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ABSTRACT: We aimed to evaluate the effects of caffeic acid phenethyl ester (CAPE) on lithium (Li)-induced lung toxicity.
Twenty-two adult male Wistar albino rats weighing between 280 and 300 g were used. The rats were randomly divided into three groups: control, Li and Li+CAPE groups. Li and CAPE were co-administered intraperitoneally twice daily for 4 weeks. Control rats were given 0.9% NaCl during the same period. All the rats were allowed to feed ad libitum until midnight after they had received the proposed treatment.
In the Li group, peribronchial and intraparenchymal lymphocyte and macrophage infiltration were observed. Atypical type II pneumocytes, alveolar destruction and emphysematous changes were also detected. Lymphocyte and macrophage infiltration was significantly decreased in the Li+CAPE group compared with the Li group. Alveolar destruction, emphysematous changes and intraparenchymal mononuclear cell infiltration were also recovered to a level close to the control group. Malondialdehyde (MDA) levels were increased in the Li group compared with the control group. CAPE administration decreased the MDA levels in the Li+CAPE group.
CAPE was found to associate with histopathological changes recovery in the lungs and oxidative stress due to Li treatment.
Pathology 03/2006; 38(1):58-62. · 2.38 Impact Factor
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ABSTRACT: To compare the effects of cigarette smoke and dried dung smoke exposure on the histopathology of lungs.
Three groups each with five rabbits were formed. The cigarette smoke group was exposed to cigarette smoke, the biomass group was exposed to dried dung smoke and the control group was exposed to dry air 1 hour daily for 1 month. At the end of 1 month, animals were sacrificed and lung tissues were examined histopathologically.
Histopathological evaluation of rabbits' lungs revealed that intraparenchymal vascular congestion and thrombosis, intraparenchymal haemorrhage, respiratory epithelial proliferation, number of macrophages in the alveolar and bronchial lumen, alveolar destruction, emphysematous changes and bronchoalveolar haemorrhage scores were significantly increased in rabbits exposed to cigarette smoke compared with the control group. Respiratory epithelial proliferation, alveoli destruction and emphysematous change scores were significantly increased in rabbits exposed to dried dung smoke compared with the control group.
Although less than the effects of cigarette smoke, dried dung smoke had severe histopathological effects on rabbits' lungs.
Pathology 03/2006; 38(1):53-7. · 2.38 Impact Factor
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ABSTRACT: The aim of this experimental study was to investigate the possible role of nitric oxide (NO) levels and activity of adenosine deaminase (ADA) in the pathogenesis of methotrexate (MTX)-induced neurotoxicity, to demonstrate the effect of caffeic acid phenethyl ester (CAPE), the potent antioxidant, in decreasing the toxicity. A total of 19 adult male rats were divided into three experimental groups, as follows: group I, control group; group II, MTX-treated group; group III, MTX+CAPE-treated group. In the second day of experiment, MTX was administered intraperitoneally (i.p.) with a single dose of 20mg/kg to group II and group III. CAPE was administered i.p. with a dose of 10 micromol/kg once daily for 7 days to group III. Histopathological findings of the inflammatory reaction were observed in spinal cord of MTX administered rats, compared with control rats. All parameters of inflammatory reaction were significantly decreased in MTX plus CAPE administered rats, compared with MTX administered rats. The injection of MTX caused significant increase in the activity of ADA and in levels NO levels in spinal cord of rats (p=0.007 and p=0.0001, respectively). Co-treatment with CAPE caused a significant decrease in activity of ADA and the levels of NO in spinal cord (p=0.024 and p=0.0001, respectively). Study indicate that NO and ADA may play an important role in the pathogenesis of MTX-induced oxidative spinal cord damage. CAPE may have protective aspects in this process by antioxidant and anti-inflammatory effect and it will become a promising drug in the prevention of undesired side effect of MTX.
Toxicology 03/2006; 218(2-3):125-33. · 3.68 Impact Factor
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ABSTRACT: We aimed to evaluate the effects of smoking on the histopathology and the oxidant-antioxidant status of lungs and to test the effects of N-acetylcysteine (NAC) on the induced changes. Rabbits were exposed to cigarette smoke (CS) in a glass chamber for one hour daily for one month. An NAC control group was given intraperitoneal NAC only. CS + NAC rats were exposed to smoke and given intraperitoneal NAC. A control group was exposed to clean air only. At the end of one month, animals were sacrificed and lung tissues were examined histopathologically. Blood levels of protein sulfhydryls, carbonyls, prostaglandin F(2alpha) (PGF(2alpha)) and malondialdehyde (MDA) were measured. Intraparenchymal vascular congestion and thrombosis, intraparenchymal hemorrhage, respiratory epithelial proliferation, number of macrophages in the alveolar and bronchial lumen, alveolar destruction, emphysematous changes and bronchoalveolar hemorrhage scores were significantly increased in rabbits exposed to CS compared with the control group. Protein sulfhydryls were significantly decreased; carbonyls, PGF(2alpha) and MDA levels were significantly increased in the smoke exposed rabbits. Administration of NAC to rabbits exposed to CS caused a reduction in the bronchoalveolar hemorrhage score and blood PGF(2alpha) levels. Other parameters were unaffected by NAC. Exposure to CS causes severe histopathological changes and negatively effects the oxidant-antioxidant status in the lungs of rabbits. A low daily dose of NAC has some ameliorative effects on histopathological changes and oxidant-antioxidant status of the lungs in smoke exposed rabbits.
Tuberkuloz ve toraks 02/2006; 54(2):144-51.
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ABSTRACT: This report describes a 45-year-old patient who was admitted to the hospital with complaints of low-back pain, lower extremity weakness, and difficulty in walking for the previous 6 mo. The patient's history revealed 2 lumbar-disc surgeries that were performed 1 y earlier. The patient underwent surgery at our hospital because of clinical symptoms and radiologic findings on magnetic resonance imaging. During the operation, 1 x 1 x 1 cm of bone wax that was compressing the dural sac and spinal root was extirpated from the surgical area. Bone wax use should be limited in spinal surgery because of the potential for compression and chronic inflammation.
Advances in Therapy 24(3):594-7. · 2.11 Impact Factor
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ABSTRACT: Chondroid syringoma is a myxoid tumor of the skin, which has a reported incidence of <0.01% among primary skin tumors. The majority of these tumors occur in the head and neck regions of adult males. The correct diagnosis is made by histopathologic examination. We present the first instance of chondroid syringoma in a child, which, to the best of our knowledge, has not been reported previously in the English language literature.
Pediatric Dermatology 24(5):505-7. · 1.07 Impact Factor
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ABSTRACT: Prostaglandins are critical mediators of inflammation and affect both humoral and cell-mediated immune responses. Recent findings show that T and B cells express COX-2 upon activation. The purpose of this study is to investigate the potential occurrence of COX-1 and COX-2 immunoreactivity in cases of chronic tonsillitis and to determine the sites of their expression. In addition, their expression in adult patients is compared with that in child patients.
Immunohistochemical techniques were used to evaluate the expression of the enzymes COX-1 and COX-2, in chronic tonsillitis tissue specimens from adults (n = 15) and children (n = 15).
There was no staining in surface epithelium or reticulated crypt epithelium. COX-1 and COX-2 expressions were observed mainly in the intraepithelial lymphoid cells in reticulated crypt epithelium and subepithelial cells. Also, COX-1 and COX-2 stained cells were found in the germinal center. There was no difference of the expressions of COX-1 and COX-2 among adults and children. The only significant difference noted between the adults and children was that, the adults had rich subepithelial plasma cells.
Activated B and T cells express COX-1 and COX-2 in paraffin-embedded tissue sections of chronic tonsillitis. Further studies need to be performed to elucidate expression of COX enzymes and their immunologic role in tonsil diseases. They will play an important role in the treatment of chronic tonsillitis. Additional studies are warranted to study the effects of NSAIDs and selective COX-2 inhibitors in chronic tonsillitis.
Indian Journal of Pathology and Microbiology 53(3):451-4. · 0.68 Impact Factor
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ABSTRACT: Mechanical trauma, thermal injury, tissue ischemia during the operation, postoperative infections, and foreign body reactions are important factors for adhesion formation. Bleeding and bile leakage after liver resections can also cause intra-abdominal adhesions. We aimed to evaluate the intra-abdominal adhesions after liver resection in rats using Ligasure and SurgRx. Twenty-seven Sprague-Dawley rats were used in the study. Three random groups were formed. Two liver lobes were resected from the middle using sutures in group A, Ligasure in group B, and SurgRx in group C. Relaparotomy was performed at postoperative day 7 to evaluate intra-abdominal adhesion formation. Adhesion formation was significantly lower in the SurgRx group compared with the suture and Ligasure groups. SurgRx and Ligasure provide effective hemostasis in liver resection without leaving foreign bodies such as clips and knots behind. SurgRx was superior to suture and Ligasure techniques in terms of adhesion formation in our model.
International surgery 92(1):20-6. · 0.36 Impact Factor
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ABSTRACT: Pilomatricoma, although rare, is the second most frequent benign skin tumor in childhood. It is a hard, painless, slowly progressing subcutaneous tumor that is commonly located in the head-neck region, especially periorbital, and in the upper extremities. Histopathologic characteristics are distinctive. In this study, we performed a retrospective review of the records of our pediatric patients with pilomatricoma. We discuss herein the diagnosis and management of this uncommon skin tumor, and compare our experience with the previous literature. Pilomatricoma should be included in the differential diagnosis of superficial pediatric head and neck masses by any physician involved with pediatric tumors.
The Turkish journal of pediatrics 51(1):44-8. · 0.44 Impact Factor
