Ahmet Yasar Turanli

Ondokuz Mayıs Üniversitesi, Djanik, Samsun, Turkey

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Publications (47)72.93 Total impact

  • E P Yuksel · F Aydin · N Senturk · M G Ozden · T Canturk · A Y Turanli ·

    Giornale italiano di dermatologia e venereologia: organo ufficiale, Societa italiana di dermatologia e sifilografia 09/2014; 150(2). · 0.86 Impact Factor
  • Esra Pancar Yuksel · Gokhan Sahin · Fatma Aydin · Nilgun Senturk · Ahmet Yasar Turanli ·
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    ABSTRACT: Introduction: Platelet-rich plasma (PRP) has been used for rapid healing and tissue regeneration in many fields of medicine. This study was conducted to evaluate the effects of PRP application procedure on human facial skin. Methods: PRP was applied thrice at 2-week intervals on the face of ten healthy volunteers. It was applied to individual's forehead, malar area, and jaw by a dermaroller, and injected using a 27-gauge injector into the wrinkles of crow's feet. Participants were asked to grade on a scale from 0 to 5 for general appearance, skin firmness-sagging, wrinkle state and pigmentation disorder of their own face before each PRP procedure and 3 months after the last PRP procedure. While volunteers were evaluating their own face, they were also assessed by three different dermatologists at the same time by the same five-point scale. Results: There was statistically significant difference regarding the general appearance, skin firmness-sagging and wrinkle state according to the grading scale of the patients before and after three PRP applications. Whereas there was only statistically significant difference for the skin firmness-sagging according to the assessment of the dermatologists. Conclusion: PRP application could be considered as an effective procedure for facial skin rejuvenation.
    Journal of Cosmetic and Laser Therapy 07/2014; 16(5):1-10. DOI:10.3109/14764172.2014.949274 · 1.11 Impact Factor
  • S. Aytekin · E. P. Yuksel · F. Aydin · N. Senturk · M. G. Ozden · T. Canturk · A. Y. Turanli ·
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    ABSTRACT: Background Nailfold capillaroscopy is used for the identification of microvascular involvement in many rheumatic and extrarheumatic diseases.AimTo determine the nailfold capillary changes in patients with Behçet disease (BD) by videodermoscopy, i.e. nailfold videocapillaroscopy (NVC).Methods We used a videodermatoscope (Molemax II, × 30 magnification) to perform nailfold capillaroscopy on 40 patients with BD and 40 healthy controls (HC). All nailfold images were evaluated for capillary density, distribution and morphology, assessing features such as enlargement or tortuosity of the capillaries, microhaemorrhages and avascular areas.ResultsEnlarged capillaries were detected in 14 patients, microhaemorrhages in 6 patients, and avascular area in 3 patients. There was a statistically significant difference between patients with BD and healthy controls for capillary dilatation and microhaemorrhages (P < 0.05). Capillaroscopic changes were not associated with sex or clinical characteristics.Conclusions Using NVC, nailfold capillary changes were apparent in patients with BD, but not in HC. NVC could be a useful technique for evaluating microvascular damage in BD.
    Clinical and Experimental Dermatology 06/2014; 39(4). DOI:10.1111/ced.12343 · 1.09 Impact Factor
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    ABSTRACT: The aim of this study was to evaluate the histologic effects of acute paroxetine administration on wound healing in healthy and streptozotocin-induced diabetic rats. This study has a randomized controlled experimental design. Healthy (n = 32) and diabetic (n = 32) rats were further divided into 2 groups of saline or paroxetine administration. Sixty-four male Sprague-Dawley rats were used in this study. Paroxetine was injected intraperitoneally every day. Full-thickness excision wounds were created with a 4-mm dermal punch on the back of all rats. The healing wound area was removed with a 6-mm dermal punch at postwounding days 1, 3, 7, and 14. Polymorphonuclear leukocyte, mononuclear inflammatory cell, fibroblast, and blood vessel counts and epithelialization were evaluated under light microscope. There was no statistically significant difference observed in the polymorphonuclear leukocyte, mononuclear inflammatory cell, and blood vessel counts in the healthy and diabetic rats with and without paroxetine administration. The number of fibroblasts was significantly higher at postwounding day 14 of the paroxetine-administered healthy rats compared with the saline-administered healthy rats (P = .04). However, the number of fibroblasts did not show any difference by paroxetine administration in the diabetic rats. There was no statistically significant difference in epithelialization regarding all the postwounding days, but complete epithelialization was observed in all rats on postwounding day 14 in the healthy and paroxetine-administered group. Short-term paroxetine administration may enhance cutaneous wound healing by increasing the number of fibroblasts and causing better epithelialization over time in healthy rats but not in diabetic rats.
    Advances in skin & wound care 05/2014; 27(5):216-21. DOI:10.1097/01.ASW.0000445920.14039.64 · 1.11 Impact Factor
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    ABSTRACT: Background Psoriasis is a systemic inflammatory disease associated with increased risk of cardiovascular diseases. The heart rate recovery index (HRRI) is an indicator of autonomic nervous system function and is an independent prognostic risk factor for cardiovascular diseases. The aim of this study was to evaluate the heart rate recovery indices in patients with psoriasis. Material/methods Thirty-three psoriasis patients (22 male; mean age 41±11 years) and 26 healthy individuals (15 male; mean age 39±11 years) as a control group were included in the study. Baseline electrocardiography, transthoracic echocardiographic examinations, and exercise stress tests were performed in psoriasis and control groups. The heart rate recovery of the psoriasis group at 1, 2, 3, 4, and 5 minutes after maximal exercise were calculated and compared to those of the control group. Results Baseline demographic and clinical characteristics of psoriasis and control groups including age, sex, body mass index, systolic blood pressure, and echocardiographic parameters were similar. Total cholesterol, low-density lipoprotein cholesterol, and triglyceride levels were significantly higher and high-density lipoprotein cholesterol levels were significantly lower in the psoriasis group (p<0.05). Heart rate recovery at 1, 2, 3, 4, and 5 minutes after maximal exercise were found to be significantly lower in the psoriasis group (p<0.05). Additionally, baseline heart rates before exercise were significantly higher in the psoriasis group (p<0.05). Conclusions We found that impaired HRRI in psoriasis patients, which indicates the underlying autonomic nervous system dysfunction, is a pathophysiologic mechanism for increased cardiovascular disease risk.
    Medical science monitor: international medical journal of experimental and clinical research 03/2014; 20:350-4. DOI:10.12659/MSM.890249 · 1.43 Impact Factor
  • Fatma Aydin · Esra Pancar Yuksel · Nilgun Senturk · Tayyar Canturk · Ahmet Yasar Turanli ·
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    ABSTRACT: Abstract Context: Combination of methotrexate and cyclosporine was used and reported to be effective for recalcitrant psoriasis patients. Also each agent is accused for development of malignancies. Objective: To evaluate the cancer-free survival of psoriasis patients who received methotrexate and cyclosporine treatment at the same time. Methods: Psoriasis patients who had been treated with combination of cyclosporine and methotrexate between March 2000 and April 2005 were questioned in 2011. A diagnosis of new cancer during follow-up period was asked and also each patient was evaluated by a questionnaire. Results: Seventeen psoriasis patients were not treated due to a diagnosis of new cancer during the follow-up period. Also none of them complained of possible symptoms of skin or lymphoproliferative malignancies. The median follow-up time was 76 months. Conclusion: Psoriasis patients who had been treated with methotrexate and cyclosporine combination did not report a detected malignant disease.
    Cutaneous and Ocular Toxicology 08/2013; 33(3). DOI:10.3109/15569527.2013.825805 · 1.12 Impact Factor

  • 03/2012; 29(1):64-67. DOI:10.5835/jecm.omu.29.01.016
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    ABSTRACT: Melasma is a pigmentary disorder often recalcitrant to treatment. Few studies have objectively evaluated the efficacy of treatment colorimetrically. To evaluate the safety and efficacy of a depigmentation cream, including mainly glycolic acid and Rumex occidentalis. Twenty-seven patients applied the cream twice daily for the first 3 months and twice weekly for the following 3 months. L*, C* and h* values of the target lesions and the perilesional area were analyzed at baseline, 12 and 24 weeks colorimetrically. The physician and patient evaluated the clinical response rate. These results were compared statistically between the lesional and perilesional area. There was a significant difference between 0-12, 0-24 (L*, C* and h* values) and 12-24 weeks (L* value) (p <0.001). For C* and h* values, the difference was not significant between 12 and 24 weeks (p = 0.464 and 0.151, respectively). Statistical significance was detected only between 3 and 6 months for C* value (p < 0.05) for the lesional and the perilesional areas. Clinical response rate was significant (p < 0.05). Our depigmentation cream is a moderate effective agent, well tolerated and can be considered as an alternative treatment of melasma. Twice-daily application may enhance the efficacy of treatment instead of twice-weekly application in the maintenance period.
    Journal of Cosmetic and Laser Therapy 07/2011; 13(5):255-9. DOI:10.3109/14764172.2011.606463 · 1.11 Impact Factor
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    ABSTRACT: Laser therapy is the treatment of choice for cherry angiomas since it is more effective and has better cosmetic results. There is no comparative study about the treatment efficacies with KTP and Nd:YAG lasers for cherry angiomas. To compare the efficacy and side effects of 532-nm KTP and 1064-nm Nd:YAG lasers for the treatment of cherry angiomas. Two comparable lesions of the same patient were chosen. One of them was treated with the KTP laser while the other was treated with the Nd:YAG laser. Sessions were repeated every 4 weeks until complete clearance was achieved. Side effects were evaluated using a severity scale (0 to 4). The number of sessions was significantly higher with the KTP than with the Nd:YAG laser (p = 0.002). Erythema, edema, pain and scar formation were higher in the Nd:YAG laser group (erythema: p = 0.001; edema: p < 0.001; pain: p < 0.001; scar: p < 0.001). The hyperpigmentation rate was statistically higher with the KTP laser (p = 0.01). Both KTP and Nd:YAG lasers were found to be effective methods. The Nd:YAG laser offered fewer treatment sessions, but a higher risk of scar formation. The KTP laser seems more advantageous, but in dark-skinned patients the Nd:YAG laser may be preferable.
    Journal of Cosmetic and Laser Therapy 06/2011; 13(4):138-41. DOI:10.3109/14764172.2011.594058 · 1.11 Impact Factor
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    ABSTRACT: The Nd:YAG laser has been considered the gold standard of treatment for leg veins, but pain and side effects have fueled physicians to use treatment alternatives. To compare the clinical efficacy of the long-pulsed 1064-nm Nd:YAG laser with KTP laser irradiation in the treatment of leg telangiectasia. A series of 16 patients with size-matched superficial telangiectases of the lower extremities were randomly assigned to receive three consecutive monthly treatments with the long-pulsed 1064-nm Nd:YAG on one leg and 532-nm KTP laser irradiation on the other. For the 16 patients who completed the study, 64 leg vein sites were treated. Average clinical improvement scores were 1.94 and 1.25 for the KTP laser-treated leg and 3.38 and 3.50 for the Nd:YAG laser-treated leg with thin (≤ 1 mm) and large (1-3 mm) vessels, respectively. After the third treatment session, average improvement scores of 2.44, 1.31 and 3.75, 3.23 were given for the KTP and Nd:YAG laser-treated sides, respectively. Both the 1064-nm Nd:YAG and KTP lasers are effective in the treatment of lower extremity telangiectases. However, the KTP laser has very low efficacy with vessels larger than 1 mm and should not be elected when treating such vessels.
    Journal of Dermatological Treatment 06/2011; 22(3):162-6. DOI:10.3109/09546631003649679 · 1.67 Impact Factor
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    ABSTRACT: Objective: Standard KOH preparation and fungal culture are the most preferred methods used for the diagnosis of onychomycosis. Alternatively used methods are histopathological examination and KOH preparation for 24 hours. Our aim was to assess the sensitivity of standard KOH preparation, KOH preparation for 24 hours, fungal culture and histopathological examination for the diagnosis of onychomycosis. Material and Methods: Nail samples were taken from 58 patients with a clinical suspicion of onychomycosis. Standard KOH preparation, KOH preparation for 24 hours, fungal culture and histopathological examination were searched for presence of fungal elements. Results: Onychomycosis was diagnosed in 46 samples. Samples of 8 patients were negative by all methods. Fungal elements were observed by standard KOH preparation in 27 patients (50%), by KOH preparation for 24 hours in 37 patients (68.5%), by culture method in 14 patients (25.9%) and by histopathological examination in 40 (74.1%) patients. The sensitivity values of these methods were 58%, 80.4%, 30.4%, and 87% respectively. Conclusion: This study showed that histopathological examination and KOH preparation for 24 hours methods are more sensitive than the KOH preparation and fungal culture.
    06/2011; 5(2):48-52. DOI:10.5152/tdd.2011.11
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    ABSTRACT: Hypereosinophilic syndrome (HES) is a multi-organ disease (heart, eye, lungs or nervous tissue). The etiology and pathogenesis of HES is still unknown. It is characterized by 1500 eosinophils/μl of eosinophils in peripheral blood observed during at least six months without any evidence for other known causes of eosinophilia. The skin manifestations of the disease were pruritic, erythematous macules, papules, plaques or nodules and rarely urticaria, angioedema, livedo reticularis, eosinophilic cellulitis, cutaneous necrotizing eosinophilic vasculitis, retiform purpura. Among the skin lesions erythroderma is a rare complication of HES and has only been reported in a few cases (Launay et al., 2002, Granjo et al., 2002). We report here a 78-yrs-old man with pruriginous erythroderma leading to the diagnosis of hypereosinophilic syndrome. In dermatological examination erythrodermia and mild desquamation was noticed entire the body surface with bilateral ectropion.
    05/2011; 28(1):26-28. DOI:10.5835/jecm.omu.28.1.007
  • Fatma Aydin · Ceyda Ozcelik · Ilkser Akpolat · Ahmet Yasar Turanli · Tekin Akpolat ·

    The Journal of Dermatology 11/2010; 38(5):513-5. DOI:10.1111/j.1346-8138.2010.01003.x · 2.25 Impact Factor
  • Sevil Aytekin · Fatma Aydin · Tekin Akpolat · Nilgun Senturk · Ahmet Yasar Turanli ·
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    ABSTRACT: Familial Mediterranean fever (FMF) is an autosomal recessive disease characterized by recurrent inflammatory febrile attacks, abdominal, chest or joint pain, myalgia, and erysipelas-like skin lesions. Several types of vasculitis are associated with FMF such as polyarteritis nodosa and Henoch-Schönlein purpura. We aimed to determine microvascular abnormalities in FMF patients via nailfold capillaroscopy using a dermoscope. Thirty-one FMF patients were assessed; capillary enlargement, tortuosity, avascular areas and microhemmoraghes were investigated. Capillary enlargement was found in five patients and microhemorrhages in one patient. Our study supports that nailfold capillary abnormalities, which are nonspecific, can be seen in FMF patients, but more studies are needed to clarify the importance of these findings.
    Clinical Rheumatology 10/2010; 30(2):255-7. DOI:10.1007/s10067-010-1609-x · 1.77 Impact Factor
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    ABSTRACT: Narrow-band ultraviolet therapy has been used successfully for the treatment of inflammatory skin disorders and generalized pruritus. We have prospectively evaluated seven consecutive patients with resistant psychogenic excoriation (PE) treated with narrow-band ultraviolet B (NB-UVB). Approximately 70% of all patients showed improvement in their condition. NB-UVB therapy was well tolerated, with no serious side effects. We may conclude that, when treating a patient with PE, NB-UVB in combination with other approaches may provide extra benefit in resistant cases.
    Photodermatology Photoimmunology and Photomedicine 06/2010; 26(3):162-4. DOI:10.1111/j.1600-0781.2010.00512.x · 1.26 Impact Factor
  • M G Ozden · Y Bek · F Aydin · N Senturk · T Canturk · AY Turanli ·

    Journal of the European Academy of Dermatology and Venereology 03/2010; 24(10):1240-2. DOI:10.1111/j.1468-3083.2010.03622.x · 2.83 Impact Factor
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    Gül FINDIK · Fatma AYDIN · Ahmet Y. TURANLI ·
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    ABSTRACT: Psoriasis patogenezinde immün sistemin öneminin anlafl›lmas› yeni tedavi ajanlar›n›n gelifl- tirilmesine yol açm›flt›r. Yeni gelifltirilen biyolojik tedavi ajanlar› immün sistem içinde yer alan reseptörler, kemokinler ve sitokinler üzerinde etkilidir. Bu makalede psoriasisde immün bazl› biyolojik tedavi ajanlar›ndaki son geliflmeler özetlenmifltir. Anahtar kelimeler: Psoriasis, immün sistem, biyolojik tedavi. Biological Treatment Agents in The Psoriasis The importance of immune system in pathogenesis of psoriasis have led to development of new therapeutic agents that selectively act on receptors, chemokines and cytokines in immune system. This article reviews recent developments in immune based therapies for psoriasis.
  • F Aydin · G S Pancar · N Senturk · Y Bek · E P Yuksel · T Canturk · A Y Turanli ·
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    ABSTRACT: Laser-assisted hair removal has become a popular treatment for eradication of body hair. Many studies have been published concerning the safety and efficacy of several laser systems. Adverse events are hyperpigmentation, hypopigmentation, erythema, oedema, scarring, pain and blistering. Changes in sweating have not previously been reported. To investigate the effects on axillary sweating of hair removal by a 1064-nm neodymium:yttrium-aluminium-garnet (Nd:YAG) laser. The sweating function of both axillae was evaluated objectively by the iodine starch test for planimetry measurement and subjectively using a visual analogue scale (VAS) before the treatment, and 1 month and 1 year after the last session. The difference in hyperhidrotic activity before and after treatment was significant (P < 0.05), and these differences persisted 1 year after the last evaluation. The results of this study confirm that treatment of axillary hair using the 1064-nm Nd:YAG laser can cause hyperhidrosis, and this effect is not transient. We did not evaluate the eccrine glands histologically, which is a limitation of the study.
    Clinical and Experimental Dermatology 10/2009; 35(6):588-92. DOI:10.1111/j.1365-2230.2009.03638.x · 1.09 Impact Factor
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    N Senturk · A Bedir · B Bilgici · F Aydin · A Okuyucu · Z C Ozmen · A Y Turanli ·
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    ABSTRACT: Several different laser types are used in cutaneous surgery. The neodymium:yttrium-aluminium-garnet (Nd:YAG) and frequency-doubled Nd:YAG (KTP, potassium titanyl phosphate) lasers are widely used in dermatology. To investigate the possible genotoxic effects on fibroblasts of irradiation with a 1064-nm Nd:YAG laser and a 532-nm KTP laser. Fibroblast cell cultures were exposed to each of the lasers, using 10-mm spot size at 60 ms pulse duration with 10, 20, 40 J/cm(2) and 3, 6, 12 J/cm(2) fluences, respectively. Fibroblasts in passages 1-6 were used. During laser irradiation, 96-well microplate cultures were kept on a cooling block and transported on ice and in the dark, and processed immediately for single-cell gel electrophoresis (SCGE) assay (also known as a comet assay). DNA damage was determined by computerized assessment of comet assay. There was increasing damage with increasing numbers of passages. For the Nd:YAG laser, the greatest damage occurred on passages 5 and 6, whereas the greatest damage appeared at passages 3 and 4 for KTP and returned to baseline at passages 5 and 6. Damage also increased with each dose increment for both wavelengths. At the highest dose for both wavelengths (Nd:YAG 40 J/cm(2) and KTP 12 J/cm(2)), damage was higher with the Nd:YAG laser. Different patterns of cellular damage were seen for different cell-culture passages, treatment doses, and laser wavelengths. These dose ranges are generally used for the treatment of vascular and pigmented lesions and for rejuvenation purposes. As replicative ageing or cell senescence is one of the critical factors determining the extent of cell damage induced by laser therapy, these results may have important implications for clinical practice.
    Clinical and Experimental Dermatology 10/2009; 35(5):516-20. DOI:10.1111/j.1365-2230.2009.03633.x · 1.09 Impact Factor

  • European journal of dermatology: EJD 09/2009; 19(6):635-6. DOI:10.1684/ejd.2009.0769 · 1.99 Impact Factor