Matti Korppi

University of Tampere, Tammerfors, Province of Western Finland, Finland

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Publications (185)441.97 Total impact

  • [Show abstract] [Hide abstract]
    ABSTRACT: AimThe Finnish national allergy programme was introduced in 2008 to decrease the burden of allergy in the population. This study, carried out in 2013, evaluated the prevalence of parent-reported food allergies, treated with an avoidance diet until early school age, and discussed the rates in relation to those found in an identical study in 2009.Methods School health nurses used a structured questionnaire to interview the parents of 1,653 children aged of six or seven in the first year of elementary school. The criterion for a parent-reported food allergy was that the parents considered it necessary for their child to follow an avoidance diet at school.ResultsIn 2013, 6.1% of the children were allergic to at least one food and 2.5% of the children were allergic to basic foods, such as cows’ milk, eggs and wheat, compared to 2.7% in 2009. A significant decrease was seen in allergies to nuts, fruits and vegetables.Conclusion Parent-reported allergies to basic foods, such as cow's milk, eggs and wheat, remained rather stable in first-graders of elementary schools during the first five years of the Finnish national allergy programme, but allergies to nuts, fruits and vegetables decreased.This article is protected by copyright. All rights reserved.
    Acta Paediatrica 09/2014; · 1.97 Impact Factor
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    ABSTRACT: To determine whether hospital length-of-stay (LOS) for bronchiolitis is influenced by the causative virus: respiratory syncytial virus (RSV) or rhinovirus.
    The Pediatric Infectious Disease Journal 08/2014; 33(8):829-834. · 3.57 Impact Factor
  • Matti Korppi
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    ABSTRACT: Bronchiolitis is a viral lower respiratory tract infection characterised by inflammation and obstruction of the small airways. Respiratory syncytial virus (RSV) is the most common causative agent, followed by parainfluenza viruses, adenoviruses and the recently discovered metapneumovirus. Birth cohort studies have reported that the incidence of bronchiolitis is 18–32% during the first year of life, and 1–3% of infants need hospitalisation for bronchiolitis, with the majority being admitted before six-months-of-age (1).This article is protected by copyright. All rights reserved.
    Acta Paediatrica 07/2014; · 1.97 Impact Factor
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    ABSTRACT: Background and AimsObesity has been linked with asthma symptoms, need for asthma treatment and reduced lung function but not with increased bronchial reactivity in children. The aim of this study was to evaluate the association between previous or current weight status and current lung function and bronchial reactivity to exercise at early school age.Methods Ninety-nine children hospitalized for bronchiolitis at the age of less than 6 months were studied with impulse oscillometry (IOS) at the mean age of 6.3 years. Data on birth weight and weight gain in infancy before hospitalization were collected during hospitalization. Current weight and height data were transformed into age- and sex-specific height-related body mass index z scores (zBMI) using the Finnish national population-based weight and height data as reference.ResultsSome significant though only low or modest correlations were found between current zBMI and baseline, post-exercise and post-bronchodilator IOS values in adjusted linear regression analysis. Seven obese children by zBMI had higher post-bronchodilator airway impedance (Zrs) and resistance (Rrs) at 5 Hz and lower post-bronchodilator frequency dependency of resistance (dRrs/df) than normal weight children. There were no significant differences in responses to exercise or to bronchodilators between currently obese or overweight children and normal weight children. Birth weight less than 3,000 g was associated with larger exercise-induced changes in Zrs and Rrs at 5 Hz, and in reactance (Xrs) at 5 Hz, than those with birth weight more than 3,000 g.Conclusions Preliminary evidence was found that obesity may be associated with airway obstruction, but not with bronchial hyper-reactivity. Pediatr Pulmonol. © 2014 Wiley Periodicals, Inc.
    Pediatric Pulmonology 07/2014; · 2.38 Impact Factor
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    ABSTRACT: All respiratory viruses are capable of causing lower respiratory tract infections. Active testing of influenza viruses during influenza epidemics is recommended. Antitussive medications are ineffective and should not be used. Croup presenting with inspiratory stridor is recommended to be treated with oral corticosteroids and inhaled racemic adrenalin. Corticosteroids and inhaled racemic adrenalin are ineffective for the treatment of bronchiolitis. Inhaled salbutamol administered by a spacer (with a mask) is recommended for wheezy bronchitis. Amoxicillin is recommended for treating pneumonia at home and intravenous penicillin in hospital (combined with macrolide if mycoplasma is suspected). Pertussis is treated with azithromycin or clarithromycin.
    The Finnish Medical Society Duodecim. 06/2014;
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    Matti Korppi
    Acta Paediatrica 05/2014; · 1.97 Impact Factor
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    ABSTRACT: Elevated white blood cells (WBC) in blood and C-reactive protein (CRP) in serum are often used as nonspecific markers for bacterial etiology of infection in children. The aim of the present study was to evaluate how rapid WBC and CRP testing influences the patient flow and costs in the pediatric emergency room (ER). The study was a retrospective chart review. In all, 166 children who were treated during three months in the ER of a children's hospital, and in whom rapid tests for WBC and CRP were done, were included. The association between rapid testing and the length of ER stay was evaluated, and the costs of rapid tests were compared with corresponding costs if done in hospital laboratory. The median ER stay lasted 147.5 min, if no other examinations than rapid CRP and WBC tests were taken and if no emergency treatments were given, compared with 201.5 min in those with other laboratory tests obtained or emergency treatments given (p<0.001). The respective figures were 142.5 and 179.5 min in those 96 children discharged home (p=0.003). The costs of rapid testing were only 41.5 % of the corresponding costs in laboratory. The simultaneous rapid testing of CRP and WBC in children with presumable infection decreased the costs and shortened the length of ER stay, if no other examinations or emergency treatment were needed. The costs of rapid testing were less than half of the corresponding costs in laboratory.
    Pediatrics International 04/2014; · 0.88 Impact Factor
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    ABSTRACT: Background The relationship between excess weight gain and asthma in childhood remains inadequately defined. The aim of this study was to evaluate, as part of a prospective post-bronchiolitis follow-up, whether there is a link between earlier or current overweight or obesity and asthma or asthma symptoms at 5–7 years of age.Methods In all, 151 former bronchiolitis patients were followed-up until the mean age of 6.45 years. At the control visit, the weights and heights were measured, and the asthma symptoms and medications for asthma were recorded. The weight status was expressed as body mass index (BMI) z-scores (zBMI).ResultsThere were 10 obese and 31 overweight (zBMI over national references) children. In adjusted analyses, presence of current asthma at 6–7 years of age (aOR 3.05, 95% CI 1.02–9.93) differed between overweight and normal weight children. Further, asthma ever, asthma at age 4–5 years, asthma at age 5–6 years, use of bronchodilators ever and use of ICSs during the last 12 months were more common in currently overweight than in normal weight children. Obesity was associated only with current asthma and asthma ever. Instead, there were no significant associations between birth weight, excess weight gain in infancy, or overweight at age 1.5 years, and later asthma, asthma symptoms or use of asthma medication.Conclusion Asthma was more common in currently overweight than in normal weight former bronchiolitis patients at preschool age and early school age. Pediatr Pulmonol. © 2014 Wiley Periodicals, Inc.
    Pediatric Pulmonology 04/2014; · 2.38 Impact Factor
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    ABSTRACT: AimThere is no widely accepted consensus on the diagnosis and treatment of bronchiolitis. This study describes current practices in Finnish and Swedish hospitals.MethodsA questionnaire on the diagnosis and treatment of bronchiolitis in children below two-years-of-age was sent to all Finnish and Swedish hospitals providing in-patient care for children. All 22 Finnish hospitals answered, covering 100% of the < 12-month-old population and 21 of the 37 Swedish hospitals responded, covering 74%.ResultsThe mean upper age limit for bronchiolitis was 12.7 months in Finnish hospitals and 12.5 months in Swedish hospitals. In both, laboured breathing, chest retractions and fine crackles were highlighted as the main clinical findings, followed by prolonged expiration. The mean value for the lowest acceptable saturation in room air was 94% in Finnish hospitals and 93% in Swedish hospitals. The most important factors influencing hospitalisation were young age, desaturation and inability to take oral fluids. Finnish doctors preferred intravenous routes and Swedish doctors preferred nasogastric tubes for supplementary feeding. The first-line drug therapy was inhaled racemic adrenaline in Finland and inhaled levo-adrenaline in Sweden.Conclusion The diagnosis and treatment of bronchiolitis is fairly similar in Finnish and Swedish hospitals.This article is protected by copyright. All rights reserved.
    Acta Paediatrica 04/2014; · 1.97 Impact Factor
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    ABSTRACT: AimTo evaluate the association between hospitalisation for respiratory syncytial virus lower respiratory tract infection (RSV LRTI) in infancy and asthma, respiratory health-related quality of life and lung function at 28 to 31-years-of-age.Methods In 2010, we carried out a 30-year follow up on 43 adults admitted to Kuopio University Hospital, Finland, for RSV LRTI, 27 for bronchiolitis and 16 for pneumonia, between 1981 and 1982. Together with 86 population-based controls, they completed the Saint George's Respiratory Questionnaire and underwent pre-bronchodilator (pre-BD) and post-BD spirometry tests to measure percentage of predicted forced vital capacity (FVC%), percentage of predicted forced expiratory volume in 1 second (FEV1%) and percentage of predicted FEV1/FVC (FEV1/FVC%).ResultsBoth the pre-BD and post-BD FEV1% and FEV1/FVC% were significantly lower in former RSV LRTI patients than in the controls. The bronchiolitis patients had more asthma in adulthood than the controls and pneumonia in infancy was associated with lower SGRQ scores.ConclusionRSV LRTI hospitalisation in infancy was associated with an increased risk of permanent obstructive lung function reduction in adulthood. The asthma risk was higher after hospitalisation for bronchiolitis, than in the controls, and respiratory health-related quality of life was lower after hospitalisation for pneumonia.This article is protected by copyright. All rights reserved.
    Acta Paediatrica 04/2014; · 1.97 Impact Factor
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    ABSTRACT: Viral bronchiolitis in infancy has been associated with increased bronchial reactivity and reduced lung function in later childhood and even in adulthood. However, lung function at preschool age is less studied, mainly due to technical difficulties. The purpose of the study was to evaluate lung function and bronchial reactivity at preschool age in children who were hospitalized for bronchiolitis in early infancy. Airway resistance and reactance, and bronchial reactivity to exercise were studied with impulse oscillometry (IOS) at the mean age of 6.3 years in 103 children hospitalized for bronchiolitis at less than 6 months of age. In baseline lung-function measurement, resistance (n = 8; 7.8%) or reactance (19; 18.4%) at 5 Hz were pathological in 20% of children compared to Finnish population-based height-adjusted reference values. Increased bronchial reactivity by exercise challenge (5; 4.9%) or bronchodilatation (11; 10.7%) tests was present in 16%. Irreversible changes were revealed in only one case. Though reduced lung function and increased airway reactivity were rather common, evidence for persistent lung function reduction was rare, less than 1%, at preschool age in children hospitalized for bronchiolitis caused mainly by respiratory syncytial virus at age less than 6 months. Pediatr Pulmonol. © 2014 Wiley Periodicals, Inc.
    Pediatric Pulmonology 03/2014; · 2.38 Impact Factor
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    ABSTRACT: Airway inflammation is involved in the pathogenesis of bronchopulmonary dysplasia (BPD). The aim of the study was to evaluate the inflammatory activity in plasma and exhaled air in very low birth weight (VLBW) BPD survivors at school age. Twenty-one 6-14-year-old former VLBW (birth weight ≤1,500 g) children with severe radiographic BPD (radBPD), 19 without radBPD (nonBPD group) and 19 non-asthmatic term controls underwent measurement of eosinophil cationic protein, IL-6, IL-8, adiponectin, adipsin, leptin, and resistin in plasma, leukotriene B4 and 8-isoprostane in exhaled breath condensate, and NO in exhaled breath. Background data were obtained from patient records, clinical examination and parental questionnaire. Both univariate and multivariate models were applied in the statistical analysis. There were no significant differences between the groups in any of the inflammatory markers measured. Five (25%) radBPD and 2 (11%) nonBPD children reported asthma (P = 0.058). In logistic regression analysis, exposure to chorioamnionitis was associated with low IL-8 (OR 29.0, 95% CI 3.27-258) and postnatal corticosteroid therapy with high adiponectin (OR 32.0, 95% CI 1.29-793). High body mass index standard deviation score (BMI-SDS) was associated with high plasma adipsin (OR 2.47, 95% CI 1.07-5.75) and leptin (OR 5.76, 95%CI 1.83-18.2) levels. The inflammatory activity seems to decrease by school age in VLBW BPD survivors. Chorioamnionitis and postnatal corticosteroid treatment may modulate the inflammatory responsiveness in VLBW subjects even up to school age. The respiratory outcome in VLBW infants might be improved by preventing excessive weight gain. Pediatr Pulmonol. © 2014 Wiley Periodicals, Inc.
    Pediatric Pulmonology 03/2014; · 2.38 Impact Factor
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    ABSTRACT: AimCorticosteroids have harmful dose-dependent effects on bone metabolism and growth. This study used a new method for volumetric measurements to evaluate the association between inhaled corticosteroids (ICS) for asthma and bone mineral density (BMD) in school-aged children. Methods We evaluated children hospitalised for wheezing at the age of <24 months at 12.3 years (median). Volumetric BMD (vBMD) was measured using peripheral quantitative computed tomography (pQCT) from the distal tibia and radius in 82 children. Data on ICSs used were collected from hospital records and parent interviews. Cumulative doses and the duration of ICS therapy were calculated. ResultsGirls had higher total and cortical vBMD in the tibia than boys. Pubertal children had higher total and cortical vBMD in the radius than pre-pubertal children. Higher cumulative doses of ICSs were associated with lower total (r= -0.175, adjusted p= 0.016), cortical (r= -0.138, adjusted p= 0.016) and trabecular (r= -0.156, adjusted p= 0.039) vBMD in the radius, but not in the tibia. Age, weight, or the cumulative dose of systemic corticosteroids had no significant associations with vBMD. Conclusion Although correlations between cumulative ICS doses and vBMD were weak, ICS use during childhood may reduce BMD in the radius at school age.This article is protected by copyright. All rights reserved.
    Acta Paediatrica 02/2014; · 1.97 Impact Factor
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    ABSTRACT: Toll-like receptors (TLR´s) are a pivotal part of the innate immunity system. Variations in TLR genes have been connected to autoimmune conditions, such as allergy and asthma. The TLR2 subfamily comprises TLR1, TLR2, TLR6 and TLR 10. We hypothesized that polymorphism of the TLR2 subfamily may be associated with prevalence of post-bronchiolitic asthma and/or atopy. TLR1rs5743618, TLR2rs5743708 and TLR6rs5743810 SNP´s of 133 children who had been hospitalized for bronchiolitis at <6months of age were analyzed. Doctor-diagnosed asthma and atopy as well as their occurrence during the first six years of life were evaluated during a follow-up visit. At the mean age of 6.4 years, asthma was present in 17 (13%) patients, there was asthma diagnosis during the first six years of life in 39 (29%) and current doctor-diagnosed allergic rhinitis in 57 (43%) patients. Twenty four (24%) children with G/G genotype in TLR1 rs5743618 were diagnosed to have asthma between 1-6 years of age (vs. 13(38%) of those with G/T or T/T genotypes; p=0.04). In addition, 11/60 children (18%) with TLR6 rs5743810 C/T vs. 36/73(49%) of other genotypes had atopic eczema at follow-up. Only two children (8%) with wild genotype in all investigated SNP´s had asthma during the first six years of life (vs. 30% in those with variant genotype of TLR1, TLR2 and/or TLR6). In this study we demonstrated that TLR1 rs5743618 was associated with asthma and atopic eczema during the first six years of life after early bronchiolitis. In addition, TLR6 rs5743810 was associated with present atopy at preschool age.
    The Pediatric Infectious Disease Journal 01/2014; · 3.57 Impact Factor
  • Pediatric emergency care 01/2014; 30(1):86. · 0.92 Impact Factor
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    ABSTRACT: The aim of the study was to evaluate the association between previous use of ICS and bone mineral density (BMD) at school age in a cohort followed after early childhood wheezing. As part of a prospective follow-up study after hospitalization for wheezing at <24 months of age, BMD was measured in 89 children at 12.3 (median) years of age. Data on ICS use were collected by interviewing the parents, and this was supplemented with data from patient records. Cumulative doses and the duration of ICS use were calculated. Areal BMD (BMDareal , g/cm(2) ) was measured by dual energy X-ray absorptiometry (DXA), and apparent volumetric BMD (aBMDvol , g/cm(3) ) was calculated, for the lumbar spine and femoral neck. Weight, height and pubertal stage were recorded. Age, sex, and pubertal stage were significantly associated with BMDareal and aBMDvol of the lumbar spine and BMDareal of the femoral neck. The regular use of ICS for >6 months at age <6 years was associated with a lower BMD of the lumbar spine. A lower BMDareal and aBMDvol of the femoral neck were associated with higher cumulative doses of ICS at age 0-12.3 (median) years. The results were robust to adjustment for age, sex, pubertal stage, height, weight, and use of systemic steroids. ICS use during childhood may be related to a decrease in BMD at late school age. It is important to use the lowest possible ICS dose that maintains adequate asthma control. Pediatr Pulmonol. © 2013 Wiley Periodicals, Inc.
    Pediatric Pulmonology 12/2013; · 2.38 Impact Factor
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    ABSTRACT: Lower respiratory infections in infancy may be associated with lung function deficits in adulthood. Our aim was to evaluate lung function, with a special focus on irreversible airway obstruction, thirty years after bronchiolitis or pneumonia in infancy. In 1981-1982, 83 children under two years of age were hospitalized for bronchiolitis and 44 for pneumonia at Kuopio University Hospital, Finland. In 2010, 47 bronchiolitis patients, 22 pneumonia patients and 138 controls attended the study, including spirometry before (pre-BD) and after bronchodilatation (post-BD). The measured indices were forced vital capacity (FVC) and forced expiratory volume in one second (FEV1), that were presented as % of predicted value (FVC% and FEV1%). FEV1/FVC was presented as both absolute FVC/FEV1-ratio and % of predicted (FEV1/FVC%). Irreversible airway obstruction was defined as post-BD FEV1/FVC% below 88% of predicted (FEV1/FVC% <88%) according to Finnish reference values or FEV1/FVC-ratio below fifth percentile (FEV1/FVC <5th percentile), according to Global Lung Function Initiative reference values. All lung function indices were lower in former bronchiolitis patients and pre- and post-BD FEV1% in pneumonia patients, compared to controls. 21% of bronchiolitis (OR, 95%CI; 5.59, 1.72-18.21) and 9% of pneumonia patients (2.24, 0.34-13.56) had FEV1/FVC% <88% compared to controls (4%). Likewise 7 (15%) of bronchiolitis (7.07, 1.33-37.22) and 1 (5%) of pneumonia patients (1.73, 0.12-24.77) had FEV1/FVC <5th percentile compared to controls 2 (1%). Evidence of reduced lung function was present 30 years after hospitalization for bronchiolitis or pneumonia in infancy. Irreversible airway obstruction after severe bronchiolitis in infancy suggests permanent, structural alterations in airways.
    Respiratory medicine 12/2013; · 2.33 Impact Factor
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    ABSTRACT: AimThe aim of this study was to evaluate whether mannose-binding lectin (MBL) plays a role in the development of osteitis after Bacillus Calmette–Guerin (BCG) vaccination as a newborn. Methods Blood samples were obtained from 132 former BCG osteitis patients, now aged 21–49 years, and analysed for MBL concentration and MBL2 genotype in a controlled setting. ResultsVariant genotypes in the MBL2 gene were more common in the former BCG osteitis patients (42.4%) than in the population controls (32.3%, p = 0.033). However, MBL concentrations at the age of 21–49 years were not lower in these patients than in the controls in the same age group. The variant MBL2 genotypes were associated with low serum MBL concentrations, and moreover, MBL concentration was not measurable in two of those three patients who were homozygous for the variant MBL2 genotype. Low serum MBL concentrations were not associated with any illnesses in the medical history of the BCG patients, their siblings or children. Conclusion Preliminary evidence was found that variant, low-MBL-producing genotypes may be associated with the increased risk of BCG osteitis in vaccinated newborns.
    Acta Paediatrica 11/2013; 102(11). · 1.97 Impact Factor
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    ABSTRACT: Viral bronchiolitis is a major cause of hospitalization in infancy, with increased asthma risk in later childhood. However, the principal mechanisms behind post-bronchiolitic asthma have remained unclear. Previously, different cytokine polymorphisms have been associated with asthma occurrence, but no previous follow-up study has investigated cytokine polymorphisms in relation to post-bronchiolitic asthma. We hypothesized that former bronchiolitis patients with cytokine gene variants associating with Th2 cell up-regulation are at asthma risk at preschool age. Our emphasis was in IL10 rs1800896, since IL-10 has an important role in immune tolerance, and lower production of IL-10 has been associated with Th2-type immunology, and accordingly, with increased asthma risk. IL10 rs1800896, IFNG rs2430561, and IL18 rs1872387 polymorphims and their associations with asthma and allergy were studied in 135 preschool-aged children hospitalized for bronchiolitis at age 0-6 months. Parents were interviewed to record asthma and allergy from infancy to present. At age 6.4 years (mean), asthma was present in 17(12.6%), atopic eczema in 47(34.8%) and allergic rhinitis in 36(26.7%) children. IL10 rs1800896 SNP associated significantly with asthma; only 1/32 (3.1%) of those with G/G genotype had asthma (P = 0.04). In logistic regression adjusted for gender, age and atopy, the carriage of allele A (rs1800896) was a significant risk factor for preschool asthma. IFNG rs2430561 or IL18 rs1872387 SNP's had no associations with asthma or allergy. In conclusion, IL10 rs1800896 SNP was significantly associated with preschool asthma after severe lower respiratory tract infection in early infancy. Pediatr Pulmonol. © 2013 Wiley Periodicals, Inc.
    Pediatric Pulmonology 10/2013; · 2.38 Impact Factor
  • Matti Korppi
    Pediatric Pulmonology 10/2013; · 2.38 Impact Factor

Publication Stats

2k Citations
441.97 Total Impact Points

Institutions

  • 2007–2014
    • University of Tampere
      • Paediatric Research Centre
      Tammerfors, Province of Western Finland, Finland
    • Tampere University Hospital (TAUH)
      Tammerfors, Province of Western Finland, Finland
  • 2011–2013
    • Seinäjoki Central Hospital
      Seinäjoki, Province of Western Finland, Finland
    • Turku University Hospital
      • Department of Pediatrics
      Turku, Western Finland, Finland
  • 2010–2013
    • University of Eastern Finland
      • School of Medicine
      Kuopio, Eastern Finland Province, Finland
  • 2012
    • National Institute for Health and Welfare, Finland
      • Department of Infectious Disease Surveillance and Control
      Helsinki, Southern Finland Province, Finland
  • 1998–2012
    • Kuopio University Hospital
      • Department of Paediatrics
      Kuopio, Province of Eastern Finland, Finland
  • 2005–2011
    • University of Udine
      Udine, Friuli Venezia Giulia, Italy
  • 2003–2009
    • University of Kuopio
      • Department of Paediatrics
      Kuopio, Eastern Finland Province, Finland
  • 2003–2006
    • National Public Health Institute
      Helsinki, Southern Finland Province, Finland