[show abstract][hide abstract] ABSTRACT: Infected aortic aneurysm and inflammatory aortic aneurysm each account for a minor fraction of the total incidence of aortic aneurysm and are associated with periaortic inflammation. Despite the similarity, infected aortic aneurysm generally shows a more rapid change in clinical condition, leading to a fatal outcome; in addition, delayed diagnosis and misuse of corticosteroid or immunosuppressing drugs may lead to uncontrolled growth of microorganisms. Therefore, it is mandatory that detection of aortic aneurysm is followed by accurate differential diagnosis. In general, infected aortic aneurysm appears usually as a saccular form aneurysm with nodularity, irregular configuration; however, the differential diagnosis may not be easy sometimes for the following reasons: (1) symptoms, such as abdominal and/or back pain and fever, and blood test abnormalities, such as elevated C-reactive protein and enhanced erythrocyte sedimentation rate, are common in infected aortic aneurysm, but they are not found infrequently in inflammatory aortic aneurysm; (2) some inflammatory aortic aneurysms are immunoglobulin (Ig) G4-related, but not all of them; (3) the prevalence of IgG4 positivity in infected aortic aneurysm has not been well investigated; (4) enhanced uptake of 18F-fluorodeoxyglucose (FDG) by 18F-FDG-positron emission tomography may not distinguish between inflammation mediated by autoimmunity and that mediated by microorganism infection. Here we discuss the characteristics of these two forms of aortic aneurysm and the points of which we have to be aware before reaching a final diagnosis.
Journal of Cardiology 01/2012; 59(2):123-31. · 2.30 Impact Factor
[show abstract][hide abstract] ABSTRACT: We have recently proposed a novel method for displaying left ventricular (LV) function and mechanical dyssynchrony, which is based on the "vector analysis" using Doppler tissue imaging (DTI). The aim of this study was to examine acute-phase impact of cardiac resynchronization therapy (CRT) on the parameters assessed by this method.
We studied a total of 25 patients with systolic heart failure, 14 undergoing simultaneous acute pacing-hemodynamic study and DTI; and 11 patients DTI within a few days before and one week after CRT. Parameters derived from the displaying method were followings: (1) percentage area of the hexagon, the area divided by the overall graph area, reflecting global LV systolic function; (2) net-delay magnitude, the length of the composite vector for the six vectors, a dyssynchrony index; and (3) delayed contraction site, graphical position of the composite vector.
CRT significantly increased cardiac output (3.1 ± 1.0 to 3.4 ± 0.7 L/min, P = 0.02) and +dp/dt (782 ± 149 to 1,089 ± 270 mm Hg/s, P < 0.01), and decreased mitral regurgitaion jet area (7.9 ± 3.0 to 4.8 ± 2.4 cm(2) , P < 0.01). As with the new method, there were significant decreases in the percentage area of the hexagon (20.7 ± 6.6 to 18.6 ± 6.5%, P < 0.01) and the net-delay magnitude (122 ± 59 to 72 ± 48 ms, P < 0.01). The reduction of net-delay magnitude accompanied alteration of delayed contraction site; 16 patients had the most delayed site between the lateral and inferior segments before CRT, and seven patients after CRT (P = 0.02).
The new method would be a useful tool to assess efficacy of CRT in patients with systolic heart failure.
[show abstract][hide abstract] ABSTRACT: Seasonal variations in blood pressure (BP) have often been attributed to meteorological factors, especially changes in outdoor temperature. We evaluated the direct association between meteorological factors and circadian BP variability. Twenty-four-hour ambulatory BP was monitored continuously for 7 days in 158 subjects. Mean awake, asleep, morning (first 2 h after waking) BP, prewaking morning BP surge (morning systolic BP (SBP)-mean SBP during the 2-h period before waking) and nocturnal BP decline were measured each day. We compared BP values for the lowest and highest days with regard to the daily mean outdoor temperature and mean atmospheric pressure. Morning BP and prewaking morning BP surge on the coldest day were significantly higher than those on the warmest day (morning SBP, 136.6 ± 1.6 vs. 133.1 ± 1.5 mm Hg, P = 0.002; morning diastolic BP, 84.4 ± 0.9 vs. 82.6 ± 0.9 mm Hg, P = 0.02; and prewaking morning BP surge, 20.8 ± 1.3 vs. 15.3 ± 1.3 mm Hg, P = 0.0004). The magnitude of nocturnal BP decline on the coldest day was significantly greater than that on the warmest day (15.8 ± 0.7 vs. 13.9 ± 0.7%, P = 0.01). Outdoor temperature is an important determinant of morning BP, prewaking morning BP surge and the magnitude of nocturnal BP decline. These findings may have important implications in management of hypertension and prevention of cardiovascular events.
Hypertension Research 09/2010; 34(1):70-3. · 2.79 Impact Factor
[show abstract][hide abstract] ABSTRACT: In patients with nonvalvular atrial fibrillation, the electrocardiographic fibrillatory wave reflects the structural and electrical remodeling of the atria. This study examined whether the fibrillatory wave amplitude could predict the risk of thromboembolism and demonstrated that this amplitude was related to the duration of atrial fibrillation. We also showed that the presence of fine fibrillatory waves (<1 mm in amplitude) could predict the thromboembolic potential in patients with chronic nonvalvular atrial fibrillation.
The American Journal of Cardiology 09/2005; 96(3):408-11. · 3.21 Impact Factor
[show abstract][hide abstract] ABSTRACT: Quantitative blood pool single photon emission computed tomography (SPECT) (QBS) can measure ejection fraction (EF) and volumes from gated blood pool single photon emission tomography (GBPS) working in fully automatic mode in 3-dimensional space. The effects of 180 degrees and 360 degrees data acquisition in GBPS have not been fully evaluated. This study compares the accuracy of 360 degrees and 180 degrees data acquisition for left ventricular (LV) systolic function in a clinical study and measures LV volume by GBPS compared with ultrasound echocardiography.
The study population comprised 9 normal volunteers and 34 patients. GBPS data were acquired by use of 360 degrees rotation and 60 stops per head. All 60 (360 degrees ) and 30 (45 degrees right anterior oblique to 45 degrees left posterior oblique) pieces of projection data that were selected for reconstructing the 180 degrees data were reconstructed and both ventricular functional parameters were automatically obtained by QBS software. The contour of the LV septal wall was concave in 6 patients (14%) when processed at 180 degrees , whereas a concave septum at 360 degrees processing was observed in only 1 patient (2%). The coefficients of correlation between 180 degrees and 360 degrees were 0.467 for the end-diastolic volume (EDV) and 0.648 for the end-systolic volume (ESV). The mean 180 degrees EDV value (152.9 +/- 46.1 mL) was significantly smaller than that of the 360 degrees EDV (191 +/- 70.8 mL) ( P < .001). However, there was no significant difference between the 360 degrees EDV (0.623) and 180 degrees EDV (0.407) as compared by echocardiography ( P = .218). The agreement of the EF between both methods was close ( r = 0.894, P < .0001). The agreement of the right ventricular volumes between the 180 degrees and 360 degrees orbits was close ( r = 0.800 for EDV and 0.706 for ESV). The EF was relatively dispersed between the 180 degrees and 360 degrees methods ( r = 0.642).
This study showed that SPECT image acquisition by use of both the 180 degrees method and the 360 degrees method considerably underestimated LV volume quantification. In addition, the LV volume with the 180 degrees method was significantly smaller than that with the 360 degrees method. Thus a 360 degrees acquisition orbit may be suitable for more quantitatively accurate results when blood pool imaging is performed with gated SPECT.
Journal of Nuclear Cardiology 03/2005; 12(2):186-94. · 2.85 Impact Factor
[show abstract][hide abstract] ABSTRACT: The ventricular phase angle, a parametric method applied to Fourier phase analysis (FPA) in radionuclide ventriculography, allows the quantitative analysis of ventricular contractile synchrony. However, FPA reproducibility using gated blood pool SPECT (GBPS) has not been fully evaluated. The present study evaluates whether by using GBPS, the reproducibility of FPA could be improved over that in planar radionuclide angiography (PRNA).
Forty-three subjects underwent both GBPS and PRNA, of which 10 subjects were normal controls, 25 had dilated cardiomyopathy, and 8 had various heart diseases. Interventricular contractile synchrony was measured as the absolute difference in RV and LV mean ventricular phase angle as delta(phi) (RV - LV). Intraventricular contractile synchrony was measured as the standard deviation of the mean phase angle for the RV and LV blood pools (RVSD(phi), LVSD(phi)). Two nuclear physicians processed the same phase images of GBPS to evaluate the interobserver reproducibility of the phase angles using data from the 43 study participants. Phase images acquired from PRNA were processed in the same manner.
Excellent reproducibility of delta(phi) (RV - LV) was obtained with both GBPS (Y = -3.10 + 0.89 x X; r = 0.901) and PRNA (Y = -4.51 + 0.81 x X; r = 0.834). In regard to RVSD(phi) reproducibility was not adequate with PRNA (Y = 18.56 + 0.35 x X; r = 0.424), while it was acceptable with GBPS (Y = 5.22 + 0.85 x X; r = 0.864). LVSD(phi) reproducibility was superior using both GBPS (Y = 4.15 + 0.97 x X; r = 0.965) and PRNA (Y = -0.55 + 0.98 x X; r = 0.910).
Our results demonstrate FPA obtained using GBPS to be highly reproducible for evaluating delta(phi) (RV - LV), RVSD(phi) and LVSD(phi), in comparison with the PRNA method. We thus consider GBPS appropriate for evaluating ventricular contractile synchrony.
Annals of Nuclear Medicine 01/2004; 17(8):711-6. · 1.41 Impact Factor
[show abstract][hide abstract] ABSTRACT: The prognosis for patients with a residual scar from myocardial infarction (MI) after coronary artery bypass grafting surgery (CABG) has not been fully evaluated, so the present study retrospectively evaluated such patients with stress myocardial single photon emission computed tomography (SPECT) at 100 months after CABG. The study group consisted of 24 subjects (23 males, 1 female; mean age, 59+/-9 years) in whom CABG had been performed more than 100 months (mean follow-up period 135+/-25 months) previously. The 24 subjects were classified into 3 groups according to their summed stress score (SSS) and summed reversibility score (SRS) in the early period after CABG. Eight subjects with MI (SSS> or =2 and SRS<2) were classified into the group MI, 8 subjects with ischemic myocardium (SSS> or =2 and SRS> or =2) was classified into the group RE, and 8 subjects with normal perfusion (SSS<2 and SRS<2) was classified into group N. None of the subjects in group MI required revascularization. Cardiac events occurred in 4 of the group RE patients and all required revascularization. As to the SPECT scoring system, the long-term SSS of group MI (6.4+/-3.1) was not different from that in the early periods (4.3+/-4.0; NS). However, the long-term SSS values of group RE (8.8+/-6.2) were significantly greater than those soon after CABG (3.4+/-1.8; p=0.03). In group N, there was also no difference in the SSS values between the early period (0.3+/-0.5) and the long-term period (0.0+/-0.0; NS). Patients with a residual scar from MI in the early period after CABG did not worsen over a period of 100 months. Moreover, there was no significant difference in the SPECT score in the segment with the residual scar in the short or long term after CABG. However, the extent of reversibility was directly associated with the presence of clinical events. Therefore scintigraphic imaging remains an important and clinically relevant risk stratification tool. Stress myocardial SPECT, early after CABG, can be used to predict the possibility of future cardiac events or the need for revascularization.
[show abstract][hide abstract] ABSTRACT: A patient with localized upper septal hypertrophy and medically uncontrolled severe outflow obstruction is described. His outflow obstruction was controlled by the implantation of a dual-chamber (DDD) permanent pacemaker.
Japanese Circulation Journal 09/1998; 62(8):621-2.