Guangyan Qing

Wuhan University of Technology, Wu-han-shih, Hubei, China

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Publications (24)203.46 Total impact

  • [Show abstract] [Hide abstract]
    ABSTRACT: Protein misfolding to form amyloid aggregates is the main cause of neurodegenerative diseases. While it has been widely acknowledged that amyloid formation in vivo is highly associated with molecular surfaces, particularly biological membranes, how their intrinsic features, e.g. chirality, influence this process still remains unclear. Here we use cysteine enantiomer modified graphene oxide (GO) as a model to show that surface chirality strongly influences this process. We report that R-cysteine modification suppresses the adsorption, nucleation and fiber elongation processes of Aβ(1-40), thus largely inhibits amyloid fibril formation on surface; while S-modification promotes these processes. And surface chirality also greatly influences the conformational transition of Aβ(1-40) from α-helix to β-sheet. More interestingly, we find that this effect is highly related to the distance between chiral moieties and GO surface, and inserting a spacer group of about 1-2 nm between them prevents the adsorption of Aβ(1-40) oligomers, which eliminates the chiral effect. Detailed study stresses the crucial roles of GO surface. It brings novel insights for better understanding the amyloidosis process on surface from a biomimetic perspective.
    Journal of the American Chemical Society 07/2014; · 10.68 Impact Factor
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    ABSTRACT: For the development of rapid glycopeptide enrichment materials, conventional monolayer phenylboronic acid (PBA) based materials inevitably encounter many problems, such as low loading efficiency, long incubation time, and unsatisfactory selectivity. Extending the materials from a 1D monolayer to a 3D polymeric matrix will be one of the best candidates tackling these problems. In this work, a PBA-based polymer material (denoted as polyPBA@SiO2) was developed, in which flexible PBA polymer brushes were immobilized on the surface of silica microspheres, constructing an ideal platform for the efficient enrichment of glycopeptides. This material exhibits stronger interaction with glycopeptides in a higher concentration of organic solvent than in aqueous solution, resulting in the high binding capacity of 60 mg g−1. Moreover, higher selectivity for glycopeptides can be achieved with polyPBA@SiO2 than with both monolayer PBA modified silica and commercial PBA-agarose. These unique features of polyPBA@SiO2 could be attributed to the synergistic effect of polyvalent interactions provided by the polymer brush, specific interaction between PBA and glycopeptides and suppression of the non-specific binding of non-glycopeptides under high ACN concentration.
    J. Mater. Chem. B. 03/2014; 2(16).
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    ABSTRACT: For chiral gels and related applications, one of the critical issues is how to modulate the stereoselective interaction between the gel and the chiral guest precisely, as well as how to translate this information into the macroscopic properties of materials. Herein, we report that this process can also be modulated by nonchiral solvents, which can induce a chiral-interaction reversion for organogel formation. This process could be observed through the clear difference in gelation speed and the morphology of the resulting self-assembly. This chiral effect was successfully applied in the selective separation of quinine enantiomers and imparts "smart" merits to the gel materials.
    Angewandte Chemie International Edition 01/2014; · 11.34 Impact Factor
  • Guangyan Qing, Taolei Sun
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    ABSTRACT: Enantioselektive Benetzbarkeit: Die Benetzbarkeit einer Materialoberfläche kann gezielt mithilfe chiraler Moleküle verändert werden. Intelligente Polymere bieten die Möglichkeit von reversiblen Konformationsübergängen und eignen sich somit ideal, um ein schwaches chirales Signal in eine makroskopische Eigenschaft eines Materials umzusetzen. Man erhält schaltbare Oberflächen, deren Benetzbarkeit durch die Chiralität von Molekülen bestimmt wird (siehe Schema).
    Angewandte Chemie 01/2014; 126(4).
  • Guangyan Qing, Taolei Sun
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    ABSTRACT: Enantioselective wetting: Regulating the surface wettability of materials through chiral molecules provides new insight into the design of chiral materials. By taking advantage of a reversible conformational transition, smart polymers present an ideal platform for translating weak chiral signals into macroscopic properties of materials, thus resulting in a distinctive wettability switching driven by chirality.
    Angewandte Chemie International Edition 11/2013; · 11.34 Impact Factor
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    ABSTRACT: Stimuli-responsive polymers could respond to external stimuli, such as temperature, pH, photo-irradiation, electric field, biomolecules in solution, etc., which further induce reversible transformations in the structures and conformations of polymers, providing an excellent platform for controllable drug release, while the accuracy of drug delivery could obtain obvious improvement in this system. In this review, recent progresses in the drug release systems based on stimuli-responsive polymers are summarized, in which drugs can be released in an intelligent mode with high accuracy and efficiency, while potential damages to normal cells and tissues can also be effectively prevented owing to the unique characteristics of materials. Moreover, we introduce some smart nanoparticles-polymers conjugates and drug release devices, which are especially suitable for the long-term sustained drug release.
    Mini Reviews in Medicinal Chemistry 05/2013; · 2.87 Impact Factor
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    ABSTRACT: A dispersion-dominated colorimetric approach for the recognition of carbohydrates based on biomolecule-responsive AuNPs is presented. Taking advantage of the unique dual-responsiveness of smart copolymers, the aggregation and dispersion of AuNPs can be modulated by both temperature and different kinds of carbohydrates, giving rise to a novel chromogenic mechanism for the recognition and testing of carbohydrates in aqueous media.
    Advanced Materials 11/2012; · 14.83 Impact Factor
  • Xiaoyan Han, Guangyan Qing, Jutang Sun, Taolei Sun
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    ABSTRACT: Die Antwort gibt es hier: Am Naphthalinderivat NTCDA wird ein neuartiges Modell für die Lithiumioneninsertion vorgestellt, bei dem jedes Ringkohlenstoffatom reversibel ein Lithiumion aufnehmen kann, was Entladekapazitäten bis fast 2000 mA h g−1 ergibt. Diese Methode bietet eine neue Strategie für den Aufbau von organischen Hochleistungselektroden.
    Angewandte Chemie 05/2012; 124(21).
  • Xiaoyan Han, Guangyan Qing, Jutang Sun, Taolei Sun
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    ABSTRACT: Kohlenstoffmaterialien wie Graphit sind die gängigsten Anoden in Lithiumionenbatterien, doch die grundlegende Frage, wie viele Li‐Ionen an aromatischen C6‐Ringen gebunden sein können, blieb bisher unbeantwortet. In der Zuschrift auf S. 5237 ff. zeigen T. Sun et al. anhand einer Modellverbindung, dass jeder C6‐Ring in einer reversiblen elektrochemischen Reaktion bis zu 6 Li‐Ionen in Li6/C6‐Additionskomplexen binden kann. Daraus ergibt sich eine Lithiumionen‐Insertionskapazität von fast 2000 mA h g−1.
    Angewandte Chemie 05/2012; 124(21).
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    Xiaoyan Han, Guangyan Qing, Jutang Sun, Taolei Sun
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    ABSTRACT: Carbon-based materials, such as graphite, are the most common anodes used in lithium ion batteries, but the fundamental question of how many Li ions can be inserted onto C(6) aromatic rings remains unsolved. In their Communication (DOI: 10.1002/anie.201109187), T. Sun and co-workers use a model compound to demonstrate that each C(6) ring can accept up to 6 Li ions to create Li(6) /C(6) additive complexes through a reversible electrochemical reaction, which results in Li ion insertion capacities of up to nearly 2000 mA h g(-1) .
    Angewandte Chemie International Edition 05/2012; 51(21). · 11.34 Impact Factor
  • Xiaoyan Han, Guangyan Qing, Jutang Sun, Taolei Sun
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    ABSTRACT: Getting a charge out of lithium: The naphthalene derivative NTCDA is used to demonstrate a novel lithium ion insertion model in which each ring carbon atom can reversibly accept a lithium ion, giving discharge capacities of up to nearly 2000 mA h g(-1) . This method provides a new strategy for the design of high-performance organic electrodes.
    Angewandte Chemie International Edition 04/2012; 51(21):5147-51. · 11.34 Impact Factor
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    Guangyan Qing, Taolei Sun
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    ABSTRACT: The ability to transform the chiral signals of molecules into the macroscopic properties of a material will offer significant advantages in the development of chiral functional devices and chirality-related applications. Chirality-responsive polymers provide an excellent platform to realize this objective, which often involves two basic strategies. The first strategy is to utilize various external stimuli to directly mediate the chiral conformations of a polymer, through which the energy input is transformed into a macroscopic change in the properties of a material. The second strategy is to utilize the enantioselective interaction between polymers and guest chiral molecules to trigger a stepwise conformational change in smart polymers, which then results in transformation of the macroscopic properties. This review summarizes recent progress in generating chirality-responsive polymers based on these strategies and discusses advances in their applications as chiral sensors, liquid crystals, optical and electrical devices, nanomachines and so on. We then introduce the emerging field of chiral bio-interface materials, in which chiral signals are transformed into changes in the macroscopic behavior of cells and biomacromolecules based on the stereo-specific interactions between biological systems and artificial materials.Keywords: chiral materials; chiral recognition; smart polymers
    NPG Asia Materials. 12/2011; 4(1):e4.
  • Mingxi Zhang, Guangyan Qing, Taolei Sun
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    ABSTRACT: Chiral phenomena are ubiquitous in nature from macroscopic to microscopic, including the high chirality preference of small biomolecules, special steric conformations of biomacromolecules induced by it, as well as chirality-triggered biological and physiological processes. The introduction of chirality into the study of interface interactions between materials and biological systems leads to the generation of chiral biointerface materials, which provides a new platform for understanding the chiral phenomena in biological system, as well as the development of novel biomaterials and devices. This critical review gives a brief introduction to the recent advances in this field. We start from the fabrication of chiral biointerface materials, and further investigate the stereo-selective interaction between biological systems and chiral interface materials to find out key factors governing the performance of such materials in given conditions, then introduce some special functionalities and potential applications of chiral biointerface materials, and finally present our own thinking about the future development of this area (108 references).
    Chemical Society Reviews 12/2011; 41(5):1972-84. · 24.89 Impact Factor
  • Taolei Sun, Guangyan Qing, Baolian Su, Lei Jiang
    ChemInform 08/2011; 42(35).
  • Guangyan Qing, Taolei Sun
    Advanced Materials 04/2011; 23(14):1614. · 14.83 Impact Factor
  • Guangyan Qing, Taolei Sun
    Advanced Materials 04/2011; 23(14):1615-20. · 14.83 Impact Factor
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    Taolei Sun, Guangyan Qing
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    ABSTRACT: Controlling the surface chemical and physical properties of materials and modulating the interfacial behaviors of biological entities, e.g., cells and biomolecules, are central tasks in the study of biomaterials. In this context, smart polymer interface materials have recently attracted much interest in biorelated applications and have broad prospects due to the excellent controllability of their surface properties by external stimuli. Among such materials, poly(N-isopropylacrylamide) and its copolymer films are especially attractive due to their reversible hydrogen-bonding-mediated reversible phase transition, which mimics natural biological processes. This platform is promising for tuning surface properties or to introduce novel biofunctionalities via copolymerization with various functional units and/or combination with other materials. Important progress in this field in recent years is highlighted.
    Advanced Materials 03/2011; 23(12):H57-77. · 14.83 Impact Factor
  • Taolei Sun, Guangyan Qing, Baolian Su, Lei Jiang
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    ABSTRACT: Controlling the interfacial chemical and physical properties, and thus modulating the behaviours of cells and biomolecules on material surfaces, form an important foundation for the development of high-performance biomaterials and devices. Biological systems in nature exhibit unique features in this aspect. The first one is that the superior properties of natural biomaterials are normally not determined by their bulk properties, but more related to the multi-scale micro- and nanostructures on the surface; the second is that biological systems usually utilize highly specific weak interactions (e.g. hydrogen bonding interaction, hydrophobic interaction, etc.) to solve the problems of biomolecule interactions; the third is that the biomolecules in nature are often chiral molecules and show high preference for one specific enantiomorphous configuration, suggesting a distinctive chiral recognition mechanism in biological systems. These features bring much inspiration to design novel biointerface materials with special functionalities, e.g. structural biointerface materials, smart biointerface materials and chiral biointerface materials. The purpose of this critical review is to give a brief introduction of recent advances in these aspects (90 references).
    Chemical Society Reviews 02/2011; 40(5):2909-21. · 24.89 Impact Factor
  • Guangyan Qing, Hai Xiong, Frank Seela, Taolei Sun
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    ABSTRACT: DNA patterning on surfaces has broad applications in biotechnology, nanotechnology, and other fields of life science. The common patterns make use of the highly selective base pairing which might not be stable enough for further manipulations. Furthermore, the fabrication of well-defined DNA nanostructures on solid surfaces usually lacks chemical linkages to the surface. Here we report a template-free strategy based on "click" chemistry to fabricate spatially controlled DNA nanopatterns immobilized on surfaces. The self-assembly process utilizes DNA with different anchoring sites. The position of anchoring is of crucial importance for the self-assembly process of DNA and greatly influences the assembly of particular DNA nanopatterns. It is shown that the anchoring site in a central position generates tunable nanonetworks with high regularity, compared to DNAs containing anchoring sites at terminal and other positions. The prepared patterns may find applications in DNA capturing and formation of pores and channels and can serve as templates for the patterning using other molecules.
    Journal of the American Chemical Society 10/2010; 132(43):15228-32. · 10.68 Impact Factor
  • Guangyan Qing, Xing Wang, Harald Fuchs, Taolei Sun
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    ABSTRACT: A smart copolymer film that is sensitive to nucleotide species in solution was developed. The film exhibits ann excellent reversible wettability response to nucleotide solutions, which is accompanied by a phase change and the corresponding swell and shrinkage of the copolymer.
    Journal of the American Chemical Society 07/2009; 131(24):8370-1. · 10.68 Impact Factor

Publication Stats

105 Citations
203.46 Total Impact Points

Institutions

  • 2010–2014
    • Wuhan University of Technology
      • State Key Laboratory of Advanced Technology for Materials Synthesis and Processing
      Wu-han-shih, Hubei, China
  • 2009–2011
    • University of Münster
      • Institute of Physical Chemistry
      Münster, North Rhine-Westphalia, Germany
  • 2008
    • Wuhan University
      • College of Chemistry and Molecular Sciences
      Wuhan, Hubei, China