Min Young Park

Chonnam National University, Gwangju, Gwangju, South Korea

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Publications (35)59.62 Total impact

  • Min Young Park, Byung Jun Kim, Eung Soo Kim
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    ABSTRACT: Prediction and mitigation of tritium permeation is an important safety issue in high temperature gas-cooled reactors (HTGRs) especially for industrial applications such as hydrogen production and process heat. This study investigated the effect of non-uniform temperature distribution on the tritium permeation rate through the heat exchanger wall and improved the prediction capability of the existing models by reflecting it. To be more explicit, the effective diffusivity (Dm) and the effective temperature (Tm) was newly defined for the heat exchanger wall, and the effective weight (xeff) was derived from one-dimensional diffusion equation. Based on the data collected by numerical methods, an empirical correlation for xeff was developed by a linear regression method and it was validated by comparisons with randomly generated separate numerical solutions. As a result, the new permeation model based on the effective temperature (Teff) showed very good agreement with the numerical results within an error of 1.28% on average while the existing model based on the average wall temperature (Tm) showed large discrepancies exceeding 200% in the maximum error. This study concludes that the newly developed tritium permeation model significantly improves the prediction capability on the tritium permeation rate through the heat exchangers. Which is the main tritium transport path in the high temperature reactor and the integrated industrial process systems.
    Annals of Nuclear Energy 01/2015; 75:413–420. · 0.80 Impact Factor
  • Min Young Park, Soo Young Kim
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    ABSTRACT: In this paper, we describe the in planta function of an Arabidopsis J protein gene, AtJ1. We isolated an ABA-hypersensitive mutant, named as793 (ABA-hypersensitive 793), by activation tagging screen. Analysis of the mutant revealed that T-DNA was inserted into the gene encoding AtJ1, thereby abolishing its expression. as793 plants grew very poorly under normal growth condition, their seed setting efficiency was lower, and their flowering was delayed compared with wild type plants. Moreover, as793 plants were ABA-hypersensitive and drought-tolerant. In parallel analyses, we found that another AtJ1 knockout mutant acquired from the Arabidopsis stock center exhibited the same phenotypes as as793 and that its phenotypes could be complemented by the wild type AtJ1. At the molecular level, we found that the expression of a large number of genes involved in embryogenesis, flowering time control and stress response was altered in as793. Others previously reported that AtJ1 is a mitochondrial protein involved in thermotolerance. Our results further indicate that AtJ1 is essential for normal plant growth, from embryogenesis to flowering and seed setting. Additionally, the ABA hypersensitivity of as793 suggests that AtJ1 may function as a negative regulator of ABA response.
    Plant and Cell Physiology 10/2014; · 4.98 Impact Factor
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    ABSTRACT: We performed activation tagging screen to isolate abscisic acid (ABA) response mutants. One of the mutants, designated ahs10 (ABA-hypersensitive 10), exhibited ABA-hypersensitive phenotypes. TAIL-PCR analysis of the mutant revealed that T-DNA was inserted in the promoter region of the Arabidopsis gene, At2g01430, which encodes a homeodomain-leucine zipper protein ATHB17. Subsequent expression analysis indicated that ATHB17 was activated in ahs10. To recapitulate the mutant phenotypes, we prepared ATHB17 OX lines and investigated their phenotypes. The results showed that ATHB17 confers ABA-hypersensitivity and drought tolerance. On the contrary, ATHB17 knockout lines were ABA-insensitive and drought-sensitive, further demonstrating that ATHB17 is involved in ABA and water-stress responses. Interestingly, the ATHB17 effect on seedling growth in the presence of ABA was observed only during the postgermination seedling establishment stage, suggesting that it functions during a narrow developmental window of early seedling growth.
    Molecules and Cells 02/2013; 35(2):125-33. · 2.21 Impact Factor
  • Min Young Park, Eung Soo Kim
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    ABSTRACT: In order to effectively tackle the two global issues, water shortage and energy demand, an integrated system of a very high temperature reactor (VHTR) and forward osmosis (FO) desalination system is proposed. The integration basically implies the coupling of the waste heat from VHTR with the draw solute recovery system of FO seawater desalination system which is the only energy consuming part of the whole FO process. By integrating the two novel technologies, several advantages can be achieved, such as production of fresh water using waste heat and environment protection through waste heat reduction. In order to thermodynamically analyze the integrated system, the FO system and the power conversion systems (PCSs) of VHTR are simulated and integrated using UNISIM program and OLI property package. As a result, the integrated system of FO–VHTR was calculated to have higher Gain Output Ratio (GOR) values ranging from 9.0 to 13.8, than the typical GOR values, ranging from 6 to 12, of multi-stage flash (MSF) and multi-effect distillation (MED). Furthermore, when the technologies were coupled to the same capacity VHTR, the proposed system was calculated to have a significantly higher waste heat utilization rate than the other systems. Accordingly, the water production of the FO–VHTR system was found to be at least 5 times larger than that of the MSF–VHTR system.
    Desalination 01/2013; · 3.04 Impact Factor
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    ABSTRACT: Tumor necrosis factor-alpha (TNF-α) is an important pathophysiologic factor involved in the development of acne. However, its role is unclear. To explore the lipogenic effect by TNF-α and possible molecular mechanisms in sebocyte. Using SZ95 human sebocytes, lipid formation by TNF-α was assessed by Oil Red O, Nile Red staining and thin layer chromatography (TLC). Expression of lipogenic genes and activation of mitogen-activated protein kinase as well as Akt were examined by real-time polymerase chain reaction and/or Western blot analysis. Activation of peroxisome proliferator-activated receptor (PPAR) was evaluated by luciferase assay using PPAR response element containing reporter plasmids. Involvement of c-Jun N-terminal kinase (JNK) and Akt in TNF-α-induced lipogenesis was investigated by molecule specific small interfering RNA and inhibitors. TNF-α treatment significantly increased formation of lipid droplets in accordance with up-regulated expression of FAS and activation of SREBP-1, but not PPARs. Suppression of phosphorylated JNK by the JNK inhibitor SP600125 greatly diminished TNF-α-induced expression of FAS and SREBP-1. TNF-α could not induce both expression of lipogenic proteins and lipid synthesis when Akt expression was attenuated with siRNA. TNF-α induces lipogenesis in SZ95 human sebocytes through the JNK and phosphoinositide-3-kinase/Akt pathways. These results will be valuable in developing therapeutic strategies for control of seborrhea and acne.
    Journal of dermatological science 03/2012; 65(3):179-88. · 3.71 Impact Factor
  • Min Young Park, Jung-Youn Kang, Soo Young Kim
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    ABSTRACT: We carried out activation tagging screen to isolate genes regulating abscisic acid (ABA) response. From the screen of approximately 10,000 plants, we isolated ca 100 ABA response mutants. We characterized one of the mutants, designated ahs1, in this study. The mutant is ABA-hypersensitive, and AtMYB52 was found to be activated in the mutant. Overexpression analysis to recapitulate the mutant phenotypes demonstrated that ATMYB confers ABA-hypersensitivity during postgermination growth. Additionally, AtMYB52 overexpression lines were drought-tolerant and their seedlings were salt-sensitive. Changes in the expression levels of a few genes involved in ABA response or cell wall biosynthesis were also observed. Together, our data suggest that AtMYB52 is involved in ABA response. Others previously demonstrated that AtMYB52 regulates cell wall biosynthesis; thus, our results imply a possible connection between ABA response and cell wall biosynthesis.
    Molecules and Cells 03/2011; 31(5):447-54. · 2.21 Impact Factor
  • Min Young Park, Vidyadhar Jadhav, Yong Hae Kim
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    ABSTRACT: For Abstract see ChemInform Abstract in Full Text.
    ChemInform 01/2011; 36(5):3367-3372.
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    ABSTRACT: ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
    ChemInform 01/2010; 32(36).
  • Min Young Park, Seung Gak Yang, Yong Hae Kim
    ChemInform 01/2010; 33(45).
  • Seung Gak Yang, Min Young Park, Yong Hae Kim
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    ABSTRACT: ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
    ChemInform 01/2010; 33(30).
  • European journal of dermatology: EJD 01/2010; 20(4):533-4. · 1.95 Impact Factor
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    ABSTRACT: Background Recent genome-wide association (GWA) studies have identified and replicated several genetic loci associated with the risk of development of coronary artery disease (CAD) in samples from populations of Caucasian and Asian descent. However, only chromosome 9p21 has been confirmed as a major susceptibility locus conferring risk for development of CAD across multiple ethnic groups. The authors aimed to find evidence of further similarities and differences in genetic risk of CAD between Korean and other populations.Methods The authors performed a GWA study comprising 230 cases and 290 controls from a Korean population typed on 490 032 single nucleotide polymorphisms (SNPs). A total of 3148 SNPs were taken forward for genotyping in a subsequent replication study using an independent sample of 1172 cases and 1087 controls from the same population.ResultsThe association previously observed on chromosome 9p21 was independently replicated (p=3.08e–07). Within this region, the same risk haplotype was observed in samples from both Korea and of Western European descent, suggesting that the causal mutation carried on this background occurred on a single ancestral allele. Other than 9p21, the authors were unable to replicate any of the previously reported signals for association with CAD. Furthermore, no evidence of association was found at chromosome 1q41 for risk of myocardial infarction, previously identified as conferring risk in a Japanese population.ConclusionA common causal variant is likely to be responsible for risk of CAD in Korean and Western European populations at chromosome 9p21.3. Further investigations are required to confirm non-replication of any other cross-race genetic risk factors.
    Heart Asia. 01/2010; 2(1):104-108.
  • Vidyadhar Jadhav, Min Young Park, Yong Hae Kim
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    ABSTRACT: ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
    12/2009; , ISBN: 9780470682531
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    ABSTRACT: Repeated exposure to ultraviolet radiation from the sun results in premature photoaging. Photodynamic therapy (PDT) has been shown to be effective for treatment of photoaging, although the data from most studies have been based on clinical observation. We investigated whether 5-aminolevulinic acid (ALA)-PDT induced histologic changes suggesting photorejuvenation. Fourteen patients with one to three actinic keratoses on the face were treated twice with ALA-PDT by using a 1200 W metal halogen lamp at 1-month intervals. Skin biopsy before and 1 month after the PDT was performed. Twenty-five pairs of specimens were obtained. We examined the specimens with routine and immunohistochemical staining and evaluated the parameters associated with photoaging by using image analysis. After ALA-PDT, the mean epidermal thickness and dermal inflammatory infiltrate were reduced. The total collagen volume in the dermis significantly increased with expression of type I and III procollagen. The level of transforming growth factor beta and transforming growth factor beta type II receptors in the epidermis also increased. The elastotic material with co-localizing fibrillin-1 and tropoelastin expression in the dermis decreased after treatment. The expression of matrix metalloproteinases-1, -3, and -12 also decreased. The study was limited by the small sample size. ALA-PDT resulted in histological changes indicating restoration of photoaged skin. These data suggest that ALA-PDT could be effective for photorejuvenation.
    Journal of the American Academy of Dermatology 11/2009; 62(1):85-95. · 4.91 Impact Factor
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    Min Young Park, Eun-So Lee
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    ABSTRACT: An eccrine nevus is a rare hamartoma characterized by an increase in the number or size of eccrine glands. Eccrine nevi usually present as localized hyperhidrosis and are not associated with overlying skin abnormalities. However, among the cases that have been reported in the literature, some unique presentations of eccrine nevi have been demonstrated, including a pigmented patch, a depressed nodule, linear papules, and a sacral skin tag. Herein, we report two unusual cases of coccygeal polypoid eccrine nevi and review the literature.
    Annals of Dermatology 11/2009; 21(4):440-2. · 0.61 Impact Factor
  • Min Young Park, You Chan Kim
    European journal of dermatology: EJD 11/2009; 20(1):133-4. · 1.95 Impact Factor
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    ABSTRACT: To identify systemic sclerosis (SSc) susceptibility loci via a genome-wide association study. A genome-wide association study was performed in 137 patients with SSc and 564 controls from Korea using the Affymetrix Human SNP Array 5.0. After fine-mapping studies, the results were replicated in 1,107 SSc patients and 2,747 controls from a US Caucasian population. The single-nucleotide polymorphisms (SNPs) (rs3128930, rs7763822, rs7764491, rs3117230, and rs3128965) of HLA-DPB1 and DPB2 on chromosome 6 formed a distinctive peak with log P values for association with SSc susceptibility (P=8.16x10(-13)). Subtyping analysis of HLA-DPB1 showed that DPB1*1301 (P=7.61x10(-8)) and DPB1*0901 (P=2.55x10(-5)) were the subtypes most susceptible to SSc in Korean subjects. In US Caucasians, 2 pairs of SNPs, rs7763822/rs7764491 and rs3117230/rs3128965, showed strong association with SSc patients who had either circulating anti-DNA topoisomerase I (P=7.58x10(-17)/4.84x10(-16)) or anticentromere autoantibodies (P=1.12x10(-3)/3.2x10(-5)), respectively. The results of our genome-wide association study in Korean subjects indicate that the region of HLA-DPB1 and DPB2 contains the loci most susceptible to SSc in a Korean population. The confirmatory studies in US Caucasians indicate that specific SNPs of HLA-DPB1 and/or DPB2 are strongly associated with US Caucasian patients with SSc who are positive for anti-DNA topoisomerase I or anticentromere autoantibodies.
    Arthritis & Rheumatology 11/2009; 60(12):3807-14. · 7.48 Impact Factor
  • Min Young Park, You Chan Kim
    Archives of dermatology 10/2009; 145(10):1200-2. · 4.76 Impact Factor
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    ABSTRACT: Tsutsugamushi disease is an acute febrile infectious disease caused by Rickettsia tsutsugamushi. An infection is heralded by the presence of an eschar at the site of the inoculating chigger bite and followed by the development of a disseminated erythematous macular rash. CD30 expression is found in anaplastic large cell lymphoma; however, expression in nonneoplastic cutaneous disorders, such as atopic dermatitis, drug reactions, scabies, and various infectious diseases, has also been reported. Study of the cutaneous histopathology of tsutsugamushi disease has been limited. In this study, we performed biopsies of both the eschar and erythematous lesions of 15 cases of tsutsugamushi disease to assess the histopathological changes including the CD3, CD4, CD20, CD30, and CD68 reactivity. Twelve women and 3 men were included with an age range from 21 to 73 years. The most common location of the eschar was the trunk (53.3%). The histological features showed increased leukocytoclastic vasculitis in the eschar (93.3%) compared with the erythematous lesions (33.3%); basal vacuolar changes were more common in the erythematous (100%) than in the eschar lesions (20%). The inflammatory infiltrate had a majority of CD3- and CD68-positive cells. Seven erythematous lesions and 7 eschar lesions showed atypical cells that were CD30-positive cells. Here, we report on the cutaneous histopathology and pattern of inflammatory infiltrates of tsutsugamushi disease. Leukocytoclastic vasculitis and basal vacuolar changes were the characteristic features of the eschar and the erythematous lesions, respectively. In addition, CD30-positive cell infiltration was identified for the first time in this disease.
    The American Journal of dermatopathology 09/2009; 31(6):551-6. · 1.30 Impact Factor
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    Min Young Park, You Chan Kim
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    ABSTRACT: Branchio-oculo-facial syndrome (BOFS) is a rare, autosomal dominant disorder. It is characterized by distinct craniofacial abnormalities including abnormal location of the ears, aplastic cervical skin lesions, malformed auricles, conductive hearing loss, ocular abnormalities, and cleft lip and palate. Herein, we describe a case of BOFS with persistent aplasia cutis of the neck in a 5-year-old girl.
    Annals of Dermatology 08/2009; 21(3):288-90. · 0.61 Impact Factor

Publication Stats

149 Citations
59.62 Total Impact Points

Institutions

  • 2011–2014
    • Chonnam National University
      • College of Agriculture and Life Sciences
      Gwangju, Gwangju, South Korea
  • 2013
    • Seoul National University
      • Department of Nuclear Engineering
      Sŏul, Seoul, South Korea
  • 2001–2011
    • Korea Advanced Institute of Science and Technology
      • Department of Chemistry
      Seoul, Seoul, South Korea
  • 2009
    • Ajou University
      • Department of Dermatology
      Seoul, Seoul, South Korea
    • Eulji University
      • Department of Dermatology
      Daiden, Daejeon, South Korea
  • 2008
    • Chonbuk National University
      • School of Medicine
      Seoul, Seoul, South Korea