Hashem Sharghi

Shiraz University of Technology, Chimaz, Fārs, Iran

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Publications (254)448.32 Total impact

  • [Show abstract] [Hide abstract]
    ABSTRACT: The fluorescence spectra and response characteristics of two porphyrin compounds meso-tetrakis(2-hydroxynaphthyl) porphyrin and meso-tetra (2-thiophene) porphyrin (MTHNP) to Hg(2+) were investigated. MTHNP showed preferable fluorescence response to Hg(2+). Thereby, an efficient and selective fluorimetric optode membrane based on the fluorescence quenching of MTHNP for Hg(2+) ion determination at low concentration levels has been developed. The sensing membrane containing MTHNP reversibly responded to Hg(2+) with a working concentration range covering from 5.0×10(-9) to 1.25×10(-5)M with a relatively fast response time less than 3min. In addition to high stability, reversibility and reproducibility, the sensor showed extremely high selectivity toward Hg(2+) ion with respect to some alkali, alkaline earth and heavy metal ions. The limit of detection for Hg(2+) was 5.0×10(-9)M. The proposed fluorescent sensor was successfully applied to the direct determination of mercury content of biofenac eye drop, hair and different water samples. Copyright © 2014 Elsevier B.V. All rights reserved.
    Materials Science and Engineering C 03/2015; 48:424-33. · 2.74 Impact Factor
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    ABSTRACT: Abstract Mo(IV) salen complex (2.5 mol%) was found to be a highly efficient catalyst for the one-pot synthesis of 2,4,5-triarylimidazoles via a three-component reaction using benzil or benzoin, aryl aldehydes, and ammonium acetate as a nitrogen source under mild conditions. In order to recover and the reuse of the catalyst, a new Mo(IV) salen–silica nanoparticle as heterogeneous catalyst was prepared by simple and successful immobilization of the catalyst onto silica (3-aminopropyl functionalized silica gel). This procedure can be applied to large-scale conditions with high efficiency. Experimental evidence showed that the catalyst is stable and can be easily recovered and reused for at least five times without significant loss of activity. The nanocatalyst was characterized using FT-IR spectroscopy, scanning electron microscopy, atomic force microscopy, powder X-ray diffraction , transmission electron microscopy, thermogravimetric instrument for analysis of nitrogen adsorption, and inductively coupled plasma spectrometer. Graphical Abstract
    Molecular Diversity 12/2014; · 2.54 Impact Factor
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    ABSTRACT: Abstract Mo(IV) salen complex (2.5 mol%) was found to be a highly efficient catalyst for the one-pot synthesis of 2,4,5-triarylimidazoles via a three-component reaction using benzil or benzoin, aryl aldehydes, and ammonium acetate as a nitrogen source under mild conditions. In order to recover and the reuse of the catalyst, a new Mo(IV) salen–silica nanoparticle as heterogeneous catalyst was prepared by simple and successful immobilization of the catalyst onto silica (3-aminopropyl functionalized silica gel). This procedure can be applied to large-scale conditions with high efficiency. Experimental evidence showed that the catalyst is stable and can be easily recovered and reused for at least five times without significant loss of activity. The nanocatalyst was characterized using FT-IR spectroscopy, scanning electron microscopy, atomic force microscopy, powder X-ray diffraction , transmission electron microscopy, thermogravimetric instrument for analysis of nitrogen adsorption, and inductively coupled plasma spectrometer. Graphical Abstract
    Molecular Diversity 12/2014; · 2.54 Impact Factor
  • Hashem Sharghi, Mahdi Aberi
    ChemInform 11/2014; 45(44).
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    ABSTRACT: The bactericidal efficiency of various positively and negatively charged silver nanoparticles has been extensively evaluated in literature, but there is no report on efficacy of neutrally charged silver nanoparticles. The goal of this study is to evaluate the role of electrical charge at the surface of silver nanoparticles on antibacterial activity against a panel of microorganisms. Three different silver nanoparticles were synthesized by different methods, providing three different electrical surface charges (positive, neutral, and negative). The antibacterial activity of these nanoparticles was tested against gram-positive (i.e., Staphylococcus aureus, Streptococcus mutans, and Streptococcus pyogenes) and gram-negative (i.e., Escherichia coli and Proteus vulgaris) bacteria. Well diffusion and micro-dilution tests were used to evaluate the bactericidal activity of the nanoparticles. According to the obtained results, the positively-charged silver nanoparticles showed the highest bactericidal activity against all microorganisms tested. The negatively charged silver nanoparticles had the least and the neutral nanoparticles had intermediate antibacterial activity. The most resistant bacteria were Proteus vulgaris. We found that the surface charge of the silver nanoparticles was a significant factor affecting bactericidal activity on these surfaces. Although the positively charged nanoparticles showed the highest level of effectiveness against the organisms tested, the neutrally charged particles were also potent against most bacterial species.
    Journal of Nanomaterials 09/2014; 2015(2015):8. · 1.61 Impact Factor
  • H. Sharghi, P. Shiri, M. Aberi
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    ABSTRACT: Export Date: 18 October 2014
    Synthesis 09/2014; 46:2489-2498. · 2.44 Impact Factor
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    ABSTRACT: AimTo synthesize and characterize silver nanoparticles (Ag NPs) with different surface charges in order to evaluate their cytotoxicity and antibacterial activity in the absence and presence of dentine compared with NaOCl and CHXMethodologyAg NPs with positive, negative and neutral surface charges were synthesized and characterized. The first phase of the experiment determined the minimum inhibitory concentrations (MICs) of NPs against planktonic E. faecalis and compared them with that of NaOCl and CHX. The second phase tested the elimination of E. faecalis at different contact times (5, 20 and 60 min and 4 and 24 h) and the role of dentine in their inactivation was assessed. In the third phase, the most effective Ag NP solution was selected for cytocompatibility assessment. An MTT-based cytotoxicity assay was used to evaluate the cytotoxicity of the selected NP solution in different concentrations on L929 fibroblasts compared to that of 2.5% NaOCl and 0.2% CHX. Student's t test and repeated measures MANOVA approach were used for statistical analyses.ResultsThe characterization revealed synthesis of colloidal NPs in the size ranges of 5–10 nm in diameter. The results indicated that Ag NP with a positive surface charge had the smallest MIC against planktonic E. faecalis and it was active in very lower concentrations compared to NaOCl, CHX and the other tested AgNPs. Positive-charged Ag NPs at 5.7×10−10 mol/L completely prevented growth of E. faecalis after 5 min of contact time, a finding comparable to 0.025% NaOCl. Dentine powder had variable inhibitory effects on all tested materials after 1 h incubation period but after 24 h, NaOCl and the positive-charged Ag NPs were not inhibited by dentine at any concentration used. CHX was the most and the positively charged Ag NP solution was the least toxic solutions to L929 fibroblasts (P < 0.001).Conclusions Ag NP surface charge was important in bactericidal efficacy against E. faecalis. The positively charged imidazolium-based ionic-liquid protected Ag NPs showed promising antibacterial results against E. faecalis and exhibited a high level of cytocompatibility to L929 cells.This article is protected by copyright. All rights reserved.
    International Endodontic Journal 09/2014; · 2.27 Impact Factor
  • Hashem Sharghi, Pezhman Shiri, Mahdi Aberi
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    ABSTRACT: In this work, the combination of 7,8-dihydroxy-4-methyl coumarin (DHMC) as a novel bidentate O,O-chelating agent and copper(II) acetate monohydrate (2:1 molar ratio) has been found to form an efficient catalytic system. This catalyst provided good to excellent yields in the multi-component click synthesis of 1,4-disubstituted-1,2,3-triazoles by using various structurally diverse organic halides, different non-activated terminal alkynes, and sodium azide. This catalytic system eliminates the need for the isolation of the hazardous azide intermediates which are generated in situ. The reaction is carried out in aqueous phase at room temperature and it can be accelerated by sonication or by increasing the reaction temperature. Moreover, the reaction can be performed in large scale. It is noteworthy that DHMC is commercially available and that it can be easily synthesized with low cost materials.
    Molecular Diversity 05/2014; 18(3). · 2.54 Impact Factor
  • Reza Khalifeh, Hashem Sharghi, Zahra Rashidi
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    ABSTRACT: The newly synthesized Zn complex is used as a catalyst for the three-component coupling reaction of aldehydes, alkynes, and secondary amines.
    ChemInform 01/2014; 45(4).
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    ABSTRACT: A poly (vinyl chloride) (PVC) matrix membrane ion-selective electrode for silver (I) ion is fabricated based on modified polypyrrole - multiwalled carbon nanotubes composite with new lariat ether. This sensor has a Nernstian slope of 59.4±0.5mV/decade over a wide linear concentration range of 1.0×10(-7) to 1.0×10(-1)molL(-1) for silver (I) ion. It has a short response time of about 8.0s and can be used for at least 50days. The detection limit is 9.3×10(-8)molL(-1) for silver (I) ion, and the electrode was applicable in the wide pH range of 1.6 -7.7. The electrode shows good selectivity for silver ion against many cations such as Hg (II), which usually imposes serious interference in the determination of silver ion concentration. The use of multiwalled carbon nanotubes (MWCNTs) in a polymer matrix improves the linear range and sensitivity of the electrode. In addition by coating the solid contact with a layer of the polypyrrole (Ppy) before coating the membrane on it, not only did it reduce the drift in potential, but a shorter response time was also resulted. The proposed electrode was used as an indicator electrode for potentiometric titration of silver ions with chloride anions and in the titration of mixed halides. This electrode was successfully applied for the determination of silver ions in silver sulphadiazine as a burning cream.
    Materials science & engineering. C, Materials for biological applications. 01/2014; 34C:326-333.
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    ABSTRACT: A novel optode for determination of Hg(II) ions is developed based on immobilization of a recently synthesized ionophore, 7-(1H-imidazol-1-ylmethyl)-5,6,7,8,9,10-hexahydro-2H-1,13,4,7,10 benzodioxatriaza cyclopentadecine-3,11(4H,12H)-dione, in a PVC membrane. Dioctyl sebacate was used as a plasticizer, sodium tetraphenylborate as an anionic additive and ETH5294 as a chromoionophore. The response of the optode was based on the complexation of Hg(II) with the ionophore in the membrane phase, resulting an ion exchange process between Hg(II) in the sample solution and H(+) in the membrane. The effects of pH and amounts of the ionophore, chromoionophore, ionic additive and type of plasticizer on the optode response were investigated. The selectivity of the optode was studied in the present of several cations. The optode has a linear response to Hg(II) in the range of 7.2×10(-13)-4.7×10(-4)molL(-1) with detection limit of 0.18pmolL(-1). The optode was successfully applied to the determination of Hg(II) in real samples.
    Materials science & engineering. C, Materials for biological applications. 10/2013; 33(7):4167-72.
  • Hashem Sharghi, Reza Khalifeh, Zahra Rashidi
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    ABSTRACT: The efficient synthesis of chromeno[3,4-[Formula: see text]]quinoline derivatives by condensation of O-propargylated salicylaldehyde, or corresponding compounds and primary aromatic amine derivatives using a catalytic amount of heterogeneous Cu(II)BHPPDAH complex without being immobilized on any supports (5.0 mol%) in PEG 300 as a "green" solvent is described. The remarkable features of this protocol are good to high yields in all cases, short reaction times, a cleaner reaction profile in an environmentally benign solvent (PEG 300), and the method is applicable to large-scale operation without any problem. Furthermore, the catalyst was quantitatively recovered from the reaction mixture by simple filtration and reused at least seven times with almost consistent activity.
    Molecular Diversity 08/2013; · 2.54 Impact Factor
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    ABSTRACT: 5-Substituted-1H-tetrazoles can conveniently be synthesized from the corresponding nitriles by reaction with NaN3 using the efficient and recyclable heterogeneous catalyst prepared by immobilization of copper(II) complex of 4′-phenyl-2,2′:6′,2″-terpyridine on activated multi-walled carbon nanotubes [AMWCNTs-O–Cu(II)–PhTPY]. Excellent results were obtained in each case affording the corresponding tetrazole adducts in good to excellent yields. In general, aromatic nitriles with electron-donating group could be accomplished as well as that with electron-withdrawing groups. By leaving out nitrile from the reaction and adding CH(OEt)3 and amines bearing various substituents, 1-substituted-1H-tetrazoles formed in water in high yields. The reported protocols have the advantages of rapid assembly of a host of heterocyclic systems in high yields with the added advantage of recycling and reuse of the catalyst.
    Journal of Organometallic Chemistry 08/2013; 738:41-48. · 2.30 Impact Factor
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    ABSTRACT: We report on the synthesis of polymeric nanoparticles (PNPs) containing a tetrakis(3-hydroxyphenyl)porphyrin, and their use for the separation of mercury(II) ion. The PNPs were prepared by bulk polymerization from methacrylic acid (the monomer), ethyleneglycol dimethacrylate (the cross-linker), 2,2′-azobisisobutyronitrile (the radical initiator) and the mercury(II) complex of 5,10,15,20-tetrakis(3-hydroxyphenyl)-porphyrin. The Hg(II) ion was then removed by treatment with dilute hydrochloric acid. The PNPs were characterized by colorimetry, FT-IR spectroscopy, and scanning electron microscopy. The material is capable of binding Hg(II) from analyte samples. Bound Hg(II) ions can be eluted with dilute nitric acid and then quantified by cold vapor AAS. The extraction efficiency, the effects of pH, preconcentration and leaching times, sample volume, and of the nature, concentration and volume of eluent were investigated. The maximum adsorption capacity of the PNPs is 249 mg g−1, the relative standard deviation of the AAS assay is 2.2 %, and the limit of detection (3σ) is 8 ng.L−1. The nanoparticles exhibit excellent selectivity for Hg(II) ion over other metal ions and were successfully applied to the selective extraction and determination of Hg(II) ion in spiked water samples. Figure Schematic presentation of leaching process of mercury(II) ion from the prepared IIP
    Microchimica Acta 07/2013; 180(9-10). · 3.72 Impact Factor
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    ABSTRACT: Iron-doped single walled carbon nanotubes (Fe/SWCNTs) is an efficient, eco-friendly, and reusable heterogeneous catalyst for the synthesis of diversely decorated α-aminophosphonates via multicomponent reaction of amines, carbonyl compounds, and phosphorus compounds under solvent-free conditions. This methodology illustrates a very simple procedure, with wide applicability, extending the scope to aliphatic and aromatic amines and carbonyl compounds. It also enabled the development of one-pot synthesis of β-phosphonomalonates during the reaction of carbonyl compounds, malononitrile and phosphorus compounds. Excellent results were obtained in each case affording the corresponding organophosphorus adducts in good yields.
    Tetrahedron 06/2013; 69(23):4708-4724. · 2.82 Impact Factor
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    ABSTRACT: Tetrakis-4-chlorophenylporpherinatoiron(III) chloride (FeT(4-ClP)PCl) was used as an ionophore for the construction of two kinds of cyanide ion selective electrodes, i.e., Polyvinilchloride (PVC) membrane and membrane coated graphite electrodes. Different membrane constituents were optimized for the electrodes. Membranes with 65.5% o-nitrophenyl octyl ether (o-NPOE), 32.7% PVC, 0.8% ionophore, and 1.0 cetyltetramethylammonium bromide (CTAB) gave the best Nernstian responses to cyanide ion activity in the concentration range of 6.3 × 10−7–1.2 × 10−2 M. A polyaniline thin film was coated over the graphite electrodes prior to membrane coating; this modification was found suitable for both smooth functioning and fast response time of the graphite electrodes. Response time of the electrodes was found to be about 5 s. Finally, a broader concentration range was found for coated graphite electrodes with respect to the PVC membrane electrodes.
    Journal of electroanalytical chemistry 01/2013; 689:63–68. · 2.87 Impact Factor
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    H Sharghi, A Khoshnood, R Khalifeh
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    ABSTRACT: Highly active Cu (II) complex with 1,4-dihydroxy anthraquinone as a cheap and accessable ligand could be used as a catalyst for the preparation of structurally different propargylamines from a one-pot, three-component reaction of terminal alkynes, aldehydes, and secondary amines with high yields under solvent-free conditions. The 1,4-dihydroxy anthraquinone is a very efficient Cu(II) scavenger that is able to catalyse the A 3 -coupling reaction without pre synthesis of the catalyst.
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    ABSTRACT: A supported catalyst has been prepared by immobilization of a copper(II) complex of 4’-phenyl- 2,2’:6’,2’’-terpyridine on activated multiwalled carbon nanotubes [AMWCNTs-O-CuII-PhTPY]. This heterogeneous catalyst was characterized by scanning electron microscopy (SEM), transmission electron microscopy (TEM), atomic force microscopy (AFM), inductively coupled plasma (ICP) analysis, UV/vis and FT-IR techniques. To ensure the efficiency and fidelity of the copper species, the implementation of three-component strategies in click chemistry was tested. The catalyst enabled the development of one-pot, two-step, mild, and environmentally benign syntheses of diversely decorated 1,2,3-triazoles from alkynes, epoxides or benzyl/alkyl halides, and sodium azide in water. The complex has high catalytic activity, regioselectivity, and was recycled five successive times. In another experiment, the vasorelaxing effect of the triazole products was studied in isolated rat thoracic aorta. All of the selected compounds are vasorelaxants, based on the IC50 values obtained, and the vasorelaxing potency and maximal response for three of the compounds are comparable to acetylcholine.
    Asian J. Org. Chem. 12/2012; 1:377-388.
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    ABSTRACT: A novel optical chemical sensor (optode) was fabricated for the determination of silver ions. The optical sensor was prepared by incorporating recently synthesized ionophore, 7-(1H-benzimidazol-1-ylmethyl)-5,6,7,8,9,10-hexahydro-2H-1,13,4,7,10-benzodioxatriaza cyclopentadecine-3,11(4H,12H)-dione, sodium tetraphenyl borate (NaTPB) as an anionic additive, 3-octadecanoylimino-7-(diethylamino)-1,2-benzophenoxazine (ETH5294) as a chromoionophore, and dioctyl phthalate (DOP) as a plasticizer in a poly(vinyl chloride) membrane. The effect of several parameters in determining Ag(+) was studied and optimized. The spectrophotometric method (λ(max) of 660nm) was used for the determination of Ag(+). Under the optimum conditions, the optical sensor has a wide dynamic range of 1.02×10(-11) to 8.94×10(-5)molL(-1) Ag(+) with the detection limit as low as 2.8×10(-12)molL(-1). The response time of the sensor was ∼150s, with a RSD% of 0.4% (for 1.0×10(-6)molL(-1), n=7). The optode could be regenerated by 0.2molL(-1) HCl solution. The interferences of potential interfering ions were studied. It was shown that the new optode was very selective to silver ions and had no significant response to common ions such as Mn(2+), Cd(2+), Ni(2+), Hg(2+), and Co(2+). It can be claimed that the sensor can specifically detect silver ions. The sensor was successfully applied for the determination of silver ions in different real samples.
    Talanta 11/2012; 101:171-6. · 3.50 Impact Factor

Publication Stats

3k Citations
448.32 Total Impact Points

Institutions

  • 2014
    • Shiraz University of Technology
      • Department of Chemistry
      Chimaz, Fārs, Iran
  • 1991–2014
    • Shiraz University
      • Department of Chemistry
      Chimaz, Fārs, Iran
  • 2012–2013
    • University of Isfahan
      • Department of Chemistry
      Eşfahān, Ostan-e Esfahan, Iran
  • 2011
    • Persian Gulf University
      • Department of Chemistry
      Abu Shehr, Bushehr, Iran
  • 1999–2010
    • Razi University
      • Department of Chemistry
      Kermānshāh, Ostan-e Kermanshah, Iran
  • 2009
    • Shiraz University of Medical Sciences
      • Department of Medicinal Chemistry
      Shīrāz, Fars, Iran
    • Sari Agricultural Sciences and Natural Resources University
      • Department of Basic Sciences
      Bābol, Mazandaran, Iran
  • 2001–2008
    • Tarbiat Modares University
      • Department of Chemistry
      Teheran, Tehrān, Iran
  • 2007
    • Payame Noor University
      • Department of Chemistry
      Teheran, Tehrān, Iran
  • 2004
    • Urmia University
      • Department of Chemistry
      Tabrīz, East Azarbaijan, Iran
  • 2003
    • University of Tehran
      • School of Chemistry
      Tehrān, Ostan-e Tehran, Iran