Stéphanie Badiou

Université de Montpellier 1, Montpelhièr, Languedoc-Roussillon, France

Are you Stéphanie Badiou?

Claim your profile

Publications (70)174.93 Total impact

  • [Show abstract] [Hide abstract]
    ABSTRACT: We sought to evaluate the added value of Heart Fatty Acid Protein assay (HFABP) for rapid diagnosis of acute myocardial infarction in a prospective cohort of emergency department (ED) patients with acute chest pain.Methods High-sensitivity cardiac troponin T (hs-cTnT, Roche Diagnostics, Meylan, France) and HFABP (Randox, Mauguio, France) were blindly assayed from venous blood samples obtained at admission. Diagnosis was made by 2 ED physicians using all available data and serial cardiac troponin I as the biochemical standard. Diagnostic performances of HFABP combined with hs-cTnT were assessed using logistic regression. Analysis was conducted in all patients and in patients without ST-elevation myocardial infarction.ResultsA total of 181 patients were included (age, 61 ± 17 years;male sex, 66%). Acute myocardial infarction occurred in 47 (25.9%) patients, including non–ST-elevation myocardial infarction (NSTEMI) in 31 (17.1%). The ROC AUC was 0.893 for hs-cTnT levels at presentation (95% CI, 0.812-0.974) and 0.908 (95% CI, 0.839-0.977) for the combination of hs-cTnT and HFABP, with no significant difference (p = 0.07). Adding HFABP to hs-cTnT increased both sensitivity and NPV for NSTEMI diagnosis, with about 13% and 3% increase, respectively, leading to a sensitivity of 97% and a NPV of 99%.Conclusion The assessment of HFABP at ED admission adds incremental value to initial hs-cTnT. The increase of sensitivity and NPV without sacrificing the specificity and PPV in patients with chest pain with non contributive ECG could potentially allow safe and early rule out of AMI without the need for further serial troponin testing.
    The American Journal of Emergency Medicine. 11/2014;
  • [Show abstract] [Hide abstract]
    ABSTRACT: Objectives To report the analytical performances of the Radiometer AQT90 FLEX® cTnT assay (Neuilly-Plaisance, France) and to evaluate the concordance with hs-cTnT results from central laboratory for the diagnosis of acute myocardial infarction (AMI) at baseline and during a short follow-up among unselected patients admitted in emergency room or cardiology department. Design and Methods Analytical performances of AQT90 FLEX® cTnT immunoassay included imprecision study with determination of a coefficient of variation at 10% and 20%, linearity, and limit of detection. The concordance study was based on samples obtained from 170 consecutive patients with chest pain suggestive of acute coronary syndrome (ACS) admitted in the emergency room or cardiology department. The kinetic study (within 62 additional samples 3 hours later) was based on absolute delta criterion and the combination of relative change of 30% with absolute change of 7 ng/L. Results The cTnT assay from Radiometer was evaluated as clinically usable, although less sensitive than the Roche hs-cTnT assay as demonstrated by the concordance and the kinetic studies. Conclusions In non selected population, the cTnT AQT Flex© assay on AQT90© with kinetic change at 3 hours, provides similar clinical classification of patients, particularly for AMI group as compared to central laboratory hs-cTnT assay and could be suitable for clinical use.
    Clinical Biochemistry. 10/2014;
  • [Show abstract] [Hide abstract]
    ABSTRACT: A new particle-enhanced turbidimetric immunossay (PETIA), QMS® everolimus, was evaluated using an Indiko® analyzer (ThermoFisher Scientific).
    Therapeutic drug monitoring. 09/2014;
  • [Show abstract] [Hide abstract]
    ABSTRACT: Abstract Background: Cardiac troponin level measured by high-sensitivity assays (hs-cTn) in the elderly is frequently found higher than the 99th percentile upper reference limit, making the diagnosis of acute coronary syndromes (ACS) difficult. This study aimed at: 1) identifying determinants of hs-cTnT levels in an unselected population of elderly subjects; and 2) assessing the prognosis value of increased hs-cTnT in elderly people free of ACS. Methods: Hs-cTnT was measured in 591 individuals aged over 65 years without suspicion of ACS. Comorbidities were assessed using the Cumulative Illness Rating Scale for Geriatrics (CIRS-G). C-reactive protein, α1-acid glycoprotein, albumin and creatinine were measured. Factors influencing hs-cTnT levels were assessed through linear regression and quantile regression was used to model percentiles of hs-cTnT. Risk of mortality was assessed through Cox regression. Results: Age, gender, cardiac CIRS-G, estimated glomerular filtration rate (p<0.001 for all), albumin (p<0.028) and α1-acid glycoprotein (p=0.002) were independent predictors of hs-cTnT. After exclusion of outliers, the median was 15 ng/L and 99th percentile was 64 ng/L. After controlling for comorbidities, the 99th percentile increased from 24 ng/L at age 65 to 53 ng/L at age 90 in females and from 33 ng/L to 75 ng/L in males. In multivariate analysis, hs-cTnT level was significantly related to mortality. Conclusions: Hs-cTnT level is associated with inflammation and renal function in the elderly. Independently of comorbidities, hs-cTnT concentration increases exponentially with age after 65 years. Decision limits adapted to age and sex may be useful to patient management.
    Clinical chemistry and laboratory medicine : CCLM / FESCC. 08/2014;
  • [Show abstract] [Hide abstract]
    ABSTRACT: This study aimed to evaluate a new ion-exchange HPLC system to measure hemoglobin A1c (HbA1c) in comparison to two other widely used HPLC systems. Analytical performance and hemoglobin variants detection was assessed on the new Arkray/ELITech ADAMS HA-8180V®, in parallel to Bio-Rad Variant(TM) II Turbo2.0® and Tosoh Bioscience HLC®-723G8. A method comparison and concordance for the classification of patients according to the American Diabetes Association (ADA) categories was performed using kappa test. ADAMS HA-8180V® demonstrated excellent within-run imprecision (0%) and between-run imprecision: ≤1.21% using blood sample and ≤0.94% using quality controls. Method comparison of ADAMS HA-8180V® with the two other systems yielded very high coefficient correlation (r > 0.995). A very good agreement (kappa value ≥0.81) was observed between methods for the classification of patients according to the ADA categories. In addition, all systems were able to detect the presence of most classical variants such as HbC, HbS, HbD, and HbE. The Arkray/ELITech ADAMS HA-8180V® demonstrated high analytical performance similar to previous systems such as Biorad(TM) Variant II Turbo 2.0® and Tosoh Bioscience HLC®-723G8. The three systems allow a high-quality HbA1c measurement and appeared interchangeable for diabetes diagnosis or for the therapeutic monitoring of patients without hemoglobin variants.
    Journal of Clinical Laboratory Analysis 03/2014; · 1.36 Impact Factor
  • [Show abstract] [Hide abstract]
    ABSTRACT: As the implementation of POC analyzers in clinical department is growing and HbA1c has been included in diagnostics, it appears mandatory to evaluate the accuracy of the POC method to be used. The aim of our study is to evaluate the analytical performance and usefulness of the Afinion analyzer, and the impact of HbF, hemoglobin variants, and changes of reagent lots. The Afinion analyzer (Axis-Shield, Oslo, Norway) is based on affinity separation methodology. Analytical performances including imprecision studies and correlation with currently used HPLC were performed on Biochemistry laboratory. We evaluated the effects of presence of variants on the results of HbA1c. Two reagent lots were evaluated on samples without variant as well as on samples with in the presence of hemoglobin variants HbA/S. The practicability of the system was also tested installing the instrument on pediatric consultation. Imprecision studies of Afinion were acceptable. Linear regression analysis indicated good correlation between HbA1c values with Afinion (r > 0.97) in comparison with HPLC method. Overall, the Afinion overestimated the HbA1 compared to the MenariniHA8140. These differences were confirmed when the estimated average glucose was calculated. In addition, the variance of cartridge lots requires its use with caution and the problem of lot number instability must be resolved, requiring an adjustment of the calibration by the manufacturer. The Afinion analyzer met the acceptance criteria of analytical performance, requires minimal operator interaction and presents good correlation with the laboratory method. Beyond the analytical performance, the different regression lines for different lots is a matter of concern. The reproductibility of the production of the different reagent lots for POC devices appears inadequate for its use in a clinical department.
    Clinical laboratory 01/2014; 60(3):369-76. · 0.92 Impact Factor
  • [Show abstract] [Hide abstract]
    ABSTRACT: Rheumatoid factor (RF) consists of autoantibodies and because of its heterogeneity its determination is not easy. Currently, nephelometry and Elisa method are considered as reference methods. Due to consolidation, many laboratories have fully automated turbidimetric apparatus, and specific nephelemetric systems are not always available. In addition, nephelemetry is more accurate, but time consuming, expensive, and requires a specific device, resulting in a lower efficiency. Turbidimetry could be an attractive alternative. The turbidimetric RF test from Diagam meets the requirements of accuracy and precision for optimal clinical use, with an acceptable measuring range, and could be an alternative in the determination of RF, without the associated cost of a dedicated instrument, making consolidation and saving blood possible.
    Clinical laboratory 01/2014; 60(4):685-8. · 0.92 Impact Factor
  • [Show abstract] [Hide abstract]
    ABSTRACT: Objectives The study was designed to evaluate the performance of five automated immunoturbidimetric assays to quantify urinary albumin, each corresponding to a combination of a reagent and an analyzer (Olympus on AU640®, Roche on Cobas Integra, Abbott on Architect, Ortho-Clinical Diagnostics Vitros on Fusion and Siemens on Dimension). Design and methods To assess imprecision, albumin was measured in three urinary pools with a mean value of 25, 66 and 131 mg/L. One hundred and eight patient urine samples were then used to compare each turbidimetric method using Passing-Bablok regression and Bland-Altman analyses. Concordance of the albumin / creatinine ratio (ACR), according to the albuminuria classifications proposed by the KDIGO, was calculated to test the agreement between the different assays. Results All immunoturbidimetric methods evaluated in this study exhibited acceptable imprecision (CV < 6%). Mean values for 108 urine samples varied from 0.5 to 762.2 mg/L. Significant differences were found (p < 0.05) between all methods except between Olympus and Ortho (p = 1.0) and between Abbott and Roche (p = 0.12). Regarding the albuminuria categories based on the ACR proposed by the KDIGO, only the classification obtained with the Roche method was significantly different from the four other methods (p < 0.001). Conclusions We demonstrated that all assays were not strictly equivalent which could affect ACR categories in clinical practice, suggesting the need for harmonization of commercial methods.
    Clinical Biochemistry. 01/2014;
  • [Show abstract] [Hide abstract]
    ABSTRACT: Transplant patients have an increase incidence of lymphoproliferative disorders. The development of sensitive immunoassay for serum free light chains (FLC) determination has improved the diagnosis of monoclonal gammapathy. However, metabolism of FLC largely depends on renal function which could lead to misinterpretation of results. The aim of this study was to assess polyclonal FLC in kidney transplant recipients in relation to markers of renal function. 97 renal transplant patients (median transplantation follow-up of 2.2years) were included in this study. Kappa FLC, Lambda FLC and cystatin C were measured by particle-enhanced turbidimetric immunoassay (PETIA) using kits from Binding Site (Birmingham, UK) on SPAPLUS® analyzer. Glomerular filtration rate was measured using urinary clearance of 99mTc-DTPA and estimated using CKD-EPI creatinine 2009, CKD-EPI cystatin C 2012 and CKD-EPI creatinine-cystatin C 2012. Sera kappa FLC was 22.38 [6.39 - 68.91] mg/L and sera lambda FLC was 15.66 [7.29 - 50.81] mg/L. Both levels of Kappa and Lambda were correlated with renal function. Median K / L ratio was 1.34 [0.57 to 2.67] leaving 19.6% of renal transplant patients outside the normal reference range ([0.26-1.65]). However, using a reference interval normalized by renal function ([0.37-3.1]), none of our patients was classified as abnormal. K / L ratio should be cautiously analyzed in renal transplantation and renal function, estimated by creatinine/cystatin C equations should be taken into account.
    Clinical biochemistry 09/2013; · 2.02 Impact Factor
  • [Show abstract] [Hide abstract]
    ABSTRACT: High prevalence of monoclonal gammopathy (MG) is observed in HIV-infected patients. We explored the conditions associated with long term persistence of serum monoclonal protein (M protein) in HIV-infected patients on antiretroviral therapy (ART). Of 21 patients with monoclonal gammopathy, M Protein disappeared in 12 patients (58%) over 5 years of ART. Higher level of serum gamma-globulin and higher percentages of circulating plasmablasts and plasma cells were observed in patients with persistent MG in comparison to patients with transient MG. MG persistence was associated with the cumulative time of detectable plasma HIV RNA after ART initiation, detection of EBV DNA in plasma and high level of EBV DNA in B cells. Poor control of HIV replication and detectable EBV replication in plasma were both associated with long-term MG persistence in patients on ART. In case of viral control, MG associated with HIV infection is usually transient.
    Blood 08/2013; · 9.78 Impact Factor
  • Clinica chimica acta; international journal of clinical chemistry 07/2013; · 2.54 Impact Factor
  • [Show abstract] [Hide abstract]
    ABSTRACT: We sought to evaluate the added value of ultrasensitive copeptin (us-copeptin) for early rule out of acute myocardial infarction in a prospective cohort of emergency department (ED) patients with acute chest pain. This was a prospective study including consecutive patients with acute chest pain presenting to the ED within 12 hours of symptom onset. High-sensitivity cardiac troponin T (hs-cTnT, Roche Diagnostics, Meylan, France) and us-copeptin (ThermoFisher Scientific, Clichy, France) were blindly assayed from venous blood samples obtained at admission. Diagnosis was made by 2 ED physicians using all available data and serial cardiac troponin I as the biochemical standard. Diagnostic performances of us-copeptin combined with hs-cTnT were assessed using logistic regression. Analysis was conducted in all patients and in patients without ST-elevation myocardial infarction. A total of 194 patients were included (age, 61 [48-75] years; male sex, 63%). Acute myocardial infarction occurred in 52 (27%) patients, including non-ST-elevation myocardial infarction (NSTEMI) in 25 (13%). Patients with acute myocardial infarction had higher levels of hs-cTnT (50 [95% confidence interval, 19-173] ng/L) and us-copeptin (30 [13-113] pmol/L) at admission compared with those without (P < .05). Combination of markers significantly improved receiver operating characteristic area under the curve (from 0.89 [0.85-0.92] for hs-cTnT alone to 0.93 [0.89-0.97], P = .018). Sensitivity and negative predictive value were increased, particularly for NSTEMI diagnosis (sensitivity, 76% [54.9-90.6] to 96% [79.6-99.9]; negative predictive value, 95% [90.4-98.3] to 98.9% [94.2 to 100]). Assessment of us-copeptin combined with hs-cTnT on ED admission could allow safe and early rule out of NSTEMI for patients with negative results on both markers and help identify patients who may be suitable for discharge.
    The American journal of emergency medicine 06/2013; · 1.54 Impact Factor
  • [Show abstract] [Hide abstract]
    ABSTRACT: OBJECTIVES: Analytical and clinical performances of the new standardized Cystatin C particle-enhanced turbidimetric immunoassay (PETIA) using Diasys reagents on Olympus AU2700® analyzer were evaluated. DESIGN AND METHODS: We have studied imprecision, linearity, limit of detection and limit of quantification of this new immunoassay. Method comparison was assessed in relation to results generated by the standardized Siemens-particle-enhanced nephelometric immunoassay (PENIA). In order to evaluate the clinical relevance of this assay, estimated glomerular filtration rate (GFR) was calculated using MDRD, CKD-EPI creatinine, CKD-EPI cystatin C 2012 and CKD-EPI creatinine-cystatin C 2012 equations and compared to GFR measured using urinary clearance of (99m)Tc-DTPA in 100 hypertensive patients. RESULTS: Cystatin C measurements using Diasys reagents have reliable analytical performances and are comparable to the standardized Siemens-PENIA method (bias of 0.01 mg/L). The mean measured GFR was 90.0 ± 29.7 mL/min/1.73m(2). Bias and accuracy of the three CKD-EPI equations were better than the MDRD. Both CKD-EPI creatinine-based and cystatin C-based formulae had similar bias, precision and accuracy. The combined creatinine-cystatin C equation was significantly more accurate and precise than the CKD-EPI creatinine equation in patients with GFR above 60 mL/min/1.73m(2). CONCLUSIONS: The use of cystatin C in a combined equation with creatinine could improve the accuracy of eGFR in the reference interval.
    Clinical biochemistry 05/2013; · 2.02 Impact Factor
  • [Show abstract] [Hide abstract]
    ABSTRACT: To assess the frequency of glomerular and tubular proteinuria in a cohort of HIV-infected patients, and to determine the factors associated with each type of injury. Cross-sectional study of 1210 consecutive HIV-infected adults followed in HIV outpatient unit (Montpellier/France). Spot urine protein to creatinine (uPCR), albumin to creatinine (uACR) and albumin to protein (uAPR) ratios were assessed. Glomerular injury was defined as uACR at least 30 mg/g or uPCR at least 200 mg/g with uAPR at least 0.4. Tubular injury was defined as uPCR 200 mg/g or more with uAPR less than 0.4. Multivariate logistic regression identified independent factors of each type of proteinuria, in the 1158 patients with estimated glomerular filtration rate (eGFR) at least 60 ml/min per 1.73 m, using re-expressed modification of diet in renal disease equation. Frequency of proteinuria was 18.2% among patients with eGFR at least 60 ml/min per 1.73 m consisting in tubular proteinuria for 50.7% of them. Factors associated with glomerular proteinuria were age [OR 1.34/10-year increment (95%CI: 1.08-1.66)], diabetes [OR 3.37 (95%CI: 1.53-7.44)], and arterial hypertension [OR 2.52 (95%CI: 1.36-4.66)]. Factors associated with tubular proteinuria were age [OR 1.43 (95%CI: 1.14-1.79)], current tenofovir use [OR 3.52 (95%CI: 1.86-6.65)], hepatitis C co-infection [OR 1.62 (95%CI: 1.00-2.65)], AIDS stage [OR 1.83 (95%CI: 1.18-2.82)], CD4 cell count less than 200 per μl [OR 2.48 (95%CI: 1.31-4.70)]. This study distinguished risk factors for tubular injury, mainly related to HIV disease and its treatment (tenofovir), and glomerular injury, linked to non HIV-related variables (age, diabetes, hypertension). Measuring uPCR, uACR and uAPR may help with the detection and specific management of early chronic kidney disease in HIV-infected patients having normal or sub-normal eGFR.
    AIDS (London, England) 05/2013; 27(8):1295-302. · 4.91 Impact Factor
  • Clinical Chemistry 03/2013; 59(3):570-2. · 7.15 Impact Factor
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: Abstract Background: Cardiac biomarkers, including cardiac troponin-I (cTn-I) and N-terminal pro brain natriuretic peptide (NT-proBNP) have been associated with poor outcome in hemodialysis (HD) patients. The present study was designed to evaluate these biomarkers as biological risk factors for early and late mortality in HD patients. In addition, a multimarker approach including inflammatory index was performed in order to improve the cardiovascular risk assessment of these patients. Methods: cTnI, NT-proBNP and C-reactive protein (CRP) were measured at baseline (October through November 2002) in 130 HD patients [median age 69.0 (23.4-87.7) years old, 76 females, 54 males]. Patients were followed during 8 years. Adjusted hazard ratios (HRs) of death and 95% confidence intervals (CIs) were estimated using Cox proportional hazard models. Results: During the follow-up, 82 patients died, mainly from cardiac cause (63.4%). Elevated cTnI, NT-proBNP or CRP were all associated with increased early (death within 2 years of follow-up) but not late mortality. Moreover, the combination of all parameters (CRP ≥10.51 mg/L and cTnI ≥0.037 µg/L and NT-proBNP ≥10,204 pg/mL) dramatically increased the short-term mortality especially the cardiovascular mortality (HR 8.58, 95% CI 1.59-46.2; p=0.0007). Conclusions: A combined index of cardiovascular risk factors could provide supplementary risk stratification in HD patients for early cardiovascular mortality, strongly supporting the annual routine determination of these biomarkers.
    Clinical Chemistry and Laboratory Medicine 02/2013; · 3.01 Impact Factor
  • Journal of diabetes science and technology 01/2013; 7(5):1408-1409.
  • [Show abstract] [Hide abstract]
    ABSTRACT: Abstract Background: Our study investigated the biochemical and anthropometric characteristics in elite athletes of rugby union based in the south of France during the different periods of the competition to identify metabolic and biochemical adaptations to particular lifestyle conditions. Methods: Participants included 35 players in 2008 and 43 players in 2009. Biochemical variables [creatinine, uric acid, creatine kinase (CK), alanine aminotransferase, aspartate aminotransferase, C-reactive protein] were evaluated. Specific protein levels (albumin, acid α-glycoprotein, prealbumin), vitamins (A, E, C), antioxidant enzymes [glutathione peroxidase (GPx), superoxide dismutase (SOD)], oligoelements (Zn, Se, Cu, erythrocyte magnesium), homocysteine (Hcy), carnitine and the distribution of amino acids were specifically determined for our study during a pre-competition period (September 2008 and 2009). Results: Globally, no deficit was observed for vitamins, oligonutrients and amino acids levels. The high SOD and GPx activities in rugby players suggest a presence of oxidative stress of exercise. The evaluation of renal function should be used with caution because of the interaction between creatinine and lean body mass. In addition, a profound effect of intense exercise on the CK values was reported to establish specific reference values for athletes. The analysis of the biological variation allows optimization of the interpretation of the changes from an increased or decreased baseline value from a season to the other one. Conclusions: The conclusions of present study were: 1) the necessity of rugby-specific reference intervals for CK and creatinine parameters; 2) the use of enzymatic creatinine for Modification of Diet in Renal Disease (MDRD) and CKD-EPI, or cystatin C to improve glomerular filtration rate estimation; 3) to take into account the oxidative stress testifying of a bad recovery; and 4) better to take care the nutritional status of the players by adapting needs and amino acids supplementations but also to consider a follow-up of oxidative stress and antioxidants according our results.
    Clinical Chemistry and Laboratory Medicine 10/2012; 50(10):1777-89. · 3.01 Impact Factor
  • [Show abstract] [Hide abstract]
    ABSTRACT: Background: Oxidative stress has emerged as a strong pathogenic cofactor implicated in the development of long-term complications in hemodialysis (HD) patients, such as anemia, and as a major component of the malnutrition inflammation complex syndrome. This prospective multicenter study aimed at evaluating the short-term effects of the new vitamin E (vitE)-coated polysulfone (PS) membrane (VitabranE) on biocompatibility performances and anemia in HD patients. Methods: After a 3-month washout period with a high-flux synthetic dialyzer, 43 HD patients were switched to a vitE-PS dialyzer. Sampling was performed at baseline (corresponding to the end of the washout period) and after 1, 2 and 3 months of treatment. Oxidative stress status, as well as inflammatory parameters, was investigated at the end of each study period. Hemoglobin levels and administered doses of recombinant human erythropoietin or epoetin (EPO) were available in each center. Results: The use of vitE-coated membranes for 3 months was not associated with any change in inflammatory parameters. By contrast, vitE-PS dialyzer resulted in a progressive increase in red blood cell (RBC) vitE concentration and in RBC superoxide dismutase activity. A concomitant progressive significant decrease in advanced oxidation protein product concentration at 2 months was observed, suggesting a preventive effect on oxidative stress. Finally, a significant decrease of the erythropoietin resistance index was obtained after 3 months of treatment. Conclusions: Use of the vitE-PS membrane during a short period improves erythrocyte antioxidant defense mechanisms and seems to lead to a reduction in EPO requirements in HD patients.
    Journal of nephrology 09/2012; · 2.02 Impact Factor
  • [Show abstract] [Hide abstract]
    ABSTRACT: A link between homocysteine (Hcy) and left ventricular ejection fraction (LVEF) emerged from recent studies but was yet not explored specifically in diabetic patients. This study aimed to assess the relationship between LVEF and Hcy in a cohort of adults with diabetes. LVEF was determined through the measure of left ventricular end-diastolic/end-systolic volumes in 409 consecutive asymptomatic patients with diabetes who underwent stress myocardial perfusion imaging. Clinical and biological parameters which were determinants of LVEF in univariate analyses with p<0.15 were included in a multivariate analysis. In univariate analyses, factors significantly associated with a LVEF<55% were gender [women vs. men, odds ratio (OR)=0.22 (0.13; 0.38)], peripheral arterial disease [OR=2.49 (1.34; 4.62)], active smoking [OR=1.97 (1.16; 3.33)], silent myocardial ischemia (SMI) [OR=2.19 (1.25; 3.86)], the highest vs. the lowest tertile of creatinine [OR=2.08 (1.17; 3.68)], of albuminuria [OR=2.22 (1.27; 3.90)] and of Hcy [OR=1.83 (1.07; 3.13)]. No relationship was observed between blood pressure and decrease in LVEF. In the multivariate analysis, female gender was confirmed as being protective for having a LVEF<55%. Presence of SMI [OR=2.20 (1.14; 4.23)] and Hcy ≥15 μmol/L [OR=1.81 (1.06; 3.07)] were the two remaining significant factors associated with an increased relative risk of having LVEF<55%. A trend was only observed for the criteria active smokers. This study highlights an inverse relationship between Hcy and LVEF in patients with diabetes, independent of age, gender, SMI, smoking, blood pressure, renal function, folates, vitamin B12, lipid parameters and hepatic enzymes.
    Clinical Chemistry and Laboratory Medicine 01/2012; 50(6):1099-106. · 3.01 Impact Factor

Publication Stats

443 Citations
174.93 Total Impact Points

Institutions

  • 2008–2014
    • Université de Montpellier 1
      Montpelhièr, Languedoc-Roussillon, France
  • 2005–2013
    • Centre Hospitalier Universitaire de Montpellier
      Montpelhièr, Languedoc-Roussillon, France
  • 2009
    • Université de Bouaké
      Bwake, Vallée du Bandama, Ivory Coast
    • Klinikum Nürnberg
      • Institut für Klinische Chemie, Laboratoriumsmedizin und Transfusionsmedizin
      Nuremberg, Bavaria, Germany