Consuelo Vicente

University of Murcia, Murcia, Murcia, Spain

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Publications (29)103.78 Total impact

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    ABSTRACT: The clinical success of cisplatin and its derivatives has had an enormous impact on the discovery of novel metal-based drugs. Extensive studies have focused on the interaction of metal complexes with their potential targets. The array of organometallic compounds with useful anticancer activity has been significantly extended with respect to metals and structures. This review highlights recent exciting results in the field of cyclometalated C-N complexes and C-N C, C-N-N and C-N-S pincer complexes of platinum, palladium, gold, ruthenium, rhodium, and iridium with potential anticancer properties.
    Coordination Chemistry Reviews 10/2013; 257(19-20):2784-2797. DOI:10.1016/j.ccr.2013.03.024 · 12.10 Impact Factor
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    ABSTRACT: A series of new organoiridium(III) complexes [Ir(N-C)(2)(N-S)]Cl (HN-C = 2-phenylpyridine (Hppy), N-S = methyl thiosemicarbazide (1), phenyl thiosemicarbazide (2) and naphtyl thiosemicarbazide (3)) have been synthesized and characterized. The crystal structure of (1) has been established by X-ray diffraction, showing the thiosemicarbazide ligand bound to the iridium atom as N,S-chelate. The cytotoxicity studies show that they are more active than cisplatin (about 5-fold) in T47D (breast cancer) at 48 h incubation time. On the other hand, very low resistance factors (RF) of 1-3 in A2780cisR (cisplatin-resistant ovarian carcinoma) at 48 h were observed (RF ≈ 1). Ir accumulation in T47D cell line after 48 h continuous exposure for complexes 1-3 are higher than that corresponding to cisplatin (about 10 times). The complexes 1-3 bind strongly to HSA with binding constants of about 10(4) M(-1) at 296 K, binding occurring at the warfarin site I for 2. Complexes 2 and 3 are also capable of binding in the minor groove of DNA as shown by Hoechst 33258 displacement experiments. Furthermore, complex 2 is also a good cathepsin B inhibitor (an enzyme implicated in a number of cancer related events), being the enzyme reactivated by cysteine.
    Inorganic Chemistry 01/2013; 52(2). DOI:10.1021/ic302219v · 4.79 Impact Factor
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    ABSTRACT: The interaction of a novel Pt complex, [Pt(dmba)(N9-9AA)(PPh(3))](+)1 (dmba = N,N-dimethylbenzylamine-κN,κC; 9AA = 9-aminoacridine), which exhibits anti-tumor activity, with certain key proteins has been monitored by ESI-MS. Also, the interaction of 1 with a designed double-stranded oligonucleotide containing the GG motif has been followed by mass spectrometry as well as by fluorimetry. The results obtained show the low interaction of 1 with the considered proteins and the absence of covalent interaction with the oligonucleotides, but the fluorimetric data confirm the π-π interaction of 1 with the double-stranded DNA, which is probably the reason of the previously reported activity of 1 in several tumor cell lines.
    Dalton Transactions 11/2011; 41(1):300-6. DOI:10.1039/c1dt11506e · 4.10 Impact Factor
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    ABSTRACT: The synthesis of the novel anthraquinone platinum derivate [Pt(ppy)Cl(1C3)] (2) [Hppy = N,C-chelating 2-phenylpyridine; 1C3 = 1-[(3-aminopropyl)amino]-anthracene-9,10-dione] and its values of IC(50) against a panel of human tumor cell lines representative of ovarian (A2780 and A2780cisR) and breast cancers (T47D) are reported. At 24 h incubation time, complex 2 was more active than cisplatin (about 9-fold) and the free ligand 1C3 (about 2-fold) in T47-D. The observation that the cisplatin IC(50) falls by about 10-fold from 24 to 72 h, whereas that for 2 changes little, suggests substantial differences in the mode of action. Complex 2 also showed high cytotoxicity against A2780 (about 3-fold greater than cisplatin at 24 h). On the other hand, very low resistance factors (RF) of 2 in A2780cisR at 24-72 h (RF = 1.3) were observed. The interaction of 2 with DNA was followed by electrophoretic mobility and UV-visible spectroscopy, and its reaction with the model nucleobase 9-EtG was studied by (1)H NMR and ESI-MS. Theoretical calculations at the B3LYP/def2-TZVPP//BP86/def2-TZVP level of theory on complex 2 show a labile Pt-Cl bond that allows easy replacement of Cl by N-nucleophiles such as 9-EtG, which forms a stronger Pt-N bond.
    Inorganic Chemistry 02/2011; 50(6):2151-8. DOI:10.1021/ic101526h · 4.79 Impact Factor
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    ABSTRACT: The new ruthenium(II) compound [(eta6-p-cymene)Ru(N insertion mark C)Cl] (HN insertion mark C=9-aminoacridine (9-HAA)) shows a potent in vitro anticancer activity.
    Dalton Transactions 08/2009; DOI:10.1039/b907296a · 4.10 Impact Factor
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    ABSTRACT: The new complexes [Pd(dmba)( N10-9AA)(PPh 3)]ClO 4 ( 1), [Pt(dmba)( N9-9AA)(PPh 3)]ClO 4 ( 2), [Pd(dmba)( N10-9AA)Cl] ( 3), and [Pd(C 6F 5)( N10-9AA)(PPh 3)Cl] ( 4) (9-AA = 9-aminoacridine; dmba = N,C-chelating 2-(dimethylaminomethyl)phenyl) have been prepared. The crystal structures have been established by X-ray diffraction. In complex 2, an anagostic C-H...Pt interaction is observed. All complexes are luminescent in the solid state at room temperature, showing important differences between the palladium and platinum complexes. Complex 2 shows two structured emission bands at high and low energies in the solid state, and the lifetimes are in agreement with excited states of triplet parentage. Density functional theory and time-dependent density functional theory calculations for complex 2 have been done. Values of IC 50 were also calculated for the new complexes 1- 4 against the tumor cell line HL-60. All of the new complexes were more active than cisplatin (up to 30-fold in some cases). The DNA adduct formation of the new complexes synthesized was followed by circular dichroism and electrophoretic mobility. Atomic force microscopy images of the modifications caused by the complexes on plasmid DNA pB R322 were also obtained.
    Inorganic Chemistry 08/2008; 47(15):6990-7001. DOI:10.1021/ic800589m · 4.79 Impact Factor
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    ABSTRACT: The syntheses and crystal structures of the first examples of an anionic 1-methylthymine [deprotonated at the endocyclic NH group N(3)] acting as a chelating ligand for the cis-Pd(C6F3H2)2 and cis-Pd(C6F5)2 moieties through N(3) and O(4) are reported.
    Inorganic Chemistry 08/2007; 46(14):5448-9. DOI:10.1021/ic700843s · 4.79 Impact Factor
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    ABSTRACT: Substituted-benzoate complexes of nickel(II) of the types bidentate [Ni(mcN3)(Bz)](PF6) and monodentate [Ni(mcN3)(Bz)(H2O)](PF6) have been prepared by acid-base reaction between the hydroxo complexes [Ni(mcN3)(μ-OH)]2(PF6)2 (mcN3=2,4,4-trimethyl-1,5,9-triazacyclododec-1-ene (Me3-mcN3) or its 9-methyl derivative (Me4-mcN3)) and the corresponding benzoic acid. The paramagnetic nickel(II) complexes have been characterized in solution by NMR spectroscopy. The influence of the substituents on the hyperfine shift patterns for substituted-benzoate complexes of nickel(II) has been studied. The substituent effects upon the coordination mode of substituted benzoates have been established by X-ray diffraction.
    Polyhedron 03/2007; 26(5):1029-1036. DOI:10.1016/j.poly.2006.09.068 · 2.05 Impact Factor
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    ABSTRACT: Pd(II) and Pt(II) complexes with the anions of the model nucleobases 1-methylthymine (1-MethyH), 1-methyluracil (1-MeuraH), and 1-methylcytosine (1-MecytH) of the types [Pd(dmba)(mu-L)]2 [dmba = N,C-chelating 2-((dimethylamino)methyl)phenyl; L = 1-Methy, 1-Meura or 1-Mecyt] and [M(dmba)(L)(L')] [L = 1-Methy or 1-Meura; L' = PPh(3) (M = Pd or Pt), DMSO (M = Pt)] have been obtained. Palladium complexes of the types [Pd(C6F5)(N-N)(L)] [L = 1-Methy or 1-Meura; N-N = N,N,N',N'-tetramethylethylenediamine (tmeda), 2,2'-bipyridine (bpy), or 4,4'-dimethyl-2,2'-bipyridine (Me2bpy)] and [NBu4][Pd(C6F5)(1-Methy)2(H2O)] have also been prepared. The crystal structures of [Pd(dmba)(mu-1-Methy)]2, [Pd(dmba)(mu-1-Mecyt)]2.2CHCl3, [Pd(dmba)(1-Methy)(PPh3)].3CHCl3, [Pt(dmba)(1-Methy)(PPh3)], [Pd(tmeda)(C6F5)(1-Methy)], and [NBu4][Pd(C6F5)(1-Methy)2(H2O)].H2O have been established by X-ray diffraction. The DNA adduct formation of the new platinum complexes synthesized was followed by circular dichroism and electrophoretic mobility. Atomic force microscopy images of the modifications caused by the platinum complexes on plasmid DNA pBR322 were also obtained. Values of IC50 were also calculated for the new platinum complexes against the tumor cell line HL-60. All the new platinum complexes were more active than cisplatin (up to 20-fold in some cases).
    Inorganic Chemistry 09/2006; 45(16):6347-60. DOI:10.1021/ic060374e · 4.79 Impact Factor
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    ABSTRACT: Palladium and platinum complexes with the model nucleobase 1-methylcytosine (1-Mecyt) of the types [Pd(N-N)(C6F5)(1-Mecyt)]ClO4 [N-N = bis(3,5-dimethylpyrazol-1-yl)methane (bpzm), bis(pyrazol-1-yl)methane (bpzm), N,N,N',N'-tetramethylethylenediamine (tmeda), or 2,2'-bipyridine (bpy)] and [M(dmba)(L')(1-Mecyt)]ClO4 [dmba = N,C-chelating 2-(dimethylaminomethyl)phenyl; L' = PPh(3) (M = Pd or Pt), DMSO (M = Pt)] have been obtained. Palladium and platinum complexes of the types cis-[M(C6F5)2(1-Mecyt)2] (M = Pd or Pt) and cis-[Pd(L')(C6F5)(1-Mecyt)2]ClO4 (L' = PPh(3) or t-BuNC) have also been prepared. The crystal structures of [Pd(bpzm)(C6F5)(1-Mecyt)]ClO4, [Pt(dmba)(DMSO)(1-Mecyt)]ClO4, cis-[Pd(C6F5)2(1-Mecyt)2], and cis-[Pd(t-BuNC)(C6F5)(1-Mecyt)2]ClO4 have been established by X-ray diffraction. There is extensive hydrogen bonding (N-H...O, C-H...F or C-H...O) in all the compounds. There are also intermolecular pi-pi interactions between pyrimidine rings of adjacent chains in [Pd(C6F5)2(1-Mecyt)2]. DNA adduct formation of the new complexes synthesized was followed by circular dichroism and electrophoretic mobility. Atomic force microscopy images of the modifications caused by the complexes on plasmid DNA pBR322 were also obtained. Values of IC(50) were also calculated for the new complexes against the tumor cell line HL-60. At a short incubation time (24 h) almost all new complexes were more active than cisplatin.
    Inorganic Chemistry 11/2005; 44(21):7365-76. DOI:10.1021/ic0502372 · 4.79 Impact Factor
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    ABSTRACT: Mononuclear palladium-hydroxo complexes of the type [Pd(N–N)(C6F5)(OH)][(N–N) = 2,2′-bipyridine (bipy), 4,4′-dimethyl-2,2′-bipyridine (Me2bipy), 1,10-phenantroline (phen) or N,N,N′,N′-tetramethylethylenediamine (tmeda) react with phenols ArOH in tetrahydrofuran giving the corresponding aryloxo complexes [Pd(N–N)(C6F5)(OAr)]. Elemental analyses and spectroscopic (IR, 1H and 19F) methods have been used to characterize the new complexes. The X-ray crystal structure of [Pd(tmeda)(C6F5)(OC6H4NO2-p)] has been determined. In the crystal packing the planes defined by two C6H4 rings show a parallel orientation. There are also intermolecular C–H···F and C-H···O hydrogen bonds.
    Zeitschrift für anorganische Chemie 08/2005; 631(11):2227-2231. DOI:10.1002/zaac.200570048 · 1.25 Impact Factor
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    ABSTRACT: Heterotrinuclear pyridinecarboxylate complexes of nickel(II) and palladium(II) of the types [Ni(mcN3)(pyridinecarboxylate)]2{μ-[Pd(C6F5)2]}(PF6)2 [mcN3 = 2,4,4-trimethyl-1,5,9-triazacyclododec-1-ene (Me3-mcN3) or 2,4,4,9-tetramethyl-1,5,9-triazacyclododec-1-ene (Me4-mcN3)] have been prepared by two different routes. The corresponding monomeric pyridinecarboxylate complexes of nickel and the monomeric pyridinecarboxylic acid/ester complexes of palladium have also been prepared. The crystal structures of two precursors [Ni(Me4-mcN3)(NC5H4-3-COO)]PF6 and cis-[Pd(C6F5)2(NC5H4-4-CH2COOCH3)2] have been established by X-ray diffraction. (© Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2005)
    Berichte der deutschen chemischen Gesellschaft 08/2005; 2005(15):3049-3056. DOI:10.1002/ejic.200500123
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    ABSTRACT: Novel N-bonded imidato complexes of general formula [Pd(N-N)(C6F5)(imidate)](imidate = maleimidate, succinimidate or phthalimidate; N-N = 2,2'-bipyridine (bipy), 4,4'-dimethyl-2,2'-bipyridine (Me2bipy) or N,N,N',N'-tetramethylethylenediamine (tmeda)), [NBu4][Pd(C6F5)(H2O)(succinimidate)2] and [NBu4][Pd(C6F5)(L)(succinimidate)2](L = PPh3 or t-BuNC) have been synthesised. These complexes are air-, light- and moisture-stable. The crystal structures of [Pd(tmeda)(C6F5)(maleimidate)].H2O.0.5CHCl3, [NBu4][Pd(C6F5)(H2O)(succinimidate)2].H2O and [NBu4][Pd(C6F5)(t-BuNC)(succinimidate)2].2H2O have been determined by X-ray diffraction. Many of these new complexes are shown to be active phosphine-free palladium catalysts/precatalysts for the Suzuki cross-coupling reactions of aryl bromides and aryl chlorides with phenylboronic acid.
    Dalton Transactions 07/2005; DOI:10.1039/b503101j · 4.10 Impact Factor
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    ABSTRACT: Mononuclear palladium-hydroxo complexes of the type [Pd(N–N)(C6F5)(OH)] [(N–N)=2,2′-bipyridine (bipy), 4,4′-dimethyl-2,2′-bipyridine (Me2bipy), or N,N,N′,N′-tetramethylethylenediamine (tmeda)] react with silanols HOSiR3 in toluene giving the corresponding siloxo complexes [Pd(N–N)(C6F5)(OSiR3)]. The X-ray crystal structure of [Pd(tmeda)(C6F5)(OSiPh3)] has been determined. In one of the two molecules in the asymmetric unit there is an intramolecular interaction by phenyl–pentafluorophenyl π-stacking.
    Journal of Organometallic Chemistry 06/2004; 689(11):1872-1875. DOI:10.1016/j.jorganchem.2004.03.009 · 2.17 Impact Factor
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    ABSTRACT: The reaction of [NBu4]2[{M(C6F5)2(μ-OH)}2] (M=Pd, Pt) with amines R2NH in the presence of the heterocumulene phenylisocyanate, PhNCO, leads to the synthesis of the ureato(1−) complexes [NBu4][M(C6F5)2{PhNC(O)NR2}] (M=Pd, Pt). The single-crystal structure of [NBu4][(C6F5)2Pt{PhNC(O)NPri 2}] revealed the presence of a N,N′-chelating ureato(1−) with a N(1)PtN(2) bite angle of 64.0(3)°.
    Inorganica Chimica Acta 07/2003; 351:114–118. DOI:10.1016/S0020-1693(03)00200-7 · 2.04 Impact Factor
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    ABSTRACT: The reactions of the hydroxo complexes [M(2)R(4)(mu-OH)(2)](2)(-) (M = Pd, R = C(6)F(5), C(6)Cl(5); M = Pt, R = C(6)F(5)), [[PdR(PPh(3))(mu-OH)](2)] (R = C(6)F(5), C(6)Cl(5)), and [[Pt(C(6)F(5))(2)](2)(mu-OH)(mu-pz)](2-) (pz = pyrazolate) with H(2)S yield the corresponding hydrosulfido complexes [M(2)(C(6)F(5))(4)(mu-SH)(2)](2-), [[PdR(PPh(3))(mu-SH)](2)], and [[Pt(C(6)F(5))(2)](2)(mu-SH)(mu-pz)](2-), respectively. The monomeric hydrosulfido complexes [M(C(6)F(5))(2)(SH)(PPh(3))](-) (M = Pd, Pt) have been prepared by reactions of the corresponding binuclear hydrosulfido complexes [M(2)(C(6)F(5))(4)(mu-SH)(2)](2-) with PPh(3) in the molar ratio 1:2, and they can be used as metalloligands toward Ag(PPh(3))(+) to form the heterodinuclear complex [(C(6)F(5))(2)(PPh(3))[S(H)AgPPh(3)]], and toward Au(PPh(3))(+) yielding the heterotrinuclear complexes [M(C(6)F(5))(2)(PPh(3))[S(AuPPh(3))(2)]]. The crystal structures of [NBu(4)](2)[[Pt(C(6)F(5))(2)(mu-SH)](2)], [Pt(C(6)F(5))(2)(PPh(3))[S(H)AgPPh(3)]], and [Pt(C(6)F(5))(2)(PPh(3))[S(AuPPh(3))(2)]] have been established by X-ray diffraction and show no short metal-metal interactions between the metallic centers.
    Inorganic Chemistry 11/2001; 40(21):5354-60. · 4.79 Impact Factor
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    ABSTRACT: The reactions of the hydroxo complexes [M2R4(mu -OH)(2)](2-) (M = Pd, R = C6F5, C6Cl5; M = Pt, R = C6F5), [{PdR(PPh3)(mu -OH)}(2)] (R = C6F5, C6Cl5), and [{Pt(C6F5)(2)}(2)(mu -OH)(mu -pz)](2-) (pz = pyrazolate) with H2S yield the corresponding hydrosulfido complexes [M-2(C6F5)(4)(mu -SH)(2)](2-), [{PdR(PPh3)(mu -SH)}(2)], and [{Pt(C6F5)(2)}(2)(mu -SH)(mu -pz)](2-), respectively. The monomeric hydrosulfido complexes [M(C6F5)(2)(SH)(PPh3)](-) (M = Pd, Pt) have been prepared by reactions of the corresponding binuclear hydrosulfido complexes [M2(C6F5)4(A-SH)2]2- with PPh3 in the molar ratio 1:2, and they can be used as metalloligands toward Ag(PPh3)(+) to form the heterodinuclear complex [(C6F5)(2)(PPh3){S(H)AgPPh3}], and toward Au(PPh3)(+) yielding the heterotrinuclear complexes [M(C6F5)(2)(PPh3){S(AuPPh3)(2)}]. The crystal structures of [NBu4](2)[{Pt(C6F5)(2)(mu -SH)}(2)], [Pt(C6F5)(2)(PPh3){S(H)AgPPh3}], and [Pt(C6F5)(2)(PPh3){S(AuPPh3)(2)}] have been established by X-ray diffraction and show no short metal-metal interactions between the metallic centers.
    Inorganic Chemistry 10/2001; 40(21):5354-5360. DOI:10.1021/ic0013633 · 4.79 Impact Factor
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    ABSTRACT: The protonation of [(C6F5)LPd(μ-OH)2PdL(C6F5)] by triflic acid (CF3SO3H) results in the formation of the diaqua complexes [Pd(C6F5)L(H2O)2][CF3SO3] (L=PPh3 (1) or AsPh3 (2)). The crystal structure of 2 was elucidated by X-ray diffraction analysis revealing the presence of tetrameric units involving hydrogen bonds.
    Inorganic Chemistry Communications 02/2000; 3(2):73–75. DOI:10.1016/S1387-7003(00)00008-3 · 2.06 Impact Factor
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    ABSTRACT: The hydroxo binuclear complexes [NBu4]2[}M(C6F5)2(μ-OH){2] (M = Pd or Pt) react with thiols in methanol at room temperature to give the binuclear di-μ-thiolato complexes [NBu4]2[}M(C6F5)2(μ-SR){2] (M = Pd, R = Et 1, t-Bu 2, C6H5, 3, and p-MeC6H44; M = Pt, R = Et 5, t-Bu 6, C6H57 or p-MeC6H48). The trinuclear palladium complexes [NBu4]2[(C6F5)2Pd(μ-SEt)2Pd(μ-SEt)2Pd(C6F5)2] 9 or [NBu4]2[(C65)2Pd(μ-1,2-S2C6H4)Pd(μ-1,2-S2C6H4)Pd(C6F5)2] 10 have been obtained by reaction of the binuclear hydroxo palladium complex [NBu4]2[}Pd(C6F5)2(μ-OH){2] with an excess of EtSH in refluxing methanol or with an excess of C6H4(SH)2-1,2, in methanol at room temperature, respectively. The mixed hydroxo-axolate bridged complexes [}M(C6F5)2{2(μ-OH)(μ-L)]2− M = Pd, L = pyrazolate (pz); M = Pt, L = pyrazolate (pz) or 3,5-dimethylpyrazolate (dmpz)]react with thiols (1 : 1 molar ratio) in methanol to give the corresponding mixed thiolato-azolate bridged palladium or platinum complexes [}M(C6F5)2{2(μ-SR)(μ-L)]2− (M = Pd, L = dmpz, R = C6H5, 11, p-MeC6H412; M = Pt, L = pz, R = C6H513, p-MeC6H4, 14, Et 15, t-Bu 16; L = dmpz, R = C6H517, R = p-MeC6H418, Et 19]. The complexes have been characterized by partial elemental analyses, conductance measurements and spectroscopic (IR and 1H and 19F NMR) methods.
    Polyhedron 05/1998; 17(9):1503-1509. DOI:10.1016/S0277-5387(97)00411-7 · 2.05 Impact Factor
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    ABSTRACT: The binuclear hydroxo complexes [{M(C6F5)2(µOH)}2]2-(M=PdandPt)reactwithN-substituted salicylaldimines (HSal=NR) or ß-ketoimines (RN=CMeCH2COR') to give the corresponding N-substituted salicylaldiminato or ß-ketoiminato mononuclear complexes, [M(C6F5)2(Sal=NR)]- (M=Pd or Pt; R= Me, Et, Ph, o-MeC6H4, p-MeC6H4 or p-ClC6H4) or [(C6F5)2M{N(R)C(CH3)CHC(O)R'}]- (M=Pd or Pt; R=o-MeC6H4 or p-MeC6H4; R'=Me or Ph), respectively. The complexes have been characterized by partial elemental analyses, conductance measurements and spectroscopic (i.r. and 1H and 19F- n.m.r.) methods.
    Transition Metal Chemistry 10/1997; 22(5):502-506. DOI:10.1023/A:1018571531737 · 1.40 Impact Factor