Wolfgang Aichhorn

Paracelsus Medical University Salzburg, Salzburg, Salzburg, Austria

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Publications (43)94.17 Total impact

  • [Show abstract] [Hide abstract]
    ABSTRACT: In healthy humans, it has been shown that executive functions are associated with increased frontal-midline EEG theta activity and theta phase coupling between frontal and posterior brain regions. In individuals with schizophrenia, central executive functions are supposed to be heavily impaired. Given that theta phase coupling is causally involved in central executive functions, one would expect that patients with an executive function deficit should display abnormal EEG theta synchronization. We therefore investigated executive functioning in 21 healthy controls and 21 individuals with schizophrenia while they performed a visuospatial delayed match to sample task. The task required either high executive demands (manipulation of content in working memory [WM]) or low executive demands (retention of WM content). In addition, WM load (one vs. three items) was varied. Results indicated higher frontal theta activity for manipulation processes than for retention processes in patients with schizophrenia, as compared with healthy controls, independently of WM load. Furthermore, individuals with schizophrenia revealed a reduction in theta phase coupling during early stages of the delay period for retention, as well as for manipulation processes at high-WM loads. Deviations in theta phase coupling in individuals with schizophrenia were mainly characterized by aberrant fronto-posterior connections, but also by attenuated posterior connections during manipulation of high-WM load. To conclude, fronto-parietal theta coupling seems to be substantially involved in executive control, whereas frontal theta activity seems to reflect general task demands, such as deployment of attentional resources during WM.
    Cognitive Affective & Behavioral Neuroscience 04/2014; · 3.87 Impact Factor
  • Günter Schiepek, Wolfgang Aichhorn
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    ABSTRACT: Since several years, internet-based technologies for the monitoring of psychotherapy processes were partially established in in-patient and day treatment centres. We discuss the usefulness and some methodological requirements of process monitoring devices, with a more detailed description of the Synergetic Navigation System (SNS). Continuous self-ratings and the use of feedback-tools like the SNS will have therapeutic implications on patients as well as therapists and their professional cooperation with the patient. Studies on the effects of feedback-systems on patients and therapists should be realized, and the quality of feedback-sessions as well as the competencies in the management of nonlinear processes and feedback-systems should be enhanced. Real-time monitoring is ready to get an integrated part of clinical practice and of clinical training programs.
    PPmP - Psychotherapie · Psychosomatik · Medizinische Psychologie 01/2013; 63(1):39-47. · 1.02 Impact Factor
  • Günter Schiepek, Guido Strunk, Wolfgang Aichhorn
    01/2013: pages 29-39;
  • Günter Schiepek, Wolfgang Aichhorn, Guido Strunk
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    ABSTRACT: This contribution looks at the factorial structure of the Therapy Process Questionnaire (TPQ), which is used for daily self-ratings of patients tested by internet-based ambulatory assessment devices. A combined explorative and confirmatory factor analysis of the TPQ. The time-series data were generated by 149 patients treated in an inpatient setting. 23 out of 42 items included in the explorative version of the TPQ are represented onto five factors, which were identified by a first explorative factor analysis and then validated by a confirmative factor analysis. We report on the psychometric data of the subscales: internal consistency (Cronbach's α), mean of item-intercorrelation, and mean of item discrimination indices. The TPQ is useful for a high-frequency and equidistant (daily) assessment of psychotherapeutic change processes.
    Zeitschrift fur Psychosomatische Medizin und Psychotherapie 01/2012; 58(3):257-66. · 0.98 Impact Factor
  • Günter Schiepek, Wolfgang Aichhorn, Guido Strunk
    Zeitschrift für Psychosomatische Medizin und Psychotherapie. 01/2012; 58(3):257-266.
  • Journal of clinical psychopharmacology 08/2011; 31(4):543-4. · 5.09 Impact Factor
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    ABSTRACT: Children of mentally ill parents are exposed to a variety of stress- and harmful life events. To which extent the mental illness of one or both parents affects their children's mental development is barely studied. Therefore, over a period of 6 months 142 patients with children below the age of 18 (n=237 children), who were admitted to the Dept. for Psychiatry and Psychotherapy 1 of the Paracelsus Medical University Salzburg, were questioned for abnormalities in their children's mental development. Additionally all these patients were assessed for their family situation, demographic data and psychiatric disorder. 38.4% (n=91) of the children showed mental abnormalities. The most common one were emotional (n=41), social (n=41) and learning (n=34) disabilities. Parental duration of the illness (p=0.001), age of the children (p=0.044), illness of both parents (p=0.008), longlasting family conflicts (p=0.003) and living with only one parent (p=0.012) were correlated significantly with mental abnormalities in children. The results confirm an increase risk for mental abnormalities in children of psychiatric patients. This risk varies with existing risk and protective factors, which can be partially influenced. Therefore children of mentally ill parents with problems in their mental development should be detected early. Even if genetic risk factors cannot be changed reducing known psychosocial risk factors and promotion protective factors can significantly influence a healthy development of these vulnerable children.
    Neuropsychiatrie: Klinik, Diagnostik, Therapie und Rehabilitation: Organ der Gesellschaft Österreichischer Nervenärzte und Psychiater 01/2011; 25(4):192-8. · 1.38 Impact Factor
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    ABSTRACT: Real-Time Monitoring in psychotherapy is a new method to increase quality and efficacy in psychotherapy. This internet-based information technology offers an online collection of psychotherapy-related data and allows insights into therapeutic patterns of change without any time-delay. The classical pre-post-evaluation is completed by an assessment of therapeutic processes. Besides an internet-based data collection the Synergetic Navigation System (SNS) integrates different methods of nonlinear time series analysis and provides a visualization of results. SNS is a new internet-based technology of data collection and data analysis. For illustration we present a single case study (avoidant personality disorder (DSM IV 301.82) with recurrent major depressive episodes) where SNS was applied in clinical practice (in-patient treatment). SNS results are used for therapy planning by repeated feedback interviews with the patients. Critical phases and nonlinearities of the ongoing self-organization processes can be identified. In addition to the practical impact of real-time monitoring SNS allows for continuous process-outcome-research in naturalistic settings. Models of change processes (e.g. sudden gains) can be tested but also used as a interpretation frame of idiographic results. In every day practice SNS enhances transparency, self-efficacy of patients, and supports the motivation to change. Compliance of patients is high, and the data show high validity. Therefore as a future perspective SNS should become routine in clinical practice and be integrated in professional psychotherapy training.
    Neuropsychiatrie: Klinik, Diagnostik, Therapie und Rehabilitation: Organ der Gesellschaft Österreichischer Nervenärzte und Psychiater 01/2011; 25(3):135-41. · 1.38 Impact Factor
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    ABSTRACT: We here report on a psychotic mother and her breast-fed infant who was treated with olanzapine. Consecutively olanzapine concentrations in the milk and plasma of the mother and in the infant were measured with tandem mass spectroscopy over a period of five month. The results show a relatively high plasma level in the infant aged four month, probably referring to an immature hepatic transformation system, especially CYP1A2. In the following four months plasma levels of olanzapine decreased to very low, even undetectable concentrations in the infant. The infant developed normally and showed no side effects during the treatment period.
    Journal of Psychopharmacology 10/2008; 24(1):121-3. · 3.37 Impact Factor
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    ABSTRACT: Little is known about the use of antipsychotics in pregnancy and the corresponding plasma levels in the newborn child. We report on a woman with schizophrenia treated with olanzapine during pregnancy. Plasma levels of olanzapine were assessed both from the mother and from umbilical cord. The plasma level of the newborn (11 ng/mL) was about one third compared to the mother (range 25-34 ng/mL).The development of the fetus, delivery and the development of the child during the first six months were normal.
    Journal of Psychopharmacology 03/2008; 22(8):923-4. · 3.37 Impact Factor
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    ABSTRACT: Recent data indicate increasing suicide rates for children and adolescents in the United States, Great Britain and the Netherlands. These facts call for a critical discussion of prescription rates of antidepressants for pediatric use. Obviously the U.S. and European regulators issued public warnings about a possible association between antidepressants and suicidal thinking and behaviour have discouraged physicians to use antidepressants in this age group. Untreated depression means impairment of psychosocial development of children and their families. Alarmingly there is no evidence of a significant increase in the use of treatment alternatives as for example psychotherapy. High relapse rate with early onset of depressions are common and therefore children with depression need all our attention and best treatment available. Current Austrian suicidal statistics do not yet demonstrate increasing suicidal rates in adolescents as seen in the U.S., the U.K. and the Netherlands. Thus all our alertness is needed to avoid any analogical progress in suicide rates and despite regulatory warnings and certainly after a careful risk-benefit analyses physicians have to consider pharmacological treatment options in depressive children and adolescents.
    Neuropsychiatrie: Klinik, Diagnostik, Therapie und Rehabilitation: Organ der Gesellschaft Österreichischer Nervenärzte und Psychiater 02/2008; 22(1):16-22. · 1.38 Impact Factor
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    ABSTRACT: Various studies show a high prevalence of mental disorders among homeless people. So far most of these studies deal solely with single men, mainly affected by homelessness. Few data exist for women, children, adolescents and whole families that are more and more affected by poverty and homelessness. This study, conducted in Innsbruck/Austria, determined the prevalence of psychiatric disorders among homeless adolescents. The adolescents were recruited in a counselling centre and homeless shelter specifically founded for homeless youth. Mental disorders were diagnosed with the Structured Clinical Interview for DSM-IV (SKID-I). 40 adolescents and young adults ranging from 14-23 years (mean 17.9 years) were included in the study. The results show that 58% of the homeless adolescents were exposed to continuous violence in their families and that violence was a major reason for them to leave home. The overall prevalence of diagnosed psychiatric disorders was 80% in the whole sample; the leading disorder was substance abuse/dependence (65%), followed by mood disorders (42.5%), anxiety disorders (17.5%) and eating disorders (17.5%). 57.5% of the adolescents had a history of self-harm and 25% reported at least one suicide attempt. Duration of homelessness had the greatest influence on the prevalence of mental disorders. Longer duration of homelessness was associated with a higher risk of psychiatric disorder or self-harm. These results demonstrate the urgent need for early psychosocial and psychiatric help for homeless adolescents.
    Neuropsychiatrie: Klinik, Diagnostik, Therapie und Rehabilitation: Organ der Gesellschaft Österreichischer Nervenärzte und Psychiater 02/2008; 22(3):180-8. · 1.38 Impact Factor
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    The Primary Care Companion to The Journal of Clinical Psychiatry 02/2008; 10(1):72-3.
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    The Primary Care Companion to The Journal of Clinical Psychiatry 02/2008; 10(2):160-1.
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    ABSTRACT: Pindolol, a 5-HT1A autoreceptor antagonist, given in combination with selective serotonin reuptake inhibitors (SSRIs), may enhance and/or accelerate the therapeutic efficacy of SSRIs. Fifty patients, meeting ICD-10 criteria for major depressive disorder or bipolar depression, were enrolled in our randomized, placebo-controlled, double-blind trial. One group received paroxetine plus pindolol (2.5 mg t.i.d.), and the other group received paroxetine plus placebo. The proportion of patients with sustained response (>or=50% reduction of baseline HAM-D 17 score maintained until the endpoint; p=0.252) and the proportion of patients with remission (HAM-D 17 <or=8 at last visit; p=0.769) did not differ significantly between the two treatment groups. However, a significantly greater proportion of patients who were not previously treated with antidepressants (n=15; p=0.041) and of patients with bipolar depression (n=11; p=0.015) had a sustained response in the paroxetine plus pindolol group compared to the paroxetine plus placebo group; furthermore there was a trend for first episode depressed patients to have a greater response in the paroxetine plus pindolol group (n=12; p=0.071). Summarizing, the entire study population showed no antidepressive benefit from pindolol augmentation. Nevertheless patients with bipolar depression irrespective of previous treatments and duration of illness, and unipolar patients not previously treated demonstrated a significant benefit from pindolol augmentation.
    European Neuropsychopharmacology 02/2008; 18(2):141-6. · 4.60 Impact Factor
  • European Psychiatry - EUR PSYCHIAT. 01/2008; 23.
  • Pharmacopsychiatry 01/2008; 41(05). · 2.11 Impact Factor
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    ABSTRACT: Propofol is often used as an anesthetic agent for electroconvulsive therapy (ECT). Whether the relatively short seizure duration, resulting from the medication, deteriorates the seizure quality and therapeutic outcomes, or whether propofol might be associated with small but significant post-ECT cognitive impairments, is still a subject of controversy. The purpose of our study was to test these hypotheses in comparison with methohexital. In a double-blind, controlled study, 50 patients with severe major depression who were to be treated with ECT were randomly assigned to anesthesia with propofol (120.9 +/- 50.0 mg) or methohexital (83 +/- 26.3 mg) and were observed for 2 months. The 2 drugs were compared on the basis of electroencephalography-registered seizure duration, mean blood pressure, as well as pulse frequency, seizure efficacy index, and postictal suppression. Systolic and diastolic blood pressure, and seizure duration and quality were recorded consecutively during ECT treatments. Changes in depressive symptoms and cognitive functions were measured at 5 time points, pre-ECT, after the third to fifth ECT, post-ECT treatment, and at a follow-up examination 2 and 8 weeks after the last ECT treatment. Patients on propofol showed a significantly lower increase in blood pressure post-ECT (P < 0.001), their seizure duration was comparable to patients on methohexital (P = 0.072), and seizure quality was significantly superior, as was measured by the Postictal Suppression Index (P = 0.020), and comparable to the methohexital group as measured by the Seizure Efficacy Index (P = 0.160). The improvement of depressive symptoms and the improvement in cognitive functions were similar in both groups (with the exception of the results from 2 cognition tests). Propofol, as compared with methohexital, results in a more moderate increase in blood pressure and shorter seizure duration. The seizure quality did not differ significantly between the 2 groups. We detected a tendency toward improved cognitive performance after anesthesia with propofol as compared with methohexital, but with statistical significance in only 2 cognition trials. Therefore, propofol is a safe and efficacious anesthetic for ECT treatment.
    Journal of Ect 12/2007; 23(4):239-43. · 1.69 Impact Factor
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    ABSTRACT: Risperidone and olanzapine are second-generation antipsychotics that are increasingly used in child and adolescent psychiatry. So far, little is known about plasma concentrations and concentration-to-dose (C/D) ratios of these agents in children and adolescents compared to adults. This study investigated whether age and gender influence risperidone and olanzapine plasma concentration by determining risperidone and olanzapine plasma levels by tandem mass spectrometry in 162 Caucasian patients (98 risperidone and 64 olanzapine). For risperidone and 9-hydroxyrisperidone, the C(total)/D ratio was almost identical in both age groups (10-18 and 19-45 years, respectively). In the younger age group, females exhibited significantly higher total plasma levels than males while receiving similar doses of risperidone. For olanzapine, in adolescents significantly higher C/D ratios were detected by an average of 43% (after adjustment for weight: 34%) compared to adults. This study demonstrates an age effect for olanzapine but not for risperidone resulting in higher olanzapine plasma levels in younger patients. For risperidone, we found a gender effect as female adolescent patients had significantly higher risperidone plasma concentrations than male adolescent patients. Future prospective studies are necessary to clarify whether the prescribed dosage should be different in young and older patients.
    Journal of Child and Adolescent Psychopharmacology 11/2007; 17(5):665-74. · 2.77 Impact Factor
  • The Journal of Clinical Psychiatry 08/2007; 68(7):1146. · 5.81 Impact Factor

Publication Stats

220 Citations
94.17 Total Impact Points

Institutions

  • 2007–2013
    • Paracelsus Medical University Salzburg
      • • Research Institute of Synergetics and Psychotherapy
      • • University Clinic of Psychiatry and Psychotherapy I
      Salzburg, Salzburg, Austria
  • 2006–2007
    • Medizinische Universität Innsbruck
      • Department of General- and Social Psychiatry
      Innsbruck, Tyrol, Austria
  • 2005–2006
    • University of Innsbruck
      • Institut für Biochemie
      Innsbruck, Tyrol, Austria