J Feyereisl

Ústav pro péči o matku a dítě, Praha, Praha, Czech Republic

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Publications (90)119.96 Total impact

  • Ultrasound in Obstetrics and Gynecology 09/2015; 46(S1):130-130. DOI:10.1002/uog.15336 · 3.85 Impact Factor
  • L. Haslik · J. Vojtech · L. Krofta · J. Feyereisl · L. Hympanova · R. Pock ·

    Ultrasound in Obstetrics and Gynecology 09/2015; 46(S1):205-205. DOI:10.1002/uog.15575 · 3.85 Impact Factor
  • K. Palasova · J. Vojtech · L. Haslik · L. Krofta · H. Herman · J. Feyereisl ·

    Ultrasound in Obstetrics and Gynecology 09/2015; 46(S1):207-207. DOI:10.1002/uog.15581 · 3.85 Impact Factor
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  • Z Pleváková · L Krofta · J Řezáčová · J Feyereisl ·
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    ABSTRACT: The aim of our study was to measure the volume of gestational sac and amniotic sac in physiological pregnancies and missed abortion. We wanted to create nomograms for individual weeks of gestation. Retrospective cohort study. Institute for the Care of Mother and Child, Prague. The study randomized 413 women after spontaneous conception. The patients were divided into two groups: women with physiological pregnancy and childbirth in the period (374), and women with pregnancy terminated by missed abortion. Both groups were performed measurement volume of gestational and amniotic sac in the first trimester of pregnancy. Analysis was performed using 4D View software applications, and volume calculations were performed using VOCAL (Virtual Organ Computer Aided anaLysis). We have created the first in the Czech Republic nomograms volumes of gestational and amniotic sac in physiological pregnancies and missed abortion. We performed a correlation between the size of gestational sac and prosperity pregnancy. In our study we found no correlation between the volume of gestational sac and the development of the pregnancy.
    Ceska gynekologie / Ceska lekarska spolecnost J. Ev. Purkyne 05/2015; 80(2):151-5.
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    ABSTRACT: Among gynaecological cancers, epithelial ovarian cancers are the most deadly cancers while endometrial cancers are the most common diseases. Efforts to establish relevant novel diagnostic, screening and prognostic markers are aimed to help reduce the high level of mortality, chemoresistance and recurrence, particularly in ovarian cancer. MicroRNAs, the class of post-transcriptional regulators, have emerged as the promising diagnostic and prognostic markers associated with various diseased states recently. Urine has been shown as the source of microRNAs several years ago; however, there has been lack of information on urine microRNA expression in ovarian and endometrial cancers till now. In this pilot study, we examined the expression of candidate cell-free urine microRNAs in ovarian cancer and endometrial cancer patients using quantitative real-time PCR. We compared the expression between pre- and post-surgery ovarian cancer samples, and between patients with ovarian and endometrial cancers and healthy controls, within three types of experiments. These experiments evaluated three different isolation methods of urine RNA, representing two supernatant and one exosome fractions of extracellular microRNA. In ovarian cancer, we found miR-92a significantly up-regulated, and miR-106b significantly down-regulated in comparison with control samples. In endometrial cancer, only miR-106b was found down-regulated significantly compared to control samples. Using exosome RNA, no significant de-regulations in microRNAs expression could be found in either of the cancers investigated. We propose that more research should now focus on confirming the diagnostic potential of urine microRNAs in gynaecological cancers using more clinical samples and large-scale expression profiling methods.
    Pathology & Oncology Research 04/2015; 21(4):1027-1035. DOI:10.1007/s12253-015-9914-y · 1.86 Impact Factor

  • Advances in Reproductive Sciences 01/2015; 03(02):34-40. DOI:10.4236/arsci.2015.32004
  • J. Vojtech · R. Pock · L. Haslik · L. Krofta · L. Hympanova · L. Haakova · V. Hejda · J. Feyereisl ·

    Ultrasound in Obstetrics and Gynecology 09/2014; 44(S1):103-103. DOI:10.1002/uog.13803 · 3.85 Impact Factor
  • L. Haslik · L. Krofta · J. Vojtech · L. Hympanova · J. Feyereisl · L. Haakova · J. Deprest ·

    Ultrasound in Obstetrics and Gynecology 09/2014; 44(S1):294-294. DOI:10.1002/uog.14362 · 3.85 Impact Factor
  • J. Hanacek · L. Krofta · J. Feyereisl ·

    Ultrasound in Obstetrics and Gynecology 09/2014; 44(S1):332-332. DOI:10.1002/uog.14484 · 3.85 Impact Factor

  • Ultrasound in Obstetrics and Gynecology 09/2014; 44(S1):277-277. DOI:10.1002/uog.14311 · 3.85 Impact Factor

  • Ultrasound in Obstetrics and Gynecology 09/2014; 44(S1):117-118. DOI:10.1002/uog.13858 · 3.85 Impact Factor
  • J Klikarová · K Snajbergová · A Měchurová · P Velebil · J Feyereisl ·
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    ABSTRACT: Objective: We made an analysis of number of intrauterine fetal deaths in our institute, it's causes, risk factors and patient's main complaints. Methods: Retrospective study of all intrauterine fetal deaths in Institute for the care of mother and child in years 2008-2012. Results: We had 60 cases of intrauterine fetal death from 2008 to 2012 which represented 2.4 of all deliveries (24884). The examination started in 45% of cases due to information about decreased fetal movements, 28.3% was diagnosed during regular visit, 13.3% came for contractions, 10% because of PPROM and 3.3% due to vaginal bleeding. In 58.3% we used induction of delivery, in 10% delivery started spontaneously and in 31.7% a caesarean section was performed. Conclusion: Decrease in fetal movements was the most frequent complaint of our patients. Spontaneously delivered 68.3% patients, caesarean section was indicated in twins, due to maternal diseases or from vital indication. In 70% of cases we approved the cause of intrauterine fetal death. Mostly umbilical cord or placental abnormalities were present.
    Ceska gynekologie / Ceska lekarska spolecnost J. Ev. Purkyne 05/2014; 79(2):120-7.
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    ABSTRACT: Selected immunological and biochemical markers in the study of preeclampsia (tested in the first trimester) Andrea Kestlerová1, 2, , Jindřich Madar1, Veronika Novotná1, Jaroslav Feyereisl1, Tomáš Zima2 Show more doi:10.1016/j.jri.2013.12.037 In this study, we selected five special groups of pregnancy pathological conditions that were connected with preeclampsia: a) Gestational hypertension with blood pressure higher than 140/90 b) Gestational hypertension with microalbuminuria (proteinuria lower than 300 mg/day) c) Preeclampsia – gestational hypertension with proteinuria d) Gestational diabetes mellitus e) Group B streptococcus positivity Patients and methods: The group of 168 women consists of two subgroups: first-trimester pregnant women in whom markers other than interleukins were determined (n = 88); first-trimester pregnant women in whom only interleukins were determined (n = 80). These subgroups were subsequently divided according to the development of pregnancy in the third trimester. Each subgroup consists of an equal number of pathological and physiological pregnancies. Measured markers: Serum anti-cardiolipin autoantibodies IgG (ACLA-G) and IgM (ACLA-M), interleukins: IL-6, IL-12, IL-15, IL-16, IL-17, IL-18, and IL-23 (by a standard ELISA). Results: In group C the percentage of IL-6 (p = 0.002), IL-18 (p = 0.016), IL-23 (p = 0.002), and ACLA-G (p < 0.001) were higher. In other pathological conditions only the percentage of ACLA-M was higher (p < 0.001). IL-15 was positive only in the patients who developed either severe preeclampsia or preeclampsia combined with lupus syndrome in the third trimester. IL-16 was elevated only in group a. Other parameters did not differ significantly. Conclusions: The positivity of some of the followed interleukins, rheumatoid factor and ACLA-G may indicate that the immune mechanism plays a key role in the onset of the pathophysiological chain of preeclampsia. We concluded that elevated biochemical and immunological markers can help to predict the threat of preeclampsia in the third trimester. Some markers can probably predict the development of particularly severe pathological conditions. Acknowledgement: This research was supported by PRVOUK – P25/LF1/2; MZČR – RVO – VFN 64165; PRVOUK – P32. Corresponding author. Copyright © 2013 Published by Elsevier Ireland Ltd.
    Journal of Reproductive Immunology 03/2014; 101-102:42-43. DOI:10.1016/j.jri.2013.12.037 · 2.82 Impact Factor
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    ABSTRACT: Problem: The in vitro fertilization-embryo transfer (IVF-ET) technique is a potent tool for the treatment of fertility disorders, but its success rate is limited by the failure of implantation. Nowadays, there is valid evidence that in many cases a discrepancy between the embryo and the mother's immunity disturbs the implantation. In this presentation, we analyze the possibility of pre-treating the mother's adverse immunity before the transfer of the embryo (ET). Methods: In this particular presentation we identified the “adverse immunity” as an increase in specific cell-mediated immunity (CMI) measured by the method of migration inhibition index (MII, Dimitrov et al., J. Immunol. Methods 154:147–153, 1992, slightly modified). Briefly, leukocytes separated from the woman's blood were allowed to migrate either alone, or in the presence of antigens (sperm, trophoblast) under the agarose layer. After a 16-h incubation (37 °C, 5% CO2), the zones of migration were measured by image analysis. When the migration in the presence of antigens was 65% or less of the control zones, the samples were considered to be CMI-positive. Immunomodulatory pretreatment (IP): At least 6 weeks prior to the ET, the couple used condom occlusion; the female partner was advised to allow any gynecological infections to heal and took a low dose of corticoids (5 mg prednisolone daily). Patients: A pool of 387 women treated by IVF-ET in the Department of Assisted Reproduction of the Institute for the Care of Mother and Child in Prague was subdivided into three groups: (1) no adverse immunity (CMI negative, n = 103); (2) CMI positive, without IP (n = 127); and (3) CMI positive, the couple underwent IP prior to the ET (n = 157). The female partners then experienced standard IVF (or ICSI, when necessary) ET treatment and the implantation was considered to be successful when the pregnancy was confirmed by ultrasound. Results: Implantation rate (IR) in untreated couples with positive CMI was 18.3%, while in immunomodulatory-pretreated ones the IR reached 33.8%. In couples with negative CMI the IR was 37.2%. Conclusion: Our data suggest that activated CMI at the feto-maternal interface could be a significant brake on implantation and that immunomodulatory pretreatment increases the implantation rate in such a case.
    Journal of Reproductive Immunology 03/2014; 101-102(March 2014):34. DOI:10.1016/j.jri.2013.12.109 · 2.82 Impact Factor
  • L Valdmanova · M Krcmar · L Krofta · L Hyncik · J Janstova · K Grohregin · J Feyereisl ·

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    P Ventruba · J Feyereisl · P Janda · E Kučera · A Martan · Z Novotný · R Pilka · L Rob · Z Rokyta · J Spaček · J Tošner ·
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    ABSTRACT: Objective: The paper addresses transfer of doctors specialty training from the national Institute of postgraduate medical education (IPVZ) to University Medical Schools (UMS) with the special focus to Obstetrics and Gynecology (OG). Methods: The National Specialty Board (NSB) has been established. NSB tasks include definition of inclusion criteria and process of specialty choice at UMS. In OG specialty there are defined mid-term and final postgraduate training courses and other requirements for final specialty exam (FSE) - in particular trainees scientific work and surgery done with the supervision of NTB member. The system of FSE, its content, application, reimbursement and mechanisms are described in details. Results: In the whole country in 2012 there have been done 864 FSE in all basic medical specialties, which took place at seven UMS. Autumn semester terms has been utilized significantly more than spring terms (57% vs. 43%). There have been differences in the numbers of specialties and also numbers of candidates in each specialty among different UMS. In total 94% of applicants succeed in the FSE. In 2012 within OG specialty training there has been held 56 FSE - 24 exams on five UMS in spring term and 32 (57%) exams only on two UMS in autumn term. In the spring 2013 FSE were organized on 1st LF UK in Prague with 23 applicants, from which 22 successfully passed. During autumn 2013 the FSE in OG will be held on LF UP in Olomouc with 44 applicants for final postgraduate training course and 39 candidates for FSE. Conclusion: Within OG specialty the transfer of doctors specialty training from IPVZ to UMS has been successfully managed. The NSB in OG specialty closely cooperates with past IPVZ and the Accreditation Commission of the Czech Ministry of Health. Thus continuity, quality and continuous enhancement of specialty training program in OG in Czech Republic is assured.
    Ceska gynekologie / Ceska lekarska spolecnost J. Ev. Purkyne 12/2013; 78(5):486-90.
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    ABSTRACT: Nocturia is the complaint that the individual has to wake at night one or more times to void, according to the International Continence Society definition from the ICS Standardisation of Terminology Report 2002. As the nocturia definition is complicated there are also other slightly modified definitions. It is currently not absolutely clear if prevalence or incidence is more important for epidemiology evaluation of nocturia. Nocturia is a variable symptom and its presence in individuals is reversible therefore it is very difficult to obtain reliable incidence data. Nocturia prevalence varies remarkably in different studies according to evaluation methodology, nocturia definition, methods of data collection and characteristics of evaluated population. There are not enough studies, especially demographic ones, evaluating lower urinary tract symptoms and/or nocturia in males and females. There is relatively large number of comparative studies confirming strong correlation between aging and prevalence of nocturia. Prevalence of two or more voids per night in individuals in their twenties varies between 5-15 %, it progresses with age, and in the seventh decade of life ranges between 35-50 %. Prevalence evaluated by gender is higher among younger women compared to older women and older men compared to younger men. Currently there are only limited sources of data regarding nocturia incidence. Incidence of nocturia (two or more voids per night) in a population older than60 years is 213 new cases/1000 persons/1 year in two year observation. Incidence of two or more voids per night is 75 new cases/1000 male/1 year in five year observation and 126 new cases/1000 male/1year in ten year observation in male population. Incidence of nocturia rises significantly with age. Incidence of two or more voids per night increases by 2,7 % in the population of women after child birth during 5 year follow up and by 5,9 % during 12 year follow up. Incidence of nocturia newly diagnosed in a pregnancy drops down by 98% in 3 month after the child birth. The incidence data indicate that incidence of nocturia rises with age and probability of nocturia relief decreases with age. Incidence of mild nocturia is higher compared to incidence of severe nocturia and significant relief of nocturia in women after child birth is very inconsistent compared to increase of other lower urinary tract symptoms. Ethiology of nocturia might be polyuria, nocturnal polyuria or reduced bladder capacity. Nocturia and its ethiology can be determined in most cases with simple and commonly used investigative methods on the out-patients bases. The diagnostic algorithm should lead to verification of nocturia and identifying its cause because treatment of nocturia differs remarkably according to the etiology.. Keywords: nocturia - prevalence - incidence - ethiology - diagnostics.
    Ceska gynekologie / Ceska lekarska spolecnost J. Ev. Purkyne 12/2013; 78(6):566-72.
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    ABSTRACT: Unlabelled: Nonpharmacologic and especially pharmacologic treatment options are available for nocturnal polyuria. Desmopressin represents the basis of pharmacologic treatment. Desmopressin acetate is a synthetic analogue of arginine vasopressin with high affinity to V2 receptors with antidiuretic effect. It is the only medicament currently registered for antidiuretic treatment. Desmopressin has not any relevant affinity to V1 receptors, and therefore there is no hypertensive effect in contrary to natural vasopressin. Desmopressin use before a bedtime leads to reduced production of urine during a sleep, therefore time between desires to void is prolonged and number of nocturia is reduced. Clinical effect, in a meaning of reduced urine production and increased osmolality of urine, lasts approximately 8-12 hours. In the treatment of nocturnal polyuria desmopressin is used orally one hour before a bedtime. It is essential to titrate an ideal dose, the initial dose is 60 µg of MELT formula (fast melting oral formulation) and it can be increased according to the clinical effect up to the maximal recommended daily dose 240 µg. Patients treated with desmopressin should cut down a fluid intake 1 hour before and 8 hours after the use of desmopressin. Total number of adverse events connected withdesmopressin treatment in clinical studies was higher compared to placebo but the side effects were mostly mild. The most common adverse events were headaches, nausea, diarrhoea, abdominal pain, dry mouth and hyponatremia both in the short-term and long-term clinical trials. Hyponatremia was observed mainly in patients over 65 year of age. Therefore treatment with desmopressin should not be commended in patients over 65 year of age without close monitoring of the natrium level in serum and all patients should be informed about the first symptoms of hyponatremia - headache, nausea and insomnia. According to Evidence Based Medicine, the level of evidence for treatment of nocturnal polyuria with desmopressin is 1b and the grade of recommendation for treatment is A. Keywords: nocturnal polyuria - treatment - desmopressin.
    Ceska gynekologie / Ceska lekarska spolecnost J. Ev. Purkyne 08/2013; 78(4):385-9.

Publication Stats

285 Citations
119.96 Total Impact Points


  • 2002-2015
    • Ústav pro péči o matku a dítě
      Praha, Praha, Czech Republic
  • 2012
    • The Police Academy of the Czech Republic in Prague
      Praha, Praha, Czech Republic
  • 2007-2009
    • Charles University in Prague
      • Department of Obstetrics and Gynaecology (1. LF)
      Praha, Praha, Czech Republic

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