Jun-Shan Yang

Publications (67)79.61 Total impact

• Article: Shancigusins E-I, five new glucosides from the tubers of Pleione yunnanensis.

  Hai-Ling Dong, Han-Qiao Liang, Chun-Lan Wang, Shun-Xing Guo, Jun-Shan Yang
  [show abstract] [hide abstract]
  ABSTRACT: Five new glucosides, shancigusins E-I (1-5) were isolated from the tubers of Pleione yunnanensis (Rolfe) together with 18 known compounds. The structures of these compounds were determined by extensive analyses of their spectroscopic data. Copyright © 2013 John Wiley & Sons, Ltd.
  Magnetic Resonance in Chemistry 04/2013; · 1.44 Impact Factor
• Source

  Available from: Zhong-Mei Zou

  Dataset: 邹国安-molecules

  Guo-An Zou, Hong-Wu Zhang, Zhong-Mei Zou, Zhi-Heng Su, Yuan Wang, Jun-Shan Yang
• Article: Characterization of aromatic glycosides in the extracts of Trollius species by ultra high-performance liquid chromatography coupled with electrospray ionization quadrupole time-of-flight tandem mass spectrometry.

  Li-Zhen Wu, Xiao-Po Zhang, Xu-Dong Xu, Qing-Xia Zheng, Jun-Shan Yang, Wan-Long Ding
  [show abstract] [hide abstract]
  ABSTRACT: Ultra high-performance liquid chromatography coupled with electrospray ionization quadrupole time-of-flight tandem mass spectrometry (UHPLC/ESI-Q-TOF MS/MS) was used to investigate the MS fragmentation behaviors of flavone C-glycosides present in the extracts of five Trollius species. In this study, the primary MS fragmentation pathways and key diagnostic fragment ions of flavone C-glycosides were systematically investigated and summarized to distinguish different types of derivatives and to trace other analogs in Trollius species. This method was useful, rapid, efficient and sensitive and allowed the simultaneous identification of different types of flavone C-glycosides present in other medicinal plants. The features of the MS fragmentation of these compounds indicated that the product ions were primarily the result of cleavage in the saccharide moiety, followed by hydrogen rearrangement and dehydration. In this study, thirty-six components including thirty-two flavone C-glycosides, two flavone O-glycosides and two phenylethanoid glycosides, were identified in the extracts of five Trollius species. Eleven of the flavone C-glycosides were identified by comparison with reference standards, and twenty-one flavone C-glycosides were tentatively identified based on their retention times, exact mass information and fragment ions. Two potentially new flavone C-glycosides (2″-O-vanilloylorientin and 2″-O-feruloylvitexin) were successfully characterized based on the summarized fragmentation pathways, and six known flavone C-glycosides (2″-O-glucosylvitexin, 2″-O-acetylorientin, 2″-O-acetylvitexin, 3″-O-acetylorientin, 3″-O-acetylvitexin and 6″-O-acetylvitexin) were identified in these plant species for the first time. In conclusion, the fragmentation pathways proposed in this paper were helpful for the identification of different types of flavone C-glycosides when no reference standards were available.
  Journal of pharmaceutical and biomedical analysis 03/2013; 75:55-63. · 2.45 Impact Factor
• Article: Biotransformation of ursolic acid by Syncephalastrum racemosum CGMCC 3.2500 and anti-HCV activity.

  Shao-Bin Fu, Jun-Shan Yang, Jin-Long Cui, Di-An Sun
  [show abstract] [hide abstract]
  ABSTRACT: Microbial transformation of ursolic acid (UA, 3β-hydroxy-urs-12-en-28 -oic acid, 1) by filamentous fungus Syncephalastrum racemosum CGMCC 3.2500 was conducted. Five metabolites 3β, 7β, 21β-trihydroxy-urs-12-en-28-oic acid (2); 3β, 21β-dihydroxy-urs-11-en-28-oic acid-13-lactone (3); 1β, 3β, 21β -trihydroxy-urs-12-en-28-oic acid (4); 3β, 7β, 21β-trihydroxy-urs-1-en-28-oic acid-13-lactone (5); 21-oxo-1β, 3β-dihydroxy-urs-12-en-28-oic acid (6) were afforded. Elucidation of the structures of these metabolites was primarily based on 1D and 2D-NMR and HR-MS data. Metabolite 2 was a new compound. In addition, the anti-HCV activity of compounds 1-6 was evaluated.
  Fitoterapia 02/2013; · 1.85 Impact Factor
• Article: Two new diterpenes, neocaesalpin MR and minaxin C, from Caesalpinia minax.

  Guo-Xu Ma, Na Xu, Jing-Quan Yuan, Hua Wei, Qing-Xia Zheng, Zhao-Cui Sun, Jun-Shan Yang, Xu-Dong Xu
  [show abstract] [hide abstract]
  ABSTRACT: Two new cassane-type diterpenes, neocaesalpin MR (1) and minaxin C (2), were isolated from Caesalpinia minax HANCE. The structures of these compounds were elucidated by means of spectroscopic analysis. Among these isolated compounds, neocaesalpin MR showed mild activities toward HeLa and colon cancer (HCT-8) human cancer cell lines.
  Journal of Asian natural products research 11/2012; · 0.61 Impact Factor
• Article: A new sesquiterpene lactone from Sarcandra glabra.

  Xiao-Ru Hu, Hai-Feng Wu, Xiao-Po Zhang, Jun-Shan Yang, Zhong Dai, Rui-Chao Lin, Xu-Dong Xu
  [show abstract] [hide abstract]
  ABSTRACT: A new eudesmanolide sesquiterpene, atractylenolide IV (1), together with seven known compounds were isolated from the 70% aqueous acetonic extract of the whole plant of Sarcandra glabra (Chloranthaceae). Their structures were established by spectral analysis, mainly UV, IR, HRESI-MS, 1D and 2D-NMR experiments (HSQC, HMBC and NOESY). Compounds 1-4 showed no remarkable cytotoxic activity against Hela, HCT-8 and MCF-7 cancer cell lines with IC(50) > 50 µg mL(-1).
  Natural product research 09/2012; · 1.01 Impact Factor
• Article: Two new diterpenes from Caesalpinia minax Hance.

  Guo-Xu Ma, Jing-Quan Yuan, Li Cao, Jun-Shan Yang, Xu-Dong Xu
  [show abstract] [hide abstract]
  ABSTRACT: Two new cassane-type diterpenes, Caesalpinolide F (1) and Caesalpinolide G (2) were isolated from Caesalpinia minax Hance. Their structures were elucidated on the basis of 1D and 2D NMR, MS and CD analysis. Compounds 1 and 2 were tested against colon carcinoma (HCT-8) and breast cancer (MCF-7) human cancer cell lines, and showed mild cytotoxicity activities.
  Natural product research 07/2012; · 1.01 Impact Factor
• Article: Cassane-type diterpenes from the seeds of Caesalpinia minax with their antineoplastic activity.

  Guo-Xu Ma, Xu-Dong Xu, Li Cao, Jing-Quan Yuan, Jun-Shan Yang, Li-Yan Ma
  [show abstract] [hide abstract]
  ABSTRACT: Five new cassane-type diterpenes, neocaesalpin AA (1), neocaesalpin AB (2), neocaesalpin AC (3), neocaesalpin AD (4) and neocaesalpin AE (5), were isolated from Caesalpinia minax together with three known compounds, 12α-methoxyl,5α,14β-dihydroxy-1α,6α,7β-triacetoxycass-13(15)-en-16,12-olide (6), spirocaesalmin (7) and magnicaesalpin (8). Their structures were elucidated based on 1D and 2D NMR, MS and CD analyses. Compounds 1-6 were tested against Hela, HCT-8, HepG-2, MCF-7 and A549 cancer cells and showed moderate cytotoxicity with IC₅₀ values from 18.4 to 83.9 µM.
  Planta Medica 06/2012; 78(12):1363-9. · 2.15 Impact Factor
• Article: The new cassane-type diterpenes from Caesalpinia minax.

  Guo-Xu Ma, Jing-Quan Yuan, Li Cao, Jun-Shan Yang, Xu-Dong Xu
  [show abstract] [hide abstract]
  ABSTRACT: Four new cassane-type diterpenes, Neocaesalpin S (1), Neocaesalpin T (2), Neocaesalpin U (3), and Neocaesalpin V (4) were isolated from Caesalpinia minax HANCE together with seven known compounds Neocaesalpin A (5), Neocaesalpin K (6), Neocaesalpin L (7), Neocaesalpin M (8), Neocaesalpin O (9), Neocaesalpin MP (10), and Magnicaesalpin (11). Their structures were elucidated on the basis of 1D- and 2D-NMR, MS, and circular dichroism (CD) analysis. Compounds 1-4 were tested against liver cancer (HepG-2) and breast cancer (MCF-7), and showed mild antiproliferative activity.
  Chemical & pharmaceutical bulletin 01/2012; 60(6):759-63. · 1.70 Impact Factor
• Article: Chemical composition of Croton laevigatus

  Guo-An Zou, Haji Akber Aisa, Hong-Wu Zhang, Jun-Shan Yang, Zhong-Mei Zou
  Chemistry of Natural Compounds 01/2012; 47(6):993-994. · 1.03 Impact Factor
• Article: Irisdichotins A-C, three new flavonoid glycosides from the rhizomes of Iris dichotoma Pall.

  Long Huang, Wen-Hui Ma, Yan-Ze Liu, Jun-Shan Yang, Yong Peng, Pei-Gen Xiao
  [show abstract] [hide abstract]
  ABSTRACT: Three new compounds including one flavonol glycoside, irisdichotin A (1), and two flavanonol glycosides, irisdichotins B (2) and C (3), were isolated from the rhizomes of Iris dichotoma Pall. Their structures were elucidated on the basis of spectroscopic methods.
  Journal of Asian natural products research 08/2011; 13(8):744-8. · 0.61 Impact Factor
• Article: Multihydroxylation of ursolic acid by Pestalotiopsis microspora isolated from the medicinal plant Huperzia serrata.

  Shao-bin Fu, Jun-shan Yang, Jin-long Cui, Qing-feng Meng, Xu Feng, Di-An Sun
  [show abstract] [hide abstract]
  ABSTRACT: The structural modification of ursolic acid by an endophytic fungus Pestalotiopsis microspora, isolated from medicinal plant Huperzia serrata was reported for the first time. The structure diversity was very important for the SAR study of ursolic acid and its derivatives. Incubation of ursolic acid 1 with P. microspora afforded four metabolites: 3-oxo-15α, 30-dihydroxy-urs-12-en-28-oic acid (2), 3β, 15α-dihydroxy-urs-12-en-28-oic acid (3), 3β, 15α, 30- trihydroxy-urs-12-en-28-oic acid (4) and 3,4-seco-ursan-4,30-dihydroxy-12-en-3,28-dioic acid (5). All products were new compounds and their structures elucidation was mainly based on the spectroscopic data.
  Fitoterapia 07/2011; 82(7):1057-61. · 1.85 Impact Factor
• Article: Two new flavone C-glycosides from Trollius ledebourii.

  Li-Zhen Wu, Hai-Feng Wu, Xu-Dong Xu, Jun-Shan Yang
  [show abstract] [hide abstract]
  ABSTRACT: Two new flavone C-glycosides, trollisin A (1) and trollisin B (2), along with seven known flavonoids, isoswertisin (3), isoswertiajaponin (4), orientin (5), 2″-O-β-L-galactopyranosylvitexin (6), 2″-O-β-L-galactopyranosylorientin (7), neodiosmin (8) and acacetin-7-O-neohesperidoside (9) were isolated from the flowers of Trollius ledebourii REICHB. The structures of the new compounds were elucidated based on spectral analysis, including MS, 1D- and 2D-NMR experimentation.
  Chemical & pharmaceutical bulletin 01/2011; 59(11):1393-5. · 1.70 Impact Factor
• Article: Biotransformation of ursolic acid by an endophytic fungus from medicinal plant Huperzia serrata.

  Shao-bin Fu, Jun-shan Yang, Jin-long Cui, Xu Feng, Di-an Sun
  [show abstract] [hide abstract]
  ABSTRACT: Endophytic fungi were used not only for their producing bioactive products but also for their ability to transform natural compounds. An endophytic fungus, isolated from medicinal plant Huperzia serrata, was identified as Umbelopsis isabellina based on the internal transcribed spacer of ribosomal DNA (rDNA-ITS) region. It was used to transform ursolic acid (1), a pentacyclic triterpene. Incubation of ursolic acid with U. isabellina afforded three products, 3β-hydroxy-urs-11-en-28,13-lactone (2), 3β,7β-dihydroxy-urs-11-en-28,13-lactone (3), 1β,3β-dihydroxy-urs-11-en-28,13-lactone (4). Although product 2 was a known compound, it was first obtained by microbial transformation. Products 3 and 4 were new compounds. The structural elucidation of the three compounds was achieved mainly by the 1D- and 2D-NMR, MS, IR data. The endophytic fungus U. isabellina can hydroxyate the C12-C13 double bond at position 13 of ursolic acid 1 and form a five-member lactone effectively. In the meantime, this fungus can also introduce the hydroxyl group at C-1 or C-7 of ursolic acid 1.
  Chemical & pharmaceutical bulletin 01/2011; 59(9):1180-2. · 1.70 Impact Factor
• Article: Laevigatbenzoate from Croton laevigatus Vahl.

  Guo-An Zou, Hong-Wu Zhang, Haji Akber Aisa, Jun-Shan Yang, Chao-Zhong Peng, Zhong-Mei Zou
  [show abstract] [hide abstract]
  ABSTRACT: A new trans-clerodane diterpenoid, laevigatbenzoate (1), was isolated from the leaves of Croton laevigatus Vahl. Its structure was established on the basis of spectroscopic analysis, and the absolute configuration was determined by application of the CD excitation chirality method. This compound showed weak cytotoxicity against HeLa cells, with an IC(50) value of 45.4 μM.
  Journal of Natural Medicines 01/2011; 65(2):391-4. · 1.39 Impact Factor
• Article: Lactonecembranoids from Croton laevigatus.

  Guo-An Zou, Gang Ding, Zhi-Heng Su, Jun-Shan Yang, Hone-Wu Zhang, Chao-Zhong Peng, Haiji Akber Aisa, Zhong-Mei Zou
  [show abstract] [hide abstract]
  ABSTRACT: Six new cembranoids, laevigatlactones A-F (1-6), and the known compound neocrotocembraneic acid (7) were isolated from leaves of Croton laevigatus. Their structures were elucidated on the basis of spectroscopic analysis, and that of 1 was confirmed by X-ray crystallography. Compound 2 exhibited modest cytotoxicity against HeLa cells, with an IC(50) value of 38.4 microM.
  Journal of Natural Products 03/2010; 73(4):792-5. · 3.13 Impact Factor
• Article: Lactonecembranoids from Croton laeWigatus

  Guo-An Zou, ‡ Gang Ding, † Zhi-Heng Su, † Jun-Shan Yang, † Hone-Wu Zhang, † Chao-Zhong Peng, † Haiji Akber Aisa, ‡ and
  J. Nat. Prod. 01/2010;
• Source

  Available from: Zhong-Mei Zou

  Article: Flavonoids from the stems of Croton caudatus Geisel. var. tomentosus Hook.

  Guo-An Zou, Zhi-Heng Su, Hong-Wu Zhang, Yuan Wang, Jun-Shan Yang, Zhong-Mei Zou
  [show abstract] [hide abstract]
  ABSTRACT: A new flavone, named crotoncaudatin (1), was isolated from the stems of Croton caudatus Geisel. var. tomentosus Hook., together with nine known analogues: 3,5,6,7,8,3',4'-heptamethoxyflavone (2), tangeretin (3), nobiletin (4), 5,6,7,4'-tetramethoxy-flavone (5), sinensetin (6), kaempferol (7), tiliroside (8), kaempferol-3-O-rutinoside (9) and rutin (10). The structures of the above compounds were established by a combination of spectroscopic methods, including HR-ESI-MS, 1H-NMR, 13C-NMR, HMQC and HMBC spectra. All compounds were isolated from and identified in this species for the first time and compounds 1-6 are new for the genus Croton.
  Molecules 01/2010; 15(3):1097-102. · 2.39 Impact Factor
• Source

  Available from: nocookie.net

  Article: Four new bibenzyl derivatives from Dendrobium candidum.

  Yan Li, Chun-Lan Wang, Ya-Jun Wang, Fang-Fei Wang, Shun-Xing Guo, Jun-Shan Yang, Pei-Gen Xiao
  [show abstract] [hide abstract]
  ABSTRACT: Four new bibenzyl derivatives, namely, dendrocandins F-I (1-4), were isolated from the stems of Dendrobium candidum. Their structures were elucidated by the analysis of spectroscopic data. Dendrocandins F and G represent the fourth and fifth example of bisbibenzyl derivates with a dibenzopyran ring between two units, respectively. Dendrocandin H represents the first example of a bibenzyl derivative formed by a bibenzyl and a 1,4-phenanthraquinone unit via a dibenzopyran ring. Compounds 1-4 were examined for antioxidant activity by 1,1-diphenyl-2-picrylhydrazyl (DPPH) free radical scavenging assay.
  Chemical & pharmaceutical bulletin 10/2009; 57(9):997-9. · 1.70 Impact Factor
• Article: Two flavonoid dimers from Sarcandra hainanensis (PEI) SWAMY et BAILEY.

  Cong-Mei Cao, Yong Peng, Li-Jia Xu, Ya-Jun Wang, Jun-Shan Yang, Pei-Gen Xiao
  [show abstract] [hide abstract]
  ABSTRACT: Two new flavonoid dimers (1, 2) consisting of flavan-chalcone together with three known compounds (3-5) were isolated from the ethanol extract of the whole plants of Sarcandra hainanensis. Their structures were determined by extensive spectroscopic analysis. Human immunodeficiency virus-1 integrase inhibition activities of compounds 1 and 2 were evaluated and they showed weak activities with IC(50) at 18.05 and 25.27 muM, respectively.
  CHEMICAL & PHARMACEUTICAL BULLETIN 08/2009; 57(7):743-6. · 1.59 Impact Factor