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ABSTRACT: IMPORTANCE To our knowledge, this is the first study to describe the correlation of anterior chamber bleeding after laser peripheral iridotomy (LPI) and antiplatelet therapy. OBJECTIVE To determine the incidence and amount of anterior chamber bleeding after laser peripheral iridotomy in patients whose condition is suggestive of primary angle-closure glaucoma (PACS) who continued their antiplatelet or anticoagulant treatment before undergoing LPI compared with when they discontinued treatment. DESIGN AND SETTING A prospective controlled trial. PATIENTS Patients with suspected bilateral primary angle-closure and no other ocular disease who take antiplatelet or anticoagulant medications regularly (from January 2010-October 2011) were enrolled. MAIN OUTCOME AND MEASURE The incidence of anterior chamber bleeding with and without antiplatelet and anticoagulant therapy. RESULTS A total of 104 patients (208 eyes) participated in the study. Thirty-six eyes (34.6%) in the treated and untreated arms bled. The amount of bleeding did not differ significantly when the patient was on or off antiplatelet or anticoagulant treatment, nor did the immediate postprocedure mean intraocular pressure (P = .13). The type of antiplatelet or anticoagulant, total laser energy, age, sex, or color of irides were not risk factors for increased bleeding (P = .156 for all parameters). CONCLUSIONS No indication was noted for discontinuing these medications before a high-powered pulsed laser peripheral iridotomy.
JAMA ophthalmology. 03/2013;
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ABSTRACT: An 86-year-old patient developed a significant intraocular inflammatory reaction after having phacoemulsification. Topical therapy did not eliminate the inflammation, and tissue plasminogen activator (tPA) was injected into the anterior chamber. A white corneal plaque appeared in the previously clear cornea within days of the injection. The lesion was diagnosed as calcific band keratopathy and successfully treated with ethylenediaminetetraacetic acid chelation. Electron microscopy and elemental analysis of a corneal scraping from the lesion established its composition to be mainly calcium and phosphate, validating the diagnosis. This is the seventh reported case of rapid formation of calcific band keratopathy after tPA injection. The pathogenesis of this rare complication involves multiple factors, including alkalinization of the intraocular pH, increased phosphate concentration, and endothelial dysfunction. FINANCIAL DISCLOSURE: No author has a financial or proprietary interest in any material or method mentioned.
Journal of cataract and refractive surgery 02/2013; 39(2):292-294. · 2.75 Impact Factor
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ABSTRACT: Myopic photorefractive surgery induces a reduction in central corneal thickness, which may lead to underestimation of intraocular pressure. This retrospective clinical study compared intraocular pressure measurements obtained by Goldmann applanation tonometry (GAT) and dynamic contour tonometry (DCT-Pascal) in eyes undergoing myopic intralaser-assisted in situ keratomileusis (IntraLASIK) or laser-assisted subepithelial keratomileusis (LASEK).
Of a total of 51 eyes, 21 underwent LASEK and 30 underwent IntraLASIK. By GAT, mean preoperative intraocular pressure was 16.2 ± 1.99 mmHg and postoperatively was 10.84 ± 1.45 mmHg. By DCT, mean preoperative intraocular pressure was 15.9 ± 2.08 mmHg and postoperatively was 16.1 ± 2.3 mmHg. Both preoperative and postoperative differences between measurements made by GAT and DCT were found to be statistically significant (P < 0.04 and P < 0.01, respectively). GAT and DCT readings were unaffected by type of surgery (P = 0.74 and P = 0.46, respectively).
Postoperative GAT measurements were lower than those obtained by DCT. The difference between preoperative and postoperative DCT measurements was minimal, so DCT may be preferable for the measurement of intraocular pressure in eyes undergoing myopic IntraLASIK or LASEK.
Clinical Ophthalmology 01/2012; 6:1967-70.
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ABSTRACT: This study evaluated and compared the efficacy of selective laser trabeculoplasty (SLT) and argon laser trabeculoplasty (ALT) in terms of intraocular pressure (IOP)-lowering effects in pseudophakic patients at various time points after treatment. The primary aim was to compare the efficacy of SLT and ALT in reducing the IOP of pseudophakic glaucoma patients who recently underwent successful cataract extraction surgery. The secondary endpoint was to determine the percentage of SLT and ALT patients whose IOP was successfully reduced by at least 15% from baseline.
This study was a follow-up of a prospective randomized clinical trial. Fifty-two eyes from 52 glaucoma patients with uncontrolled IOP who had previously undergone successful phacoemulsification-assisted cataract excision surgery with intracapsular lens implantation were randomly assigned to treatment with either ALT (n = 30) or SLT (n = 22). Fifteen patients were excluded due to adverse events encountered during the study, leaving a total of 18 and 19 patients in the ALT and SLT groups, respectively. IOP measurements were carried out at scheduled intervals until 12 months post-laser treatment.
There were no significant differences in the IOP-lowering effects between the two methods at any time point during the follow-up period. The greatest differences between the two groups were observed at 1 week posttreatment and at the 3-month time point, but neither reached a level of significance. At the final checkup, the mean IOP reduction from baseline was 3.23 mmHg in the ALT group and 4.30 mmHg in the SLT group (P = 0.269). At that visit, six (35.3%) patients in the ALT group and 15 (75%) patients in the SLT group had a reduction of ≥15% from their baseline IOP.
SLT and ALT are equally effective in their IOP-lowering capabilities in new pseudophakic glaucoma patients during the first 12 months after treatment.
Clinical Ophthalmology 01/2012; 6:1935-40.
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ABSTRACT: To evaluate the safety and efficacy in intraocular pressure (IOP) reduction of increasing Cosopt dosage from twice to three times a day.
The study included patients with primary open-angle glaucoma or ocular hypertension. After a washout period, IOP was measured at baseline, after 4 weeks of treatment with Cosopt twice a day, and after another 4 weeks of treatment with Cosopt three times a day. Blood pressure, heart rate, and oxygen saturation levels were also recorded.
Twenty-nine eyes of 29 patients were included. Increasing Cosopt dosage resulted in a statistically significant (P < 0.001) additional reduction in IOP of 2.2 ± 1.58 mmHg (10.69% ± 7.49% of the baseline IOP values). There were no local or systemic adverse effects.
Treatment with Cosopt three times a day was more effective in reducing IOP than twice a day, with no effect on safety.
Clinical Ophthalmology 01/2012; 6:283-7.
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ABSTRACT: To evaluate the effect of brimonidine tartrate 0.10% ophthalmic solution on pupil diameter under light and dark luminance conditions.
Ophthalmology Department, Tel Aviv Medical Center, Tel Aviv, Israel.
Case series.
The pupil diameter was measured with a Colvard pupillometer in eyes of healthy volunteers under light (5.0 candelas [cd]/m(2)) and dark (0.0 cd/m(2)) luminance conditions before brimonidine 0.10% instillation and after 30 minutes, 3 hours, and 6 hours.
The mean age of the 26 volunteers (52 eyes) was 34.73 years (range 19 to 60 years). Under light conditions, the mean pupil diameter was 4.98 mm ± 0.83 (SD) before instillation of brimonidine 0.10% and 4.64 ± 0.82 mm after instillation. The difference was not statistically significant, with 13.4% of eyes having a clinically significant reduction (>1.0 mm) in pupil diameter after 6 hours. Under dark conditions, the mean pupil diameter was 6.76 ± 1.08 mm before instillation of brimonidine 0.10% and 5.30 ± 0.85 mm after instillation; the difference was statistically significant (P<.001). There was a clinically significant reduction in pupil diameter after 6 hours in 90.4% of eyes. The antimydriatic effect under dark luminance conditions was more pronounced in eyes with light irides.
Brimonidine 0.10% ophthalmic solution had an antimydriatic effect under dark luminance conditions and had a negligible effect on pupil diameter under light luminance conditions. The effect was similar to that reported in studies using higher concentrations of brimonidine.
Journal of cataract and refractive surgery 03/2011; 37(3):486-9. · 2.75 Impact Factor
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ABSTRACT: to compare the reproducibility of three portable instruments-the Tono-Pen tonometer (Reichert Ophthalmic Instruments, Depew, NY), the Phosphene tonometer (Bausch & Lomb, Rochester, NY), and the TERT (Through Eyelid Russian Tonometer; Rjazan State Instrument Making, Rjazan, Russia)-in the measurement of intraocular pressure (IOP) with and without soft contact lenses and in different head positions.
twenty-six eyes of healthy volunteers were examined by the three instruments while the subjects were sitting, recumbent, and hyperextending their heads, and with and without contact lenses. IOP measurements were compared and the effects of head position and presence of contact lenses on the resultant values were analyzed.
the average difference between the recumbent and sitting positions was 3.56, 2.68, and 2.62 mm Hg for the Tono-Pen tonometer, Phosphene tonometer, and TERT, respectively. There was an increase of 5.60, 2.78, and 2.63 mm Hg in hyperextension compared to sitting for the Tono-Pen tonometer, Phosphene tonometer, and TERT, respectively. The difference in the IOP values obtained in the presence and absence of therapeutic contact lens for the three instruments in the three positions was between -1.23 and +1.47 mm Hg.
IOP measurements of bedridden patients are only slightly higher than those of sitting patients except for the Tono-Pen tonometer in the hyperextension position. The presence of contact lenses does not affect IOP values obtained by the three evaluated instruments.
Ophthalmic Surgery Lasers and Imaging 01/2011; 42(1):64-71. · 0.62 Impact Factor
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ABSTRACT: This study aimed to compare intraocular pressure (IOP) measurements obtained by the transpalpebral tonometer TGDc-01 and by the Goldmann applanation tonometer (GAT).
IOP was measured by the conventional GAT and the TGDc-01 tonometer. Central corneal thickness (CCT) was measured for all eyes.
Sixty-seven consecutive patients (123 eyes) participated. The mean difference between the 2 techniques (TGDc-01-GAT) was -0.93 mmHg, SD=2.74 (p=0.0002, paired t-test), and 70% of the measurements were within +/-2 mmHg. The correlation coefficient was 0.67 (p<0.0001). A subgroup analysis according to CCT was conducted. For CCT <520 microm, the mean IOP difference was 0.67 mmHg (p=0.13); r=0.75 (p<0.001). For CCT 520 microm-580 microm, the mean IOP difference was -1.08 mmHg (p=0.001); r=0.69 (p<0.0001). For CCT>580 microm, the mean IOP difference was -2.29 mmHg (p=0.0003); r=0.57 (p=0.003).
TGDc-01 may estimate IOP with a fair agreement to the Goldmann tonometer, although caution should be used for patients who require precise IOP measurements. TGDc-01 measured higher IOPs than Goldman tonometry for thinner corneas, a trend that was reversed for thicker corneas. This tonometer is a portable device, easy to use, does not require anesthetic drops, and may be suitable for IOP screening.
European journal of ophthalmology 03/2010; 20(5):902-6. · 0.96 Impact Factor
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ABSTRACT: The aim of this study was to compare intraocular pressure (IOP) measurements obtained by Goldmann tonometry (GT), the Tonopen XL, and a new transpalpebral tonometer, TGDc-01, in eyes that had undergone penetrating keratoplasty (PKP).
IOP was measured in post-PKP eyes by means of GT, Tonopen XL, and TGDc-01. Central corneal thickness measurements were also obtained for all eyes.
Forty-five eyes of 43 patients were enrolled in the study. The mean IOP difference (+/-SD) was -0.42 +/- 5.83 mm Hg between GT and Tonopen and 3.20 +/- 7.55 mm Hg between GT and TGDc-01. The correlation coefficient was 0.84 between GT and Tonopen XL (P < 0.001) and 0.71 between GT and TGDc-01 (P < 0.001). Overall 2-way analysis of variance between the means showed no significant differences between the 3 devices (P = 0.077).
A closer agreement was found between GT and Tonopen XL in post-PKP eyes. TGDc-01 yielded lower IOP readings than the other 2 devices. It remains uncertain whether this new transpalpebral tonometer is simply inaccurate or whether avoiding contact with the corneal graft by measuring IOP through the eyelid enables it to provide more accurate IOP readings than those obtained by transcorneal techniques.
Cornea 08/2009; 28(7):724-7. · 1.73 Impact Factor
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ABSTRACT: To compare pressure phosphene tonometry with Goldmann applanation tonometry for measuring intraocular pressure (IOP) before and after LASIK.
Forty-three (18 men and 25 women) consecutive healthy patients underwent complete pre- and postoperative LASIK ophthalmologic assessments including manifest and cycloplegic refraction, keratometry, and central corneal thickness. Three repetitive sets of pressure phosphene tonometry and Goldmann applanation tonometry measurements were performed the day before and 3 months following uneventful LASIK.
Mean preoperative spherical equivalent refraction was -4.70 +/- 2.50 diopters (D) (range: -1.50 to -12.90 D) and mean preoperative keratometry was 43.95 +/- 1.08 D. After LASIK, spherical equivalent refraction was +0.23 +/- 0.11 D and mean keratometry was 39.46 +/- 2.28 D. Preoperative pressure phosphene tonometry (12.16 +/- 1.58 mmHg) and Goldmann applanation tonometry (12.01 +/- 1.55 mmHg) IOP measurements were similar. Postoperative IOP was 10.30 +/- 1.16 mmHg with Goldmann applanation tonometry and 12.20 +/- 1.62 mmHg with pressure phosphene tonometry. The postoperative IOP difference between Goldmann applanation tonometry and pressure phosphene tonometry was 0.15 +/- 1.12 mmHg (P = .41). The mean change in pachymetry after LASIK was 68.73 +/- 73 microm. The change in Goldmann applanation between preoperative and postoperative LASIK values was 1.71 +/- 1.43 mmHg (P < .0001), a change that was strongly correlated with changes in corneal thickness (R = 0.75, P < .0001) and keratometry (R = 0.72, P < .0001). No such correlations were found with pressure phosphene tonometry.
Goldmann applanation tonometry-measured IOP decrease after LASIK is strongly correlated with a decrease in central corneal thickness and changes in keratometry, whereas pressure phosphene tonometry-measured IOP is independent of corneal thickness. Pressure phosphene tonometry appears to be a more reliable method for recording tonometry in these patients.
Journal of refractive surgery (Thorofare, N.J.: 1995) 04/2007; 23(4):405-9. · 2.54 Impact Factor
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ABSTRACT: To determine C-reactive protein (CRP) levels in patients with normal tension glaucoma (NTG).
This study included 20 cases with NTG and 30 controls, with no history of ocular disease. Plasma CRP levels of all the study participants were determined using a highly sensitive CRP kit.
Twenty cases (11 males, 9 females, mean age 69 +/- 5 years) with NTG and 30 age-matched controls (15 males, 15 females, mean age 68 +/- 6) were evaluated. Both groups had similar demographic parameters (age, sex, BMI). Plasma CRP levels were significantly higher in the NTG cases than in controls (median [range], 3.20 [0.17-8.4] mg/dL compared with 0.5 [0.1-3.2], P < 0.001). The mean plasma CRP level was significantly elevated in the NTG cases compared with the controls (3.21 +/- 0.6 mg/dL and 0.85 +/- 0.17 mg/dL, respectively, P < 0 0.01).
Our findings suggest that higher CRP levels may be associated with NTG. It is possible that a vascular inflammatory process is involved in the etiology of this glaucoma.
Journal of Glaucoma 11/2005; 14(5):384-6. · 1.78 Impact Factor
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ABSTRACT: We evaluated the efficacy and safety of latanoprost eye drops once-weekly, compared to once-daily for improving patient compliance. Twenty (20) patients (11 women and 9 men), 12 with ocular hypertension and 8 with early glaucoma, were studied after washout of the antiglaucoma treatment. One (1) group was treated with latanoprost once-daily (control). The other group was treated once-weekly (study group). Intraocular pressure (IOP) was measured at baseline and on the 2nd, 4th, 6th, and 9th day after the last drop in the study group, and for 3 months on the same schedule thereafter. The mean baseline IOP was 24.3 +/- 3.9 mmHg in the study group (range, 18-29) and 24.4 +/- 4.4 mmHg in the control group (range, 17-32). The average IOP at all time points of post-treatment was 17.7 +/- 1.5 mmHg (range, 14-23) and 16.9 +/- 2.30 mmHg (range, 13-21), respectively. Latanoprost significantly lowered IOP in both groups (study group, p = 0.005; controls, p = 0.0019). The difference between post-treatment IOP was insignificant in both groups at each time point. The study group had fewer minor side effects than the control group (1/10 versus 6/10, respectively). Latanoprost treatment once-weekly was as effective, and bore fewer minor side effects, as once-daily treatment after 3 months of follow-up.
Journal of Ocular Pharmacology and Therapeutics 09/2004; 20(4):321-7. · 1.51 Impact Factor
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ABSTRACT: To evaluate the effect of brimonidine tartrate 0.2% ophthalmic solution on pupil size under scotopic and photopic luminance conditions in persons considering laser refractive surgery.
Ophthalmic Health Center, Tel Aviv, Israel.
The pupil size was measured in 36 eyes of 36 participants under scotopic and photopic conditions using the Colvard pupillometer (Oasis Medical) before and after brimonidine tartrate drops were administered. The pupil size was subsequently measured after 30 minutes and 4 and 6 hours.
No difference was found in pupil size before brimonidine tartrate instillation in eyes with light or dark irides. Before instillation, the mean photopic pupil size was 4.81 mm +/- 0.54 (SD) (range 4.0 to 6.0 mm). At 30 minutes, all pupils became miotic, with a mean size of 3.77 +/- 0.51 mm (range 3.0 to 5.0 mm) (P<.0001). After 6 hours, 27.8% of the pupils had returned to their previous size. Before brimonidine tartrate administration, the mean scotopic pupil size was 6.22 +/- 0.73 mm (range 5.0 to 8.0 mm). There was significant miosis to 4.57 +/- 0.84 mm (range 3.0 to 6.5 mm) (P<.0001) that continued for at least 6 hours. The miotic effect of brimonidine tartrate was stronger in eyes with light irides.
Brimonidine tartrate caused significant miosis, especially under scotopic conditions, most likely from its alpha-2 adrenergic effect. Under photopic luminance conditions, the miotic effect was pronounced.
Journal of Cataract [?] Refractive Surgery 08/2004; 30(8):1707-10. · 2.26 Impact Factor
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ABSTRACT: To determine whether topical latanoprost 0.005% had an effect on accommodative capacity after 1 month of treatment in young patients with ocular hypertension.
Fifteen patients (9 men and 6 women, aged 20-40 years) with ocular hypertension were instructed to instill the drug to their right eye for 1 month; the left eye received no medication and served as control. Near point of accommodation, refraction, and intraocular pressure (IOP) were determined after 1 month of treatment.
After 1 month of treatment with latanoprost, the mean IOP was reduced by 22.8% (5.8 mm Hg) in the treated eye and 1.86% (0.47 mm Hg) in the untreated control eye. No significant changes in refraction or near point of accommodation were observed in the treated or untreated eye.
Short-term treatment with latanoprost 0.005% does not effect refraction or accommodation in young patients with ocular hypertension.
Journal of Glaucoma 03/2003; 12(1):54-6. · 1.78 Impact Factor
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ABSTRACT: To determine the prevalence of hyperhomocystinemia in patients with pseudoexfoliation glaucoma.
This prospective study included 30 patients with glaucoma and 30 age-matched controls with no history of ocular disease who were undergoing routine physical checkups. Plasma homocysteine levels of all the study participants were determined using high-performance liquid chromatography, and values exceeding 15 micromol/L were considered elevated.
The mean plasma homocysteine level was 16.80 +/- 3.20 and 12.39 +/- 1.97 micromol/L in glaucoma patients and controls, respectively (P<0.0001). Fifteen glaucoma patients (50%) had hyperhomocystinemia compared with 3 controls (10%) (P=0.0015).
Hyperhomocystinemia may be associated with pseudoexfoliation glaucoma, which may partially explain the increased risk of vascular diseases among patients with pseudoexfoliation syndrome.
Journal of Glaucoma 02/2003; 12(1):36-9. · 1.78 Impact Factor
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ABSTRACT: To compare the accuracy and consistency of corneal flap thickness in the right and left eye created by three different widely used microkeratomes during consecutive laser in situ keratomileusis (LASIK).
Corneal thickness of 132 eyes of 66 patients was measured preoperatively and intraoperatively. Corneal flap thickness was calculated by subtracting the corneal stromal thickness from the total corneal thickness. Three different microkeratomes were used for creating the corneal flap: Chiron Automated Corneal Shaper (ACS), Baush and Lomb Surgical Hansatome, and Nidek MK 2000 microkeratomes. The same surgeon performed all procedures on the right eye first and then on the left eye using the same blade and the same surgical technique.
Mean corneal flap thickness created by the ACS (160-microm depth setting) microkeratome was 128.30 +/- 12.57 microm in the right eye and 122.96 +/- 13.30 microm in the left eye. The Hansatome (160-microm depth plate) microkeratome created a flap of mean 141.16 +/- 20.11 microm in the right eye and 120.95 +/- 26.95 microm in the left eye, and the Nidek MK 2000 (130-microm depth plate) microkeratome created a flap of 127.25 +/- 4.12 microm in the right eye and 127.54 +/- 3.7 microm in the left eye.
Corneal flap thickness tended to be considerably thinner than expected on both eyes using the ACS and Hansatome. With the ACS and Hansatome, the difference in corneal flap thickness between the first and second operated eye was statistically significant. With the Nidek MK 2000 microkeratome, there was no statistically significant difference between the first and second operated eye and measurements were close to desired corneal flap thickness. Intraoperative pachymetry is recommended for every LASIK procedure.
Journal of refractive surgery (Thorofare, N.J.: 1995) 18(3 Suppl):S347-51. · 2.54 Impact Factor
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ABSTRACT: To compare corneal flap thickness created in laser in situ keratomileusis (LASIK) in primary (right) and fellow (left) eyes (same blade for both eyes) using three microkeratomes.
The corneal thickness of 132 eyes (66 patients) was measured preoperatively and intraoperatively after flap creation. Corneal flap thickness was calculated by subtracting stromal bed thickness from total corneal thickness. Three microkeratomes were used: Nidek MK-2000, Bausch and Lomb Surgical Hansatome, and the Chiron Automated Corneal Shaper (ACS). Each patient had both corneas cut by one microkeratome and one blade at the same session.
Mean corneal flap thickness created in primary eyes was 128.30 +/- 12.57 microm (range 105 to 147 microm) for the ACS (160-microm plate and 8.5-mm ring) and 122.96 +/- 13.30 microm (range 86 to 140 microm) for fellow eyes; Hansatome (160-microm plate and 8.5-mm ring): 141.16 +/- 20.11 microm (range 101 to 169 microm) in primary eyes and 120.95 +/- 26.95 microm (range 107 to 151 microm) in fellow eyes; Nidek (130-microm plate and 8.5-mm ring): 127.25 +/- 4.12 microm (range 116 to 134 microm) in primary eyes and 127.54 +/- 3.7 microm (range 119 to 134 microm) in fellow eyes. The corneal flap in the ACS and Hansatome microkeratomes was always thicker in the primary than the fellow eye, using the same blade for both eyes. No significant difference was found using the Nidek microkeratome.
Corneal flap thickness tended to be thinner in fellow eyes than in primary eyes for the ACS and Hanstome microkeratomes. The Nidek microkeratome results were closer to specified corneal flap thickness than the ACS and Hanstome microkeratomes.
Journal of refractive surgery (Thorofare, N.J.: 1995) 20(5):417-21. · 2.54 Impact Factor
