Mami Sanagawa

Publications (3)14.54 Total impact

• Article: Structure-activity relationships study of bastadin 6, an anti-angiogenic brominated-tyrosine derived metabolite from marine sponge.

  Naoyuki Kotoku, Atsushi Hiramatsu, Hiroaki Tsujita, Yoichi Hirakawa, Mami Sanagawa, Shunji Aoki, Motomasa Kobayashi
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  ABSTRACT: A structure-activity relationship (SAR) study of bastadin 6 (1), a brominated tyrosine-derived metabolite from Indonesian marine sponge having a potent anti-angiogenic activity, was executed. The syntheses and their biological evaluation of the oxime-modified analogues and bromine-modified analogues revealed that both the oxime moieties and bromine atoms in bastadin 6 (1) play an important role to show the potent and selective anti-proliferative activity against human umbilical vein endothelial cells (HUVECs).
  Archiv der Pharmazie 10/2008; 341(9):568-77. · 1.71 Impact Factor
• Article: Novel isomarabarican triterpenes, exhibiting selective anti-proliferative activity against vascular endothelial cells, from marine sponge Rhabdastrella globostellata.

  Shunji Aoki, Mami Sanagawa, Yasuo Watanabe, Andi Setiawan, Masayoshi Arai, Motomasa Kobayashi
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  ABSTRACT: Four novel globostellatic acid X methyl esters (1-4) having isomarabarican-type triterpenoidal skeleton and three related new compounds (5-7) were isolated from the marine sponge Rhabdastrella globostellata, as selective anti-proliferative agents against human umbilical vein endothelial cells (HUVECs). Those chemical structures were elucidated by the detailed 2D NMR analysis. Two globostellatic acid X methyl esters (3 and 4) having 13E-geometry were found to inhibit proliferation of HUVECs, 80- to 250-fold selectively in comparison with several other cell lines. 13E,17E-Globostellatic acid X methyl ester (4) also inhibited bFGF-induced tubular formation and VEGF-induced migration of HUVECs. Moreover, 4 induced apoptosis of HUVECs, whereas it exhibited no effect on VEGF-induced phosphorylation of ERK1/2 in HUVECs.
  Bioorganic & Medicinal Chemistry 08/2007; 15(14):4818-28. · 2.92 Impact Factor
• Source

  Available from: aseanbiodiversity.info

  Article: Cortistatins A, B, C, and D, anti-angiogenic steroidal alkaloids, from the marine sponge Corticium simplex.

  Shunji Aoki, Yasuo Watanabe, Mami Sanagawa, Andi Setiawan, Naoyuki Kotoku, Motomasa Kobayashi
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  ABSTRACT: Four novel steroidal alkaloids named cortistatins A (1), B (2), C (3), and D (4) consisting of a 9(10-19)-abeo-androstane and isoquinoline skeleton have been isolated from the marine sponge Corticium simplex. The absolute stereostructures of 1-4 were elucidated by detailed 2D NMR, CD, and X-ray crystallographic analyses. Cortistatins A-D inhibited proliferation of human umbilical vein endothelial cells (HUVECs) with high selectivity. Among the four substances, cortistatin A (1) showed the strongest anti-proliferative activity (IC50 = 0.0018 muM) against HUVECs, in which the selective index was more than 3000-fold in comparison with that of normal fibroblast or several tumor cell lines.
  Journal of the American Chemical Society 04/2006; 128(10):3148-9. · 9.91 Impact Factor