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O I Epshtein,
A M Dygai,
V V Zhdanov,
S A Sergeeva,
G N Zyuz'kov, E V Udut,
T Yu Khrichkova,
E V Simanina,
L A Gur'yantseva,
L A Stavrova,
E D Gol'dberg
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ABSTRACT: We compared the stimulatory effects of a preparation of antibodies against erythropoietin in ultralow doses (Poetam) and recombinant erythropoietin (Recormon) on erythropoiesis that was suppressed by carboplatin. Both drugs possessed high erythropoiesis-stimulating activity, which was manifested in an increase in the number of erythrokaryocytes and erythroid precursors in hemopoietic tissue and count of erythrokaryocytes and reticulocytes in the peripheral blood during postcytostatic recovery. Recormon produced a rapid and short-term stimulatory effect on the erythron. The effect of Poetam developed slowly, but persisted for a longer time.
Bulletin of Experimental Biology and Medicine 07/2007; 143(6):699-702. · 0.27 Impact Factor
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A M Dygai,
V V Zhdanov,
G N Zyuz'kov, E V Udut,
E V Simanina,
L A Gur'yantseva,
T Yu Khrichkova,
L A Stavrova,
O I Epshtein,
S A Sergeeva,
E D Gol'dberg
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ABSTRACT: The mechanisms of suppression and recovery of the bone marrow erythroid stem were studied on the model of myelosuppression induced by administration of carboplatin in the maximum tolerated dose. Single administration of the cytostatic led to the development of long-term hypoplasia of hemopoiesis. Despite enhanced proliferation of erythroid precursor caused by increased erythropoietic activity of blood plasma and bone marrow cells, inhibition of cell maturation prevented recovery of the content of morphologically recognizable erythrokaryocytes in the bone marrow.
Bulletin of Experimental Biology and Medicine 06/2007; 143(5):581-4. · 0.27 Impact Factor
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O. I. Epshtein,
A. M. Dygai,
V. V. Zhdanov,
S. A. Sergeeva,
G. N. Zyuz’kov, E. V. Udut,
T. Yu. Khrichkova,
E. V. Simanina,
L. A. Gur’yantseva,
L. A. Stavrova,
E. D. Gol’dberg
[show abstract]
[hide abstract]
ABSTRACT: We compared the stimulatory effects of a preparation of antibodies against erythropoietin in ultralow doses (Poetam) and recombinant
erythropoietin (Recormon) on erythropoiesis that was suppressed by carboplatin. Both drugs possessed high erythropoiesis-stimulating
activity, which was manifested in an increase in the number of erythrokaryocytes and erythroid precursors in hemopoietic tissue
and count of erythrokaryocytes and reticulocytes in the peripheral blood during postcytostatic recovery. Recormon produced
a rapid and short-term stimulatory effect on the erythron. The effect of Poetam developed slowly, but persisted for a longer
time.
Bulletin of Experimental Biology and Medicine 05/2007; 143(6):699-702. · 0.27 Impact Factor
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[show abstract]
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ABSTRACT: We compared the capacity of superlow-dose of antibodies to erythropoietin (Poetam) and recombinant erythropoietin (Recormon) to stimulate the recovery of adriamycin-suppressed erythropoiesis in mice. Both preparations exhibited high erythron activation capacity and considerably increased the content of erythrocytes and reticulocytes in the peripheral blood and content of erythrokaryocytes and erythroid precursors in the hemopoietic tissue of experimental animals. The effect of Recormon manifested immediately after injection, while the effect of Poetam was somewhat delayed, but more lasting (due to activation of host erythropoietin system).
Bulletin of Experimental Biology and Medicine 09/2006; 142(3):320-3. · 0.27 Impact Factor
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[show abstract]
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ABSTRACT: We compared the capacity of superlow-dose of antibodies to erythropoietin (Poetam) and recombinant erythropoietin (Recormon)
to stimulate the recovery of adriamycin-suppressed erythropoiesis in mice. Both preparations exhibited high erythron activation
capacity and considerably increased the content of erythrocytes and reticulocytes in the peripheral blood and content of erythrokaryocytes
and erythroid precursors in the hemopoietic tissue of experimental animals. The effect of Recormon manifested immediately
after injection, while the effect of Poetam was somewhat delayed, but more lasting (due to activation of host erythropoietin
system).
Bulletin of Experimental Biology and Medicine 08/2006; 142(3):320-323. · 0.27 Impact Factor
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ABSTRACT: We compared the function of hemopoietic stem cells under conditions of cytostatic myelosuppression (cyclophosphamide treatment) and during treatment with granulocytopoiesis stimulators. It was found that unipotent hemopoietic precursor cells are most sensitive to cyclophosphamide. Different effects of hemostimulators on stem cells are determined by different proportions between proliferation and differentiation processes.
Bulletin of Experimental Biology and Medicine 12/2005; 140(5):631-4. · 0.27 Impact Factor
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ABSTRACT: We studied processes of proliferation and differentiation of hemopoietic precursor cells in mice treated with granulocyte CSF under conditions of cytostatic myelodepression. It was found that the hemostimulating effect of original granulocyte CSF preparation consists in accelerated maturation of hemopoietic precursors and increased content of DNA-synthesizing CFU-GM in the bone marrow.
Bulletin of Experimental Biology and Medicine 02/2005; 139(1):154-7. · 0.27 Impact Factor
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ABSTRACT: We studied processes of proliferation and differentiation of hemopoietic precursor cells in mice treated with granulocyte CSF under conditions of cytostatic myelodepression. It was found that the hemostimulating effect of original granulocyte CSF preparation consists in accelerated maturation of hemopoietic precursors and increased content of DNA-synthesizing CFU-GM in the bone marrow.
Bulletin of Experimental Biology and Medicine 12/2004; 139(1):154-157. · 0.27 Impact Factor
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ABSTRACT: The content of hemopoietic precursors in the bone marrow, its morphological composition, production of hemopoietic growth factors by cells of the hemopoietic microenvironment, erythropoietic activity, and plasma content of endogenous erythropoietin were studied in CBA/CaLac mice with hypoplasia of hemopoiesis induced by adriamycin in a maximum permissible dose. Cytostatic treatment affected production of substances determining erythropoietic activity by adherent and nonadherent cells of the bone marrow. Erythropoietic activity of peripheral blood plasma considerably increased. Recovery of erythroid hemopoiesis was determined by the effects of endogenous erythropoietin and other substances secreted by cells of the hemopoietic microenvironment and present in the peripheral blood.
Bulletin of Experimental Biology and Medicine 07/2003; 135(6):548-51. · 0.27 Impact Factor
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ABSTRACT: The content of hemopoietic precursors in the bone marrow, its morphological composition, structural and functional organization, binding of hemopoietic precursors by adherent cells, and expression of receptors for erythroblasts and sialoadhesin on bone marrow macrophages were studied in CBA/CaLac mice with hypoplasia of hemopoiesis caused by etoposide in a maximum permissible dose. It was found that recovery of hemopoiesis after cytostatic treatment was related to accelerated maturation of hemopoietic precursors and increased ability of microenvironmental cells to bind hemopoietic cells.
Bulletin of Experimental Biology and Medicine 09/2001; 132(2):744-7. · 0.27 Impact Factor
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ABSTRACT: The content of hemopoietic precursors in the bone marrow, its morphological composition, structural and functional organization, binding of hemopoietic precursors by adherent cells, and expression of receptors for erythroblasts and sialoadhesin on bone marrow macrophages were studied in CBA/CaLac mice with hypoplasia of hemopoiesis caused by etoposide in a maximum permissible dose. It was found that recovery of hemopoiesis after cytostatic treatment was related to accelerated maturation of hemopoietic precursors and increased ability of microenvironmental cells to bind hemopoietic cells.
Bulletin of Experimental Biology and Medicine 07/2001; 132(2):744-747. · 0.27 Impact Factor
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ABSTRACT: We studied structural and functional organization of the bone marrow, production of hemopoietic growth factors by hemopoietic cells, and plasma colony-stimulating and erythropoietic activities in CBA/CaLac mice treated with etoposide. The effects of etoposide on cultured hemopoietic and microenvironmental cells were also evaluated. Our results indicate that hemopoietic growth factors secreted by adherent bone marrow cells play the major role in the normalization of hemopoiesis during etoposide-induced myelosuppression.
Bulletin of Experimental Biology and Medicine 06/2001; 131(5):432-6. · 0.27 Impact Factor
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ABSTRACT: We studied structural and functional organization of the bone marrow, production of hemopoietic growth factors by hemopoietic cells, and plasma colony-stimulating and erythropoietic activities in CBA/CaLac mice treated with etoposide. The effects of etoposide on cultured hemopoietic and microenvironmental cells were also evaluated. Our results indicate that hemopoietic growth factors secreted by adherent bone marrow cells play the major role in the normalization of hemopoiesis during etoposide-induced myelosuppression.
Bulletin of Experimental Biology and Medicine 04/2001; 131(5):432-436. · 0.27 Impact Factor
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E D Gol'dberg,
A M Dygai,
L A Gur'yantseva,
V V Zhdanov,
N S Pozhen'ko,
E V Simanina,
N I Suslov,
T Y Khrichkova, E V Udut,
V E Gol'dberg,
M G Matyash,
N O Popova
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ABSTRACT: We compared hemopoiesis-stimulating activities of dry pantohematogen and recombinant granulocyte colony-stimulating factor under conditions of cyclophosphamide-induced myelosuppression. These preparations stimulated regeneration of bone marrow granulomonocytopoiesis by various mechanisms.
Bulletin of Experimental Biology and Medicine 12/2000; 130(11):1051-4. · 0.27 Impact Factor
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ABSTRACT: Mechanisms of action of pantogematogen (PG), granulocyte colony-stimulating factor (G-CSF), glycyram, and D-glucuronic asid (D-GA) have been investigated under the conditions of myelosuppression caused by the introduction of cyclophosphane. It is established that the activation of granulocytopoiesis by these preparations is based on various mechanisms: G-CSF directly stimulates the proliferation and differentiation of hemopoietic cells; PG enhances the proliferation of granulocytes due to activation of the regulatory systems; D-GA and glycyram normalize the structural and functional organization of a bone marrow, thus providing intensive maturing of the colony-forming units.
Eksperimental'naia i klinicheskaia farmakologiia 69(2):44-7.
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ABSTRACT: The qualitative and quantitative composition of the hemopoietic tissue has been studied and the processes of erythropoiesis regeneration in mice treated with cyclophosphamide and skullcap (Scutellaria Baicalensis) extract against a background of cyclophosphamide treatment have been studied. The skullcap extract produced a significant erythropoiesis-stimulating effect under the conditions of cytostatic myclosuppression. Activation of the erythroid branch of hemopoiesis was related to the growing number of erythropoiesis precursor cells in the bone marrow and also to an increase in the concentration of humoral factors of erythropoiesis regulation in the peripheral blood serum.
Eksperimental'naia i klinicheskaia farmakologiia 68(4):43-5.
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ABSTRACT: The myelotoxicity and the hemopoiesis recovery effect of etoposide, an antitumor preparation of the podophyllotoxin group, were experimentally studied on mice. It was found that the main role in the hemopoiesis recovery after etoposide administration is related to accelerated proliferation and increased differentiation of the hemopoietic precursor cells.
Eksperimental'naia i klinicheskaia farmakologiia 64(5):31-3.
