Yasuto Sato

Tokyo Women's Medical University, Edo, Tōkyō, Japan

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Publications (20)27.56 Total impact

  • [Show abstract] [Hide abstract]
    ABSTRACT: This study aimed to elucidate the recall accuracy of mobile phone calls among young people using new software-modified phone (SMP) technology. A total of 198 Japanese students aged between 10 and 24 years were instructed to use a SMP for 1 month to record their actual call statuses. Ten to 12 months after this period, face-to-face interviews were conducted to obtain the self-reported call statuses during the monitoring period. Using the SMP record as the gold standard of validation, the recall accuracy of phone calls was evaluated. A total of 19% of the participants (34/177) misclassified their laterality (i.e., the dominant side of ear used while making calls), with the level of agreement being moderate (κ-statistics, 0.449). The level of agreement between the self-reports and SMP records was relatively good for the duration of calls (Pearson's r, 0.620), as compared with the number of calls (Pearson's r, 0.561). The recall was prone to small systematic and large random errors for both the number and duration of calls. Such a large random recall error for the amount of calls and misclassification of laterality suggest that the results of epidemiological studies of mobile phone use based on self-assessment should be interpreted cautiously.Journal of Exposure Science and Environmental Epidemiology advance online publication, 18 March 2015; doi:10.1038/jes.2015.13.
    Journal of Exposure Science and Environmental Epidemiology 03/2015; DOI:10.1038/jes.2015.13 · 3.05 Impact Factor
  • Ying Li, Lu Meng, Yue Li, Yasuto Sato
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    ABSTRACT: Although the association between depression and body composition has been widely discussed, the effects of depression on lean body mass (LBM) are unclear. The present study aimed to investigate the association of depression with LBM. The study included 2406 participants aged 18-69 years. The sex and body mass index (BMI) stratified analysis of covariance was performed to compare total LBM and percentage LBM (%LBM) in subjects with different depression score levels. Multiple linear regression analysis was conducted to estimate the association between depression score and serum albumin level. An analysis of covariance stratified by sex showed that participants with moderate-to-severe depression had significantly decreased total LBM and total and regional %LBM in men, except for total LBM and percentage gynoid LBM, which was observed in women. In the BMI stratified analysis of covariance, depression was significantly associated with decreased total and regional %LBM and with increased total and regional percentage fat body mass. In people with BMI≥25kg/m(2), the associations between depression or depressive syndrome and LBM, and total and regional %LBM are stronger compared to those with BMI<25kg/m(2). Multiple linear regression analysis showed that depression score was significantly negatively associated with serum albumin level. This is a cross-sectional study based on a general population, some information about clinical diagnosis and medication use is not available. Depression had a significant negative association with LBM and serum albumin level.
    Journal of Affective Disorders 03/2014; 157:1-7. DOI:10.1016/j.jad.2013.12.040 · 3.71 Impact Factor
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    Ying Li, Hua Liu, Yasuto Sato
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    ABSTRACT: Although serum C-peptide was previously considered biologically inactive, a growing number of recent studies have shown that it is an active peptide with important physiologic functions. The present study aimed to investigate the association of serum C-peptide level with bone mineral density (BMD) in residents of the United States. The study included 6,625 participants aged 12-85 years. Total and regional BMD were measured using dual-energy X-ray absorptiometry. Stratified multiple linear regression analysis was performed to determine the association of the serum C-peptide level with BMD. Three regression models were produced for each stratum. All models were adjusted for ethnicity, height, weight, education level, physical activity, smoking status, alcohol use, triglycerides and creatinine level, and models 2 and 3 were further adjusted for the fasting plasma glucose (FPG) and alkaline phosphatase (ALP) levels, respectively. Sex-specific results showed a significant association between the serum C-peptide level and total BMD in both sexes. Stratified analyses based on age and body mass index showed that serum C-peptide levels were significantly negatively associated with most regional BMD, and most of these associations remained significant after stratification based on the serum insulin level. The serum C-peptide level was significantly negatively associated with the total and most regional BMD. These findings suggest that serum C-peptide may have biological activity associated with bone metabolism and therefore serum C-peptide control is advisable in order to reduce the risk of low bone mineral density.
    PLoS ONE 12/2013; 8(12):e83107. DOI:10.1371/journal.pone.0083107 · 3.53 Impact Factor
  • Ying Li, Lu Meng, Yue Li, Yasuto Sato
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    ABSTRACT: Although elevated serum C-peptide level as an indicator of insulin resistance increases the obesity-associated risk of cardiovascular disease among diabetic patients, evidence indicating that serum C-peptide level is associated with stroke in nondiabetic subjects is limited. The aim of this study is to evaluate the association between serum C-peptide level and ever stroke in nondiabetic subjects and investigated the associations of serum C-peptide level with body fat distribution and stroke events among nondiabetic subjects. This study was a population-based cross-sectional study that included 7030 participants aged 12-85 years. Body fat distribution was determined by dual-energy X-ray absorptiometry. Serum C-peptide level was measured using the radioimmunoassay method. The association between serum C-peptide level and body fat distribution was evaluated by multiple linear regression models. Logistic regression analysis was performed to calculate the odds ratio (OR) of serum C-peptide level being associated with ever stroke. A total of 103 nondiabetic subjects reported having a stroke. Logistic regression analysis revealed a high-serum C-peptide level significantly associated with ever stroke among nondiabetic subjects (OR: 3.71, 95% confidence interval: 1.78-7.75). Meanwhile, in multiple linear regression analysis, serum C-peptide level was positively associated with total and regional fat distribution among nondiabetic subjects. The serum C-peptide level is strongly associated with the ever stroke in nondiabetic subjects and significantly associated with total and regional body fat distribution.
    Journal of stroke and cerebrovascular diseases: the official journal of National Stroke Association 10/2013; 23(3). DOI:10.1016/j.jstrokecerebrovasdis.2013.09.013 · 1.99 Impact Factor
  • Ying Li, Lu Meng, Qianqian Miao, Yasuto Sato
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    ABSTRACT: Serum C-peptide is an active peptide that has important physiological functions and characteristics in the elderly. The present study aimed to investigate the association between physical activity and serum C-peptide level independent of insulin level among the elderly. The study included 1700 elderly participants aged ≥65 years. Stratified analysis of covariance was used to compare serum C-peptide levels in participants with different physical activity levels. Two separate multiple linear regression models were created to estimate the association between physical activity and serum C-peptide level. The results of analysis of covariance stratified by sex, body mass index and serum insulin level showed that those who engaged in vigorous physical activity had lower serum C-peptide levels than those who engaged in light or no physical activity. Separate multiple linear regression analysis showed that in those with low serum C-peptide levels (≤0.621 nmol/L), physical activity was significantly positively associated with the serum C-peptide level. In contrast, physical activity was negatively associated with the serum C-peptide level among those with serum C-peptide level >0.621 nmol/L. The serum C-peptide level showed a significant two-way association with physical activity. The present findings suggest that physical activity modification is important for improving serum C-peptide levels among the elderly. Geriatr Gerontol Int 2013; ●●: ●●-●●.
    Geriatrics & Gerontology International 09/2013; 14(3). DOI:10.1111/ggi.12152 · 1.58 Impact Factor
  • Ying Li, Yasuto Sato, Naohito Yamaguchi
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    ABSTRACT: OBJECTIVE: The objective of this study was to elucidate new evidence on the presence of a relationship among sleep duration, cardiovascular mortality and total mortality, and to investigate sleep duration-related multiple biochemical changes. METHODS: The longitudinal study is based on the SAKUCESS study of 12,489 residents of Japan aged 20-79years at baseline. RESULTS: In the study, compared to respondents who reported 7h of sleep, long sleep duration (⩾9h) was associated with an increased risk of cardiovascular disease mortality and total mortality in men, hazard ratios (HRs) were 1.70 (95% confidence interval [CI]=1.07-2.70) and 2.73 (95% CI=1.22-6.11) and an increased risk of total mortality in women, HR was 1.85 (95% CI=1.09-3.13). Sleep duration was significantly associated with changes in blood biochemical levels. The results of the logistic regression analysis showed that the levels of multiple biochemical parameters are associated with increased risk of total mortality. CONCLUSIONS: This is the first large longitudinal study to indicate that sleep duration was associated with changes in multiple biochemical levels in the blood and total mortality.
    Sleep Medicine 11/2012; 14(1). DOI:10.1016/j.sleep.2012.08.020 · 3.10 Impact Factor
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    ABSTRACT: To better understand the role of motivation in determining exercise participation at the population level, we performed a questionnaire survey of 385 Japanese adults (mean age: 55.0 years, SD: 10.9 years). At baseline, the motivation subscales (intrinsic motivation, identified regulation, and external regulation), self-efficacy, and enjoyment all showed significant differences across the stages of change for exercise. Intrinsic motivation and enjoyment had similar findings, with the highest scores being noted in the maintenance stage. Among the 385 subjects, 183 completed the follow-up questionnaire 3 months later. After 3 months, most of the participants (86.9%) who were in the maintenance stage at baseline remained in the same stage. The number of participants who dropped to a lower stage after 3 months was 23. The changes of exercise stage over the 3-month period differed significantly for identified regulation, introjected regulation, and motivation. There were significant time and group interactions for intrinsic motivation and identified regulation. These findings suggest the importance of intrinsic motivation and identified regulation for performance of regular exercise, as well as the role of introjected regulation for promoting behavioral change among Japanese adults.
    Global Health Promotion 03/2012; 19(1):14-22. DOI:10.1177/1757975911423073
  • 01/2012; 35(3):195-203. DOI:10.14442/generalist.35.195
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    ABSTRACT: BACKGROUND: The Japanese government amended the Preventive Vaccination Law in November 2001 to specify elderly people aged ≥65 years as the target population for influenza vaccinations. The vaccine coverage among this age group rapidly increased thereafter. Our goal was to evaluate how this amendment affected the nationwide mortality rate of chronic obstructive pulmonary disease (COPD). METHODS: The number of monthly COPD deaths by gender and age was obtained from the Monthly Vital Statistics Reports of the Ministry of Health, Labour and Welfare. Data between January 1995 and December 2009 were used for analyses. The COPD mortality rate for each month was calculated separately for the two age groups: age <65 years and age ≥65 years. Changes in the COPD mortality rates after amendment were evaluated each month using the Poisson regression analysis to calculate risk ratios (RRs) and to compute 95% confidence intervals (95% CIs) adjusting for gender, age, trend and seasonal variations. RESULTS: After amendments to the law, a statistically significant reduction in the COPD mortality rates were observed in January (RR 0.84; 95% CI 0.81-0.88), February (RR 0.85; 95% CI 0.81-0.89) and March (RR 0.92; 95% CI 0.88-0.96) among the population aged ≥65 years. However, in the population aged <65 years, statistically no significant changes in the COPD mortality rate were found in any month after the amendments were made. CONCLUSION: A legal approach to improving influenza vaccine coverage for the elderly population would contribute to the risk reduction of COPD deaths during the influenza season.
    The European Journal of Public Health 12/2011; 23(1). DOI:10.1093/eurpub/ckr172 · 2.46 Impact Factor
  • Ying Li, Yasuto Sato, Naohito Yamaguchi
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    ABSTRACT: This study aims to examine the effectiveness of lifestyle factors in predicting general cardiovascular events and to investigate the feasibility of using the lifestyle model as a self-screening tool. The authors conducted a longitudinal study over a 10-year follow-up in Japan. Logistic regression analysis was used to create prediction models for general cardiovascular disease (CVD) death. The authors estimated the predictive power of the models by calculating the area under the receiver operating characteristic (AUROC) curve. The total of 6 traditional and 5 lifestyle risk factors were significantly associated with the incidence of CVD events. Hazard ratios (HRs) were 0.26 (95% confidence interval [CI] = 0.17, 0.41) for regular physical activity, 0.57 (95% CI = 0.50, 0.67) for moderate- or high-intensity work, and 1.72 (95% CI = 1.31-2.26) for short sleep duration; the HRs for traditional and Western dietary patterns were 1.53 (95% CI = 1.12, 2.09) and 2.62 (95% CI = 1.46, 4.68), respectively. The AUROC curve was significantly different between the classic and lifestyle prediction models. These results suggest that lifestyle factors are significant predictors of CVD events.
    Asia-Pacific Journal of Public Health 12/2011; DOI:10.1177/1010539511423067 · 1.11 Impact Factor
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    ABSTRACT: Preferences among people for health system goals are important determinants in developing health policy. The aim of this study was to determine preferences for health system goals and their associations with sociodemographic characteristics in Japan. Participants were randomly selected from the general population in 5 prefectures and were asked to rank 5 health system goals in order of preference: health, health inequality, responsiveness, responsiveness inequality, and fair financing. Associations between sociodemographic characteristics and preferences for health system goals were examined using multinomial logistic regression analysis. A total of 4936 persons responded to this study. Health system goals in order of preference were health inequality (37.6%), responsiveness inequality (20.9%), health (18.4%), responsiveness (16.0%), and fair financing (7.1%). Sociodemographic characteristics such as gender, age, family status, education completed, and usage of health care services were associated with the preferred health system goal. Health policy makers should take these associations into account when developing prospective policy.
    Asia-Pacific Journal of Public Health 08/2011; 23(5):721-9. DOI:10.1177/1010539511418101 · 1.11 Impact Factor
  • Ying Li, Yasuto Sato, Naohito Yamaguchi
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    ABSTRACT: The aim of the present study was to examine the association between shift work and the metabolic syndrome (MetS) using a large-scale longitudinal study design. Data were collected from a historical cohort of health checkups in the Japanese population. The baseline survey, which involved 16,952 inhabitants of the Minami Saku area of the Nagano Prefecture, was started in 1978. A nested case-control study was conducted between 1987 and 1990. This analysis was restricted to 6,712 men and women (age range 25-59 years). A conditional logistic regression model was used to estimate the risk of MetS associated with shift work. Compared with the day workers, shift workers had a significantly higher risk of MetS (odds ratio 1.87; 95% CI, 1.13-3.08). Our results demonstrate that shift work was strongly associated with MetS. The study suggests appropriate dietary habits as a basis for managing the MetS risk of shift workers.
    International journal of occupational and environmental health 04/2011; 17(2):154-60. DOI:10.1179/oeh.2011.17.2.154 · 1.10 Impact Factor
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    ABSTRACT: Results of case-control studies of mobile phone use and acoustic neuroma have been inconsistent. We conducted a case-case study of mobile phone use and acoustic neuroma using a self-administered postal questionnaire. A total of 1589 cases identified in 22 hospitals throughout Japan were invited to participate, and 787 cases (51%) actually participated. Associations between laterality of mobile phone use prior to the reference dates (1 and 5 years before diagnosis) and tumor location were analyzed. The overall risk ratio was 1.08 (95% confidence interval (CI), 0.93-1.28) for regular mobile phone use until 1 year before diagnosis and 1.14 (95% CI, 0.96-1.40) for regular mobile phone use until 5 years before diagnosis. A significantly increased risk was identified for mobile phone use for >20 min/day on average, with risk ratios of 2.74 at 1 year before diagnosis, and 3.08 at 5 years before diagnosis. Cases with ipsilateral combination of tumor location and more frequently used ear were found to have tumors with smaller diameters, suggesting an effect of detection bias. Furthermore, analysis of the distribution of left and right tumors suggested an effect of tumor-side-related recall bias for recall of mobile phone use at 5 years before diagnosis. The increased risk identified for mobile phone users with average call duration >20 min/day should be interpreted with caution, taking into account the possibilities of detection and recall biases. However, we could not conclude that the increased risk was entirely explicable by these biases, leaving open the possibility that mobile phone use increased the risk of acoustic neuroma.
    Bioelectromagnetics 02/2011; 32(2):85-93. DOI:10.1002/bem.20616 · 1.86 Impact Factor
  • Iryo To Shakai 01/2009; 19(2):141-150. DOI:10.4091/iken.19.141
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    ABSTRACT: In this study, we compared the choice of medical specialty and subspecialty interest among problem-based-learning (PBL) graduates and non-PBL graduates. Questionnaires were mailed to a total of 1398 female doctors who graduated from Tokyo Women's Medical University (TWMU) between 1989 and 2003. The response rate was over 30%, giving 248 respondents who had undergone a PBL curriculum (PBL+) and 220 subjects who had not (PBL-). Current specialty of the graduates were compared between the PBL+ and PBL-, and also compared with the general Japanese female doctors (Control 1 and 2) of similar age groups. Respondents were analysed in terms of their interests in subspecialty medical care or general medical practise, which includes comprehensive medical care, primary care and basic medicine. Internal medicine doctors working in the university hospitals were compared with those working outside the university hospitals. Internal medicine doctors were also compared with specialists in ophthalmology, otolaryngology, dermatology and psychiatry. Subjects were compared by odds ratio (OR) to examine group difference in the field of interest. OR >2.0 was considered statistically significant. Most doctors in all groups chose internal medicine. More PBL+ internal medicine doctors showed interests in comprehensive medical care and primary care; more PBL+ internal medicine doctors working outside university hospitals showed interest in comprehensive medical care and primary care when compared with those who were working in the university hospitals. The PBL- graduates did not show such a characteristic. More PBL+ graduates who chose internal medicine showed interest in holistic medical practices such as primary care and community medicine and more PBL+ specialists showed sustained interest in their respective fields.
    Annals of the Academy of Medicine, Singapore 01/2007; 36(1):67-71. · 1.22 Impact Factor
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    ABSTRACT: BACKGROUND: The purpose of our study was to compare the characteristics of medical practitioners who prefer using the Internet as their information resource and those who prefer using printed materials.METHODS: From December 2002 to January 2003, a non-anonymous questionnaire was sent out by post to members of the Japanese Medical Association (JMA) and physicians working in hospitals. Contributing factors were examined by using logistic regression analysis.RESULTS: The response rates for the questionnaires were 18.7% (n=1868) for JMA physicians and 68.0% (n=5901) for hospital physicians. Factors associated with the preference for using the Internet were: ‘younger age’; ‘use of the Internet to solve clinical problems and uncertainties’; ‘use of personal computers at work’; and, ‘use of personal computers at home’.CONCLUSION: The results of this study show that, although some younger physicians prefer printed materials, providing medical information via the Internet is better suited for younger physicians who are making full use of computers. In contrast, older physicians prefer printed materials because they tend to be less familiar with using computers and may have limited accessibility to the Internet. Therefore, using both the Internet and printed materials to provide medical information is necessary to meet the needs of the larger physician population.
    01/2006; 7(2):45-52. DOI:10.14442/general2000.7.45
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    ABSTRACT: To evaluate the effectiveness of mass treatment with ivermectin of scabies outbreak in institutional settings. To determine the factors, such as host susceptibility and scabetic exposure level associated with the onset of scabies. The authors investigated a nosocomial scabies outbreak in a close psychiatric ward. The index case was a man with steroid-induced localized crusted scabies. Twenty-six patients were diagnosed with scabies, 4 of them had relapse of scabies, while no staff was infested. Despite frequent surveillance and treatment of symptomatic patients with 1% gamma-benzenehexachloride (gamma-BHC: Lindane), new cases were observed. Thus, all 69 patients in the ward were treated with ivermectin (200 microg/kg) simultaneously on day 105 of the outbreak (the mass treatment). Patients who had scabies were compared with patients who had no scabies in terms of age, body weight, diabetes, physical functions, topical administration of corticosteroid, proximity to the index patient, and problematic behavior. The mass treatment was implemented without a significant adverse event. Although two patients developed symptoms of scabies after the mass treatment, no patient in the ward had been diagnosed with scabies since the 98th day of the treatment. Regarding factors associated with the scabies onset, the only statistically significant factor was proximity to the index patient with crusted scabies. Oral ivermectin was safe and effective for controlling scabies in institutional settings. The exposure level to scabetic mites was more important than host susceptibility in determining the risk of scabies onset.
    Nippon Eiseigaku Zasshi (Japanese Journal of Hygiene) 12/2005; 60(4):450-60. DOI:10.1265/jjh.60.450
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    ABSTRACT: BACKGROUND: physicians' awareness regarding evidence-based medicine (EBM), clinical practice guidelines, and clinical information resources were rarely examined in Japan. We need to know them prior to the initiation of the Medical Information Network Distribution Service (Minds) by the Japan Council for Quality Health Care (JCQHC) .METHODS: A total of 10, 000 directors/owners of private clinics (CDs: clinic physicians) affiliated with the Japan Medical Association (JMA) and 8682 physicians working for hospitals certified by the JCQHC (HDs: hospital physicians) were randomly selected and surveyed by a mailed questionnaire.RESULTS: The response rate to the questionnaire was 18.7% (n=1865) among CDs and 67.8% (n=5885) among HDs. The percentage of respondents who uses internet was 39.9% among CDs and 69.3% among HDs. The information resource most commonly used by all respondents was medical journals, followed by textbooks. The percentage of respondents who used medical literature database was 10.8% among CDs and 49.7% among HDs, respectively. Approximately 80% of all respondents approved implementing EBM in daily practice. Fifty percent of all respondents indicated to have used clinical practice guidelines, and 90% of all the guideline users replied that clinical practice guidelines are useful tools for clinical decision-making. Over half of HDs required to access to the abstracts of the literature cited in the guidelines.CONCLUSIONS: Many physicians who responded to the survey acknowledged that EBM will contribute to improving the quality of medical services. They are positive in using clinical practice guidelines that include a series of recommendations proposed by specialists in the relevant field (s) in accordance to the reviewed evidence.
    01/2004; 5(1):13-20. DOI:10.14442/general2000.5.13
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    ABSTRACT: The National Cancer Center (NCC) was established in 1962 in Tokyo as a national institute within the Ministry of Health and Welfare of the national government of Japan. However, there has not been a report on the long-term trends in survival rates at the NCC Hospital. In this paper, we show time trends in 5- year relative survival rates (RSR) at the NCC Hospital from 1962 to 1994. All patients who were hospitalized at the NCC Hospital and diagnosed as having malignant neoplasms were registered, at each admission, with the hospital registration system managed by the Statistics and Survey Section. The subjects of this study were selected from this hospital cancer registry database. Patients of nationality other than Japanese were excluded from the study, because such patients could not easily be followed up to assess survival. All registered patients were tracked by the Statistics and Survey Section, using residential records of patients kept by municipal governments throughout Japan. Tracking surveys were conducted every year for the patients whose first admission was within 5 years from the date of the survey. The survival time of each patient was calculated from the date of first admission and either the date of death or the latest date at which the patient could be confirmed to be alive using residential records or hospital records of outpatient visits. The 5-year crude survival rate was calculated using the life table method and the 5-year RSR was calculated by adjusting for deaths from causes other than cancer, using the life table of the entire Japanese population (1,2,3). The number of patients who were hospitalized at the NCC Hospital for the first time for the treatment of malignant neo- plasms is shown in Table 1 by gender, 10-year age group and the year of first admission. In total, 48 745 patients, compris- ing 24 976 males and 23 769 females, were treated for malig- nant neoplasms during their first hospitalization. Time trends in 5-year relative survival rates are shown for all sites com- bined and major sites by gender in Table 2. Time trends in RSR for major sites are shown in Fig. 1(a) for males and Fig. 1(b) for females. The RSR for all sites combined showed a substan- tial improvement for both males and females. In particular, those sites that had poorer survival rates early in the studied time period showed larger improvements.
    Japanese Journal of Clinical Oncology 06/2002; 32(5):181-6. · 1.75 Impact Factor
  • Ying Li, Yasuto Sato, Naohito Yamaguchi
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    ABSTRACT: 〔背景〕中国と日本における平均寿命の大きな差は,2ヵ国間の早世の比較を行うことが中国における有効な公衆衛生対策を見いだすことに有用であることを示唆している.〔目的〕本研究は中国における早世の予防可能な原因を同定することを目的とした.適切な予防対策の有効性についても検討した.〔方法〕中国で影響の大きい早世の原因を明らかにするため,2002年の中国黒龍江省および1960~2002年の日本における65歳未満の損失生存可能年数(YPLL)を計算した.続いて,中国における早世を減少させるための主要なリスク因子を明らかにするため,16,953名の健診参加者のコホートデータベースを分析した.人口寄与危険度割合によりリスク減少の効果を推定した.〔結果〕日本と中国の間には,男性では不慮の事故および脳血管疾患,女性では不慮の事故,脳血管疾患および心臓病のYPLLに大きな差が観察された.コホートデータの多変量解析においては,男性では高血圧および喫煙が,女性では高血圧が脳血管疾患死亡のリスク因子になっていた.有病率の変化により,コホートにおける脳血管疾患死亡リスクは男性では19.2%,女性では9.5%減少することが見込まれた.中国において高血圧と喫煙に対して適切な対策を行うことで,同様なリスク減少を見込むことができる.〔結論〕中国黒龍江省においては,脳血管疾患による早世を減少させる,ため,高血圧が最も効果のある対象であることが明らかとなった. Background: The large difference in life expectancy between China and Japan indicates that the comparison of premature deaths between two countries is worth identifying public health measures to be taken in China. Objectives: This study aimed at identifying preventable causes of premature deaths in China. The effectiveness of appropriate preventive measures was also examined. Methods: The years of potential life lost (YPLL) before age 65 was calculated for Heilongjiang Province of China (China, hereafter) for 2002 and for Japan from 1960 to 2002 to find the causes of premature deaths predominant in China. A cohort database of 16,953 screening participants was then analyzed to identify the major risk factors, by which the premature deaths in China could be reduced. The impact of risk reduction was then estimated by the method of population attributable risk percent. Results: A large difference in YPLL was observed between Japan and China for accidents and cerebrovascular diseases in males, and accidents, cerebrovascular diseases and heart diseases in females. By the multivariate analysis of cohort data, hypertension and smoking were identified as risk factors of cerebrovascular deaths for men, and only hypertension for women. From the changes in prevalence, the cerebrovascular mortality risk in the cohort was expected to reduce by 19.2% in males and 9.5% in females, respectively. Similar reduction was expected in China when appropriate measures were taken for hypertension and smoking. Conclusions: Hypertension seems the most promising target in reducing premature deaths by cerebrovascular diseases in Heilongjiang Province of China.

Publication Stats

47 Citations
27.56 Total Impact Points

Institutions

  • 2011–2015
    • Tokyo Women's Medical University
      • • Department of Hygiene and Public Health II
      • • School of Medicine
      Edo, Tōkyō, Japan
    • Zhejiang University
      • School of Public Health
      Hangzhou, Zhejiang Sheng, China
  • 2005
    • Fukushima Medical University
      • Division of Medicine
      Hukusima, Fukushima, Japan