T P Ranke

Publications (6)0 Total impact

• Article: [Quantitative analysis of cell density and pattern of chondrocytes in transitory hyaline cartilage anlagen of human tarsal bones].

  P Rother, T P Ranke, F Forriol, J Banusch, L Bauer
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  ABSTRACT: Changes in the distribution patterns of chondrocytes in the embryonic transitory hyaline cartilage of the tarsus were studied using 56 sagittal section of tarsi from 28 human embryos, with a vertex-foot length from 7.0 to 44.0 cm. The os naviculare and os cuboideum were not sliced in all sections. A total of 93,931 cells were transferred via a mirror to paper, and the resulting patterns were analyzed. Determinations included the numerical surface and volume density of the chondrocytes and the cell distribution patterns using the dispersion index. In the case of the calcaneus, talus, os naviculare and os cuboideum, the number of sliced cells found over a constant area decreases at a continuous linear rate in the course of the embryonic period. In all tarsal primordia the distribution pattern developed from regular to random. Particular conditions prevail immediately below the perichondrium and near the ossification centers which can be found in the calcaneus from the 6th month onwards.
  Acta Anatomica 02/1990; 138(4):327-31.
• Article: [Quantitative analysis of chondrocyte distribution patterns in hyaline cartilage tissue--a comparison of different models].

  T P Ranke, I Ranke, A Schwandtke, P Rother
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  ABSTRACT: The purpose of our investigations were aging changes in hyaline cartilage of the trachea and of the larynx. 42 samples of carina tracheae and 29 samples of arytenoid cartilage were used in both organs from the newborn age up to the age of 91 a. We have examined patterns of cell distribution with the help of the computer programme "Dichte" ("density") using the following methods of stochastic geometry: product density, L function, and others. Product density allows for a reliable destination between a regular pattern of cells (hard-core distribution), a random pattern (soft-core distribution), and a typical clustering of chondrocytes. 2 examples of arytenoid cartilage have been selected to demonstrate the possibilities of interpretation of product density supported by the L function. Soft-core and in few cases hard-core distribution have been found both with the carina tracheae and the cartilago arytaenoidea in the 1st decade of life. Beginning with the 2nd decade of life, the typical clustering of chondrocytes have been confirmed with both organs.
  Gegenbaurs morphologisches Jahrbuch 02/1989; 135(1):125-31.
• Article: [Quantitative analysis of the pattern of distribution of chondrocytes in transitory hyaline cartilage of the embryonic anlage of the sternum and patella].

  P Rother, D Stoyan, T P Ranke, I Ranke, W Kreutz
  Zeitschrift für mikroskopisch-anatomische Forschung 02/1987; 101(1):69-78.
• Article: [Age-related changes in systematic inhomogeneities of articular cartilage].

  S Löffler, T P Ranke, P Rother
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  ABSTRACT: We have considered the question of the quantification of differentiation processes. We investigated articular cartilage of the Caput femoris in 22 cases aged from 0 to 77 years. We measured cell size and volume density. During aging a shifting of the layer with the maximum cell size in relation to the joint surface as well as the formation of two layers with different volume densities take place. We believe that the changes in nutritional and load conditions during life play a role in these processes. We describe these with the term "diversification", characterizing the process of the changing of the degree of structural order.
  Zeitschrift für Gerontologie 26(4):247-50.
• Article: [Quantitative detection of the differentiation processes of cartilage tissue].

  P Rother, T P Ranke, I Ranke
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  ABSTRACT: The onset of ageing during childhood and adolescence is accompanied by a variety of differentiation processes, whereas ageing later in life is characterized by dysdifferentiation. One of the subjects in the present discussion is the "Dysdifferentiation hypothesis of ageing". So far differentiation has been described only in qualitative terms. The paper uses the example of hyaline cartilage development (chondrogenesis) to show that a quantitative approach to differentiation is possible, which at the same time enables random-critical study. The method used for this is stochastic geometry.
  Zeitschrift für Alternsforschung 41(4):213-7.
• Article: [Quantitative analysis of a differentiation characteristic of hyaline cartilage in the aging process].

  T P Ranke, I Ranke, P Rother
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  ABSTRACT: Changes in the distribution patterns of chondrocytes in the permanent hyaline cartilage were studied in order to analyze a process of differentiation quantitatively. Sections of 29 specimens of arytenoid cartilage and 42 specimens of Carina tracheae from newborn up to the age of 91 years were used. The chondrocytes were transferred via a mirror to paper, and the resulting patterns were analyzed. Various distribution functions were calculated. The most important one is the pair correlation function. The behavior of the differentiation is resembling in both organs. Especially in arytenoid cartilage there were found the following results: The clearest process of differentiation took place up to the 3rd decade of life. Initial hard core distribution is followed by soft core distribution up to the final of puberty. After the 2nd decade of life clustering was found. The grade of differentiation decreases in the 5th decade of life and later.
  Zeitschrift für Gerontologie 24(6):311-5.