Sabri Selcuk Atamanalp

Ataturk University, Kalikala, Erzurum, Turkey

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Publications (79)98.94 Total impact

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    ABSTRACT: Sigmoid volvulus during pregnancy is a rare complication, and as of 2012, fewer than 100 cases had been reported. In this report, we present a 30 year-old pregnant woman with sigmoid volvulus, and we discuss this rare entity.
    02/2015; 47(1):75-6. DOI:10.5152/eajm.2014.0105
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    ABSTRACT: Obturator hernia is a rare hernia in the world, diagnosed late since it has no specific symptoms and findings and generally occur in thin and old women with comorbidity.For this reason obturator hernia has high morbidity and mortality rates. In this study, we present an obturator hernia case that Howship-Romberg sign is positive and has typical appearance in computerized tomography. Laparotomy was performed on 89 years old female patient with body mass index 18.08 kg/m(2) by low middle line incision. Following the segmentectomy to the strangulated small bowel loop, obturator canal is repaired by retroperitoneal application. No complication occurred in the postoperative period. Obturator hernia should be taken into consideration in old and thin female patients with intestinal obstruction. Computerized tomography should be performed for early diagnosis of the obturator hernia.
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    ABSTRACT: Previous studies have evaluated the presence of juxtapapillary duodenal diverticula (JPDD) and the association with pancreatobiliary disease, but not the association of the papilla with an existing JPDD. We investigated the association of different localizations of the papilla with JPDD.
    Canadian journal of surgery. Journal canadien de chirurgie 10/2014; 57(5):337-341. DOI:10.1503/cjs.021113 · 1.27 Impact Factor
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    ABSTRACT: Background This study investigated the effect of thiamine pyrophosphate (TPP) on oxidative liver damage induced in rats with high-dose paracetamol. Methods Rats for this experiment were divided into the following groups: healthy control, paracetamol control, thiamine + paracetamol, TPP + paracetamol, and N-acetylcysteine + paracetamol. Oxidant and antioxidant parameters and liver function test levels were compared between the groups. Results The results show that TPP and N-acetylcysteine with paracetamol equally prevented a rise in oxidants such as malondialdehyde and nitric oxide. They also prevented a decrease in enzymatic and nonenzymatic antioxidants such as glutathione, glutathione peroxidase, glutaredoxin, glutathione S-transferase, superoxide dismutase, and catalase in the rat liver. Conclusion Thiamine pyrophosphate and N-acetylcysteine had a similar positive effect on oxidative damage caused by paracetamol hepatotoxicity. These findings show that TPP may be beneficial in paracetamol hepatotoxicity.
    Journal of the Chinese Medical Association 09/2014; 77(9). DOI:10.1016/j.jcma.2014.01.011 · 0.75 Impact Factor
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    ABSTRACT: We investigated the utility of the red cell distribution width (RDW) in diagnosing acute mesenteric ischemia (AMI) in patients with abdominal pain. The patients were divided into two groups in this retrospective case-control study: patients with AMI and patients with abdominal pain who did not require urgent surgery. Venous blood was collected from the patients upon admission to the emergency department, and abdominal computed tomography angiography was performed. The RDW and hematological and biochemical parameters of the groups were compared. The primary outcome was AMI among the patients with abdominal pain. The secondary outcome was mortality, complaint period, and size of ischemia/necrosis among the AMI patients. The RDW, white blood cell lactate dehydrogenase, and blood urea nitrogen of the patients with AMI were significantly different from those of the control group. When the average RDW (15.04 %) of the patients with AMI was used as a cut-off value, the sensitivity, specificity, positive likelihood ratio (+LR), and negative likelihood (-LR) were 40.8 %, 81.2 %, 2.17, and 0.73, respectively. When patients with AMI and anemia were included in the group, the sensitivity and specificity values did not change. There was no relation between the RDW and mortality, size of the ischemia/necrosis, and complaint period. Furthermore, there was no significant difference in the average RDW between the patients with ischemia/necrosis in the small intestine only and those with ischemia/necrosis in the colon. The RDW on admission is of marginal help to diagnose AMI among patients with abdominal pain.
    World Journal of Surgery 08/2014; 38(11). DOI:10.1007/s00268-014-2706-9 · 2.35 Impact Factor
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    ABSTRACT: To evaluate the effectiveness of serum levels of resistin and CD14 expression in monocytes, and high-sensitivity C-reactive protein (hsCRP) in early stages of acute pancreatitis and correct prediction of the severity of acute pancreatitis (AP) using scoring systems. The study involved 10 (29.41%) male and 24 (70.59%) female patients (total n=34) followed for AP diagnosis at the Department of General Surgery, Ataturk University Medical School between July 2008 and September 2009. In all the patients, Ranson and APACHE II scores, serum resistin, hsCRP, and monocyte CD14 expression levels were determined. The patients were divided into two groups as mild and severe AP groups. A control group was formed and the intergroup comparisons were made. Values ≥ 3 based on the Ranson scoring scale and values ≥ 8 in APACHE II scoring scale were considered to indicate severe AP. Evaluations were based on the values obtained on the 1st and 7th days for serum resistin and hsCRP levels and monocyte CD 14 expression. In 17 (50%) patients, severe AP was determined. No statistically significant differences were found between the mean serum resistin levels of AP groups, while the difference for the same parameter between the mild and severe AP groups and the control group was statistically significant. In the severe AP group, the mean 1st day and 7th day serum hsCRP levels were statistically significantly higher. The CD14 expression in monocytes was similar in all the groups. Serum hsCRP concentrations and Ranson and APACHE II scores and serum resistin and hsCRP concentrations on the 1st day were positively correlated. Serum hsCRP measurement is effective in determining the severity of acute pancreatitis. Serum resistin measurement may be a useful early marker in determining the inflammatory response in AP. However, CD14 expression in monocytes was not found to be a useful marker in the diagnosis and prediction of the disease severity in AP patients.
    Central European Journal of Medicine 08/2014; 9(4):556-564. DOI:10.2478/s11536-014-0501-5 · 0.21 Impact Factor
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    ABSTRACT: Aim: The present study aimed to compare the effects of different routes of salbutamol administration (oral and nebulized) at different doses in a cecal ligation and puncture-induced (CLP-induced) sepsis model of rats. Methods: Rats were separated into 8 groups: 1) sham, 2) sham+4 mg/kg oral salbutamol, 3) sham+6 min 2 mg/ml nebulized salbutamol, 4) CLP, 5) CLP+2 mg/kg oral salbutamol, 6) CLP+4 mg/kg oral salbutamol, 7) CLP+3 min 2 mg/ml nebulized salbutamol, 8) CLP+6 min 2 mg/ml nebulized salbutamol. Subsequently, sepsis was induced by CLP through 16 h. Results: CLP-induced sepsis increased serum cytokine levels (TNF-α, IL-1β, and IL-6), increased tissue oxidative stress (8-Isoprosraglandin F2α), decreased antioxidant parameters (SOD, GSH), and increased lung injury by inflammatory cell accumulation. Conclusion: This study showed for the first time that oral administration of salbutamol exerted protective effects on CLP-induced sepsis and related lung injury in rats. We conclude that despite the greater side effects of oral salbutamol, it should be considered for administration in oral form due to its systemic effectiveness during septic conditions in emergency settings.
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    ABSTRACT: Liver is the most frequently injured organ upon abdominal trauma. We present a group of patients with blunt hepatic trauma who were managed without any invasive diagnostic tools and/or surgical intervention. A total of 80 patients with blunt liver injury who were hospitalized to the general surgery clinic or other clinics due to the concomitant injuries were followed non-operatively. The normally distributed numeric variables were evaluated by Student's t-test or one way analysis of variance, while non-normally distributed variables were analyzed by Mann-Whitney U-test or Kruskal-Wallis variance analysis. Chi-square test was also employed for the comparison of categorical variables. Statistical significance was assumed for p<0.05. There was no significant relationship between patients' Hgb level and liver injury grade, outcome, and mechanism of injury. Also, there was no statistical relationship between liver injury grade, outcome, and mechanism of injury and ALT levels as well as AST level. There was no mortality in any of the patients. During the last quarter of century, changes in the diagnosis and treatment of liver injury were associated with increased survival. NOM of liver injury in patients with stable hemodynamics and hepatic trauma seems to be the gold standard.
    Ulusal travma ve acil cerrahi dergisi = Turkish journal of trauma & emergency surgery: TJTES 03/2014; 20(2):97-100. DOI:10.5505/tjtes.2014.20737 · 0.38 Impact Factor
  • Turkish Journal of Medical Sciences 01/2014; 44(6):1134-5. · 0.84 Impact Factor
  • Turkish Journal of Medical Sciences 01/2014; 44(2):352. DOI:10.3906/sag-1307-147 · 0.84 Impact Factor
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    ABSTRACT: Incidental removal of the parathyroid glands is common in some cases. In this trial, we investigated the risk factors, incidence, and outcomes associated with incidental excision of the parathyroid glands during thyroid surgery. The records of patients who had undergone thyroid surgery in our department between January 2006 and December 2011 were retrospectively evaluated. A total of 801 patients were enrolled in the trial. The number of incidental parathyroidectomies was determined as 19 (2.3%). Statistical evaluation revealed that sex (P > 0.05) and type of surgical operation (P > 0.05) were not associated with a significant impact on incidental parathyroidectomies. However, the rate of incidental parathyroidectomies was determined to be statistically significantly high among patients with malignant conditions (P < 0.05). Hypocalcemia was observed to be statistically significant in patients with an incidental parathyroidectomy (P < 0.05). Incidental parathyroidectomy is a rare condition in centers specializing in endocrine surgery. Furthermore, the parathyroid glands should always be explored during dissection in patients with malignancies. The clinical manifestation of hypocalcemia is a common condition observed after incidental parathyroidectomy.
    Turkish Journal of Medical Sciences 01/2014; 44(1):84-8. DOI:10.3906/sag-1211-56 · 0.45 Impact Factor
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    ABSTRACT: Objective: Gallbladder stones are common in the Western world, and 70% to 80% of gallstones are cholesterol stones. This study investigates the effects of serum cholesterol, LDL, and HDL levels on gallstone cholesterol concentration. Methodology: The gallstones of 75 patients with cholelithiasis were examined using spectrophotometry. Results: High serum cholesterol and LDL levels were associated with high cholesterol stone rates (86.7% vs. 40.0%, P < 0.001; 75.0% vs. 48.9%, P < 0.05, respectively). Similarly, high serum cholesterol and LDL levels were correlated with high gallbladder stone cholesterol concentrations (63.6% vs. 44.4%, P < 0.001; 62.3% vs. 46.0%, P < 0.001, respectively). In contrast, low serum HDL levels do not seem to affect the occurrence of gallbladder cholesterol stones (60.0% vs. 58.3%, respectively, P > 0.05) or gallbladder stone cholesterol concentrations (50.8% vs. 52.4%, respectively, P > 0.05). Conclusion: The relationship between cholesterol, LDL, and HDL levels and cholesterol gallstone formation is multifactorial and complex and is also dependent on other individual properties.
    Pakistan Journal of Medical Sciences Online 09/2013; 29(1):187-90. DOI:10.12669/pjms.291.2798 · 0.10 Impact Factor
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    ABSTRACT: ABSTRACT Background: Intestinal ischemia reperfusion (IR) is associated with morbidity and mortality. We first examined the role of levosimendan in the protection of intestine after mesenteric IR. Methods: The rats were divided into six groups: (1) Control group; (2) Levosimendan group; (3) Ischemia group (60 min of occlusion); (4) IR group (60 min of occlusion and then 60 min reperfusion); (5) IR + 1 mg/kg levosimendan group: Levosimendan was given intraperitonally 30 min prior to the ischemia; (6) IR + 2 mg/kg levosimendan group. Results: The levels of TNF-α, IL-6, and IL-1β were found to have increased in the IR group. The serum levels of TNF-α, IL-6, and IL-1β were found to have decreased as a result of the administration of both doses of levosimendan in the IR. Relative TNF-α and NFκB mRNA levels was decreased by administration of both doses of levosimendan in the IR. SOD activity and GSH levels for IR group were lower than, and 8-ISO levels were higher than, those of the sham-operated rat and ischemia alone group. Conclusions: Both doses of levosimendan had preventive effects on the alterations that occurred in the intestinal tissues after IR. Levosimendan administration attenuated in reperfusion injury of intestine and consequently protects intestinal mucosa and oxidant-antioxidant balance of ileum.
    Journal of Investigative Surgery 08/2013; DOI:10.3109/08941939.2013.806615 · 1.32 Impact Factor
  • S. Selcuk Atamanalp
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    ABSTRACT: Ileosigmoid knotting (ISK) is the wrapping of the ileum around the base of the sigmoid colon. The purpose of this study was to investigate the outcomes for patients undergoing various treatments for ISK. The clinical records of 74 ISK patients, over 46.5 years, were reviewed retrospectively. Emergency surgical procedures included resection with primary anastomosis or stoma for patients with gangrenous bowel segments, and detorsion or an additional definitive procedure for patients with viable bowel. Application of these procedures resulted in mortality rates of 0.0 % in 14 patients with viable bowel, 12.5 % in 8 patients with ileal gangrene, 14.3 % in 7 patients with sigmoid colon gangrene, and 28.9 % in 45 patients with double-segment gangrene. The principal strategy in the treatment for ISK is early and effective resuscitation followed by emergency surgery, including untying the knot, excising the gangrenous bowel segment, restoring intestinal continuity by primary anastomosis if possible, and preventing recurrence in selected patients.
    Techniques in Coloproctology 07/2013; 18(3). DOI:10.1007/s10151-013-1046-3 · 1.54 Impact Factor
  • S S Atamanalp
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    ABSTRACT: BACKGROUND: Sigmoid volvulus describes the wrapping of the sigmoid colon around itself and its mesentery, causing an intestinal obstruction. The aim of this study was to assess the outcomes of 952 patients treated for sigmoid volvulus over a period of 46.5 years. METHODS: Clinical records were reviewed retrospectively. RESULTS: Nonsurgical detorsion was performed in 686 patients with 77.1 % success, 2.5 % morbidity, 0.7 % mortality, and 4.5 % early recurrence rates; emergency surgical procedures were performed in 447 patients with 35.3 % morbidity, 16.1 % mortality, 0.7 % early recurrence, and 7.4 % late recurrence rates, while elective surgical treatment was performed in 104 patients with 12.5 % morbidity, no mortality, and no recurrence. CONCLUSIONS: The principal strategy in the treatment for sigmoid volvulus is early nonsurgical detorsion followed by elective surgery in uncomplicated patients, while emergency surgical treatment is performed for patients with bowel gangrene, perforation, or peritonitis, other difficulties with diagnosis, unsuccessful nonsurgical detorsion, and early recurrence.
    Techniques in Coloproctology 05/2013; 17(5). DOI:10.1007/s10151-013-1019-6 · 1.54 Impact Factor
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    ABSTRACT: Sepsis is a complex pathophysiological event involving metabolic acidosis, systemic inflammatory response syndrome, tissue damage and multiple organ dysfunction syndrome. Although many new mechanisms are being investigated to enlighten the pathophysiology of sepsis, there is no effective treatment protocol yet. Presence of 5-HT7 receptors in immune tissues prompted us to hypothesize that these receptors have roles in inflammation and sepsis. We investigated the effects of 5-HT7 receptor agonists and antagonists on serum cytokine levels, lung oxidative stress, lung histopathology, nuclear factor κB (NF-κB) positivity and lung 5-HT7 receptor density in cecal ligation and puncture (CLP) induced sepsis model of rats. Agonist administration to septic rats increased survival time; decreased serum cytokine response against CLP; decreased oxidative stress and increased antioxidant system in lungs; decreased the tissue NF-κB immunopositivity, which is high in septic rats; and decreased the sepsis-induced lung injury. In septic rats, as a result of high inflammatory response, 5-HT7 receptor expression in lungs increased significantly and agonist administration, which decreased inflammatory response and related mortality, decreased the 5-HT7 receptor expression. In conclusion, all these data suggest that stimulation of 5-HT7 receptors may be a new therapeutic target for prevention of impaired inflammatory response related lung injury and mortality.
    Immunobiology 04/2013; DOI:10.1016/j.imbio.2013.04.012 · 2.81 Impact Factor
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    ABSTRACT: Sepsis is the systemic response of an organism against microorganisms and toxins. Lithium is a therapeutic agent used for bipolar disorder and neurodegenerative disease, and it exerts pleiotropic effects on various cellular processes. The present study aimed to determine the effect of lithium on cecal ligation and puncture (CLP)-induced tissue injury in the lungs, by inhibiting the pro-inflammatory cytokine response, and the generation of reactive oxygen species (ROS) triggered by polymicrobial sepsis. Five groups of 20 rats each were used: 1) sham-operated control group; 2) CLP group; 3) 50mg/kg lithium-treated control healthy group; 4) 25mg/kg lithium-treated CLP group; and 5) 50mg/kg lithium-treated CLP group. A CLP polymicrobial sepsis model was applied to the rats. All rat groups were killed 16h later, and lung and blood samples were analyzed histopathologically and biochemically. The 25 and 50mg/kg of lithium decreased the level of interleukin-1 beta (IL-1β), interleukin-6 (IL-6), and the tumor necrosis factor-α (TNF-α) in the serum, and the 8-iso-prostaglandin F2α (8-ISO) level in lung tissue. The lithium also increased the activity of superoxide dismutase (SOD) and the total levels of glutathione (GSH) in the lung tissues of rats. The histopathological scores and examinations were in accordance with the biochemical results, and revealed significant differences in the inflammation scores between the sepsis group and the other groups. The CLP+lithium 50mg/kg group had the lowest inflammation score among the CLP groups. Our results indicated that the therapeutic administration of lithium prevented oxidative stress changes and cytokine changes, and also protected vital tissues.
    International immunopharmacology 03/2013; 16(1). DOI:10.1016/j.intimp.2013.03.018 · 2.21 Impact Factor
  • Sabri Selcuk Atamanalp, Abdullah Kisaoglu, Bunyami Ozogul
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    ABSTRACT: Sigmoid gangrene develops in 6.1% to 93.4% of sigmoid volvulus (SV) cases, and increases the mortality rate from 0% to 40% without bowel gangrene to 3.7% to 80%. This study aimed to investigate factors that induce bowel gangrene development in SV patients. Retrospective study from a single center. We determined whether there was any correlation between sigmoid gangrene and the following factors: age, gender, a previous history of a volvulus, previous history of abdominal surgery, pregnancy, major comorbidities, shock, duration of symptoms, direction and degree of rotation of volvulus, and ileosigmoid knotting. Of 442 patients, 271 (61.3%) had sigmoid gangrene. The presence of pregnancy was negatively cor.related with sigmoid gangrene development (P < .05), while comorbid diseases (P < .01), associated shock (P < .01), prolonged symptom duration (P < .05), overrotation (P < .05), and associated ileosigmoid knotting (P < .01) were positively correlated with bowel gangrene. However, no correlation was observed between sigmoid gangrene and the other studied factors. An inverse correlation between pregnancy and sigmoid gangrene was observed. On the other hand, a positive correlation was noted between bowel gangrene and comorbid diseases, shock, prolonged duration of symptoms, overrotation, and associated ileosigmoid knotting.
    Annals of Saudi medicine 03/2013; 33(2):144-8. DOI:10.5144/0256-4947.2013.144 · 0.71 Impact Factor
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    ABSTRACT: In this study, we investigated the diaphragmatic ruptures that accompanied penetrating abdominal injury. Records of 237 patients with penetrating abdominal trauma seen in the General Surgery Clinic between January 1996 and December 2010 were investigated retrospectively. Patients without diaphragmatic rupture were allocated to Group I and those with were allocated to Group II. Diaphragmatic injury was not present in 177 patients and present in 60 patients. Diaphragmatic injury was on the right side in 12, left side in 41, and bilateral in 7. Eleven had thoracic herniation, and the most common hernia contents were the colon, stomach, greater omentum, small bowel, and spleen. The postoperative complication rate was 50% in Group I (n=89) and 47% in Group II (n=28), and there was no significant difference between the two groups (p>0.05). The length of hospital stay was slightly increased in Group II, but not significant (p>0.05). Seventeen patients (9.6%) in Group I and four patients (6.6%) in Group II died. The difference in mortality rates between the two groups was not significant (p>0.05). Diaphragmatic rupture is not common among patients with penetrating abdominal trauma. There was no difference between patients with penetrating injuries and with versus without diaphragmatic injuries in terms of mortality and morbidity.
    Ulusal travma ve acil cerrahi dergisi = Turkish journal of trauma & emergency surgery: TJTES 01/2013; 19(1):45-8. DOI:10.5505/tjtes.2013.14194 · 0.38 Impact Factor
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    ABSTRACT: Aim: To clarify the role of ganglion cells in Auerbach's plexus of the sigmoid colon in the development and recurrence of sigmoid volvulus (SV). Materials and methods: Pathological block samples of colonic resection materials of 28 patients who underwent sigmoidectomy for SV and, for comparison, samples of 28 patients who underwent sigmoidectomy or low anterior resection for rectosigmoid cancer (RSC) were analyzed using stereological methods. Results: The mean numerical density of ganglion cells was significantly lower in the SV group than in the RSC group (140.70 mm(-2) and 669.42 mm(-2), respectively, P = 0.005), whereas there was no significant difference between the revolvulus and nonrevolvulus SV groups (128.45 mm(-2) and 185.67 mm(-2), respectively, P > 0.05). Similarly, the mean numerical density of ganglion cells in elderly SV patients was found to be significantly lower than that in nonelderly SV patients (66.57 mm(-2) and 214.86 mm(-2), respectively, P = 0.002), while there was no significant difference between elderly and nonelderly RSC patients (638.60 mm(-2) and 705.00 mm(-2), respectively, P > 0.05). Conclusion: SV may be related to a decreased numerical density of ganglion cells in Auerbach's plexus, and the degenerative loss of ganglion cells due to advancing age is possible in elderly SV patients.
    Turkish Journal of Medical Sciences 01/2013; 43(4):509-514. DOI:10.3906/sag-1209-104 · 0.84 Impact Factor

Publication Stats

511 Citations
98.94 Total Impact Points

Institutions

  • 2002–2015
    • Ataturk University
      • Department of General Surgery
      Kalikala, Erzurum, Turkey
  • 2010
    • Dumlupinar Üniversitesi
      Dumlupınar, Kütahya, Turkey
  • 2007
    • University of Gaziantep
      Ayıntap, Gaziantep, Turkey