Carolina Palacios

Publications (1)6.17 Total impact

• Source

  Available from: Carolynn Debyle

  Article: Epidemiology of Haemophilus influenzae serotype a, North American Arctic, 2000-2005.

  Michael G Bruce, Shelley L Deeks, Tammy Zulz, Christine Navarro, Carolina Palacios, Cheryl Case, Colleen Hemsley, Tom Hennessy, Andre Corriveau, Bryce Larke, Isaac Sobel, Marguerite Lovgren, Carolynn Debyle, Raymond Tsang, Alan J Parkinson
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  ABSTRACT: Before the introduction of Haemophilus influenzae type b (Hib) conjugate vaccines, rates of invasive H. influenzae disease among indigenous people of the North American Arctic were among the highest in the world. Routine vaccination reduced rates to low levels; however, serotype replacement with non-type b strains may result in a reemergence of invasive disease in children. We reviewed population-based data on invasive H. influenzae in Alaska and northern Canada from 2000-2005; 138 cases were reported. Among 88 typeable isolates, 42 (48%) were H. influenzae type a (Hia); 35 (83%) occurred in indigenous peoples. Among Hia patients, median age was 1.1 years; 62% were male; 1 adult died. Common clinical manifestations included meningitis, pneumonia, and septic arthritis. Overall annual incidence was 0.9 cases per 100,000 population. Incidence among indigenous children <2 years of age in Alaska and northern Canada was 21 and 102, respectively. Serotype a is now the most common H. influenzae serotype in the North American Arctic; the highest rates are among indigenous children.
  Emerging infectious diseases 01/2008; 14(1):48-55. · 6.17 Impact Factor
• Article: Epidemiology of Haemophilus infl uenzae Serotype a, North

  Michael G. Bruce, Shelley L. Deeks, Tammy Zulz, Christine Navarro, Carolina Palacios, Cheryl Case, Colleen Hemsley, Tom Hennessy, Andre Corriveau, Bryce Larke, Isaac Sobel, Marguerite Lovgren
  [show abstract] [hide abstract]
  ABSTRACT: Before the introduction of Haemophilus infl uenzae type b (Hib) conjugate vaccines, rates of invasive H. infl uenzae disease among indigenous people of the North American Arctic were among the highest in the world. Routine vaccina- tion reduced rates to low levels; however, serotype replace- ment with non-type b strains may result in a reemergence of invasive disease in children. We reviewed population-based data on invasive H. infl uenzae in Alaska and northern Can- ada from 2000-2005; 138 cases were reported. Among 88 typeable isolates, 42 (48%) were H. infl uenzae type a (Hia); 35 (83%) occurred in indigenous peoples. Among Hia pa- tients, median age was 1.1 years; 62% were male; 1 adult died. Common clinical manifestations included meningitis, pneumonia, and septic arthritis. Overall annual incidence was 0.9 cases per 100,000 population. Incidence among indigenous children