Filiz Tuna

State Hospital of Ercis, Turkey, Arcis, Van, Turkey

Are you Filiz Tuna?

Claim your profile

Publications (9)10.46 Total impact

  • H Tuna, T F Cermik, F Tuna
    [Show abstract] [Hide abstract]
    ABSTRACT: The aim of this study was to assess the degree of alterations of renal function by using 99m-technetium dimercaptosuccinic acid ((99m)Tc-DMSA) and 99m-technetium diethylenetriaminepentaacetic acid ((99m)Tc-DTPA) scintigraphy in spinal cord injury (SCI) patients. Twenty-two consecutive SCI (15 paraplegic and 7 tetraplegic) patients (mean age: 49.1±13.4 years) who had no urinary symptoms participated in this prospective study. The mean duration of injury was 45.6±48.8 months before. Sixteen patients had at least one urinary tract infection history. Renal cortical scintigraphy with (99m)Tc-DMSA, radionuclide renography with (99m)Tc-DTPA and renal ultrasound were performed within 2-week period. Four (18%) patients had serious pathology on their kidneys such as unilateral or bilateral parenchymal scarring and increased background uptake in their renal cortical scintigraphy with (99m)Tc-DMSA. Two of them had grade 3-4 pelvicaliceal ectasia on ultrasound. Additionally, 2 of 18 remaining patients had grade 2 pelvicaliceal ectasia on ultrasound. Sixteen (73%) patients had markedly delayed or delayed and decreased functions of one or both of kidneys on radionuclide renography. However, only four patients had grade 2-4 pelvicaliceal ectasia and none of them had a finding of loosening of renal parenchyma. Combined use of renal cortical scintigraphy and radionuclide renography appears to be contributive to renal ultrasound in the long-term follow-up of patients with SCI. Patients with abnormal findings should be closely followed, and early therapeutic interventions may enable lower morbidity and mortality rates in these patients.
    Revista española de medicina nuclear e imagen molecular. 11/2012; 31(6):322-7.
  • H. Tuna, T.F. Çermik, F. Tuna
    [Show abstract] [Hide abstract]
    ABSTRACT: AimThe aim of this study was to assess the degree of alterations of renal function by using 99m-technetium dimercaptosuccinic acid (99mTc-DMSA) and 99m-technetium diethylenetriaminepentaacetic acid (99mTc-DTPA) scintigraphy in spinal cord injury (SCI) patients.Material and methodsTwenty-two consecutive SCI (15 paraplegic and 7 tetraplegic) patients (mean age: 49.1 ± 13.4 years) who had no urinary symptoms participated in this prospective study. The mean duration of injury was 45.6 ± 48.8 months before. Sixteen patients had at least one urinary tract infection history. Renal cortical scintigraphy with 99mTc-DMSA, radionuclide renography with 99mTc-DTPA and renal ultrasound were performed within 2-week period.ResultsFour (18%) patients had serious pathology on their kidneys such as unilateral or bilateral parenchymal scarring and increased background uptake in their renal cortical scintigraphy with 99mTc-DMSA. Two of them had grade 3–4 pelvicaliceal ectasia on ultrasound. Additionally, 2 of 18 remaining patients had grade 2 pelvicaliceal ectasia on ultrasound. Sixteen (73%) patients had markedly delayed or delayed and decreased functions of one or both of kidneys on radionuclide renography. However, only four patients had grade 2–4 pelvicaliceal ectasia and none of them had a finding of loosening of renal parenchyma.Conclusion Combined use of renal cortical scintigraphy and radionuclide renography appears to be contributive to renal ultrasound in the long-term follow-up of patients with SCI. Patients with abnormal findings should be closely followed, and early therapeutic interventions may enable lower morbidity and mortality rates in these patients.ResumenObjetivoEl objetivo de este estudio fue evaluar el grado de alteración funcional renal mediante el estudio gammagráfico con 99mTc-ácido demercaptosuccínico (99mTc-DMSA) y 99mTc-ácido dietilentriaminopentaacético (99mTc-DTPA) en pacientes con lesión de médula espinal (SCI).Material y métodosEstudio prospectivo que incluye a 22 pacientes consecutivos con SCI (15 parapléjicos y 7 tetrapléjicos) (media de edad: 49,1 ± 13,4 años) sin síntomas urinarios. La lesión medular se había producido hacía, 45,6 ± 48,8 meses. Dieciséis pacientes tenían al menos historia de infección del tracto urinario. La gammagrafía renal con 99mTc-DMSA, el renograma con 99mTc-DTPA y la ecografía renal se realizaron en un periodo de 2 semanas.ResultadosEn la gammagrafía cortical con 99mTc-DMSA 4 pacientes (18%) presentaron alteraciones severas, unilaterales o bilaterales, en el parénquima renal y aumento de la captación de fondo. Dos de ellos tenían ectasia pielocalicial grado 3–4 en la ecografía. Además, 2 de los 18 pacientes restantes tenían ectasia pielocalicial grado 2 en la ecografía. En el renograma con 99mTc-DTPA 16 pacientes (73%) presentaron retraso, o retraso y disminución de la función, en uno o en los 2 riñones. Sin embargo, solo 4 pacientes tenían ectasia pélvica grado 2 a 4 y ninguno de ellos, cicatrices corticales.ConclusiónEl uso combinado de la gammagrafía cortical renal y el renograma con radiotrazadores puede contribuir, junto con la ecografía, en el seguimiento a largo plazo de pacientes con SCI. Los casos con alteraciones en la gammagrafía o en el renograma deben tener un seguimiento más estrecho; de este modo, un tratamiento adecuado precoz puede reducir la morbilidad y la mortalidad en este tipo de pacientes.
    Revista Española de Medicina Nuclear e Imagen Molecular (English Edition). 01/2012; 31(6):322–327.
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: Efforts for the early detection of bone loss and subsequent fracture risk by quantitative ultrasound (QUS), which is a non-invasive, radiation free, and cheaper method, seem rational to reduce the management costs. We aimed in this study to assess the probable correlation of speed of sound (SOS) values obtained by QUS with bone mineral density (BMD) as measured by the gold standard method, dual energy X-ray absorptiometry (DEXA), and to investigate the diagnostic value of QUS to define low BMD. One hundred twenty-two postmenopausal women having prior standard DEXA measurements were included in the study. Spine and proximal femur (neck, trochanter and Ward's triangle) BMD were assessed in a standard protocol by DEXA. The middle point of the right tibia was chosen for SOS measurement by tibial QUS. The SOS values were observed to be significantly higher in the normal BMD (t score > -1) group at all measurement sites except for the lumbar region, when compared with the low BMD group (t score < -1). SOS was negatively correlated with age (r= -0.66) and month since menopause (r= -0.57). The sensitivity, specificity, and positive and negative predictive values for QUS t score to diagnose low BMD did not seem to be satisfactory at either of the measurement sites. Tibial SOS was correlated weakly with BMD values of femur and lumbar spine as measured by DEXA and its diagnostic value did not seem to be high for discriminating between normal and low BMD, at these sites.
    Yonsei Medical Journal 06/2008; 49(3):436-42. · 1.31 Impact Factor
  • [Show abstract] [Hide abstract]
    ABSTRACT: We assessed the presence and the degree of alteration of the regional blood flow (rCBF) as visualized by Tc-99m HMPAO brain rest SPECT in the sensory motor cortex and subcortical structure in spinal cord injury (SCI) patients, who suffered from various levels of motor and sensory function loss. Twenty-two patients (mean age: 42.1+/-13.4 years, 18 M, 4 F) and 11 control subjects (mean age: 32.2+/-6.4 years, 8 M, 3 F) participated in this study. The spinal cord injury group was consisted of 2 groups (14 paraplegic and 8 tetraplegic patients). The corticocortical rCBF ratios were calculated by using region of interests obtained from 34 cortical areas on coronal slices. Significantly reduced rCBF were measured from 11 cortical areas in tetraplegic patients and 11 cortical areas in paraplegic patients. Some of these areas were different in each group. In the tetraplegic group, significant reduction was observed in the following rCBF areas: left anterior cingulate gyrus, left medial supplementary motor area, bilateral front and back aspects of posterior cingulate gyrus, right lateral primary motor area, right medial primary sensory area, bilateral putamen, and right cerebellum. In the paraplegic group, reduced rCBF areas were as follows: bilateral anterior cingulate gyrus, right lateral supplementary motor area, left front aspect of posterior cingulate gyrus, left lateral primary motor area, bilateral back aspects of posterior cingulate gyrus, right medial primary sensory area, left lateral primary sensory area and bilateral putamen. In conclusion, in some of the movement-cortical and subcortical areas having significantly reduced blood flow in SCI may be helpful to demonstrate the disrupted areas of rCBF by SPECT. We believe that it may be useful if these findings should be considered during the evaluations related to the reorganization in SCI cases.
    Brain Research 10/2006; 1109(1):54-9. · 2.88 Impact Factor
  • Source
    Developmental Medicine & Child Neurology 10/2004; 46(9):647-8. · 2.68 Impact Factor
  • [Show abstract] [Hide abstract]
    ABSTRACT: To test the applicability of Tc-dextran joint scintigraphy in the assessment of disease activity in patients with rheumatoid arthritis (RA), and to compare it with the clinical disease activity scores and laboratory parameters. Twenty-seven patients with RA were investigated using Tc-dextran joint scintigraphy. The images were evaluated semi-quantitatively and the regional uptakes of the radiopharmaceutical were calculated for the knee, wrist and ankle joints. The clinical and laboratory parameters were collected and fully analysed. An articular Ritchie index (a tender joint score), the number of swollen joints (Sw), the number of tender joints, the morning stiffness (h), the total Ritchie articular index (R), the visual analogue scale (VAS) and the Disease Activity Score (DAS) were determined for all patients. Compared with controls, patients with RA had significantly higher regional Tc-dextran uptake in the knee, wrist and ankle joints (P=0.001). The regional Tc-dextran uptake showed no correlation with the patient's age, gender, duration of disease, number of swollen joints (Sw), number of tender joints, morning stiffness (h), VAS, total Ritchie articular index and DAS, or any laboratory parameters. There was a significant correlation between the regional Tc-dextran uptake for individual joints and the articular Ritchie index of the right and left wrist (r=0.42, P=0.03; r=0.45, P=0.02), right and left knee (r=0.66, P<0.0001; r=0.80, P<0.0001) and right and left ankle (r=0.47, P=0.014; r=0.76, P<0.0001), respectively. This study demonstrates that Tc-dextran scintigraphy is a sensitive method to detect active joint inflammation and could be useful in the management of patients with RA.
    Nuclear Medicine Communications 06/2004; 25(6):597-601. · 1.38 Impact Factor
  • [Show abstract] [Hide abstract]
    ABSTRACT: Previous literature investigating bone pain in osteoporosis has prominently focused on painful conditions following osteoporotic fractures. "Is osteoporosis really a silent disease without bone pain and tenderness unless a fracture occurs?" Our aim in this study was to answer the question by assessing the questionable tenderness on tibia bones of fracture-free patients with low bone density and to compare the findings with a normal population. One-hundred-thirty-three consecutive postmenopausal female patients with the mean age of 56 years admitted to our clinic for bone mass measurement were included in the study. Bone mineral density (BMD) values of lumbar spine (L2-L4) and right proximal femur (neck, trochanter, Ward's triangle) were measured by dual-energy X-ray absorptiometry (DXA). Patients with T scores lower than -1 formed the osteopenic-osteoporotic group of patients (low BMD group) whereas those with T scores higher than -1 constituted the normal BMD group according to the osteoporosis definition regarding T score for DXA. Mechanical pressure was applied by a hand algometer on the middle points of three equally divided sections on the anterior part of tibia, and the pressure levels starting the pain sensation (POPL) were recorded. Although the patients in the normal BMD group reported consistently high POPL at all regions of tibia for all BMD measurement sites, this difference reached to a statistical significance level only for the femur neck region. Only mean POPL for the whole tibia had independent association with only femur neck BMD by multiple linear regression analysis. These results are encouraging for assessing the significance of pressure-induced tibial pain as an indicator of low BMD in the future.
    Journal of Bone and Mineral Metabolism 02/2004; 22(5):456-61. · 2.22 Impact Factor
  • Nuclear Medicine Communications - NUCL MED COMMUN. 01/2004; 25(6):597-601.
  • Hakan TUNA, Filiz TUNA, Halil ÜNALAN