Publications (23)63.4 Total impact
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Article: [Marjolin's ulcer in a patient with residual Hansen's disease].
Enfermedades Infecciosas y Microbiología Clínica 06/2011; 29(10):781-3. · 1.49 Impact Factor -
Article: [Acute encephalopathy and mononucleosis syndrome associated with tuberculosis chemoprophylaxis].
Enfermedades Infecciosas y Microbiología Clínica 11/2010; 28(9):657-8. · 1.49 Impact Factor -
Article: The population-based prevalence of osteoporotic vertebral fracture and densitometric osteoporosis in postmenopausal women over 50 in Valencia, Spain (the FRAVO study).
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ABSTRACT: To estimate the prevalence of vertebral fracture and densitometric osteoporosis in postmenopausal women over the age of 50 in Valencia, Spain. This cross-sectional study was conducted in 2006-2007. An age-stratified population-based random sample of 824 postmenopausal women over the age of 50 answered a questionnaire and received a densitometric examination of the lumbar spine and hip with dual-energy X-ray absorptiometry and a lateral X-ray of the thoracic spine and lumbar regions. Osteoporosis was defined as a T-score less than or equal to -2.5 compared to a population of young women, and the presence of vertebral fractures was classified according to Genant's semiquantitative method. The average age of the women was 64 years (range 50-87 years). The prevalence for all vertebral fractures was 21.4% (95% CI: 17.7%-25.1%) and 9.7% (95% CI: 6.7%-12.7%) for moderate-severe fractures. In women over the age of 75, the respective values were 46.3% (95% CI: 34.2%-58.3%) and 23.9% (95% CI:13.6%-34.2%). Only 1.5% of the women with vertebral fractures were aware of their condition. The prevalence of osteoporosis was estimated as 27.0% (95% CI:23.1%-30.8%) for the lumbar spine, 15.1% (95% CI:11.7%-18.5%) in the femoral neck, and 31.8% (95% CI:27.8%-35.7%) at either sites. The study confirms that osteoporosis (1 in 3 women over the age of 50) and vertebral fracture (1 in 5 for all fractures and 1 in 10 for moderate-severe fractures) constitute a major public health and healthcare challenge; measuring their real impact will depend in part on the criteria used to define a fracture.Bone 09/2010; 47(3):610-6. · 4.02 Impact Factor -
Article: Development and validation of a population-based prediction scale for osteoporotic fracture in the region of Valencia, Spain: the ESOSVAL-R study.
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ABSTRACT: Today, while there are effective drugs that reduce the risk of osteoporotic fracture, yet there are no broadly accepted criteria that can be used to estimate risks and decide who should receive treatment. One of the actual priorities of clinical research is to develop a set of simple and readily-available clinical data that can be used in routine clinical practice to identify patients at high risk of bone fracture, and to establish thresholds for therapeutic interventions. Such a tool would have high impact on healthcare policies. The main objective of the ESOSVAL-R is to develop a risk prediction scale of osteoporotic fracture in adult population using data from the Region of Valencia, Spain. Study design: An observational, longitudinal, prospective cohort study, undertaken in the Region of Valencia, with an initial follow-up period of five years; Subjects: 14,500 men and women over the age of 50, residing in the Region and receiving healthcare from centers where the ABUCASIS electronic clinical records system is implanted; Sources of data: The ABUCASIS electronic clinical record system, complemented with hospital morbidity registers, hospital Accidents & Emergency records and the Regional Ministry of Health's mortality register; Measurement of results: Incident osteoporotic fracture (in the hip and/or major osteoporotic fracture) during the study's follow-up period. Independent variables include clinical data and complementary examinations; Analysis: 1) Descriptive analysis of the cohorts' baseline data; 2) Upon completion of the follow-up period, analysis of the strength of association between the risk factors and the incidence of osteoporotic fracture using Cox's proportional hazards model; 3) Development and validation of a model to predict risk of osteoporotic fracture; the validated model will serve to develop a simplified scale that can be used during routine clinical visits. The ESOSVAL-R study will establish a prediction scale for osteoporotic fracture in Spanish adult population. This scale not only will constitute a useful prognostic tool, but also it will allow identifying intervention thresholds to support treatment decision-making in the Valencia setting, based mainly on the information registered in the electronic clinical records.BMC Public Health 03/2010; 10:153. · 2.00 Impact Factor -
Article: [Persistent fever due to ingestion of Hypericum perforatum (St. Johns wort)].
Medicina Clínica 10/2007; 129(9):356-7. · 1.38 Impact Factor -
Article: [Persistent proteinuria in an HIV-infected hypertensive woman].
Enfermedades Infecciosas y Microbiología Clínica 04/2007; 25(3):220-1. · 1.49 Impact Factor -
Article: Inadequate cytoplasmic antioxidant enzymes response contributes to the oxidative stress in human hypertension.
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ABSTRACT: Untreated hypertensive patients show increased oxidative stress and decreased antioxidant enzyme activity in mononuclear cells. Therefore, the objective of this study was to determine whether or not the low antioxidant enzyme activity observed in mononuclear cells of hypertensive subjects is in part dependent on a defective activity of antioxidant mechanisms. Activity and mRNA level of antioxidant enzymes, CuZn- and Mn-superoxide dismutases, catalase, glutathione peroxidase type 1, and glutathione reductase were simultaneously measured in mononuclear cells of controls (n = 38) and hypertensive subjects (n = 35), in the absence of and during antihypertensive treatment. An increase in oxidative stress and a decrease in the activity of cytoplasmic enzymes were observed in untreated hypertensive patients. Concurrently, CuZn-superoxide dismutase and glutathione reductase mRNA levels were significantly reduced, and glutathione peroxidase type 1 mRNA was slightly reduced. In contrast, increased activity and mRNA levels of the mitochondrial Mn-superoxide dismutase were observed. Antihypertensive treatment, nonpharmacologic with or without a drug regimen of beta-blocker or angiotensin AT1 receptor blocker was administered for a 3-month period. Afterward, after the improvement in oxidative stress during treatment, a recovery of the cytoplasmic antioxidant enzymatic activity and a more profound decrease in mRNA levels were observed for CuZn-superoxide dismutase, glutathione peroxidase type 1, and glutathione reductase. Meanwhile mitochondrial enzymatic activity decreased, as did the mRNA level. The inadequate response of the main cytoplasmatic antioxidant systems, as well as of the enzymes participating in the maintenance of glutathione levels, may contribute to the vulnerability of hypertensives to oxidative stress.American Journal of Hypertension 02/2007; 20(1):62-9. · 3.18 Impact Factor -
Article: [Limitations of blood pressure measurement outside the arm].
Medicina Clínica 03/2005; 124(6):217-9. · 1.38 Impact Factor -
Article: Factors related to the impact of antihypertensive treatment in antioxidant activities and oxidative stress by-products in human hypertension.
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ABSTRACT: The objective was to study factors related to the changes induced by antihypertensive treatment on oxidative status, antioxidant activities, and reactive oxygen species by-products in whole blood and mononuclear peripheral cells. Eighty-nine hypertensive patients (mean age 46 years, 46 men, average 24-h blood pressure 139/88 mm Hg, body mass index 29) were included. After 3 months of nonrandomized allocation to antihypertensive treatment (20 nonpharmacologic, 36 beta-blockers, 33 angiotensin receptor blocker), oxidized/reduced glutathione ratio and malondialdehyde were significantly reduced, and the activity of superoxide dismutase, catalase, and glutathione peroxidase was significantly increased in both whole blood and peripheral mononuclear cells. The content of damaged base 8-oxo-2'-deoxyguanosine in nuclear and mitochondrial DNA in hypertensive subjects was also significantly reduced during the antihypertensive treatment. In a group of 42 subjects, the oxidative stress was further reduced and the antioxidant enzyme activities further increased after 12 months of antihypertensive treatment. The changes were independent of the kind of antihypertensive treatment. In conclusion, antihypertensive treatment improved the increased oxidative stress and the decreased antioxidant mechanisms. It is independent of the type of treatment and the beneficial effect of treatment increases over time.American Journal of Hypertension 10/2004; 17(9):809-16. · 3.18 Impact Factor -
Article: [Renal involvement in the human immunodeficiency virus infection].
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ABSTRACT: Although renal pathologies are becoming an emergent problem in the population infected by the human immunodeficiency virus (HIV), there is very scarce information about the natural course of this problem. The objective of the present study is to describe renal lesions in an autopsy series of HIV-infected patients never treated with antiretroviral therapies. Autopsy information has been retrospectively retrieved from 61 HIV-infected subjects (mean age, 36,9 [8,4] years; 58,6% drug abusers, 84% males) died in our hospital between 1984 and 1997. None of the patients received antiretroviral therapy. All autopsy and clinical reports were considered, as well as basic analytical parameters about renal function. Renal autopsy samples were specifically reviewed. At the time of the last admission, 9.8% of patients had renal insufficiency, who made up 44.3% of patients having renal insufficiency anytime. Infections were the main cause of death (76%). The majority of patients (93.4%) showed histopathological renal abnormalities, which were highly heterogeneous. Renal lesions were mainly located on the tubules (96.7%) and the interstitium (60.7%). Moreover, glomeruli were affected in 55.7% of patients. Most frequent histopathological diagnosis was acute tubular necrosis (16.4%) and septic nephritic abscesses (16.4%), followed by tubulointerstitial nephritis (9%). HIV-associated nephropathy was present in two patients (3.3%). There were no significant differences when considering the existent of renal failure. Renal histological abnormalities are frequent in the natural evolution of HIV infection. There is an important heterogeneity of lesions, mainly involving tubules, interstitium and mesangium. The cause of renal lesions is predominantly septic, according to the chief systemic process. It does not exist any relationship between renal analytical parameters and the presence of renal damage.Medicina Clínica 06/2004; 122(16):601-4. · 1.38 Impact Factor -
Article: Antioxidant activities and oxidative stress byproducts in human hypertension.
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ABSTRACT: The objective was to study oxidative status, antioxidant activities, and reactive oxygen species byproducts in whole blood and mononuclear peripherals cells and their relationship with blood pressure. Sixty-six hypertensive patients and 16 normotensive volunteers as a control group were studied. In both, whole blood and peripheral mononuclear cells oxidized/reduced glutathione ratio and malondialdehyde was significantly higher, and the activity of superoxide dismutase, catalase, and glutathione peroxidase was significantly lower in hypertensive patients when compared with normal subjects. The content of damaged base 8-oxo-2'-deoxyguanosine in nuclear and mitochondrial deoxyribonucleoproteins of hypertensive subjects was also significantly higher than that of the normotensive control subjects. No differences in these measurements were found among hypertensive subjects grouped in tertiles of 24-hour average mean blood pressure or between "white-coat" and established hypertensive subjects. Furthermore, no relationship was observed between the average of 24-hour mean blood pressure and oxidized/reduced glutathione ratio, reactive oxygen species byproducts, malondialdehide, or genomic 8-oxo-2'-deoxyguanosine. In whole blood and in mononuclear cells from hypertensive subjects, there was an increase in oxidative stress and a reduction in the activity of antioxidant mechanisms that appeared to be independent of the blood pressure values.Hypertension 06/2003; 41(5):1096-101. · 6.21 Impact Factor -
Article: Thrombocytopenia associated with levodopa treatment.
Archives of Internal Medicine 04/2003; 163(6):735-6. · 11.46 Impact Factor -
Article: Association of the G protein beta3 subunit T allele with insulin resistance in essential hypertension.
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ABSTRACT: A polymorphism (C825T) in the gene encoding the G protein beta3 subunit (GNB3) has recently been associated with hypertension and obesity in several populations. The aim of the study was to analyse the relationship between this polymorphism and insulin sensitivity, an hypothesised unifying factor for hypertension and obesity. One hundred thirty unrelated patients with essential hypertension, 70 female and 60 male, aged 58 +/- 1 years with systolic blood pressure of 173 +/- 2 mm Hg and diastolic blood pressure of 105 +/- 1 mm Hg, were genotyped for the GNB3 polymorphism by PCR and restriction digestion with BseDI, and classified in two groups according to the genotypes CC and CT + TT. Body mass index (BMI) was significantly higher in patients with the T allele as compared with patients without the T allele (29.3 +/- 0.4 vs. 26.7 +/- 0.6 kg/m2, p<0.001). On the contrary, there were no differences in the level of systolic or diastolic blood pressure among the genotypes. Insulin sensitivity was measured in a subgroup of 35 patients by means of an euglycemic hyperinsulinemic clamp test. In this subgroup, patients with the T allele displayed lower insulin sensitivity index (1.6 +/- 0.3 vs. 2.7 +/- 0.3 mg/kg/min, p = 0.022), higher fasting serum insulin (121 +/- 16 vs. 77 +/- 11 pmol/L, p = 0.032), higher serum glucose 120 min after 75 g load (9.8 +/- 1.2 vs. 7.0 +/- 0.5 mmol/L, p = 0.038), and higher glycosilated haemoglobin (5.7 +/- 0.4 vs. 4.7 +/- 0.2%; p = 0.042) as compared with patients without the T allele. A regression analysis showed that the association between the T allele and insulin sensitivity was independent of BMI (beta coefficient -0.386, p = 0.022). These results suggest a relationship between the 825T allele of GNB3 and insulin resistance in the essential hypertensive patients studied, which seems to be independent of BMI.Clinical and Experimental Hypertension 07/2002; 24(5):345-53. · 1.07 Impact Factor -
Article: Reversible posterior leukoencephalopathy secondary to indinavir-induced hypertensive crisis: a case report.
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ABSTRACT: Reversible posterior leukoencephalopathy syndrome (RPLS) is an uncommon entity related to multiple and different pathologies, the most common being hypertensive crisis. It is believed to be secondary to the breakdown on the blood-brain barrier. At the beginning, it is undistinguishable from other leukoencephalopathies. However, the disappearance of brain lesions after removal of the potential cause, establish the differential diagnosis with other leukoencephalopathies. We present the case of an HIV-infected patient with a RPLS related to a hypertensive crisis short after the initiation of indinavir-containing highly active antiretroviral therapy. Once blood pressure was controlled and indinavir replaced by nelfinavir, white matter lesions at magnetic resonance imaging disappeared. The clinical and radiologic evolution excludes other diagnosis as progressive multifocal leukoencephalopathy and points indinavir as a potential hypertension-inducing agent in HIV-infected predisposed subjects.American Journal of Hypertension 06/2002; 15(5):465-7. · 3.18 Impact Factor -
Article: [Genetic polymorphisms of the renin-angiotensin system and essential hypertension].
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ABSTRACT: The renin-angiotensin system (RAS) is known to regulate the blood pressure (BP). Several RAS polymorphisms have been associated with essential hypertension (EH), but there is uncertainty about this association. We examined whether the insertion/deletion (I/D) polymorphism of the angiotensin converting enzyme (ACE) gene, and the M235T polymorphism of the angiotensinogen (AGT) gene were associated with EH in a sample of Spanish hipertensive patients. We studied 1,204 patients with EH (BP > 140/90 mmHg): 668 males, aged 50.8 (13.6) years with systolic BP 151.7 (19.1) and diastolic BP 94.3 (13) mmHg [mean (SD)] and 536 females, aged 52.4 (13.9) years with systolic BP 155.1 (19.8) and diastolic BP 94.5 (12.3) mmHg. As a control group, 367 men and 280 women with no family history of cardiovascular disease who had a normal blood pressure were included. Polymorphisms were determined by PCR amplification of genomic DNA, followed by enzyme digestion for the AGT gene polymorphism. The genotype distribution and allele frequencies of the two RAS polymorphisms were similar in hypertensive and control subjects. Similarly, there were no differences in BP level with regard to the genotype in male or female patients. In addition, we did not find any compound effect of the I/D ACE gene and M235T AGT gene polymorphisms on BP levels in hypertensive subjects. This study suggests that in the population studied, the contribution of the ACE I/D polymorphism and the AGT M235T polymorphism in the development of EH is less important than previously estimated.Medicina Clínica 04/2002; 118(15):575-9. · 1.38 Impact Factor -
Article: P-75: Antihypertensive treatment, oxidative stress and activity of antioxidant enzymes
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ABSTRACT: Am J Hypertens (2002) 15, 59A–59A; doi:10.1016/S0895-7061(02)02426-3 P-75: Antihypertensive treatment, oxidative stress and activity of antioxidant enzymes Vicente Giner1,2,3,4,5,6,7, Guillermo Saez1,2,3,4,5,6,7, Maria C. Tormos1,2,3,4,5,6,7, Felipe J. Chaves1,2,3,4,5,6,7, Jose V. Lozano1,2,3,4,5,6,7, Maria E. Armengod1,2,3,4,5,6,7 and Josep Redon1,2,3,4,5,6,71Hypertension Clinic, Hospital Clinico. University of Valencia, Valencia, Spain2Biochemestry Department, Medical School. University of Valencia, Valencia, Spain3Biochemestry Department, Medical School. University of Valencia, Valencia, Spain4Fundacion Valenciana Investigaciones Biomedicas, Valencia, Spain5Hypertension Clinic, University of Valencia, Valencia, Spain6Fundacion Valenciana Investigaciones Biomedicas, Valencia, Spain7Hypertension Clinic, Hospital Clinico. University of Valencia, Valencia, SpainAmerican Journal of Hypertension 03/2002; · 3.18 Impact Factor -
Article: P-282: Antioxidant enzymes in lymphocites from essential hypertension patients
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ABSTRACT: Am J Hypertens (2002) 15, 132A–133A; doi:10.1016/S0895-7061(02)02633-X P-282: Antioxidant enzymes in lymphocites from essential hypertension patients Felipe J. Chaves1, Maria C. Tormos2, Pablo Marin1, Vicente Giner3, Guillermo Saez2, Jose V. Lozano4, Maria E. Armengod1 and Josep Redon31Fundacion Valenciana Investigaciones Biomedicas, Valencia, Spain2Biochemestry Department, Medical School. University of Valencia, Valencia, Spain3Hypertension Clinic, Hospital Clinico. University of Valencia, Valencia, Spain4Hypertension Clinic Investigaciones Biomedicas, Hospital Clinico. University of Valencia, Valencia, SpainAmerican Journal of Hypertension 03/2002; · 3.18 Impact Factor -
Article: P-334: A-6G polymorphism of the angiotensinogen gene and body weight changes in essential hypertension: A prospective study
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ABSTRACT: Am J Hypertens (2001) 14, 141A–141A; doi:10.1016/S0895-7061(01)01855-6 P-334: A-6G polymorphism of the angiotensinogen gene and body weight changes in essential hypertension: A prospective study Felipe J. Chaves1,2, Vicente Giner1,2, Dolores Corella1,2, Pablo Marin1,2, Jose M. Pascual1,2, Maria E. Armengod1,2 and Josep Redon1,21Molecular Medicine Fundacion Valenciana Investigaciones Biomedicas, Valencia, Spain2Hypertension Clinic Hospital Clinico University of Valencia, Valencia, SpainAmerican Journal of Hypertension 03/2001; · 3.18 Impact Factor -
Article: P-654: Oxidative stress and early organ damage in essential hypertension
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ABSTRACT: Am J Hypertens (2001) 14, 248A–249A; doi:10.1016/S0895-7061(01)01984-7 P-654: Oxidative stress and early organ damage in essential hypertension Vicente Giner1,2, Jose V. Lozano1,2, Guillermo Saez1,2, Maria C. Tormo1,2, Felipe J. Chaves1,2, Maria E. Armengod1,2 and Josep Redon1,21Hypertension Clinic Hospital Clinico University of Valencia, Valencia, Spain2Biochemestry University of Valencia, Valencia, Spain3Molecular Medicine Fundacion Valenciana Investigaciones Biomedicas, Valencia, SpainAmerican Journal of Hypertension 03/2001; · 3.18 Impact Factor -
Article: P-653: Oxidative stress and enzymatic antioxidant mechanisms in essential hypertension
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ABSTRACT: Am J Hypertens (2001) 14, 248A–248A; doi:10.1016/S0895-7061(01)01983-5 P-653: Oxidative stress and enzymatic antioxidant mechanisms in essential hypertension Guillermo Saez1,2, Maria C. Tormos1,2, Vicente Giner1,2, Jose V. Lozano1,2, Felipe J. Chaves1,2, Maria E. Armengod1,2 and Josep Redon1,21Biochemestry University of Valencia, Valencia, Spain2Molecular Medicine Fundacion Valenciana Investigaciones Biomedicas, Valencia, Spain3Hypertension Clinic Hospital Clinico University of Valencia, Valencia, SpainAmerican Journal of Hypertension 03/2001; · 3.18 Impact Factor
Top co-authors
Top Journals
Institutions
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2010
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Centro Superior de Investigación en Salud Pública (CSISP)
Valencia, Valencia, Spain
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2001–2007
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University of Valencia
- Departamento de Medicina
Valencia, Valencia, Spain
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2001–2003
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Hospital Clínico Universitario de Valencia
Valencia, Valencia, Spain
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2000
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University of Barcelona
Barcelona, Catalonia, Spain
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