Journal of the American Academy of Dermatology 06/2010; 62(6):1073-4. DOI:10.1016/j.jaad.2009.02.034 · 4.45 Impact Factor
Journal of dermatological science 08/2009; 56(1):69-72. DOI:10.1016/j.jdermsci.2009.06.014 · 3.42 Impact Factor
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ABSTRACT: Activating transcription factor 2 (ATF2) and signal transducer and activator of transcription 3 (STAT3) play important roles in the pathogenesis of various tumors, but ATF2 expression/activation and the relationship with STAT3 activation have not yet been investigated in extramammary Paget's disease (EMPD).
To investigate potential contributions of ATF2 and STAT3 pathways to the pathogenesis of EMPD.
Paraffin-embedded 45 EMPD specimens (43 primary EMPD and 2 nodal metastases) were subjected to immunohistochemical staining for ATF2, phosphorylated (p)-ATF2 and p-STAT3.
P-ATF2 expression in advanced EMPD, non-invasive EMPD and normal skin (NS) controls were 97.9 +/- 1.8%, 82.0 +/- 23.4% and 45.8 +/- 3.2%, respectively, and p-STAT3 expression in advanced EMPD, non-invasive EMPD and NS were 97.0 +/- 2.9%, 83.2 +/- 23.3% and 50.1 +/- 6.7%, respectively. P-ATF2 and p-STAT3 expressions in EMPD were significantly higher than those in NS, indicating a possible contribution of these pathways to the tumor development. P-ATF2 and p-STAT3 expressions in advanced EMPD were significantly higher than those in non-invasive EMPD, possibly indicating that these pathways might also contribute to the tumor invasion and/or metastasis. We also found an exceptionally high positive correlation between p-ATF2 and p-STAT3 expressions in EMPD.
P-ATF2 and p-STAT3 are concordantly overexpressed in EMPD and their expressions may possibly be associated with the tumor stage.
Journal of Cutaneous Pathology 05/2009; 36(4):402-8. DOI:10.1111/j.1600-0560.2008.01076.x · 1.58 Impact Factor
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ABSTRACT: Activating transcription factor-2/Activator protein-1 (AP-1), Signal transducer and activator of transcription-3 and p53 are important regulators of cellular proliferation, apoptosis, differentiation in the pathogenesis of many human tumors, but the expression of phosphorylated (p)-activating transcription factor-2 (p-ATF2), phosphorylated (p)-signal transducer and activator of transcription-3 (p-STAT3) and p53 family (p63 and p73) has not been investigated in cutaneous angiosarcoma (CAS) and pyogenic granuloma (PG) so far.
To investigate the expression of p-ATF2, p-STAT3 and p53 and its family in cutaneous vascular tumors (CAS and PG).
Paraffin-embedded specimens of 14 CAS and 19 PG were subjected to immunohistochemical staining for p-ATF2, p-STAT3, p53, p63 and p73.
P-ATF2 was expressed in 13 out of 14 CAS and in all of 19 PG. P-STAT3 was expressed in all of 14 CAS and 19 PG. P53 was expressed in all of 14 CAS and 19 PG, while both p63 and p73 were negative in CAS and PG. The p-ATF2-, p-STAT3- and p53 expression (% positive cells) in CAS and PG were significantly higher than in normal dermal vessels, but none of these transcription factors distinguished malignant (CAS)- from benign (PG) vascular tumor.
The present study suggests that overexpression of p-ATF2, p-STAT3 and possibly p53, but not p63 or p73, may contribute to the tumorigenesis of cutaneous vascular tumors.
Journal of Cutaneous Pathology 09/2008; 35(8):722-30. DOI:10.1111/j.1600-0560.2007.00887.x · 1.58 Impact Factor
Journal of Dermatological Science 07/2008; 51(3):210-5. DOI:10.1016/j.jdermsci.2008.04.008 · 3.42 Impact Factor
Journal of Dermatological Science 03/2008; 49(2):170-3. DOI:10.1016/j.jdermsci.2007.08.001 · 3.42 Impact Factor
Nishi Nihon Hifuka 01/2007; 69(3):290-294. DOI:10.2336/nishinihonhifu.69.290