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ABSTRACT: The objective of this study was to analyze adherence and side effects of three iron supplement regimens (ferrous sulfate) on anemic pregnant women. The clinical trial involved 150 women between the 16th and 20th gestational weeks, at low obstetric risk and with hemoglobin concentration of between 8.0 and 11.0 g/dL. Treatment was provided by ferrous sulfate with 60 mg of elemental iron during 16 (+/- 1) weeks, in three regimens: single tablet a week (n = 48); single tablet twice a week (n = 53) or single tablet a day (n = 49). The outcomes were adherence, assessed through interviews and by counting tablets, and side effects, according to patient information. The adherence showed a declining trend (92%, 83% and 71%; p = 0.010) and the side effects revealed a growing trend (40%, 45% and 71%; p = 0.002) as the dosage increased. Diarrhea and epigastric pain were significantly associated with the dose administered (p = 0.002). These results suggest that in anemic pregnant women, complaints are directly proportional and the compliance is inversely proportional to the amount of medicinal iron.
Cadernos de saúde pública / Ministério da Saúde, Fundação Oswaldo Cruz, Escola Nacional de Saúde Pública 07/2009; 25(6):1225-33. · 0.83 Impact Factor
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ABSTRACT: We assessed HIV-related risk behavior in a time-location sampling (TLS) interviewer administered survey of male truck drivers at the crossroads of two of the major highways used for trucking in Northeast Brazil (N = 686). Overall, 21.3% had sex while on the road (2.8% unprotected); 12.3% had sex with commercial sex workers (1.4% unprotected); 1.8% had sex with hitch-hikers (0.3% unprotected). Unprotected sex with non-wife partners while on the road was independently associated with stimulant use, lack of religious affiliation and being separated or divorced. Stimulant use may be a particular occupational hazard associated with risk for HIV among truck drivers in Brazil and should be considered as a point of intervention. The TLS sampling approach can form the basis of systematic behavioral surveillance in this highly mobile population.
AIDS and Behavior 07/2008; 12(4 Suppl):S32-8. · 3.49 Impact Factor
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ABSTRACT: The aim of this study was to identify and analyze risk factors for perinatal mortality in Recife, Pernambuco State, Brazil, in 2003, using a multilevel hierarchical model. In this case-control study, cases consisted of all perinatal deaths in 2003 in singleton infants with birth weight > 500g and without congenital malformations. The controls were live births from December 26, 2002, to December 31, 2003, with the same characteristics as the study group, but who survived > 6 days. By using record linkage techniques, 403 cases and 1,612 controls were obtained. All variables, when submitted jointly to multiple logistic regression, showed statistical significance in decreasing order of risk, as follows: prematurity (OR = 18.23), low birth weight (OR = 4.90), maternal age > 35 (OR = 1.97), delivery in public hospitals (OR = 1.93), and maternal schooling < 4 years (OR = 1.78).
Cadernos de Saúde Pública 01/2008; 23(12):2853-61. · 0.89 Impact Factor
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ABSTRACT: This study aimed to evaluate the efficacy of weekly iron supplementation with or without vitamin A in the treatment of iron deficiency anemia, using an experimental, randomized, non-placebo-controlled design in 1999. 267 schoolchildren 6 to 14 years of age were randomized to two treatment groups: one group (144) received 200mg iron sulfate alone, with 40 mg of elemental iron, while the other (123) received the same iron supplementation dose plus 10,000 IU of vitamin A (both groups for 30 weeks). Final anemia prevalence was reduced from 48.4% to 17.7% (p < 0.001) in the group receiving iron supplementation alone and 58.1% to 14.3% (p < 0.001) in the group receiving iron plus vitamin A. There was no significant difference between the groups at the end of the study according to mean Hb (p = 0.355) and anemia (p = 0.479). There was a significant correction for iron deficiency anemia with weekly iron-alone supplementation, but with no additional advantage of vitamin A. New studies on the synergism between these two micronutrients are recommended.
Cadernos de Saúde Pública 07/2007; 23(6):1415-21. · 0.89 Impact Factor
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ABSTRACT: To evaluate the effectiveness of three regimens employing ferrous sulfate to treat pregnant women with anemia.
The study was carried out at the Women's Health Center of the Pernambuco Institute of Maternal and Child Health in the city of Recife, Pernambuco, Brazil, from May 2000 to December 2001. A randomized clinical trial with blinded laboratory analysis was conducted. Iron (60 mg) was administered as 300-mg ferrous sulfate tablets. The women were allocated to three treatment groups, according to the frequency of ingesting the tablets: once a week (48 women), twice a week (53 women), and once a day (49 women). The groups were compared for the values for hemoglobin (Hb) concentration, mean corpuscular volume, and ferritin before and after the treatment.
Before the intervention, the groups were homogeneous. They had the following mean (+/- standard deviation) concentrations of hemoglobin: 10.2 +/- 0.5 g/dL for the group receiving iron once a week, 10.2 +/- 0.6 g/dL for the group receiving iron twice a week, and 10.1 +/- 0.6 g/dL for the group receiving iron once a day. The means of corpuscular volume were, respectively: 88.5 +/- 5.0 fL, 87.6 +/- 5.9 fL, and 88.7 +/- 5.1 fL. The respective medians for ferritin were 30.2 ng/mL, 37.1 ng/mL, and 52.9 ng/mL. The cure rate (Hb > 11 g/dL) was 27% in the patients treated once a week, 34% in those treated twice a week, and 47% in the women treated daily. Treatment failure (hemoglobin < 10 g/dL) was seen in 41.6%, 13.2%, and 2.0% of the patients in the respective groups. Interruption of treatment due to diarrhea or epigastric pain occurred only among the patients treated daily.
The regimen with iron administered daily is still the best option for treating anemia. However, treatment with ferrous sulfate administered twice a week is an alternative for patients who are unable to adhere to daily treatment.
Revista Panamericana de Salud Pública 05/2004; 15(5):313-9. · 0.85 Impact Factor
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ABSTRACT: This study evaluates the effectiveness of an experimental project for combating anemia in children ages 6-23 months using weekly doses of iron sulfate within the Family Health Program. In 1999, the Brazilian Ministry of Health began an experimental program to combat anemia in 300,000 children from 512 municipalities in the Northeast of the country. Children received a weekly dose of 50mg of elementary iron for approximately 24 weeks. Two hundred and ninety-three children ages 6-23 months from the urban and rural areas of the municipality of Caruaru in Pernambuco State were evaluated. Before the trial, mean hemoglobin was 10.1 (+/- 0.98) g/dl, and 77.5% of the children were anemic. Following treatment, mean hemoglobin rose to 11.1 (+/- 0.87) g/dl, while the prevalence of anemia fell to 40.3%. This strategy represents a promising tool to reduce prevalence and to control severe forms of anemia in children.
Cadernos de Saúde Pública 19(2):375-81. · 0.89 Impact Factor
