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Yoshio Sumida, Yoshikazu Yonei,
Kazuyuki Kanemasa,
Tasuku Hara,
Yutaka Inada,
Kyoko Sakai,
Shunsuke Imai,
Sawako Hibino,
Kanji Yamaguchi,
Hironori Mitsuyoshi,
Kohichiroh Yasui,
Masahito Minami,
Yoshito Itoh,
Yuji Naito,
Toshikazu Yoshikawa,
Takeshi Okanoue
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ABSTRACT: Aim: The biological basis of variability in histological progression of non-alcoholic fatty liver disease (NAFLD) remains unknown. Dehydroepiandrosterone (DHEA), the most abundant steroid hormone, has been shown to influence sensitivity to reactive oxygen species, insulin sensitivity and expression of peroxisome proliferator-activated receptor-α. Our aim was to determine whether more histologically advanced NAFLD is associated with low circulating levels of DHEA in Japanese patients. Methods: Serum samples were obtained in 133 Japanese patients with biopsy-proven NAFLD and in 399 sex- and age-matched healthy people undergoing health checkups. Serum levels of sulfated DHEA (DHEA-S) were measured by chemiluminescent enzyme immunoassay. Results: Serum DHEA-S levels in NAFLD patients were similar to those in the control group. Of 133 patients, 90 patients were diagnosed as non-alcoholic steatohepatitis (NASH): 73 patients had stage 0-2, and 17 had stage 3 or 4. Patients with advanced NAFLD (NASH with fibrosis stage 3 or 4) had lower plasma levels of DHEA-S than patients with mild NAFLD (simple steatosis or NASH with fibrosis stage 0-2). The area under the receiver operating characteristic curve for DHEA in separating patients with and without advanced fibrosis was 0.788. A "dose effect" of lower DHEA-S and incremental fibrosis stage was observed with a mean DHEA-S of 170.4 ± 129.2, 137.6 ± 110.5, 96.2 ± 79.3, 61.2 ± 46.3 and 30.0 ± 32.0 µg/dL for fibrosis stages 0, 1, 2, 3, and 4, respectively. The association between DHEA-S and severity of NAFLD persisted after adjusting for age, sex and insulin resistance. Conclusion: Low circulating DHEA-S might have a role in the development of advanced NASH.
Hepatology Research 09/2010; 40(9):901-10. · 2.20 Impact Factor
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Nippon rinsho. Japanese journal of clinical medicine 08/2009; 67(7):1256-60.
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Yoshikazu Yonei
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ABSTRACT: The aging balance and the risk factor are considered from a whole body viewpoint whenever it thinks about the anti-aging treatment for calcium metabolism. The aging balance attaches to the muscles, the blood vessel, the nerve, the hormone, and the bone, and the aging risk factor evaluates immunity, the oxidation stress, the mental stress, the lifestyle, and the metabolic states. The basis of treatment is improvement of life styles in daily meal, physical activities, and the spirit. The drug therapy is used to the end assisting. It thought about the aging risk factor by describing the calcium abnormal metabolizing according to aging influence on the whole body, the prevention, and treatment in this text.
Clinical calcium 08/2008; 18(7):995-1005.
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ABSTRACT: The effect of a dietary supplement with L-carnitine (600 mg/day) and Garcinia cambogia extract (500 mg/day as hydroxycitric acid) as main ingredients was studied in 35 healthy volunteers {48.3 +/- 6.9 years, body mass index (BMI): 26.3 +/- 1.7} in a double-blind test (18 subjects in the Test Group and 17 in the Control Group). The yearly examination includes the standard yearly medical tests done in Japan, tests for assessing hormonal age, and a survey for assessing physical and mental fitness of the subjects, called the Anti-Aging QOL Common Questionnaire (AAQol). Use of this supplement significantly improved the level of lipid peroxides (-12.8%) in the blood as well as physical symptoms such as "tired eyes," "blurry eyes," "muscle pain/stiffness," "early satiety," "epigastralgia," "dizziness," "arthralgia" and "easily breaking into a sweat." The Control Group showed a significantly favorable improvement rate, especially for "dizziness." On the other hand, groups of subjects using the test compounds saw a significant rise in total cholesterol (4.5%), fasting blood sugar (4.1%) and HbA1c (3.4%). Our findings suggest that the consumption of the supplement can reduce the oxidative damage; however, the effect on QOL was equivocal. Garcinia cambogia extract did not show dietary efficacy.
Journal of Clinical Biochemistry and Nutrition 04/2008; 42(2):89-103. · 1.98 Impact Factor
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ABSTRACT: The purpose of anti-aging medicine is to raise quality of life (QOL) and to aim at healthy longevity. Melatonin, DHEA(-s) (dehydroepiandrosterone [sulfate]), somatotropin/IGF-I (insulin-like growth factor-I), male and female hormone decrease with aging, that can be prevented by hormone replacement therapy. This therapy has two sides of supplement of the deficit and a healthy increase. Hormone age is "the function age that expressed whether you are equivalent to a hormone secretion state of how old average" and 30 years old or 70-80% of chronological age regard the targeted value of hormone age. We do not decide quantity of hormone replacement uniformly. The reasonable quantity should be determined based on each figure, active mass, life level, and/or blood levels of hormones. Data accumulation for a long term in multiple institutions is important.
Clinical calcium 10/2007; 17(9):1400-6.
