with an aerodynamic diameter of less than 10 μm (PM(10)) with daily mortality in 16 Chinese cities between 1996 and 2008. Two-stage Bayesian hierarchical models were applied to obtain city-specific and national average estimates. Poisson regression models incorporating natural spline smoothing functions were used to adjust for long-term and seasonal trends of mortality, as well as other time-varying covariates. The averaged daily concentrations of PM(10) in the 16 Chinese cities ranged from 52 μg/m(3) to 156 μg/m(3). The 16-city combined analysis showed significant associations of PM(10) with mortality: A 10-μg/m(3) increase in 2-day moving-average PM(10) was associated with a 0.35% (95% posterior interval (PI): 0.18, 0.52) increase of total mortality, 0.44% (95% PI: 0.23, 0.64) increase of cardiovascular mortality, and 0.56% (95% PI: 0.31, 0.81) increase of respiratory mortality. Females, older people, and residents with low educational attainment appeared to be more vulnerable to PM(10) exposure. Conclusively, this largest epidemiologic study of particulate air pollution in China suggests that short-term exposure to PM(10) is associated with increased mortality risk.
    American journal of epidemiology 04/2012; 175(11):1173-81. DOI:10.1093/aje/kwr425 · 4.98 Impact Factor
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    ABSTRACT: Few studies have explored concentration-response (C-R) relationships between levels of particulate matter (PM) and respiratory morbidity in terms of the susceptibility of children to respiratory diseases. We sought to determine whether the shapes of C-R curves for comparing total suspended particle (TSP) concentration versus the adjusted prevalence of bronchitis (persistent cough or phlegm) and asthma (current wheeze or asthma) symptoms between children with a different susceptibility status. We used the restricted cubic spline (RCS) function to characterize the C-R relationships between TSP and the adjusted prevalence rates of four respiratory symptoms, after controlling for possible confounding by SO(2) and NO(2) levels, in 11,860 children selected from 18 districts of six cities in Liaoning province. Susceptible children exhibited a 2- to 3-fold elevation in the prevalence of all four respiratory symptoms across the entire TSP range (188-689μg/m(3)). Significant differences in the shapes of C-R curves were evident in children with symptoms of bronchitis (ballistic "S"-shaped curves) and asthma (flattened "U"-shaped curves), as well as between the low and high TSP ranges of such curves, when children were grouped by susceptibility status. A significant linear association between TSP levels and current asthma prevalence was found only among susceptible children exposed to high levels of TSP. The shapes and properties of the TSP-morbidity C-R curves differed significantly by type of respiratory symptom, susceptibility status, and TSP range. More work is required to characterize CR relationships in terms of susceptibility status in countries with different PM levels.
    Science of The Total Environment 02/2012; 421-422:111-7. DOI:10.1016/j.scitotenv.2012.01.008 · 3.16 Impact Factor
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    ABSTRACT: Evidence concerning the health risks of coarse particles (PM(10-2.5)) is limited. There have been no multi-city epidemiologic studies of PM(10-2.5) in developing Asian countries. We examine the short-term association between PM(10-2.5) and daily mortality in three Chinese cities: Beijing, Shanghai, and Shenyang. PM(10-2.5) concentrations were estimated by subtracting PM(2.5) from PM(10) measurements. Data were analyzed using the over-dispersed generalized linear Poisson models. The average daily concentrations of PM(10-2.5) were 101 μg/m(3) for Beijing (2007-2008), 50 μg/m(3) for Shanghai (2004-2008), and 49 μg/m(3) for Shenyang (2006-2008). In the single-pollutant models, the three-city combined analysis showed significant associations between PM(10-2.5) and daily mortality from both total non-accidental causes and from cardiopulmonary diseases. A 10-μg/m(3) increase in 1-day lagged PM(10-2.5) was associated with a 0.25% (95% CI: 0.08 to 0.42) increase in total mortality, 0.25% (95% CI: 0.10 to 0.40) increase in cardiovascular mortality, and 0.48% (95% CI: 0.20 to 0.76) increase in respiratory mortality. However, these associations became statistically insignificant after adjustment for PM(2.5). PM(2.5) was significantly associated with mortality both before and after adjustment for PM(10-2.5). In conclusion, there were no statistically significant associations between PM(10-2.5) and daily mortality after adjustment for PM(2.5) in the three Chinese cities.
    Science of The Total Environment 09/2011; 409(23):4934-8. DOI:10.1016/j.scitotenv.2011.08.058 · 3.16 Impact Factor
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    ABSTRACT: Ambient carbon monoxide (CO) is an air pollutant primarily generated by traffic. CO has been associated with increased mortality and morbidity in developed countries, but few studies have been conducted in Asian developing countries. In the China Air Pollution and Health Effects Study (CAPES), the short-term associations between ambient CO and daily mortality were examined in three Chinese cities: Shanghai, Anshan and Taiyuan. Poisson regression models incorporating natural spline smoothing functions were used to adjust for long-term and seasonal trend of mortality, as well as other time-varying covariates. Effect estimates were obtained for each city and then for the cities combined. In both individual-city and combined analysis, significant associations of CO with both total non-accidental and cardiovascular mortality were observed. In the combined analysis, a 1 mg/m(3) increase of 2-day moving average concentrations of CO corresponded to 2.89% (95%CI: 1.68, 4.11) and 4.17% (95%CI: 2.66, 5.68) increase of total and cardiovascular mortality, respectively. CO was not significantly associated with respiratory mortality. Sensitivity analyses showed that our findings were generally insensitive to alternative model specifications. In conclusion, ambient CO was associated with increased risk of daily mortality in these three cities. Our findings suggest that the role of exposure to CO and other traffic-related air pollutants should be further investigated in China.
    Science of The Total Environment 09/2011; 409(23):4923-8. DOI:10.1016/j.scitotenv.2011.08.029 · 3.16 Impact Factor
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    ABSTRACT: The knowledge on the dose-response relationships between cumulative phthalate exposure and reproductive hormones in human are lacking. To assess the characteristics of the associations between hazard index (HI) of cumulative di-n-butylphthalate (DBP) and di-2-ethylhexylphthalate (DEHP) exposures and serum concentrations of free testosterone (fT), estradiol, luteinizing hormone (LH) and follicle-stimulating hormone (FSH), we used restricted cubic spline function to characterize the dose-response curves between the HI values and reproductive hormones for 74 male workers occupationally exposed to high levels of DBP and DEHP, and 63 male construction workers as comparison group matched for age and smoking status. The median of HI value was 5.30 for exposed workers, 53.0-fold that of unexposed workers (0.10). 89.2% of exposed workers and 1.6% of unexposed workers have HI over 1.00. We observed a borderline significantly negative association between HI and fT in exposed workers (r=-0.195, p=0.096), but not in unexposed workers. The exposed workers showed inverted long-tailed J-shaped fT and FSH curves, and small changes in the LH curve, whereas unexposed workers had inverted and flattened-S-shaped fT and mirror-S-shaped LH and FSH curves. Both T production and hypothalamo-pituitary-testis (HPT) axis function were damaged in workers with high HI of phthalate exposures. HPT feedback function was activated in workers with both high and low HI, and plays an important role in preventing fT level from further decreasing with a rise in HI.
    International Journal of Andrology 07/2011; 34(5 Pt 2):e397-406. DOI:10.1111/j.1365-2605.2011.01201.x · 3.21 Impact Factor
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    ABSTRACT: Fine particulate matter (PM₂.₅) is not a criteria pollutant in China, and few studies were conducted in the country to investigate the health impact of PM₂.₅. In this study, we did a time-stratified case-crossover analysis to examine the association between PM₂.₅ and daily mortality in Shenyang, an industrial center in northeast China. Daily mortality, air pollution and weather data from August 1, 2006 to December 31, 2008 in Shenyang were collected. A time-stratified case-crossover approach was used to estimate the association of PM₂.₅ with both total and cause-specific mortality. Controls were selected as matched days of the week in the same month. Potential effect modifiers, such as age, gender, and season, were also examined. We found significant associations between PM₂.₅ and daily mortality in Shenyang. A 10 μg/m³ increment in the 2-day moving average (lag 01) concentrations of PM₂.₅ corresponded to 0.49% (95% CI: 0.19%, 0.79%), 0.53% (95% CI: 0.09%, 0.97%), and 0.97% (95% CI: 0.01%, 1.94%) increase of total, cardiovascular, and respiratory mortality, respectively. The associations appeared to be stronger in older people (aged ≥ 75 years), in females and during the warm season. To our knowledge, this is the longest PM₂.₅ health study in time duration in China. Our findings provide new information on the adverse health effects of PM₂.₅, and may have implications for environmental policy making and standard setting in China.
    Science of The Total Environment 06/2011; 409(13):2473-7. DOI:10.1016/j.scitotenv.2011.03.017 · 3.16 Impact Factor
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    ABSTRACT: The associations between air pollution and children's respiratory health in the high pollution range have not yet been clearly characterized. We evaluated the effects of outdoor air pollution on respiratory morbidity in children selected from multiple sites in a heavy industrial province of northeastern China. The study included 11,860 children aged 3-12 years, selected from 18 districts of 6 cities in Liaoning province, the participation rate is 89.9%. Informed consent and written responses to surveys about children's historic and current health status, personal and household characteristics, and other information were obtained from parents. A two-stage regression approach was applied in data analyses. There were wide gradients for TSP (188-689 μg/m(3)), SO(2) (14-140 μg/m(3) and NO(2) (29-94 μg/m(3)) across the 18 districts of 6 cities. The three air pollutants significantly increased the prevalence of persistent cough (21-28%), persistent phlegm (21-30%) and current asthma (39-56%) for each interquartile range increment (172 μg/m(3) for TSP, 69 μg/m(3) for SO(2), 30 μg/m(3) for NO(2)), showing larger between-city effects than within-city. Rates of respiratory symptoms were significantly higher for children with younger age, atopy, respiratory disease in early age, family history of asthma or chronic bronchitis, and tobacco smoke exposure. The high levels of outdoor air pollution in north China are positively associated with children's respiratory symptoms, the associations with TSP appear to be stronger than SO(2) and NO(2).
    Respiratory medicine 12/2010; 104(12):1903-11. DOI:10.1016/j.rmed.2010.07.018 · 2.92 Impact Factor
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    ABSTRACT: Few case-crossover studies were conducted in China to investigate the acute health effects of air pollution. We conducted a time-stratified case-crossover analysis to examine the association between air pollution and daily mortality in Anshan, a heavily-polluted industrial city in northeastern China. Daily mortality, air pollution, and weather data in 2004-2006 in Anshan were collected. Time-stratified case-crossover approach was used to estimate the effect of air pollutants (PM(10), SO(2), NO(2) and CO) on total and cardiopulmonary mortality. Controls were selected as matched days of the week in the same month. Potential effect modifiers, such as gender and age, were also examined. We found significant associations between air pollution and daily mortality from cardiovascular diseases in Anshan. A 10μg/m(3) elevation of 2-day moving average (lag 01) concentration in PM(10), SO(2), NO(2) and CO corresponded to 0.67% (95% CI: 0.29%, 1.04%), 0.38% (95% CI: -0.06%, 0.83%), 2.11% (95% CI: 0.22%, 4.00%) and 0.04% (95% CI: 0.01%, 0.07%) increase of cardiovascular mortality. The associations for total and respiratory mortality were generally positive but statistically insignificant. The air pollution health effects were significantly modified by age, but not by gender. Conclusively, our study showed that short-term exposure to air pollution was associated with increased cardiovascular mortality in Anshan. These findings may have implications for local environmental and social policies.
    Science of The Total Environment 10/2010; 408(24):6086-91. DOI:10.1016/j.scitotenv.2010.09.018 · 3.16 Impact Factor
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    ABSTRACT: National disparities in asbestos use will likely lead to an unequal burden of asbestos diseases. As economic status may be linked to asbestos use, we assessed, globally, the relationship between indicators of national economic development and asbestos use. For the 135 countries that have ever used asbestos, per capita asbestos use (kilograms per capita per year) was compared with per capita gross domestic product (GDP) in 1990 Geary-Khamis dollars (GKD) for the period 1920-2003. Countries were grouped into three income levels (high, middle, and low) that were adapted from the 2003 World Bank categories. The historical pattern of asbestos use followed the environmental Kuznets curve in which use by high-income countries peaked when incomes attained 10,000-15,000 GKD and essentially ceased at income levels over 20,000 GKD. Currently, middle- and low-income countries are increasing their use of asbestos, closely following the paths once traced by higher income countries. Developing countries have the opportunity to eliminate asbestos use sooner than high-income countries and thus reduce the future burden of asbestos diseases.
    Environmental Health Perspectives 01/2010; 118(1):116-9. DOI:10.1289/ehp.0901196 · 7.03 Impact Factor
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    ABSTRACT: In response to the health risks posed by asbestos exposure, some countries have imposed strict regulations and adopted bans, whereas other countries have intervened less and continue to use varying quantities of asbestos. This study was designed to assess, on a global scale, national experiences of recent mortality from pleural mesothelioma, historical trends in asbestos use, adoption of bans, and their possible interrelationships. For 31 countries with available data, we analyzed recent pleural mesothelioma (International Classification of Diseases, 10th Revision) mortality rates (MRs) using age-adjusted period MRs (deaths/million/year) from 1996 to 2005. We calculated annual percent changes (APCs) in age-adjusted MRs to characterize trends during the period. We characterized historical patterns of asbestos use by per capita asbestos use (kilograms per capita/year) and the status of national bans. Period MRs increased with statistical significance in five countries, with marginal significance in two countries, and were equivocal in 24 countries (five countries in Northern and Western Europe recorded negative APC values). Countries adopting asbestos bans reduced use rates about twice as fast as those not adopting bans. Turning points in use preceded bans. Change in asbestos use during 1970-1985 was a significant predictor of APC in mortality for pleural mesothelioma, with an adjusted R(2) value of 0.47 (p < 0.0001). The observed disparities in global mesothelioma trends likely relate to country-to-country disparities in asbestos use trends.
    Environmental Health Perspectives 12/2008; 116(12):1675-80. DOI:10.1289/ehp.11272 · 7.03 Impact Factor
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    ABSTRACT: In China, significant levels of environmental pollution, substandard worksite quality and high rates of smoking predispose the population to potentially high risks of respiratory illnesses and other diseases. We assessed the prevalence of respiratory symptoms and their risks in relation to personal, occupational and environmental risk factors in a heavy-industry province of northeastern China. Lifestyle, health, residential and occupational data were obtained in 2002 from 31,704 adults of six cities in Liaoning, China, using self-assessment questionnaires. General linear and multi-level models were used to evaluate prevalence rates and risks of respiratory symptoms, related to both individual and combined exposures to environmental and occupational risk factors. The crude prevalence rates (PRs) for persistent cough, persistent phlegm, wheeze and asthma were 2.3, 3.8, 2.1 and 1.0%, respectively. The odds ratios (ORs) of all four respiratory symptoms examined were increased by: smoking (ORs from 2.06 to 5.02), occupational dust (ORs from 1.35 to 1.72), occupational gas (ORs from 1.48 to 1.72) and presence of irritating smoke during cooking (ORs from 1.54 to 2.22). An index combining proximity of residence to road, factory or chimney, indoor coal use and presence of irritating smoke during cooking was associated with up to 3.9-fold increased risks of all symptoms. Increasing values of each risk factor were generally associated with dose-response trends in prevalence rates and risks (all p for trend <0.01). The crude PRs of symptoms were lower than those reported by European and American studies but closer to those of previous Chinese studies. The risks of respiratory symptoms in this population were increased by smoking, occupational exposures to dust and gas, and combined residence-related exposures such as living close to a main road, factory or chimney, indoor coal use and the presence of irritating smoke during cooking, among other risk factors.
    Respiratory medicine 08/2008; 102(11):1536-44. DOI:10.1016/j.rmed.2008.06.010 · 2.92 Impact Factor
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    ABSTRACT: Observations of adverse developmental and reproductive effects in laboratory animals and wildlife have fueled increasing public concern regarding the potential for various chemicals to impair human fertility. Our objective in this study was to assess the effect of occupational exposure to high levels of phthalate esters on the balance of gonadotropin and gonadal hormones including luteinizing hormone, follicle-stimulating hormone, free testosterone (fT), and estradiol. We examined urine and blood samples of 74 male workers at a factory producing unfoamed polyvinyl chloride flooring exposed to di-n-butyl phthalate (DBP) and di-2-ethylhexyl phthalate (DEHP) and compared them with samples from 63 male workers from a construction company, group matched for age and smoking status. Compared to the unexposed workers, the exposed workers had substantially and significantly elevated concentrations of mono-n-butyl phthalate (MBP; 644.3 vs. 129.6 microg/g creatinine, p < 0.001) and mono-2-ethylhexyl phthalate (MEHP; 565.7 vs. 5.7 microg/g creatinine, p < 0.001). fT was significantly lower (8.4 vs. 9.7 microg/g creatinine, p = 0.019) in exposed workers than in unexposed workers. fT was negatively correlated to MBP (r = -0.25, p = 0.03) and MEHP (r = -0.19, p = 0.095) in the exposed worker group. Regression analyses revealed that fT decreases significantly with increasing total phthalate ester score (the sum of quartiles of MBP and MEHP; r = -0.26, p = 0.002). We observed a modest and significant reduction of serum fT in workers with higher levels of urinary MBP and MEHP compared with unexposed workers.
    Environmental Health Perspectives 11/2006; 114(11):1643-8. · 7.03 Impact Factor
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    ABSTRACT: Although adequate assessment of exposure is needed in epidemiological studies among foundry workers, previous studies are often lacking in this aspect. We conducted a retrospective cohort study of a Chinese iron and steel company with a 14-yr follow up during 1980-1993. Exposure assessment was performed for a single job, i.e., the current job for the active worker and the longest job for the retired or deceased worker as of the end of the follow-up, which was allocated as the surrogate of lifetime job and was applied to a job-exposure matrix. Of the 147,062 cohort members, 52,394 males (43%) and 5,291 females (21%) were exposed to any of 15 hazardous factors such as dust, silica, PAHs (polycyclic aromatic hydrocarbons), CO (carbon monoxide) and heat. In 2,104 randomly selected samples, the exposure assessment of exposed workers based on a single job was found to be 12-14% lower than the real situation. This study suggests that the exposure assessment is valuable in evaluating the health effects among the foundry workers, despite some limitations such as underestimation of exposure assessment and the lack of data regarding smoking and drinking habits.
    Journal of UOEH 10/2006; 28(3):253-63.
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    ABSTRACT: Foundry workers have increased mortality and morbidity risks from numerous causes, including various cancers. A retrospective Chinese iron-steel cohort study was conducted to examine the mortality effects of exposure to foundry work. Standardized mortality ratios (SMRs) and standardized rate ratios (SRRs) were calculated to evaluate mortality risks among male workers with exposure to 15 hazardous factors, adjusting for confounders. During 14 years of follow-up, 13,363 of 121,846 male workers died. SMR analysis showed a healthy-worker effect in comparison with the general population. SRR analysis showed increased risks for all causes, all neoplasms, and others among the exposed workers compared with non-exposed blue-collar workers. Combined exposure to polycyclic aromatic hydrocarbons and two or more dusts increased the risks of lung cancer (SRR = 654; 95% CI: 113-3,780) and other malignancies. Foundry work has adverse health effects, including carcinogenic risks.
    International journal of occupational and environmental health 07/2006; 12(3):193-202. DOI:10.1179/oeh.2006.12.3.193 · 1.10 Impact Factor
  • Environmental Health Perspectives 01/2006; DOI:10.1289/ehp.9016 · 7.03 Impact Factor
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    ABSTRACT: The line of research focusing on the human, especially male, reproductive system in relation to occupational exposure has diversified since the infiltration of the concept of endocrine disrupting chemicals (EDC), early in the 1990s. The main stream, until then, was the study of reproductive toxicity caused by single albeit relatively heavy exposures to chemicals of limited range (conventional scheme). The new and increasingly important stem is the search for a wider range of chemicals with endocrine disrupting potential, and health effects due to multiple low-dose exposures of potent chemicals (new scheme). There are also studies having aspects of both the conventional and new schemes. For studies with the new scheme, progress has been made in areas such as adherence to standardized techniques in evaluating male reproductive function and more sensitive study designs. Indeed, some studies have suggested the presence of EDCs in the occupational setting. However, epidemiological findings are still constrained by difficulties in the identification of occupationally-exposed populations and evaluation of exposure. There is thus a need for convergence of knowledge and a widening of the scope of epidemiological research targeting occupationally exposed populations under a carefully-designed protocol.
    Journal of UOEH 04/2004; 26(1):23-40.
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    ABSTRACT: To investigate the potential for exposure to polycyclic aromatic hydrocarbons (PAHs) to induce oxidative DNA damage, we conducted a cross-sectional study in coke-oven workers employed at an iron-steel factory. The study population contained 119 coke-oven workers from different work areas of the oven and 38 controls. Personal information on age, employment duration, smoking habit and alcohol consumption was obtained at an interview. Leukocyte 8-hydroxydeoxyguanosine (8-OHdG) was measured by high performance liquid chromatography with electrochemical detection. Leukocyte aromatic DNA adducts as effective dose, and urinary 1-hydroxypyren as internal dose, were also measured, and used to analyze the relationship of 8-OHdG with other biomarkers for PAH exposure, tobacco smoke and alcohol consumption. The leukocyte 8-OHdG revealed a wide inter-individual variation. The highest 8-OHdG level was detected in bottom-workers of the coke-oven. There were significant differences among the four different work areas ( P=0.02). We could not find significant correlation between 8-OHdG levels and urinary 1-hydroxypyrene, but a weakly positive correlation was found between 8-OHdG and leukocyte aromatic DNA adducts among all subjects (r=0.19 P=0.03). We could not observe any effect of smoking and alcohol drinking on 8-OHdG production. We could not find clear evidence that PAH exposure induces oxidative DNA damage.
    International Archives of Occupational and Environmental Health 10/2003; 76(7):499-504. DOI:10.1007/s00420-003-0449-2 · 2.20 Impact Factor
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    ABSTRACT: As a preliminary epidemiological study, we evaluated the geographical correlation between estimated ambient ultraviolet B (UVB) levels and the mortality risk of leukemia in Japan. Ambient UVB levels were estimated from meteorological data for several successive periods. The standardized mortality ratio (SMR) was calculated for the 11 regions or 38 large cities and different times for nine types of leukemia [the International Classification of Diseases, ninth revision (ICD-9), ICD 200-208]. The ecological relationship was assessed by calculating Spearman's correlation coefficient. Among the nine types of leukemia, geographical correlation was found for two types of leukemia: "other malignant neoplasms of lymphoid and histiocytic tissue" (ICD 202) and "lymphoid leukemia" (ICD 204). The correlation coefficients between the SMR and UVB levels were statistically significant and ranged from 0.4 to 0.7 for the former and from 0.3 to 0.6 for the latter type of leukemia. This ecological study generated the hypothesis that UVB exposure may increase the risk of leukemias of lymphatic origin.
    Environmental Research 07/2003; 92(2):78-84. · 3.95 Impact Factor

Publication Stats

617 Citations
88.95 Total Impact Points


  • 2013
    • Shenyang Medical College
      Feng-t’ien, Liaoning, China
  • 2003–2013
    • Jiangsu Provincial Center for Disease Control and Prevention
      Chiang-tu, Jiangsu Sheng, China
  • 2012
    • Fudan University
      • School of Public Health
      Shanghai, Shanghai Shi, China
  • 2004–2006
    • University of Occupational and Environmental Health
      • Department of Environmental Epidemiology
      Kitakyūshū, Fukuoka, Japan
  • 2001
    • Tokyo Women's Medical University
      • Department of Hygiene and Public Health II
      Edo, Tōkyō, Japan